Two Listeria monocytogenes vaccine vectors that express different molecular forms of human papilloma virus-16 (HPV-16) E7 induce qualitatively different T cell immunity that correlates with their ability to induce regression of established tumors immortalized by HPV-16

Journal of Immunology

Volumn 167, Issue 11, 2001, Pages 6471-6479

  Gunn, G R ^a   Zubair, A ^a   Peters, C ^a   Pan, Z K ^a   Wu, T C ^a   Paterson, Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMIUM 51; HYBRID PROTEIN; LISTERIOLYSIN; TUMOR VACCINE; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN E6; VIRUS PROTEIN E7;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOTHERAPY; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; T LYMPHOCYTE SUBPOPULATION; TUMOR REGRESSION; UTERINE CERVIX CANCER; WART VIRUS;

EID: 0035576230     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.11.6471     Document Type: Article

References (40)

1. Immortalization of primary rat cells by human papillomavirus type 16 subgenomic DNA fragments controlled by the SV40 promoter
2. The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells
3. * alleles and cervical cancer in British women
4. Population-based study of human papillomavirus infection and cervical neoplasia in rural Costa Rica
5. Seroresponses to human papillomavirus types 16, 18, 31, 33, and 45 virus-like particles in South African women with cervical cancer and cervical intraepithelial neoplasia
6. Differentiation-independent constitutive expression of the human papillomavirus type 16 E6 and E7 oncogenes in the CaSki cervical tumour cell line
7. The influence of immunologically committed lymphoid cells on macrophage activity in vivo
8. Role of listeriolysin O in cell-to-cell spread of Listeria monocytogenes
9. MHC class I antigen processing of Listeria monocytogenes proteins: Implications for dominant and subdominant CTL responses
10. Regression of established tumors in mice mediated by the oral administration of a recombinant Listeria monocytogenes vaccine
11. A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours
12. Regression of established B16F10 melanoma with a recombinant Listeria monocytogenes vaccine
13. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
14. The viral transcriptional regulatory region upstream of the E6 and E7 genes is a major determinant of the differential immortalization activities of human papillomavirus types 16 and 18
15. Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7
16. Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs
17. Antigen-specific immunotherapy for murine lung metastatic tumors expressing human papillomavirus type 16 E7 oncoprotein
18. Deliver of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes
19. Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge
20. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells
21. The tumor recall response of antitumor immunity primed by a live, recombinant Listeria monocytogenes vaccine comprises multiple effector mechanisms
22. + regulatory T cells induced by an agonist self-peptide
23. Thl. T cell responses to HIV-I Gag protein delivered by a Listeria monocytogenes vaccine are similar to those induced by endogenous listerial antigens
24. The MHC class I-restricted immune response to HIV-gag in BALB/c mice selects a single epitope that does not have a predictable MHC-binding motif and binds to Kd through interactions between a glutamine at P3 and pocket D
25. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
26. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
27. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
28. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody
29. A highly immunogenic tumor transfected with a murine transforming growth factor type βI cDNA escapes immune surveillance
30. Increased transforming growth factor β expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells
31. Cytotoxic T lymphocyte-associated antigen plays an essential role in the function of CD25(+)CD4(+) regulator, cells that control intestinal inflammation
32. Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope
33. Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes
34. The Listeria monocytogenes-secreted p60 protein is an N-end rule substrate in the cytosol of infected cells. Implications for major histocompatibility complex class I antigen processing of bacterial proteins
35. Murine listeriosis as a model of antimicrobial defense
36. Differential expression of Listeria monocytogenes virulence genes in mammalian host cells
37. + T cells requires tumor responsiveness to IFN-gamma
38. Immunotherapy of human cancer: Lessons from mice