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Volumn 70, Issue 10, 2010, Pages 4081-4091

In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; GENOMIC DNA; GLYCOPROTEIN E2; HISTONE H3; HISTONE H4; INTERFERON; MESSENGER RNA; PROTEIN E6; PROTEIN E7; PROTEIN P53; VIRUS DNA;

EID: 77952821748     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-3335     Document Type: Article
Times cited : (71)

References (50)
  • 2
    • 34547099574 scopus 로고    scopus 로고
    • Integration of high-risk human papillomavirus: A key event in cervical carcinogenesis?
    • Pett M, Coleman N. Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis? J Pathol 2007;212:356-367
    • (2007) J Pathol , vol.212 , pp. 356-367
    • Pett, M.1    Coleman, N.2
  • 3
    • 0033572319 scopus 로고    scopus 로고
    • Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes
    • Klaes R, Woerner SM, Ridder R, et al. Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 1999;59:6132-6136
    • (1999) Cancer Res , vol.59 , pp. 6132-6136
    • Klaes, R.1    Woerner, S.M.2    Ridder, R.3
  • 4
    • 0028122935 scopus 로고
    • Prevalence of deletions of YY1-binding sites in episomal HPV 16 DNA from cervical cancers
    • Dong XP, Stubenrauch F, Beyer-Finkler E, Pfister H. Prevalence of deletions of YY1-binding sites in episomal HPV 16 DNA from cervical cancers. Int J Cancer 1994;58:803-808
    • (1994) Int J Cancer , vol.58 , pp. 803-808
    • Dong, X.P.1    Stubenrauch, F.2    Beyer-Finkler, E.3    Pfister, H.4
  • 5
    • 0028324821 scopus 로고
    • The E6/E7 promoter of extrachromosomal HPV16 DNA in cervical cancers escapes from cellular repression by mutation of target sequences for YY1
    • May M, Dong XP, Beyer-Finkler E, Stubenrauch F, Fuchs PG, Pfister H. The E6/E7 promoter of extrachromosomal HPV16 DNA in cervical cancers escapes from cellular repression by mutation of target sequences for YY1. EMBO J 1994;13:1460-1466
    • (1994) EMBO J , vol.13 , pp. 1460-1466
    • May, M.1    Dong, X.P.2    Beyer-Finkler, E.3    Stubenrauch, F.4    Fuchs, P.G.5    Pfister, H.6
  • 6
    • 67650928010 scopus 로고    scopus 로고
    • Upstream regulatory region alterations found in human papillomavirus type 16 (HPV-16) isolates from cervical carcinomas increase transcription, ori function, and HPV immortalization capacity in culture
    • Lace MJ, Isacson C, Anson JR, et al. Upstream regulatory region alterations found in human papillomavirus type 16 (HPV-16) isolates from cervical carcinomas increase transcription, ori function, and HPV immortalization capacity in culture. J Virol 2009;83:7457-7466
    • (2009) J Virol , vol.83 , pp. 7457-7466
    • Lace, M.J.1    Isacson, C.2    Anson, J.R.3
  • 7
    • 0032929290 scopus 로고    scopus 로고
    • Functional significance of sequence variation in the E2 gene and the long control region of human papillomavirus type 16
    • Veress G, Szarka K, Dong XP, Gergely L, Pfister H. Functional significance of sequence variation in the E2 gene and the long control region of human papillomavirus type 16. J Gen Virol 1999;80:1035-1043
    • (1999) J Gen Virol , vol.80 , pp. 1035-1043
    • Veress, G.1    Szarka, K.2    Dong, X.P.3    Gergely, L.4    Pfister, H.5
  • 8
    • 0036895804 scopus 로고    scopus 로고
    • Changes in cervical keratinocyte gene expression associated with integration of human papillomavirus 16
    • Alazawi W, Pett M, Arch B, et al. Changes in cervical keratinocyte gene expression associated with integration of human papillomavirus 16. Cancer Res 2002;62:6959-6965
    • (2002) Cancer Res , vol.62 , pp. 6959-6965
    • Alazawi, W.1    Pett, M.2    Arch, B.3
  • 9
    • 54249105939 scopus 로고    scopus 로고
    • Characterization of naturally occurring HPV16 integration sites isolated from cervical keratinocytes under noncompetitive conditions
    • Dall KL, Scarpini CG, Roberts I, et al. Characterization of naturally occurring HPV16 integration sites isolated from cervical keratinocytes under noncompetitive conditions. Cancer Res 2008;68:8249-8259
    • (2008) Cancer Res , vol.68 , pp. 8249-8259
    • Dall, K.L.1    Scarpini, C.G.2    Roberts, I.3
  • 10
    • 33750440566 scopus 로고    scopus 로고
    • Interferon-β treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrants
    • Herdman MT, Pett MR, Roberts I, et al. Interferon-β treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrants. Carcinogenesis 2006;27:2341-2353
    • (2006) Carcinogenesis , vol.27 , pp. 2341-2353
    • Herdman, M.T.1    Pett, M.R.2    Roberts, I.3
  • 11
    • 34547114724 scopus 로고    scopus 로고
    • Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels
    • Muralidhar B, Goldstein LD, Ng G, et al. Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels. J Pathol 2007;212:368-377
    • (2007) J Pathol , vol.212 , pp. 368-377
    • Muralidhar, B.1    Goldstein, L.D.2    Ng, G.3
  • 12
    • 1242316161 scopus 로고    scopus 로고
    • Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes
    • Pett MR, Alazawi WO, Roberts I, et al. Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes. Cancer Res 2004;64:1359-1368
    • (2004) Cancer Res , vol.64 , pp. 1359-1368
    • Pett, M.R.1    Alazawi, W.O.2    Roberts, I.3
  • 13
    • 33644870575 scopus 로고    scopus 로고
    • Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response
    • Pett MR, Herdman MT, Palmer RD, et al. Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response. Proc Natl Acad Sci U S A 2006;103:3822-3827
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3822-3827
    • Pett, M.R.1    Herdman, M.T.2    Palmer, R.D.3
  • 14
    • 0024591199 scopus 로고
    • Properties of a non-tumorigenic human cervical keratinocyte cell line
    • Stanley MA, Browne HM, Appleby M, Minson AC. Properties of a non-tumorigenic human cervical keratinocyte cell line. Int J Cancer 1989;43:672-676
    • (1989) Int J Cancer , vol.43 , pp. 672-676
    • Stanley, M.A.1    Browne, H.M.2    Appleby, M.3    Minson, A.C.4
  • 16
    • 0642276749 scopus 로고    scopus 로고
    • Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer
    • Gonzalez MA, Pinder SE, Callagy G, et al. Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer. J Clin Oncol 2003;21:4306-4313
    • (2003) J Clin Oncol , vol.21 , pp. 4306-4313
    • Gonzalez, M.A.1    Pinder, S.E.2    Callagy, G.3
  • 17
    • 0027328650 scopus 로고
    • The dynamics of keratin expression in malignant transformation of cervical epithelium: A review
    • Smedts F, Ramaekers FC, Vooijs PG. The dynamics of keratin expression in malignant transformation of cervical epithelium: a review. Obstet Gynecol 1993;82:465.
    • (1993) Obstet Gynecol , vol.82 , pp. 465
    • Smedts, F.1    Ramaekers, F.C.2    Vooijs, P.G.3
  • 18
    • 0028927065 scopus 로고
    • The interaction between human papillomavirus type 16 E1 and E2 proteins is blocked by an antibody to the N-terminal region of E2
    • Hibma MH, Raj K, Ely SJ, Stanley M, Crawford L. The interaction between human papillomavirus type 16 E1 and E2 proteins is blocked by an antibody to the N-terminal region of E2. Eur J Biochem 1995;229:517-525
    • (1995) Eur J Biochem , vol.229 , pp. 517-525
    • Hibma, M.H.1    Raj, K.2    Ely, S.J.3    Stanley, M.4    Crawford, L.5
  • 19
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M, McDonald LE, Millar DS, et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A 1992;89:1827-1831
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3
  • 20
    • 0036856355 scopus 로고    scopus 로고
    • MethPrimer: Designing primers for methylation PCRs
    • Li LC, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002;18:1427-1431
    • (2002) Bioinformatics , vol.18 , pp. 1427-1431
    • Li, L.C.1    Dahiya, R.2
  • 21
    • 0034812860 scopus 로고    scopus 로고
    • Differentiation-dependent chromatin rearrangement coincides with activation of human papillomavirus type 31 late gene expression
    • del Mar Pena LM, Laimins LA. Differentiation-dependent chromatin rearrangement coincides with activation of human papillomavirus type 31 late gene expression. J Virol 2001;75:10005-10013
    • (2001) J Virol , vol.75 , pp. 10005-10013
    • Del Mar Pena, L.M.1    Laimins, L.A.2
  • 22
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 2007;26:5541-5552
    • (2007) Oncogene , vol.26 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 23
    • 33644750203 scopus 로고    scopus 로고
    • Effects of histone deacetylase inhibitor (HDACi); trichostatin-A (TSA) on the expression of housekeeping genes
    • Mogal A, Abdulkadir SA. Effects of histone deacetylase inhibitor (HDACi); trichostatin-A (TSA) on the expression of housekeeping genes. Mol Cell Probes 2006;20:81-86
    • (2006) Mol Cell Probes , vol.20 , pp. 81-86
    • Mogal, A.1    Abdulkadir, S.A.2
  • 24
    • 42649098257 scopus 로고    scopus 로고
    • Regulation of human papillomavirus type 31 gene expression during the differentiation-dependent life cycle through histone modifications and transcription factor binding
    • Wooldridge TR, Laimins LA. Regulation of human papillomavirus type 31 gene expression during the differentiation-dependent life cycle through histone modifications and transcription factor binding. Virology 2008;374:371-380
    • (2008) Virology , vol.374 , pp. 371-380
    • Wooldridge, T.R.1    Laimins, L.A.2
  • 26
    • 0025262180 scopus 로고
    • In vitro differentiation of epithelial cells from cervical neoplasias resembles in vivo lesions
    • Rader JS, Golub TR, Hudson JB, Patel D, Bedell MA, Laimins LA. In vitro differentiation of epithelial cells from cervical neoplasias resembles in vivo lesions. Oncogene 1990;5:571-576
    • (1990) Oncogene , vol.5 , pp. 571-576
    • Rader, J.S.1    Golub, T.R.2    Hudson, J.B.3    Patel, D.4    Bedell, M.A.5    Laimins, L.A.6
  • 27
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-1136
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 29
    • 0028937867 scopus 로고
    • Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells
    • Jeon S, Allen-Hoffmann BL, Lambert PF. Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells. J Virol 1995;69:2989-2997
    • (1995) J Virol , vol.69 , pp. 2989-2997
    • Jeon, S.1    Allen-Hoffmann, B.L.2    Lambert, P.F.3
  • 30
    • 0038365277 scopus 로고    scopus 로고
    • CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: Genomic hypomethylation correlates with carcinogenic progression
    • Badal V, Chuang LS, Tan EH, et al. CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression. J Virol 2003;77:6227-6234
    • (2003) J Virol , vol.77 , pp. 6227-6234
    • Badal, V.1    Chuang, L.S.2    Tan, E.H.3
  • 31
    • 4644332773 scopus 로고    scopus 로고
    • Clonal selection for transcriptionally active viral oncogenes during progression to cancer
    • Van Tine BA, Kappes JC, Banerjee NS, et al. Clonal selection for transcriptionally active viral oncogenes during progression to cancer. J Virol 2004;78:11172-11186
    • (2004) J Virol , vol.78 , pp. 11172-11186
    • Van Tine, B.A.1    Kappes, J.C.2    Banerjee, N.S.3
  • 32
    • 0037302447 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA
    • Bechtold V, Beard P, Raj K. Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA. J Virol 2003;77:2021-2028
    • (2003) J Virol , vol.77 , pp. 2021-2028
    • Bechtold, V.1    Beard, P.2    Raj, K.3
  • 33
    • 0036939240 scopus 로고    scopus 로고
    • Growth arrest of HPV-positive cells after histone deacetylase inhibition is independent of E6/E7 oncogene expression
    • Finzer P, Ventz R, Kuntzen C, Seibert N, Soto U, Rosl F. Growth arrest of HPV-positive cells after histone deacetylase inhibition is independent of E6/E7 oncogene expression. Virology 2002;304:265-273
    • (2002) Virology , vol.304 , pp. 265-273
    • Finzer, P.1    Ventz, R.2    Kuntzen, C.3    Seibert, N.4    Soto, U.5    Rosl, F.6
  • 34
    • 0033040350 scopus 로고    scopus 로고
    • Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes
    • Zhao W, Noya F, Chen WY, Townes TM, Chow LT, Broker TR. Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes. J Virol 1999;73:5026-5033
    • (1999) J Virol , vol.73 , pp. 5026-5033
    • Zhao, W.1    Noya, F.2    Chen, W.Y.3    Townes, T.M.4    Chow, L.T.5    Broker, T.R.6
  • 35
    • 0023809597 scopus 로고
    • Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells
    • von Knebel Doeberitz M, Oltersdorf T, Schwarz E, Gissmann L. Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells. Cancer Res 1988;48:3780-3786
    • (1988) Cancer Res , vol.48 , pp. 3780-3786
    • Von Knebel Doeberitz, M.1    Oltersdorf, T.2    Schwarz, E.3    Gissmann, L.4
  • 36
    • 0028147144 scopus 로고
    • The human papillomavirus type 16 E5 gene cooperates with the E7 gene to stimulate proliferation of primary cells and increases viral gene expression
    • Bouvard V, Matlashewski G, Gu ZM, Storey A, Banks L. The human papillomavirus type 16 E5 gene cooperates with the E7 gene to stimulate proliferation of primary cells and increases viral gene expression. Virology 1994;203:73-80.
    • (1994) Virology , vol.203 , pp. 73-80
    • Bouvard, V.1    Matlashewski, G.2    Gu, Z.M.3    Storey, A.4    Banks, L.5
  • 37
    • 40449129515 scopus 로고    scopus 로고
    • Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts
    • Hafner N, Driesch C, Gajda M, et al. Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts. Oncogene 2008;27:1610-1617
    • (2008) Oncogene , vol.27 , pp. 1610-1617
    • Hafner, N.1    Driesch, C.2    Gajda, M.3
  • 39
    • 0038032792 scopus 로고    scopus 로고
    • RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells
    • Hall AH, Alexander KA. RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. J Virol 2003;77:6066-6069
    • (2003) J Virol , vol.77 , pp. 6066-6069
    • Hall, A.H.1    Alexander, K.A.2
  • 40
    • 0036334198 scopus 로고    scopus 로고
    • Long-term effect of interferon on keratinocytes that maintain human papillomavirus type 31
    • Chang YE, Pena L, Sen GC, Park JK, Laimins LA. Long-term effect of interferon on keratinocytes that maintain human papillomavirus type 31. J Virol 2002;76:8864-8874
    • (2002) J Virol , vol.76 , pp. 8864-8874
    • Chang, Y.E.1    Pena, L.2    Sen, G.C.3    Park, J.K.4    Laimins, L.A.5
  • 41
    • 6344253201 scopus 로고    scopus 로고
    • Mechanisms of human papillomavirus-induced oncogenesis
    • Munger K, Baldwin A, Edwards KM, et al. Mechanisms of human papillomavirus-induced oncogenesis. J Virol 2004;78:11451-11460
    • (2004) J Virol , vol.78 , pp. 11451-11460
    • Munger, K.1    Baldwin, A.2    Edwards, K.M.3
  • 42
    • 0032128003 scopus 로고    scopus 로고
    • Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity
    • Ronco LV, Karpova AY, Vidal M, Howley PM. Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. Genes Dev 1998;12:2061-2072
    • (1998) Genes Dev , vol.12 , pp. 2061-2072
    • Ronco, L.V.1    Karpova, A.Y.2    Vidal, M.3    Howley, P.M.4
  • 43
    • 55249105739 scopus 로고    scopus 로고
    • The E8-E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes
    • Lace MJ, Anson JR, Thomas GS, Turek LP, Haugen TH. The E8-E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes. J Virol 2008;82:10841-10853
    • (2008) J Virol , vol.82 , pp. 10841-10853
    • Lace, M.J.1    Anson, J.R.2    Thomas, G.S.3    Turek, L.P.4    Haugen, T.H.5
  • 44
    • 0034614650 scopus 로고    scopus 로고
    • The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway
    • Webster K, Parish J, Pandya M, Stern PL, Clarke AR, Gaston K. The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. J Biol Chem 2000;275:87-94.
    • (2000) J Biol Chem , vol.275 , pp. 87-94
    • Webster, K.1    Parish, J.2    Pandya, M.3    Stern, P.L.4    Clarke, A.R.5    Gaston, K.6
  • 45
    • 0033619108 scopus 로고    scopus 로고
    • Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line
    • Flores ER, Allen-Hoffmann BL, Lee D, Sattler CA, Lambert PF. Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line. Virology 1999;262:344-354
    • (1999) Virology , vol.262 , pp. 344-354
    • Flores, E.R.1    Allen-Hoffmann, B.L.2    Lee, D.3    Sattler, C.A.4    Lambert, P.F.5
  • 46
    • 1242319286 scopus 로고    scopus 로고
    • Propagation of infectious human papillomavirus type 16 by using an adenovirus and Cre/LoxP mechanism
    • Lee JH, Yi SM, Anderson ME, et al. Propagation of infectious human papillomavirus type 16 by using an adenovirus and Cre/LoxP mechanism. Proc Natl Acad Sci U S A 2004;101:2094-2099
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2094-2099
    • Lee, J.H.1    Yi, S.M.2    Anderson, M.E.3
  • 47
    • 0036402419 scopus 로고    scopus 로고
    • Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomes
    • Sprague DL, Phillips SL, Mitchell CJ, et al. Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomes. Virology 2002;301:247-254
    • (2002) Virology , vol.301 , pp. 247-254
    • Sprague, D.L.1    Phillips, S.L.2    Mitchell, C.J.3
  • 48
    • 0025820471 scopus 로고
    • Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation
    • Bedell MA, Hudson JB, Golub TR, et al. Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation. J Virol 1991;65:2254-2260
    • (1991) J Virol , vol.65 , pp. 2254-2260
    • Bedell, M.A.1    Hudson, J.B.2    Golub, T.R.3
  • 49
    • 0029863784 scopus 로고    scopus 로고
    • In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression
    • Frattini MG, Lim HB, Laimins LA. In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression. Proc Natl Acad Sci U S A 1996;93:3062-3067
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 3062-3067
    • Frattini, M.G.1    Lim, H.B.2    Laimins, L.A.3
  • 50
    • 39149114758 scopus 로고    scopus 로고
    • Type-dependent integration frequency of human papillomavirus genomes in cervical lesions
    • Vinokurova S, Wentzensen N, Kraus I, et al. Type-dependent integration frequency of human papillomavirus genomes in cervical lesions. Cancer Res 2008;68:307-313
    • (2008) Cancer Res , vol.68 , pp. 307-313
    • Vinokurova, S.1    Wentzensen, N.2    Kraus, I.3


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