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Volumn 39, Issue 5, 2016, Pages 325-339

Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?

Author keywords

Conversion; Multiple sclerosis; Neurodegeneration; Progression; Secondary progressive; Senescence

Indexed keywords

CARRIER PROTEIN; GADOLINIUM; INTERFERON; NEUROTRANSMITTER; REACTIVE OXYGEN METABOLITE;

EID: 84961147904     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2016.02.001     Document Type: Review
Times cited : (82)

References (140)
  • 1
    • 77954382272 scopus 로고    scopus 로고
    • Evidence for a two-stage disability progression in multiple sclerosis
    • Leray E., et al. Evidence for a two-stage disability progression in multiple sclerosis. Brain 2010, 133:1900-1913.
    • (2010) Brain , vol.133 , pp. 1900-1913
    • Leray, E.1
  • 2
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin F.D., Reingold S.C. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996, 46:907-911.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 3
    • 84956576994 scopus 로고    scopus 로고
    • Cognitive impairment in a population-based study of patients with multiple sclerosis: differences between late relapsing-remitting, secondary progressive and primary progressive multiple sclerosis
    • Planche V., et al. Cognitive impairment in a population-based study of patients with multiple sclerosis: differences between late relapsing-remitting, secondary progressive and primary progressive multiple sclerosis. Eur. J. Neurol. 2016, 23:282-289.
    • (2016) Eur. J. Neurol. , vol.23 , pp. 282-289
    • Planche, V.1
  • 4
    • 84873694378 scopus 로고    scopus 로고
    • Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis
    • Tutuncu M., et al. Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis. Mult. Scler. 2013, 19:188-198.
    • (2013) Mult. Scler. , vol.19 , pp. 188-198
    • Tutuncu, M.1
  • 5
    • 84925936255 scopus 로고    scopus 로고
    • Relapses and disability accumulation in progressive multiple sclerosis
    • Paz Soldan M.M., et al. Relapses and disability accumulation in progressive multiple sclerosis. Neurology 2015, 84:81-88.
    • (2015) Neurology , vol.84 , pp. 81-88
    • Paz Soldan, M.M.1
  • 6
    • 84890350507 scopus 로고    scopus 로고
    • Identification of inflammatory neuronal injury and prevention of neuronal damage in multiple sclerosis: hope for novel therapies?
    • Zipp F., et al. Identification of inflammatory neuronal injury and prevention of neuronal damage in multiple sclerosis: hope for novel therapies?. JAMA Neurol. 2013, 70:1569-1574.
    • (2013) JAMA Neurol. , vol.70 , pp. 1569-1574
    • Zipp, F.1
  • 7
    • 77954364428 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability
    • Scalfari A., et al. The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability. Brain 2010, 133:1914-1929.
    • (2010) Brain , vol.133 , pp. 1914-1929
    • Scalfari, A.1
  • 8
    • 73449141779 scopus 로고    scopus 로고
    • Impact of multiple sclerosis relapses on progression diminishes with time
    • Tremlett H., et al. Impact of multiple sclerosis relapses on progression diminishes with time. Neurology 2009, 73:1616-1623.
    • (2009) Neurology , vol.73 , pp. 1616-1623
    • Tremlett, H.1
  • 9
    • 3242748913 scopus 로고    scopus 로고
    • Differences in cognitive impairment of relapsing remitting, secondary, and primary progressive MS
    • Huijbregts S.C., et al. Differences in cognitive impairment of relapsing remitting, secondary, and primary progressive MS. Neurology 2004, 63:335-339.
    • (2004) Neurology , vol.63 , pp. 335-339
    • Huijbregts, S.C.1
  • 10
    • 84922522615 scopus 로고    scopus 로고
    • Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives
    • Ontaneda D., et al. Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives. Lancet Neurol. 2015, 14:208-223.
    • (2015) Lancet Neurol. , vol.14 , pp. 208-223
    • Ontaneda, D.1
  • 11
    • 84903318797 scopus 로고    scopus 로고
    • Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial
    • Chataway J., et al. Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial. Lancet 2014, 383:2213-2221.
    • (2014) Lancet , vol.383 , pp. 2213-2221
    • Chataway, J.1
  • 12
    • 84925057313 scopus 로고    scopus 로고
    • High doses of biotin in chronic progressive multiple sclerosis: a pilot study
    • Sedel F., et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. Mult. Scler. Relat. Disord. 2015, 4:159-169.
    • (2015) Mult. Scler. Relat. Disord. , vol.4 , pp. 159-169
    • Sedel, F.1
  • 13
    • 84928046797 scopus 로고    scopus 로고
    • Effectiveness and cost-effectiveness of interferon beta and glatiramer acetate in the UK Multiple Sclerosis Risk Sharing Scheme at 6 years: a clinical cohort study with natural history comparator
    • Palace J., et al. Effectiveness and cost-effectiveness of interferon beta and glatiramer acetate in the UK Multiple Sclerosis Risk Sharing Scheme at 6 years: a clinical cohort study with natural history comparator. Lancet Neurol. 2015, 14:497-505.
    • (2015) Lancet Neurol. , vol.14 , pp. 497-505
    • Palace, J.1
  • 14
    • 84896765960 scopus 로고    scopus 로고
    • Vitamin D as an early predictor of multiple sclerosis activity and progression
    • Ascherio A., et al. Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol. 2014, 71:306-314.
    • (2014) JAMA Neurol. , vol.71 , pp. 306-314
    • Ascherio, A.1
  • 15
    • 84944069641 scopus 로고    scopus 로고
    • Effect of smoking cessation on multiple sclerosis prognosis
    • Ramanujam R., et al. Effect of smoking cessation on multiple sclerosis prognosis. JAMA Neurol. 2015, 72:1117-1123.
    • (2015) JAMA Neurol. , vol.72 , pp. 1117-1123
    • Ramanujam, R.1
  • 16
    • 84874074752 scopus 로고    scopus 로고
    • Early relapses, onset of progression, and late outcome in multiple sclerosis
    • Scalfari A., et al. Early relapses, onset of progression, and late outcome in multiple sclerosis. JAMA Neurol. 2013, 70:214-222.
    • (2013) JAMA Neurol. , vol.70 , pp. 214-222
    • Scalfari, A.1
  • 17
    • 0037441370 scopus 로고    scopus 로고
    • Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis
    • Vukusic S., Confavreux C. Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis. J. Neurol. Sci. 2003, 206:135-137.
    • (2003) J. Neurol. Sci. , vol.206 , pp. 135-137
    • Vukusic, S.1    Confavreux, C.2
  • 18
    • 84929834621 scopus 로고    scopus 로고
    • The outcome spectrum of multiple sclerosis: disability, mortality, and a cluster of predictors from onset
    • Tedeholm H., et al. The outcome spectrum of multiple sclerosis: disability, mortality, and a cluster of predictors from onset. J. Neurol. 2015, 262:1148-1163.
    • (2015) J. Neurol. , vol.262 , pp. 1148-1163
    • Tedeholm, H.1
  • 19
    • 67349107233 scopus 로고    scopus 로고
    • HLA-DRB115 and cerebrospinal-fluid-specific oligoclonal immunoglobulin G bands lower age at attainment of important disease milestones in multiple sclerosis
    • Imrell K., et al. HLA-DRB115 and cerebrospinal-fluid-specific oligoclonal immunoglobulin G bands lower age at attainment of important disease milestones in multiple sclerosis. J. Neuroimmunol. 2009, 210:128-130.
    • (2009) J. Neuroimmunol. , vol.210 , pp. 128-130
    • Imrell, K.1
  • 20
    • 33749830743 scopus 로고    scopus 로고
    • Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis
    • Rinker J.R., et al. Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis. Neurology 2006, 67:1288-1290.
    • (2006) Neurology , vol.67 , pp. 1288-1290
    • Rinker, J.R.1
  • 21
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium (IMSGC), et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat. Genet. 2013, 45:1353-1360.
    • (2013) Nat. Genet. , vol.45 , pp. 1353-1360
  • 22
    • 77954674602 scopus 로고    scopus 로고
    • Does MRI lesion activity regress in secondary progressive multiple sclerosis?
    • Zhao Y., et al. Does MRI lesion activity regress in secondary progressive multiple sclerosis?. Mult. Scler. 2010, 16:434-442.
    • (2010) Mult. Scler. , vol.16 , pp. 434-442
    • Zhao, Y.1
  • 23
    • 84883308394 scopus 로고    scopus 로고
    • The changing clinical course of multiple sclerosis: a matter of gray matter
    • Calabrese M., et al. The changing clinical course of multiple sclerosis: a matter of gray matter. Ann. Neurol. 2013, 74:76-83.
    • (2013) Ann. Neurol. , vol.74 , pp. 76-83
    • Calabrese, M.1
  • 24
    • 54849431166 scopus 로고    scopus 로고
    • Gray matter atrophy in multiple sclerosis: a longitudinal study
    • Fisher E., et al. Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann. Neurol. 2008, 64:255-265.
    • (2008) Ann. Neurol. , vol.64 , pp. 255-265
    • Fisher, E.1
  • 25
    • 39749200152 scopus 로고    scopus 로고
    • Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis
    • Fisniku L.K., et al. Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain 2008, 131:808-817.
    • (2008) Brain , vol.131 , pp. 808-817
    • Fisniku, L.K.1
  • 26
    • 84891832014 scopus 로고    scopus 로고
    • Onset of secondary progressive phase and long-term evolution of multiple sclerosis
    • Scalfari A., et al. Onset of secondary progressive phase and long-term evolution of multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 2014, 85:67-75.
    • (2014) J. Neurol. Neurosurg. Psychiatry , vol.85 , pp. 67-75
    • Scalfari, A.1
  • 27
    • 84945133122 scopus 로고    scopus 로고
    • Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque
    • Frischer J.M., et al. Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque. Ann. Neurol. 2015, 78:710-721.
    • (2015) Ann. Neurol. , vol.78 , pp. 710-721
    • Frischer, J.M.1
  • 28
    • 84867093390 scopus 로고    scopus 로고
    • T cell recruitment in the brain during normal aging
    • Gemechu J.M., Bentivoglio M. T cell recruitment in the brain during normal aging. Front. Cell Neurosci. 2012, 6:38.
    • (2012) Front. Cell Neurosci. , vol.6 , pp. 38
    • Gemechu, J.M.1    Bentivoglio, M.2
  • 29
    • 84901650432 scopus 로고    scopus 로고
    • T cells and their cytokines in persistent stimulation of the immune system
    • Kared H., et al. T cells and their cytokines in persistent stimulation of the immune system. Curr. Opin. Immunol. 2014, 29:79-85.
    • (2014) Curr. Opin. Immunol. , vol.29 , pp. 79-85
    • Kared, H.1
  • 30
    • 84864380170 scopus 로고    scopus 로고
    • - T cells in immune disorders
    • - T cells in immune disorders. Trends Mol. Med. 2012, 18:446-453.
    • (2012) Trends Mol. Med. , vol.18 , pp. 446-453
    • Broux, B.1
  • 31
    • 25444527944 scopus 로고    scopus 로고
    • Premature immunosenescence in rheumatoid arthritis and multiple sclerosis patients
    • Thewissen M., et al. Premature immunosenescence in rheumatoid arthritis and multiple sclerosis patients. Ann. N. Y. Acad. Sci. 2005, 1051:255-262.
    • (2005) Ann. N. Y. Acad. Sci. , vol.1051 , pp. 255-262
    • Thewissen, M.1
  • 32
    • 34247108103 scopus 로고    scopus 로고
    • Analyses of immunosenescent markers in patients with autoimmune disease
    • Thewissen M., et al. Analyses of immunosenescent markers in patients with autoimmune disease. Clin. Immunol. 2007, 123:209-218.
    • (2007) Clin. Immunol. , vol.123 , pp. 209-218
    • Thewissen, M.1
  • 33
    • 0034773579 scopus 로고    scopus 로고
    • - costimulation-independent T cells in multiple sclerosis
    • - costimulation-independent T cells in multiple sclerosis. J. Clin. Invest. 2001, 108:1185-1194.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1185-1194
    • Markovic-Plese, S.1
  • 34
    • 0032519421 scopus 로고    scopus 로고
    • Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells
    • Lovett-Racke A.E., et al. Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells. J. Clin. Invest. 1998, 101:725-730.
    • (1998) J. Clin. Invest. , vol.101 , pp. 725-730
    • Lovett-Racke, A.E.1
  • 35
    • 58149359339 scopus 로고    scopus 로고
    • - T cells producing high levels of interferon-γ in peripheral blood of patients with multiple sclerosis
    • - T cells producing high levels of interferon-γ in peripheral blood of patients with multiple sclerosis. Mult. Scler. 2008, 14:1044-1055.
    • (2008) Mult. Scler. , vol.14 , pp. 1044-1055
    • Miyazaki, Y.1
  • 36
    • 0031892792 scopus 로고    scopus 로고
    • Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation
    • Scholz C., et al. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J. Immunol. 1998, 160:1532-1538.
    • (1998) J. Immunol. , vol.160 , pp. 1532-1538
    • Scholz, C.1
  • 37
    • 84856650320 scopus 로고    scopus 로고
    • - T cells into the brain of multiple sclerosis patients
    • - T cells into the brain of multiple sclerosis patients. J. Autoimmun. 2012, 38:10-19.
    • (2012) J. Autoimmun. , vol.38 , pp. 10-19
    • Broux, B.1
  • 38
    • 38449099960 scopus 로고    scopus 로고
    • null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation
    • null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation. J. Immunol. 2007, 179:6514-6523.
    • (2007) J. Immunol. , vol.179 , pp. 6514-6523
    • Thewissen, M.1
  • 39
    • 84908022527 scopus 로고    scopus 로고
    • IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: current and future developments
    • Luchtman D.W., et al. IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: current and future developments. Cytokine Growth Factor Rev. 2014, 25:403-413.
    • (2014) Cytokine Growth Factor Rev. , vol.25 , pp. 403-413
    • Luchtman, D.W.1
  • 40
    • 78649960164 scopus 로고    scopus 로고
    • Potentiation of Th17 cytokines in aging process contributes to the development of colitis
    • Ouyang X., et al. Potentiation of Th17 cytokines in aging process contributes to the development of colitis. Cell Immunol. 2011, 266:208-217.
    • (2011) Cell Immunol. , vol.266 , pp. 208-217
    • Ouyang, X.1
  • 41
    • 46749093740 scopus 로고    scopus 로고
    • Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines
    • Huang M.C., et al. Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J. 2008, 22:2142-2150.
    • (2008) FASEB J. , vol.22 , pp. 2142-2150
    • Huang, M.C.1
  • 42
    • 1842732224 scopus 로고    scopus 로고
    • + regulatory T cells in patients with multiple sclerosis
    • + regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 2004, 199:971-979.
    • (2004) J. Exp. Med. , vol.199 , pp. 971-979
    • Viglietta, V.1
  • 43
    • 84860887914 scopus 로고    scopus 로고
    • Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells
    • Sun L., et al. Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells. Aging Cell 2012, 11:509-519.
    • (2012) Aging Cell , vol.11 , pp. 509-519
    • Sun, L.1
  • 44
    • 84896501298 scopus 로고    scopus 로고
    • Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans
    • Wertheimer A.M., et al. Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J. Immunol. 2014, 192:2143-2155.
    • (2014) J. Immunol. , vol.192 , pp. 2143-2155
    • Wertheimer, A.M.1
  • 45
    • 84884136543 scopus 로고    scopus 로고
    • A comparative review of aging and B cell function in mice and humans
    • Scholz J.L., et al. A comparative review of aging and B cell function in mice and humans. Curr. Opin. Immunol. 2013, 25:504-510.
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 504-510
    • Scholz, J.L.1
  • 46
    • 66549130329 scopus 로고    scopus 로고
    • The relation between inflammation and neurodegeneration in multiple sclerosis brains
    • Frischer J.M., et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 2009, 132:1175-1189.
    • (2009) Brain , vol.132 , pp. 1175-1189
    • Frischer, J.M.1
  • 47
    • 84931318891 scopus 로고    scopus 로고
    • Innate immune memory: a paradigm shift in understanding host defense
    • Netea M.G., et al. Innate immune memory: a paradigm shift in understanding host defense. Nat. Immunol. 2015, 16:675-679.
    • (2015) Nat. Immunol. , vol.16 , pp. 675-679
    • Netea, M.G.1
  • 48
    • 84955409052 scopus 로고    scopus 로고
    • From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation
    • Fulop T., et al. From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation. Biogerontology 2016, 17:147-157.
    • (2016) Biogerontology , vol.17 , pp. 147-157
    • Fulop, T.1
  • 49
    • 84890453940 scopus 로고    scopus 로고
    • Aging enhances release of exosomal cytokine mRNAs by Abeta1-42-stimulated macrophages
    • Mitsuhashi M., et al. Aging enhances release of exosomal cytokine mRNAs by Abeta1-42-stimulated macrophages. FASEB J. 2013, 27:5141-5150.
    • (2013) FASEB J. , vol.27 , pp. 5141-5150
    • Mitsuhashi, M.1
  • 50
    • 84903156812 scopus 로고    scopus 로고
    • Comparison of chosen activation markers of human monocytes/macrophages isolated from the peripheral blood of young and elderly volunteers
    • Suchy D., et al. Comparison of chosen activation markers of human monocytes/macrophages isolated from the peripheral blood of young and elderly volunteers. Pharmacol. Rep. 2014, 66:759-765.
    • (2014) Pharmacol. Rep. , vol.66 , pp. 759-765
    • Suchy, D.1
  • 51
    • 77957803871 scopus 로고    scopus 로고
    • Human NK cells display major phenotypic and functional changes over the life span
    • Le Garff-Tavernier M., et al. Human NK cells display major phenotypic and functional changes over the life span. Aging Cell 2010, 9:527-535.
    • (2010) Aging Cell , vol.9 , pp. 527-535
    • Le Garff-Tavernier, M.1
  • 52
    • 33746001386 scopus 로고    scopus 로고
    • Cytokine-induced activation of glial cells in the mouse brain is enhanced at an advanced age
    • Deng X.H., et al. Cytokine-induced activation of glial cells in the mouse brain is enhanced at an advanced age. Neuroscience 2006, 141:645-661.
    • (2006) Neuroscience , vol.141 , pp. 645-661
    • Deng, X.H.1
  • 53
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: too much or too little?
    • Lucin K.M., Wyss-Coray T. Immune activation in brain aging and neurodegeneration: too much or too little?. Neuron 2009, 64:110-122.
    • (2009) Neuron , vol.64 , pp. 110-122
    • Lucin, K.M.1    Wyss-Coray, T.2
  • 54
    • 84936129121 scopus 로고    scopus 로고
    • Microglial cell dysregulation in brain aging and neurodegeneration
    • von Bernhardi R., et al. Microglial cell dysregulation in brain aging and neurodegeneration. Front. Aging Neurosci. 2015, 7:124.
    • (2015) Front. Aging Neurosci. , vol.7 , pp. 124
    • von Bernhardi, R.1
  • 55
    • 0344742225 scopus 로고    scopus 로고
    • Inflammation is detrimental for neurogenesis in adult brain
    • Ekdahl C.T., et al. Inflammation is detrimental for neurogenesis in adult brain. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:13632-13637.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 13632-13637
    • Ekdahl, C.T.1
  • 56
    • 76649123575 scopus 로고    scopus 로고
    • CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosis
    • Liu Y., et al. CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosis. J. Neurosci. 2010, 30:2025-3208.
    • (2010) J. Neurosci. , vol.30 , pp. 2025-3208
    • Liu, Y.1
  • 57
    • 34547680192 scopus 로고    scopus 로고
    • CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4
    • Lyons A., et al. CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4. J. Neurosci. 2007, 27:8309-8313.
    • (2007) J. Neurosci. , vol.27 , pp. 8309-8313
    • Lyons, A.1
  • 58
    • 84865199264 scopus 로고    scopus 로고
    • Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study
    • Cribbs D.H., et al. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J. Neuroinflammation 2012, 9:179.
    • (2012) J. Neuroinflammation , vol.9 , pp. 179
    • Cribbs, D.H.1
  • 59
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • Lu T., et al. Gene regulation and DNA damage in the ageing human brain. Nature 2004, 429:883-891.
    • (2004) Nature , vol.429 , pp. 883-891
    • Lu, T.1
  • 60
    • 84922485376 scopus 로고    scopus 로고
    • Pathological mechanisms in progressive multiple sclerosis
    • Mahad D.H., et al. Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol. 2015, 14:183-193.
    • (2015) Lancet Neurol. , vol.14 , pp. 183-193
    • Mahad, D.H.1
  • 61
    • 84892915145 scopus 로고    scopus 로고
    • Iron and neurodegeneration in the multiple sclerosis brain
    • Hametner S., et al. Iron and neurodegeneration in the multiple sclerosis brain. Ann. Neurol. 2013, 74:848-861.
    • (2013) Ann. Neurol. , vol.74 , pp. 848-861
    • Hametner, S.1
  • 62
    • 84878828439 scopus 로고    scopus 로고
    • Disease-specific molecular events in cortical multiple sclerosis lesions
    • Fischer M.T., et al. Disease-specific molecular events in cortical multiple sclerosis lesions. Brain 2013, 136:1799-1815.
    • (2013) Brain , vol.136 , pp. 1799-1815
    • Fischer, M.T.1
  • 63
    • 84878864199 scopus 로고    scopus 로고
    • The hallmarks of aging
    • Lopez-Otin C., et al. The hallmarks of aging. Cell 2013, 153:1194-1217.
    • (2013) Cell , vol.153 , pp. 1194-1217
    • Lopez-Otin, C.1
  • 64
    • 84924760978 scopus 로고    scopus 로고
    • The central role of mitochondria in axonal degeneration in multiple sclerosis
    • Campbell G.R., et al. The central role of mitochondria in axonal degeneration in multiple sclerosis. Mult. Scler. 2014, 20:1806-1813.
    • (2014) Mult. Scler. , vol.20 , pp. 1806-1813
    • Campbell, G.R.1
  • 65
    • 80053458900 scopus 로고    scopus 로고
    • Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases
    • Grammas P., et al. Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases. Expert Rev. Mol. Med. 2011, 13:e19.
    • (2011) Expert Rev. Mol. Med. , vol.13 , pp. e19
    • Grammas, P.1
  • 66
    • 34547749000 scopus 로고    scopus 로고
    • Inflammatory processes in the aging mouse brain: participation of dendritic cells and T-cells
    • Stichel C.C., Luebbert H. Inflammatory processes in the aging mouse brain: participation of dendritic cells and T-cells. Neurobiol. Aging 2007, 28:1507-1521.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1507-1521
    • Stichel, C.C.1    Luebbert, H.2
  • 67
    • 84928748740 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment
    • Elahy M., et al. Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment. Immun. Ageing 2015, 12:2.
    • (2015) Immun. Ageing , vol.12 , pp. 2
    • Elahy, M.1
  • 68
    • 84888152974 scopus 로고    scopus 로고
    • Normal-appearing white matter permeability distinguishes poor cognitive performance in processing speed and working memory
    • Eilaghi A., et al. Normal-appearing white matter permeability distinguishes poor cognitive performance in processing speed and working memory. AJNR Am. J. Neuroradiol. 2013, 34:2119-2124.
    • (2013) AJNR Am. J. Neuroradiol. , vol.34 , pp. 2119-2124
    • Eilaghi, A.1
  • 69
    • 84961726935 scopus 로고    scopus 로고
    • Multi-parametric structural magnetic resonance imaging in relation to cognitive dysfunction in long-standing multiple sclerosis
    • Published online July 24, 2105
    • Daams M., et al. Multi-parametric structural magnetic resonance imaging in relation to cognitive dysfunction in long-standing multiple sclerosis. Mult. Scler. 2015, Published online July 24, 2105. 10.1177/1352458515596598.
    • (2015) Mult. Scler.
    • Daams, M.1
  • 70
    • 84937696171 scopus 로고    scopus 로고
    • Unraveling the neuroimaging predictors for motor dysfunction in long-standing multiple sclerosis
    • Daams M., et al. Unraveling the neuroimaging predictors for motor dysfunction in long-standing multiple sclerosis. Neurology 2015, 85:248-255.
    • (2015) Neurology , vol.85 , pp. 248-255
    • Daams, M.1
  • 71
    • 84887618546 scopus 로고    scopus 로고
    • Assessment of system dysfunction in the brain through MRI-based connectomics
    • Filippi M., et al. Assessment of system dysfunction in the brain through MRI-based connectomics. Lancet Neurol. 2013, 12:1189-1199.
    • (2013) Lancet Neurol. , vol.12 , pp. 1189-1199
    • Filippi, M.1
  • 72
    • 84908609848 scopus 로고    scopus 로고
    • Modern network science of neurological disorders
    • Stam C.J. Modern network science of neurological disorders. Nat. Rev. Neurosci. 2014, 15:683-695.
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 683-695
    • Stam, C.J.1
  • 73
    • 84863012575 scopus 로고    scopus 로고
    • Age-related changes in topological organization of structural brain networks in healthy individuals
    • Wu K., et al. Age-related changes in topological organization of structural brain networks in healthy individuals. Hum. Brain Mapp. 2012, 33:552-568.
    • (2012) Hum. Brain Mapp. , vol.33 , pp. 552-568
    • Wu, K.1
  • 74
    • 84904806945 scopus 로고    scopus 로고
    • Changes in functional network centrality underlie cognitive dysfunction and physical disability in multiple sclerosis
    • Schoonheim M., et al. Changes in functional network centrality underlie cognitive dysfunction and physical disability in multiple sclerosis. Mult. Scler. 2013, 20:1058-1065.
    • (2013) Mult. Scler. , vol.20 , pp. 1058-1065
    • Schoonheim, M.1
  • 75
    • 80053519272 scopus 로고    scopus 로고
    • Diffusion tensor tractography reveals disrupted topological efficiency in white matter structural networks in multiple sclerosis
    • Shu N., et al. Diffusion tensor tractography reveals disrupted topological efficiency in white matter structural networks in multiple sclerosis. Cereb. Cortex 2011, 21:2565-2577.
    • (2011) Cereb. Cortex , vol.21 , pp. 2565-2577
    • Shu, N.1
  • 76
    • 84896694559 scopus 로고    scopus 로고
    • Functional brain network analysis using minimum spanning trees in multiple sclerosis: an MEG source-space study
    • Tewarie P., et al. Functional brain network analysis using minimum spanning trees in multiple sclerosis: an MEG source-space study. Neuroimage 2014, 88:308-318.
    • (2014) Neuroimage , vol.88 , pp. 308-318
    • Tewarie, P.1
  • 77
    • 79951625758 scopus 로고    scopus 로고
    • Reorganization in cognitive networks with progression of multiple sclerosis: insights from fMRI
    • Loitfelder M., et al. Reorganization in cognitive networks with progression of multiple sclerosis: insights from fMRI. Neurology 2011, 76:526-533.
    • (2011) Neurology , vol.76 , pp. 526-533
    • Loitfelder, M.1
  • 78
    • 79955688967 scopus 로고    scopus 로고
    • Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus
    • Encinas J.M., et al. Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell 2011, 8:566-579.
    • (2011) Cell Stem Cell , vol.8 , pp. 566-579
    • Encinas, J.M.1
  • 79
    • 84938933122 scopus 로고    scopus 로고
    • Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice
    • Littlefield A.M., et al. Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice. J. Neuroinflammation 2015, 12:138.
    • (2015) J. Neuroinflammation , vol.12 , pp. 138
    • Littlefield, A.M.1
  • 80
    • 77955484670 scopus 로고    scopus 로고
    • Quantification of the spatiotemporal microstructural organization of the human brain association, projection and commissural pathways across the lifespan using diffusion tensor tractography
    • Hasan K.M., et al. Quantification of the spatiotemporal microstructural organization of the human brain association, projection and commissural pathways across the lifespan using diffusion tensor tractography. Brain Struct. Funct. 2010, 214:361-373.
    • (2010) Brain Struct. Funct. , vol.214 , pp. 361-373
    • Hasan, K.M.1
  • 81
    • 77955549592 scopus 로고    scopus 로고
    • Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry
    • Westlye L.T., et al. Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. Cereb. Cortex 2010, 20:2055-2068.
    • (2010) Cereb. Cortex , vol.20 , pp. 2055-2068
    • Westlye, L.T.1
  • 82
    • 84884909035 scopus 로고    scopus 로고
    • Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain
    • Vigano F., et al. Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain. Nat. Neurosci. 2013, 16:1370-1372.
    • (2013) Nat. Neurosci. , vol.16 , pp. 1370-1372
    • Vigano, F.1
  • 83
    • 84862908705 scopus 로고    scopus 로고
    • Rejuvenation of regeneration in the aging central nervous system
    • Ruckh J.M., et al. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell 2012, 10:96-103.
    • (2012) Cell Stem Cell , vol.10 , pp. 96-103
    • Ruckh, J.M.1
  • 84
    • 64249134817 scopus 로고    scopus 로고
    • CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis
    • Wolf S.A., et al. CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J. Immunol. 2009, 182:3979-3984.
    • (2009) J. Immunol. , vol.182 , pp. 3979-3984
    • Wolf, S.A.1
  • 85
    • 31544460682 scopus 로고    scopus 로고
    • Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
    • Ziv Y., et al. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat. Neurosci. 2006, 9:268-275.
    • (2006) Nat. Neurosci. , vol.9 , pp. 268-275
    • Ziv, Y.1
  • 86
    • 84922148661 scopus 로고    scopus 로고
    • + T cells protect injured CNS neurons via IL-4
    • + T cells protect injured CNS neurons via IL-4. J. Clin. Invest. 2015, 125:2547.
    • (2015) J. Clin. Invest. , vol.125 , pp. 2547
    • Walsh, J.T.1
  • 87
    • 84941808746 scopus 로고    scopus 로고
    • Pathological differences between white and grey matter multiple sclerosis lesions
    • Prins M., et al. Pathological differences between white and grey matter multiple sclerosis lesions. Ann. N. Y. Acad. Sci. 2015, 1351:99-113.
    • (2015) Ann. N. Y. Acad. Sci. , vol.1351 , pp. 99-113
    • Prins, M.1
  • 88
    • 84940180598 scopus 로고    scopus 로고
    • A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis
    • Published online August 13, 2015
    • Sethi V., et al. A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 2015, Published online August 13, 2015. 10.1136/jnnp-2015-311102.
    • (2015) J. Neurol. Neurosurg. Psychiatry
    • Sethi, V.1
  • 89
    • 80052927697 scopus 로고    scopus 로고
    • Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis
    • Howell O.W., et al. Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain 2011, 134:2755-2771.
    • (2011) Brain , vol.134 , pp. 2755-2771
    • Howell, O.W.1
  • 90
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi R., et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007, 130:1089-1104.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1
  • 91
    • 2442708947 scopus 로고    scopus 로고
    • Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    • Serafini B., et al. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol. 2004, 14:164-174.
    • (2004) Brain Pathol. , vol.14 , pp. 164-174
    • Serafini, B.1
  • 92
    • 84890599669 scopus 로고    scopus 로고
    • Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats
    • Gardner C., et al. Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats. Brain 2013, 136:3596-3608.
    • (2013) Brain , vol.136 , pp. 3596-3608
    • Gardner, C.1
  • 93
    • 84874566824 scopus 로고    scopus 로고
    • Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression
    • Romme Christensen J., et al. Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression. PLoS ONE 2013, 8:e57820.
    • (2013) PLoS ONE , vol.8 , pp. e57820
    • Romme Christensen, J.1
  • 94
    • 84355166761 scopus 로고    scopus 로고
    • Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation
    • Peters A., et al. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity 2011, 35:986-996.
    • (2011) Immunity , vol.35 , pp. 986-996
    • Peters, A.1
  • 95
    • 84964962399 scopus 로고    scopus 로고
    • ECTRIMS 2015 (Barcelona): efficacy and safety of ocrelizumab in primary progressive multiple sclerosis - results of the placebo-controlled, double-blind, Phase III ORATORIO study
    • Montalban X., et al. ECTRIMS 2015 (Barcelona): efficacy and safety of ocrelizumab in primary progressive multiple sclerosis - results of the placebo-controlled, double-blind, Phase III ORATORIO study. Mult. Scler. 2015, 23:780.
    • (2015) Mult. Scler. , vol.23 , pp. 780
    • Montalban, X.1
  • 96
    • 27644552194 scopus 로고    scopus 로고
    • Cortical demyelination and diffuse white matter injury in multiple sclerosis
    • Kutzelnigg A., et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 2005, 128:2705-2712.
    • (2005) Brain , vol.128 , pp. 2705-2712
    • Kutzelnigg, A.1
  • 97
    • 84864200035 scopus 로고    scopus 로고
    • Oligodendroglia metabolically support axons and contribute to neurodegeneration
    • Lee Y., et al. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 2012, 487:443-448.
    • (2012) Nature , vol.487 , pp. 443-448
    • Lee, Y.1
  • 98
    • 84861429431 scopus 로고    scopus 로고
    • Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
    • Funfschilling U., et al. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 2012, 485:517-521.
    • (2012) Nature , vol.485 , pp. 517-521
    • Funfschilling, U.1
  • 99
    • 84908657998 scopus 로고    scopus 로고
    • Molecular mechanisms linking neuroinflammation and neurodegeneration in MS
    • Ellwardt E., Zipp F. Molecular mechanisms linking neuroinflammation and neurodegeneration in MS. Exp. Neurol. 2014, 262:8-17.
    • (2014) Exp. Neurol. , vol.262 , pp. 8-17
    • Ellwardt, E.1    Zipp, F.2
  • 100
    • 84879970347 scopus 로고    scopus 로고
    • Sodium accumulation is associated with disability and a progressive course in multiple sclerosis
    • Paling D., et al. Sodium accumulation is associated with disability and a progressive course in multiple sclerosis. Brain 2013, 136:2305-2317.
    • (2013) Brain , vol.136 , pp. 2305-2317
    • Paling, D.1
  • 101
    • 77952368229 scopus 로고    scopus 로고
    • Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport
    • Kiryu-Seo S., et al. Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport. J. Neurosci. 2010, 30:6658-56666.
    • (2010) J. Neurosci. , vol.30 , pp. 6658-56666
    • Kiryu-Seo, S.1
  • 102
    • 70349135156 scopus 로고    scopus 로고
    • Enhanced number and activity of mitochondria in multiple sclerosis lesions
    • Witte M.E., et al. Enhanced number and activity of mitochondria in multiple sclerosis lesions. J. Pathol. 2009, 219:193-204.
    • (2009) J. Pathol. , vol.219 , pp. 193-204
    • Witte, M.E.1
  • 103
    • 79953291261 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
    • Campbell G.R., et al. Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann. Neurol. 2011, 69:481-492.
    • (2011) Ann. Neurol. , vol.69 , pp. 481-492
    • Campbell, G.R.1
  • 104
    • 66549118688 scopus 로고    scopus 로고
    • Mitochondrial changes within axons in multiple sclerosis
    • Mahad D.J., et al. Mitochondrial changes within axons in multiple sclerosis. Brain 2009, 132:1161-1174.
    • (2009) Brain , vol.132 , pp. 1161-1174
    • Mahad, D.J.1
  • 105
    • 0029840465 scopus 로고    scopus 로고
    • Induction of myelination in the central nervous system by electrical activity
    • Demerens C., et al. Induction of myelination in the central nervous system by electrical activity. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:9887-9892.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 9887-9892
    • Demerens, C.1
  • 106
    • 84900453362 scopus 로고    scopus 로고
    • Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
    • Gibson E.M., et al. Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science 2014, 344:1252304.
    • (2014) Science , vol.344 , pp. 1252304
    • Gibson, E.M.1
  • 107
    • 84876475744 scopus 로고    scopus 로고
    • Neuronal activity promotes myelination via a cAMP pathway
    • Malone M., et al. Neuronal activity promotes myelination via a cAMP pathway. Glia 2014, 61:843-854.
    • (2014) Glia , vol.61 , pp. 843-854
    • Malone, M.1
  • 108
    • 84946866438 scopus 로고    scopus 로고
    • Effectiveness of rehabilitation in multiple sclerosis relapse on fatigue, self-efficacy and physical activity
    • Published online November 12, 2015
    • Nedeljkovic U., et al. Effectiveness of rehabilitation in multiple sclerosis relapse on fatigue, self-efficacy and physical activity. Acta Neurol. Belg. 2015, Published online November 12, 2015. 10.1007/s13760-015-0563-4.
    • (2015) Acta Neurol. Belg.
    • Nedeljkovic, U.1
  • 109
    • 0141740713 scopus 로고    scopus 로고
    • A randomised controlled trial comparing rehabilitation against standard therapy in multiple sclerosis patients receiving intravenous steroid treatment
    • Craig J., et al. A randomised controlled trial comparing rehabilitation against standard therapy in multiple sclerosis patients receiving intravenous steroid treatment. J. Neurol. Neurosurg. Psychiatry 2003, 74:1225-1230.
    • (2003) J. Neurol. Neurosurg. Psychiatry , vol.74 , pp. 1225-1230
    • Craig, J.1
  • 110
    • 84940021635 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D predicts cognitive performance in adults
    • Darwish H., et al. Serum 25-hydroxyvitamin D predicts cognitive performance in adults. Neuropsychiatry Dis. Treat. 2015, 11:2217-2223.
    • (2015) Neuropsychiatry Dis. Treat. , vol.11 , pp. 2217-2223
    • Darwish, H.1
  • 111
    • 84945539242 scopus 로고    scopus 로고
    • Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis
    • Grover S.A., et al. Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis. Neurology 2015, 85:1663-1669.
    • (2015) Neurology , vol.85 , pp. 1663-1669
    • Grover, S.A.1
  • 112
    • 84870539847 scopus 로고    scopus 로고
    • Impaired adult myelination in the prefrontal cortex of socially isolated mice
    • Liu J., et al. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat. Neurosci. 2012, 15:1621-1623.
    • (2012) Nat. Neurosci. , vol.15 , pp. 1621-1623
    • Liu, J.1
  • 113
    • 84866130476 scopus 로고    scopus 로고
    • A critical period for social experience-dependent oligodendrocyte maturation and myelination
    • Makinodan M., et al. A critical period for social experience-dependent oligodendrocyte maturation and myelination. Science 2012, 337:1357-1360.
    • (2012) Science , vol.337 , pp. 1357-1360
    • Makinodan, M.1
  • 114
    • 84866093038 scopus 로고    scopus 로고
    • Experience-dependent regulation of NG2 progenitors in the developing barrel cortex
    • Mangin J.M., et al. Experience-dependent regulation of NG2 progenitors in the developing barrel cortex. Nat. Neurosci. 2012, 15:1192-1194.
    • (2012) Nat. Neurosci. , vol.15 , pp. 1192-1194
    • Mangin, J.M.1
  • 115
    • 79954605805 scopus 로고    scopus 로고
    • Progenitors in the adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury
    • Simon C., et al. Progenitors in the adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury. Glia 2011, 59:869-881.
    • (2011) Glia , vol.59 , pp. 869-881
    • Simon, C.1
  • 116
    • 84964061891 scopus 로고    scopus 로고
    • Altering the CNS microenvironment during neurodegeneration to promote remyelination
    • Yong V.W., et al. Altering the CNS microenvironment during neurodegeneration to promote remyelination. Mult. Scler. 2015, 21:68.
    • (2015) Mult. Scler. , vol.21 , pp. 68
    • Yong, V.W.1
  • 117
    • 84867064116 scopus 로고    scopus 로고
    • Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination
    • Lau L.W., et al. Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination. Ann. Neurol. 2012, 72:419-432.
    • (2012) Ann. Neurol. , vol.72 , pp. 419-432
    • Lau, L.W.1
  • 118
    • 84951832271 scopus 로고    scopus 로고
    • Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?
    • Ryan S.M., Nolan Y.M. Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?. Neurosci. Biobehav. Rev. 2015, 61:121-131.
    • (2015) Neurosci. Biobehav. Rev. , vol.61 , pp. 121-131
    • Ryan, S.M.1    Nolan, Y.M.2
  • 119
    • 84869187974 scopus 로고    scopus 로고
    • Molecular imaging of microglia/macrophages in the brain
    • Venneti S., et al. Molecular imaging of microglia/macrophages in the brain. Glia 2013, 61:10-23.
    • (2013) Glia , vol.61 , pp. 10-23
    • Venneti, S.1
  • 120
    • 84964054182 scopus 로고    scopus 로고
    • ECTRIMS 2015 (Barcelona): microglial activation correlates with disease progression in multiple sclerosis
    • Rissanen E., et al. ECTRIMS 2015 (Barcelona): microglial activation correlates with disease progression in multiple sclerosis. Mult. Scler. 2015, 23(Suppl. 11):7-75.
    • (2015) Mult. Scler. , vol.23 , pp. 7-75
    • Rissanen, E.1
  • 121
    • 84920410942 scopus 로고    scopus 로고
    • Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation
    • Moore C.S., et al. Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation. J. Immunol. 2015, 194:761-772.
    • (2015) J. Immunol. , vol.194 , pp. 761-772
    • Moore, C.S.1
  • 122
    • 84867139126 scopus 로고    scopus 로고
    • Theiler's murine encephalomyelitis virus induced phenotype switch of microglia in vitro
    • Gerhauser I., et al. Theiler's murine encephalomyelitis virus induced phenotype switch of microglia in vitro. J. Neuroimmunol. 2012, 252:49-55.
    • (2012) J. Neuroimmunol. , vol.252 , pp. 49-55
    • Gerhauser, I.1
  • 123
    • 84883454794 scopus 로고    scopus 로고
    • M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
    • Miron V.E., et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat. Neurosci. 2013, 16:1211-1218.
    • (2013) Nat. Neurosci. , vol.16 , pp. 1211-1218
    • Miron, V.E.1
  • 124
    • 84929340488 scopus 로고    scopus 로고
    • MSX3 switches microglia polarization and protects from inflammation-induced demyelination
    • Yu Z., et al. MSX3 switches microglia polarization and protects from inflammation-induced demyelination. J. Neurosci. 2015, 35:6350-6365.
    • (2015) J. Neurosci. , vol.35 , pp. 6350-6365
    • Yu, Z.1
  • 125
    • 84908076319 scopus 로고    scopus 로고
    • Measurement of regional variation of GABA in the human brain by optimized point-resolved spectroscopy at 7 T in vivo
    • Ganji S.K., et al. Measurement of regional variation of GABA in the human brain by optimized point-resolved spectroscopy at 7 T in vivo. NMR Biomed. 2014, 27:1167-1175.
    • (2014) NMR Biomed. , vol.27 , pp. 1167-1175
    • Ganji, S.K.1
  • 126
    • 84940780748 scopus 로고    scopus 로고
    • Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis
    • Cawley N., et al. Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis. Brain 2015, 138:2584-2595.
    • (2015) Brain , vol.138 , pp. 2584-2595
    • Cawley, N.1
  • 127
    • 84942364958 scopus 로고    scopus 로고
    • 11C]flumazenil positron emission tomography study
    • 11C]flumazenil positron emission tomography study. Ann. Neurol. 2015, 78:554-567.
    • (2015) Ann. Neurol. , vol.78 , pp. 554-567
    • Freeman, L.1
  • 128
    • 30344437563 scopus 로고    scopus 로고
    • Insights into the molecular pathogenesis of progression in multiple sclerosis: potential implications for future therapies
    • Imitola J., et al. Insights into the molecular pathogenesis of progression in multiple sclerosis: potential implications for future therapies. Arch. Neurol. 2006, 63:25-33.
    • (2006) Arch. Neurol. , vol.63 , pp. 25-33
    • Imitola, J.1
  • 129
    • 84907598301 scopus 로고    scopus 로고
    • In vivo evidence of glutamate toxicity in multiple sclerosis
    • Azevedo C.J., et al. In vivo evidence of glutamate toxicity in multiple sclerosis. Ann. Neurol. 2014, 76:269-278.
    • (2014) Ann. Neurol. , vol.76 , pp. 269-278
    • Azevedo, C.J.1
  • 130
    • 77956369535 scopus 로고    scopus 로고
    • Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis
    • Baranzini S.E., et al. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Brain 2010, 133:2603-2611.
    • (2010) Brain , vol.133 , pp. 2603-2611
    • Baranzini, S.E.1
  • 131
    • 41849124231 scopus 로고    scopus 로고
    • Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis
    • Basso A.S., et al. Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis. J. Clin. Invest. 2008, 118:1532-1543.
    • (2008) J. Clin. Invest. , vol.118 , pp. 1532-1543
    • Basso, A.S.1
  • 132
    • 0033958462 scopus 로고    scopus 로고
    • Glutamate excitotoxicity in a model of multiple sclerosis
    • Pitt D., et al. Glutamate excitotoxicity in a model of multiple sclerosis. Nat. Med. 2000, 6:67-70.
    • (2000) Nat. Med. , vol.6 , pp. 67-70
    • Pitt, D.1
  • 133
    • 1542616888 scopus 로고    scopus 로고
    • Microglia express GABA(B) receptors to modulate interleukin release
    • Kuhn S.A., et al. Microglia express GABA(B) receptors to modulate interleukin release. Mol. Cell. Neurosci. 2004, 25:312-322.
    • (2004) Mol. Cell. Neurosci. , vol.25 , pp. 312-322
    • Kuhn, S.A.1
  • 134
    • 84919455244 scopus 로고    scopus 로고
    • Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain
    • Chen Z., et al. Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nat. Commun. 2014, 5:4486.
    • (2014) Nat. Commun. , vol.5 , pp. 4486
    • Chen, Z.1
  • 135
    • 84945463582 scopus 로고    scopus 로고
    • Rescue of long-range circuit dysfunction in Alzheimer's disease models
    • Busche M.A., et al. Rescue of long-range circuit dysfunction in Alzheimer's disease models. Nat. Neurosci. 2015, 18:1623-1630.
    • (2015) Nat. Neurosci. , vol.18 , pp. 1623-1630
    • Busche, M.A.1
  • 136
    • 84957831119 scopus 로고    scopus 로고
    • Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial
    • Raftopoulos R., et al. Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2016, 15:259-269.
    • (2016) Lancet Neurol. , vol.15 , pp. 259-269
    • Raftopoulos, R.1
  • 137
    • 85014734417 scopus 로고    scopus 로고
    • ECTRIMS 2015 (Barcelona): anti-LINGO-1 monoclonal antibody BIIB033 improves optic nerve latency in acute optic neuritis: primary efficacy analysis of the RENEW study
    • Aktas O., et al. ECTRIMS 2015 (Barcelona): anti-LINGO-1 monoclonal antibody BIIB033 improves optic nerve latency in acute optic neuritis: primary efficacy analysis of the RENEW study. Mult. Scler. 2015, 23(Suppl. 11):7-75.
    • (2015) Mult. Scler. , vol.23 , pp. 7-75
    • Aktas, O.1
  • 138
    • 8844222623 scopus 로고    scopus 로고
    • Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study
    • Panitch H., et al. Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study. Neurology 2004, 63:1788-1795.
    • (2004) Neurology , vol.63 , pp. 1788-1795
    • Panitch, H.1
  • 139
    • 78649996252 scopus 로고    scopus 로고
    • Brainstem lesions in clinically isolated syndromes
    • Tintore M., et al. Brainstem lesions in clinically isolated syndromes. Neurology 2010, 75:1933-1938.
    • (2010) Neurology , vol.75 , pp. 1933-1938
    • Tintore, M.1
  • 140
    • 53549115639 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis with childhood onset
    • Renoux C., et al. The natural history of multiple sclerosis with childhood onset. Clin. Neurol. Neurosurg. 2008, 110:897-904.
    • (2008) Clin. Neurol. Neurosurg. , vol.110 , pp. 897-904
    • Renoux, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.