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Volumn 70, Issue 2, 2013, Pages 214-222

Early relapses, onset of progression, and late outcome in multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANADA; COHORT ANALYSIS; CONTROLLED STUDY; DISABILITY STATUS SCALE SCORE OF 6; DISABILITY STATUS SCALE SCORE OF 8; DISEASE COURSE; DISEASE SEVERITY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTIPLE SCLEROSIS; ONSET AGE; PHYSICAL DISABILITY; POPULATION RESEARCH; PRIORITY JOURNAL; PROBABILITY; SCORING SYSTEM;

EID: 84874074752     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2013.599     Document Type: Article
Times cited : (90)

References (44)
  • 1
    • 0037379402 scopus 로고    scopus 로고
    • Early clinical predictors and progression of irreversible disability in multiple sclerosis: An amnesic process
    • Confavreux C, Vukusic S, Adeleine P. Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process. Brain. 2003; 126(pt 4):770-782.
    • (2003) Brain , vol.126 , Issue.PART 4 , pp. 770-782
    • Confavreux, C.1    Vukusic, S.2    Adeleine, P.3
  • 2
    • 77954382272 scopus 로고    scopus 로고
    • Evidence for a two-stage disability progression in multiple sclerosis
    • Leray E, Yaouanq J, Le Page E, et al. Evidence for a two-stage disability progression in multiple sclerosis. Brain. 2010;133(pt 7):1900-1913.
    • (2010) Brain , vol.133 , Issue.PART 7 , pp. 1900-1913
    • Leray, E.1    Yaouanq, J.2    Le Page, E.3
  • 3
    • 77954364428 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis: A geographically based study 10: Relapses and long-term disability
    • Scalfari A, Neuhaus A, Degenhardt A, et al. The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability. Brain. 2010;133(pt 7):1914-1929.
    • (2010) Brain , vol.133 , Issue.PART 7 , pp. 1914-1929
    • Scalfari, A.1    Neuhaus, A.2    Degenhardt, A.3
  • 4
    • 33244486947 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis: A geographically based study 9: Observations on the progressive phase of the disease
    • Kremenchutzky M, Rice GP, Baskerville J, Wingerchuk DM, Ebers GC. The natural history of multiple sclerosis: a geographically based study 9: observations on the progressive phase of the disease. Brain. 2006;129(pt 3):584-594.
    • (2006) Brain , vol.129 , Issue.PART 3 , pp. 584-594
    • Kremenchutzky, M.1    Rice, G.P.2    Baskerville, J.3    Wingerchuk, D.M.4    Ebers, G.C.5
  • 5
    • 33244466021 scopus 로고    scopus 로고
    • Natural history of multiple sclerosis: A unifying concept
    • Confavreux C, Vukusic S. Natural history of multiple sclerosis: a unifying concept. Brain. 2006;129(pt 3):606-616.
    • (2006) Brain , vol.129 , Issue.PART 3 , pp. 606-616
    • Confavreux, C.1    Vukusic, S.2
  • 6
    • 67349277156 scopus 로고    scopus 로고
    • Natural history comparisons of primary and secondary progressive multiple sclerosis reveals differences and similarities
    • UBC Neurologists
    • Tremlett H, Zhao Y, Devonshire V; UBC Neurologists. Natural history comparisons of primary and secondary progressive multiple sclerosis reveals differences and similarities. J Neurol. 2009;256(3):374-381.
    • (2009) J Neurol. , vol.256 , Issue.3 , pp. 374-381
    • Tremlett, H.1    Zhao, Y.2    Devonshire, V.3
  • 7
    • 49549118231 scopus 로고    scopus 로고
    • Natural history of multiple sclerosis in a population-based cohort
    • LORSEP Group
    • Debouverie M, Pittion-Vouyovitch S, Louis S, Guillemin F; LORSEP Group. Natural history of multiple sclerosis in a population-based cohort. Eur J Neurol. 2008;15(9):916-921.
    • (2008) Eur J Neurol. , vol.15 , Issue.9 , pp. 916-921
    • Debouverie, M.1    Pittion-Vouyovitch, S.2    Louis, S.3    Guillemin, F.4
  • 8
    • 0037983828 scopus 로고    scopus 로고
    • Long-term follow up of patients with clinically isolated syndromes, relapsing-remitting and secondary progressive multiple sclerosis
    • Eriksson M, Andersen O, Runmarker B. Long-term follow up of patients with clinically isolated syndromes, relapsing-remitting and secondary progressive multiple sclerosis. Mult Scler. 2003;9(3):260-274.
    • (2003) Mult Scler. , vol.9 , Issue.3 , pp. 260-274
    • Eriksson, M.1    Andersen, O.2    Runmarker, B.3
  • 9
    • 77950493741 scopus 로고    scopus 로고
    • What is the risk of permanent disability from a multiple sclerosis relapse?
    • Bejaoui K, Rolak LA. What is the risk of permanent disability from a multiple sclerosis relapse? Neurology. 2010;74(11):900-902.
    • (2010) Neurology , vol.74 , Issue.11 , pp. 900-902
    • Bejaoui, K.1    Rolak, L.A.2
  • 10
    • 77956203302 scopus 로고    scopus 로고
    • Clinical overview of neuromyelitis optica
    • Weinshenker BG. Clinical overview of neuromyelitis optica. Rinsho Shinkeigaku. 2009;49(11):894-895.
    • (2009) Rinsho Shinkeigaku. , vol.49 , Issue.11 , pp. 894-895
    • Weinshenker, B.G.1
  • 11
    • 19944415573 scopus 로고    scopus 로고
    • Identifying and treating patients with suboptimal responses
    • Cohen BA, Khan O, Jeffery DR, et al. Identifying and treating patients with suboptimal responses. Neurology. 2004;63(12)(suppl 6):S33-S40.
    • (2004) Neurology , vol.63 , Issue.12 SUPPL. 6
    • Cohen, B.A.1    Khan, O.2    Jeffery, D.R.3
  • 12
  • 13
    • 82955243995 scopus 로고    scopus 로고
    • Combined MRI lesions and relapses as a surrogate for disability in multiple sclerosis
    • Sormani MP, Li DK, Bruzzi P, et al. Combined MRI lesions and relapses as a surrogate for disability in multiple sclerosis. Neurology. 2011;77(18):1684-1690.
    • (2011) Neurology , vol.77 , Issue.18 , pp. 1684-1690
    • Sormani, M.P.1    Li, D.K.2    Bruzzi, P.3
  • 14
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis, I: Clinical results of a multicenter, randomized, doubleblind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis, I: clinical results of a multicenter, randomized, doubleblind, placebo-controlled trial. Neurology. 1993;43(4):655-661.
    • (1993) Neurology , vol.43 , Issue.4 , pp. 655-661
  • 15
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcuta-neously in Multiple Sclerosis) Study Group [publishsed correction appears in Lancet. 1999;353(9153):678]
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcuta-neously in Multiple Sclerosis) Study Group. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis [publishsed correction appears in Lancet. 1999;353(9153):678]. Lancet. 1998; 352(9139):1498-1504.
    • (1998) Lancet , vol.352 , Issue.9139 , pp. 1498-1504
  • 16
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
    • The Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Jacobs LD, Cookfair DL, Rudick RA, et al; The Multiple Sclerosis Collaborative Research Group (MSCRG). Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol. 1996;39(3):285-294.
    • (1996) Ann Neurol. , vol.39 , Issue.3 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 17
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial
    • Copolymer 1 Multiple Sclerosis Study Group
    • Johnson KP, Brooks BR, Cohen JA, et al; Copolymer 1 Multiple Sclerosis Study Group. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. Neurology. 1995;45(7):1268-1276.
    • (1995) Neurology , vol.45 , Issue.7 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 18
    • 0032494792 scopus 로고    scopus 로고
    • Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis
    • European Study Group on Interferon beta-1b in Secondary Progressive MS
    • European Study Group on Interferon beta-1b in Secondary Progressive MS. Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. Lancet. 1998;352(9139): 1491-1497.
    • (1998) Lancet , vol.352 , Issue.9139 , pp. 1491-1497
  • 19
    • 0032882173 scopus 로고    scopus 로고
    • Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis
    • Coles AJ, Wing MG, Molyneux P, et al. Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis. Ann Neurol. 1999;46(3):296-304.
    • (1999) Ann Neurol. , vol.46 , Issue.3 , pp. 296-304
    • Coles, A.J.1    Wing, M.G.2    Molyneux, P.3
  • 20
    • 0034646216 scopus 로고    scopus 로고
    • Cladribine and progressive MS: Clinical and MRI outcomes of a multicentre controlled trial
    • Cladribine MRI Study Group
    • Rice FM, Filippi M, Comi G; Cladribine MRI Study Group. Cladribine and progressive MS: clinical and MRI outcomes of a multicentre controlled trial. Neurology. 2000;54(5):1145-1155.
    • (2000) Neurology , vol.54 , Issue.5 , pp. 1145-1155
    • Rice, F.M.1    Filippi, M.2    Comi, G.3
  • 21
    • 77955762153 scopus 로고    scopus 로고
    • Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial
    • Investigators of the 16-Year Long-Term Follow-up Study
    • Ebers GC, Traboulsee A, Li D, et al; Investigators of the 16-Year Long-Term Follow-up Study. Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial. J Neurol Neurosurg Psychiatry. 2010; 81(8):907-912.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , Issue.8 , pp. 907-912
    • Ebers, G.C.1    Traboulsee, A.2    Li, D.3
  • 22
    • 0031750982 scopus 로고    scopus 로고
    • Survival and predictors of disability in Turkish MS patients
    • Turkish Multiple Sclerosis Study Group (TUMSSG)
    • Kantarci O, Siva A, Eraksoy M, et al; Turkish Multiple Sclerosis Study Group (TUMSSG). Survival and predictors of disability in Turkish MS patients. Neurology. 1998;51(3):765-772.
    • (1998) Neurology , vol.51 , Issue.3 , pp. 765-772
    • Kantarci, O.1    Siva, A.2    Eraksoy, M.3
  • 23
    • 73449141779 scopus 로고    scopus 로고
    • Impact of multiple sclerosis relapses on progression diminishes with time
    • UBC Neurologists
    • Tremlett H, Yousefi M, Devonshire V, Rieckmann P, Zhao Y; UBC Neurologists. Impact of multiple sclerosis relapses on progression diminishes with time. Neurology. 2009;73(20):1616-1623.
    • (2009) Neurology , vol.73 , Issue.20 , pp. 1616-1623
    • Tremlett, H.1    Yousefi, M.2    Devonshire, V.3    Rieckmann, P.4    Zhao, Y.5
  • 24
    • 33745115644 scopus 로고    scopus 로고
    • The contribution of demyelination to axonal loss in multiple sclerosis
    • DeLuca GC, Williams K, Evangelou N, Ebers GC, Esiri MM. The contribution of demyelination to axonal loss in multiple sclerosis. Brain. 2006;129(pt 6):1507-1516.
    • (2006) Brain , vol.129 , Issue.PART 6 , pp. 1507-1516
    • DeLuca, G.C.1    Williams, K.2    Evangelou, N.3    Ebers, G.C.4    Esiri, M.M.5
  • 25
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: An immune or neurodegenerative disorder?
    • Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci. 2008;31:247-269.
    • (2008) Annu Rev Neurosci. , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 26
    • 53049101849 scopus 로고    scopus 로고
    • Reconsidering clinical outcomes in multiple sclerosis: Relapses, impairment, disability and beyond
    • D'Souza M, Kappos L, Czaplinski A. Reconsidering clinical outcomes in multiple sclerosis: relapses, impairment, disability and beyond. J Neurol Sci. 2008; 274(1-2):76-79.
    • (2008) J Neurol Sci. , vol.274 , Issue.1-2 , pp. 76-79
    • D'Souza, M.1    Kappos, L.2    Czaplinski, A.3
  • 27
    • 64149124286 scopus 로고    scopus 로고
    • Clinical trials in multiple sclerosis: Current and future requirements: Potential pitfalls
    • Rieckmann P. Clinical trials in multiple sclerosis: current and future requirements: potential pitfalls. J Neurol. 2008;255(suppl 6):66-68.
    • (2008) J Neurol. , vol.255 , Issue.SUPPL. 6 , pp. 66-68
    • Rieckmann, P.1
  • 28
    • 79953180064 scopus 로고    scopus 로고
    • Surrogate endpoints for EDSS worsening in multiple sclerosis: A meta-analytic approach: Measuring disability in relapsing-remitting MS
    • Ebers GC, Daumer M, Scalfari A. Surrogate endpoints for EDSS worsening in multiple sclerosis: a meta-analytic approach: measuring disability in relapsing-remitting MS. Neurology. 2011;76(11):1025-1026.
    • (2011) Neurology , vol.76 , Issue.11 , pp. 1025-1026
    • Ebers, G.C.1    Daumer, M.2    Scalfari, A.3
  • 30
    • 0000830502 scopus 로고
    • A new scale for evaluating disability in multiple sclerosis
    • Kurtzke JF. A new scale for evaluating disability in multiple sclerosis. Neurology. 1955;5(8):580-583.
    • (1955) Neurology , vol.5 , Issue.8 , pp. 580-583
    • Kurtzke, J.F.1
  • 31
    • 0020686503 scopus 로고
    • New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
    • Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983;13(3):227-231.
    • (1983) Ann Neurol. , vol.13 , Issue.3 , pp. 227-231
    • Poser, C.M.1    Paty, D.W.2    Scheinberg, L.3
  • 32
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey
    • National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin FD, Reingold SC; National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology. 1996;46(4):907-911.
    • (1996) Neurology , vol.46 , Issue.4 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 33
    • 0032881051 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis: A geographically based study, 7: Progressive-relapsing and relapsing-progressive multiple sclerosis: A re-evaluation
    • Kremenchutzky M, Cottrell D, Rice G, et al. The natural history of multiple sclerosis: a geographically based study, 7: progressive-relapsing and relapsing-progressive multiple sclerosis: a re-evaluation. Brain. 1999;122(pt 10):1941-1950.
    • (1999) Brain , vol.122 , Issue.PART 10 , pp. 1941-1950
    • Kremenchutzky, M.1    Cottrell, D.2    Rice, G.3
  • 34
    • 43149104388 scopus 로고    scopus 로고
    • Reducing the probability of false positive research findings by pre-publication validation: Experience with a large multiple sclerosis database
    • doi:10.1186/1471-2288-8-18
    • Daumer M, Held U, Ickstadt K, Heinz M, Schach S, Ebers G. Reducing the probability of false positive research findings by pre-publication validation: experience with a large multiple sclerosis database. BMC Med Res Methodol. 2008; 8:18. doi:10.1186/1471-2288-8-18.
    • (2008) BMC Med Res Methodol. , vol.8 , pp. 18
    • Daumer, M.1    Held, U.2    Ickstadt, K.3    Heinz, M.4    Schach, S.5    Ebers, G.6
  • 35
  • 36
    • 66549130329 scopus 로고    scopus 로고
    • The relation between inflammation and neurodegeneration in multiple sclerosis brains
    • Frischer JM, Bramow S, Dal-Bianco A, et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain. 2009;132(pt 5): 1175-1189.
    • (2009) Brain , vol.132 , Issue.PART 5 , pp. 1175-1189
    • Frischer, J.M.1    Bramow, S.2    Dal-Bianco, A.3
  • 37
    • 0037441370 scopus 로고    scopus 로고
    • Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis
    • Vukusic S, Confavreux C. Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis. J Neurol Sci. 2003;206 (2):135-137.
    • (2003) J Neurol Sci. , vol.206 , Issue.2 , pp. 135-137
    • Vukusic, S.1    Confavreux, C.2
  • 38
    • 77955662205 scopus 로고    scopus 로고
    • New treatment strategies in multiple sclerosis
    • Jones JL, Coles AJ. New treatment strategies in multiple sclerosis. Exp Neurol. 2010;225(1):34-39.
    • (2010) Exp Neurol. , vol.225 , Issue.1 , pp. 34-39
    • Jones, J.L.1    Coles, A.J.2
  • 39
    • 84874031393 scopus 로고    scopus 로고
    • When to initiate disease-modifying drugs for relapsing remitting multiple sclerosis in adults?
    • 72487110.1155/2011/724871
    • Alkawajah M, Oger J. When to initiate disease-modifying drugs for relapsing remitting multiple sclerosis in adults? Mult Scler Int. 2011;2011:72487110.1155/2011/724871.
    • (2011) Mult Scler Int. , vol.2011
    • Alkawajah, M.1    Oger, J.2
  • 40
    • 33947102185 scopus 로고    scopus 로고
    • Progression in multiple sclerosis: Further evidence of an age dependent process
    • Koch M, Mostert J, Heersema D, De Keyser J. Progression in multiple sclerosis: further evidence of an age dependent process. J Neurol Sci. 2007;255(1-2): 35-41.
    • (2007) J Neurol Sci. , vol.255 , Issue.1-2 , pp. 35-41
    • Koch, M.1    Mostert, J.2    Heersema, D.3    De Keyser, J.4
  • 41
    • 33244469927 scopus 로고    scopus 로고
    • Age at disability milestones in multiple sclerosis
    • Confavreux C, Vukusic S. Age at disability milestones in multiple sclerosis. Brain. 2006;129(pt 3):595-605.
    • (2006) Brain , vol.129 , Issue.PART 3 , pp. 595-605
    • Confavreux, C.1    Vukusic, S.2
  • 42
    • 43549113832 scopus 로고    scopus 로고
    • Natural history of secondary-progressive multiple sclerosis
    • Tremlett H, Yinshan Zhao, Devonshire V. Natural history of secondary-progressive multiple sclerosis. Mult Scler. 2008;14(3):314-324.
    • (2008) Mult Scler. , vol.14 , Issue.3 , pp. 314-324
    • Tremlett, H.1    Zhao, Y.2    Devonshire, V.3
  • 43
    • 0024504359 scopus 로고
    • The natural history of multiple sclerosis: A geographically based study, I: Clinical course and disability
    • Weinshenker BG, Bass B, Rice GP, et al. The natural history of multiple sclerosis: a geographically based study, I: clinical course and disability. Brain. 1989; 112(pt 1):133-146.
    • (1989) Brain , vol.112 , Issue.PART 1 , pp. 133-146
    • Weinshenker, B.G.1    Bass, B.2    Rice, G.P.3
  • 44
    • 38049170558 scopus 로고    scopus 로고
    • An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus
    • DeLuca GC, Ramagopalan SV, Herrera BM, et al. An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus. Proc Natl Acad Sci U S A. 2007;104(52):20896- 20901.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.52 , pp. 20896-20901
    • DeLuca, G.C.1    Ramagopalan, S.V.2    Herrera, B.M.3


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