The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect

Pharmacology and Therapeutics

Volumn 162, Issue , 2016, Pages 179-187

  Chu, Shifeng ^a,b   Liu, Shaolin ^c   Duan, Wenzhen ^d   Cheng, Yong ^a   Jiang, Xueying ^e   Zhu, Chuanjiang ^a   Tang, Kang ^f   Wang, Runsheng ^g   Xu, Lin ^h   Wang, Xiaoying ⁱ   Yu, Xiaoming ^a   Wu, Kemei ^a   Wang, Yan ^a   Wang, Muzou ^a   Huang, Huiyong ^b   Zhang, Juntian ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^f UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^g UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^h Franciscan Hospital for Children   (United States)

ⁱ INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

Calcium; Chirality; Clausenamide; Dementia; Long term potentiation; Signaling pathway

Indexed keywords

CALCIUM ION; CLAUSENAMIDE; NOOTROPIC AGENT; TAU PROTEIN; LACTAM; LIGNAN;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CHIRALITY; CHOLINERGIC SYSTEM; COGNITION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENANTIOMER; HERBAL MEDICINE; HIPPOCAMPUS; INTRACELLULAR SPACE; LEARNING; LONG TERM POTENTIATION; MEMORY DISORDER; NERVE CELL PLASTICITY; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CHEMISTRY; CHINESE MEDICINE; DEMENTIA; HUMAN; MEMORY DISORDERS;

ANIMALS; DEMENTIA; HUMANS; LACTAMS; LIGNANS; MEDICINE, CHINESE TRADITIONAL; MEMORY DISORDERS;

EID: 84961141577     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2016.01.002     Document Type: Review

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