Stereoselective pharmacokinetics of clausenamide enantiomers and their major metabolites after single intravenous and oral administration to rats

Chirality

Volumn 15, Issue 8, 2003, Pages 668-673

  Zhu, Chuan Jiang ^a   Zhang, Jun Tian ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

4 hydroxyclausenamide; 7 hydroxyclausenamide; Clausenamide enantiomers; Rat; Stereoselective pharmacokinetics

Indexed keywords

4 HYDROXYCLAUSENAMIDE; 7 HYDROXYCLAUSENAMIDE; CLAUSENAMIDE; CYTOCHROME P450; CYTOCHROME P450 3A; NEFIRACETAM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG PROTEIN BINDING; ENANTIOMER; FEMALE; FIRST PASS EFFECT; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ALGORITHMS; ANIMALS; AREA UNDER CURVE; BIOTRANSFORMATION; FEMALE; HALF-LIFE; INJECTIONS, INTRAVENOUS; LACTAMS; LIGNANS; MAGNETIC RESONANCE SPECTROSCOPY; RATS; RATS, WISTAR; STEREOISOMERISM;

EID: 0141790337     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.10278     Document Type: Article

References (18)

1. Yang MH, Cao YH, Li WX, Yang YQ, Chen YY, Huang L. Isolation and structural elucidation of clausenamide from the leaves of Clausena lansium (Lour.) Skeels. Acta Pharm Sin 1987;22:33-40.
2. Duan WZ, Zhang JT. Effects of (-),(+)-clausenamide on anisodine-induced acetylcholine decrease and associated memory deficits in the mouse brain. Acta Pharm Sin 1998a;33:259-263.
3. Duan WZ, Zhang JT. Stimulation of central cholinergic neurons by (-)-clausenamide in vitro. Acta Pharamcol Sin 1998b;19:332-336.
4. Liu SL, Zhang JT. Difference between the effects of (-)-clausenamide and (+)-clausenamide on the synaptic transmission in the dentate gyrus of anesthetized rats. Acta Pharm Sin 1998;33:254-258.
5. Liu SL, Zhang JT. Effects of clausenamide on the synaptic transmission of the dentate gyrus in freely moving rats. Acta Pharm Sin 1999;34: 325-328.
6. Jiang XY, Zhang JT. Study of the nootropic mechanism of (-)-clausenamide-influence on the formation of synapses in mouse brain. J Asian Nat Prod Res 1998;1:53-58.
7. Yao QQ, Wang MZ. Metabolic transformation of (-)-clausenamide in rat liver microsomes. Acta Pharm Sin 1998;33:296-299.
8. Yao QQ, Wang MZ. Metabolic transformation of (+)-clausenamide in rat liver microsomes. Acta Pharm Sin 1999;34:303-307.
9. Sakurai T, Ojima H, Yamasaki T. Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)-acetamide (DM-9384) on learning and memory in rats. Jpn J Pharmacol 1989;50:47-53.
10. Zhu CJ, Zhang JT, Qu ZW. Determination of plasma concentration of (-)-clausenamide and 6-hydroxy-clausenamide in rats by HPLC and their pharmacokinetics. Acta Pharm Sin 2000;35:500-504.
11. Liu CX, Liu DY. Pharmacokinetics. Beijing: China Academic Press; 1984. 86 p.
12. Zhu CJ, Zhang JT. Identification of rat cytochrome P450 forms involved in the metabolism of clausenamide enantiomers. Chirality 2003;15:448-455.
13. Lin JH, Chiba M, Chen I-W, Nishime JA, Deluna FA, Yamazaki M, Lin YJ. Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A and P-glycoprotein induction. Drug Metab Dispos 1999;27:1187-1193.
14. Johnson TN, Tanner MS, Tucker GT. A comparison of the ontogeny of enterocytic and hepatic cytochromes P450 3A in the rat. Biochem Pharmacol 2000;60:1601-1610.
15. Yokogawa K, Shimada T, Higashi Y, Itoh Y, Masue T, Ishizaki J, Asahi M, Miyamoto K. Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin: a disposition kinetics by dexamethasone. Biochem Pharmacol 2002;63: 777-783.
16. Schuetz EG, Schuetz JD, Grogan WM, Naray-Fejes-Toth A, Fejes-Toth G, Raucy J, Guzelian P, Gionela K, Watlington CO. Expression of cytochrome P450 3A in amphibian, rat, and human kidney. Arch Biochem Biophys 1992;294:206-214.
17. Zhu CJ, Zhang JT. Enzyme kinetics of clausenamide enantiomers in rat liver microsornes. Acta Pharm Sin 2003;38.
18. Arimori K, Yasuda K, Katsuki H, Nakano M. Pharmacokinetics differences between lansoprazole enantiomers in rats. J Pharm Pharmacol 1998;50:1241-1245.