Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

Journal of Medicinal Chemistry

Volumn 59, Issue 5, 2016, Pages 1830-1839

  Rutaganira, Florentine U ^a   Fowler, Melissa L ^b   McPhail, Jacob A ^b   Gelman, Michael A ^c,e   Nguyen, Khanh ^c   Xiong, Anming ^c   Dornan, Gillian L ^b   Tavshanjian, Brandon ^a   Glenn, Jeffrey S ^c,d   Shokat, Kevan M ^a   Burke, John E ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF VICTORIA   (Canada)

^c STANFORD UNIVERSITY   (United States)

^d VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PHOSPHATIDYLINOSITOL 4 KINASE 3BETA INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 4-KINASE IIIBETA, HUMAN; PHOSPHOTRANSFERASE; PROTEIN KINASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HEPACIVIRUS; METABOLISM; MICROBIAL SENSITIVITY TEST; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HEPACIVIRUS; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84960857267     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01311     Document Type: Article

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