Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action

Journal of Medicinal Chemistry

Volumn 58, Issue 9, 2015, Pages 3767-3793

  Mejdrová, Ivana ^a   Chalupská, Dominika ^a   Kögler, Martin ^a   Šála, Michal ^a   Plačková, Pavla ^a   Baumlová, Adriana ^a   Hřebabecký, Hubert ^a   Procházková, Eliška ^a   Dejmek, Milan ^a   Guillon, Rémi ^a   Strunin, Dmytro ^a   Weber, Jan ^a   Lee, Gary ^b   Birkus, Gabriel ^b   Mertlíková Kaiserová, Helena ^a   Boura, Evzen ^a   Nencka, Radim ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ADENOSINE TRIPHOSPHATE; ANTIVIRUS AGENT; PHOSPHATIDYLINOSITOL 4 KINASE IIIBETA; PHOSPHATIDYLINOSITOL 4 KINASE IIIBETA INHIBITOR; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; ETHYLENEDIAMINE DERIVATIVE; IMIDAZOLE DERIVATIVE; ISOENZYME; PHOSPHATIDYLINOSITOL 4-KINASE IIIBETA, HUMAN; PHOSPHOTRANSFERASE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIAZINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTRACELLULAR MEMBRANE; MOLECULAR DOCKING; NONHUMAN; PHOSPHORYLATION; SINGLE-STRANDED RNA VIRUS; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG EFFECTS; HELA CELL LINE; PROTEIN CONFORMATION; RNA VIRUS; SYNTHESIS;

ADENOSINE TRIPHOSPHATE; ANTIVIRAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ETHYLENEDIAMINES; HELA CELLS; HUMANS; IMIDAZOLES; ISOENZYMES; MOLECULAR DOCKING SIMULATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN CONFORMATION; PYRAZOLES; PYRIDINES; PYRIMIDINES; RNA VIRUSES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 84929376559     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00499     Document Type: Article

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