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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3714-3718

2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication

(13) Keaney, Erin P a Connolly, Michael a Dobler, Markus a Karki, Rajeshri a Honda, Ayako a Sokup, Samantha a Karur, Subramanian a Britt, Shawn a Patnaik, Anup a Raman, Prakash a Hamann, Lawrence G a Wiedmann, Brigitte a Lamarche, Matthew J a

a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

Author keywords

HCV; PI4K

Indexed keywords

2 ALKYLOXAZOLE DERIVATIVE; ANTIVIRUS AGENT; OXAZOLE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4 KINASE III BETA; PHOSPHATIDYLINOSITOL 4 KINASE III BETA INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; PHOSPHOTRANSFERASE; PROTEIN KINASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CYCLIZATION; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; GENOTYPE; HEPATITIS C VIRUS; IN VITRO STUDY; PHARMACOPHORE; REPLICON; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; HEPACIVIRUS; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

HEPATITIS C VIRUS;

ANTIVIRAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPACIVIRUS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXAZOLES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84905903216 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.07.015 Document Type: Article

Times cited : (22)

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