SIRT1 exerts protective effects against paraquat-inducedinjury in mouse type II alveolar epithelial cellsby deacetylating NRF2 in vitro

International Journal of Molecular Medicine

Volumn 37, Issue 4, 2016, Pages 1049-1058

  Ding, Ying Wei ^a   Zhao, Guang Ju ^a   Li, Xiao Lin ^a   Hong, Guang Liang ^a   Li, Meng Fang ^a   Qiu, Qiao Meng ^a   Wu, Bin ^a   Lu, Zhong Qiu ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Deacetylate; Nuclear factor E2 related factor 2; Oxidative stress; Paraquat; Silent information regulator 2 related enzyme 1

Indexed keywords

CATALASE; CYCLOHEXIMIDE; GLUTATHIONE; HEME OXYGENASE 1; MALONALDEHYDE; PARAQUAT; SHORT HAIRPIN RNA; SIRTUIN 1; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; NFE2L2 PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE;

ACETYLATION; ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM CELL; LUNG INJURY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARAQUAT POISONING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN TARGETING; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY;

ACETYLATION; ALVEOLAR EPITHELIAL CELLS; ANIMALS; CELLS, CULTURED; LUNG INJURY; MICE; MICE, INBRED ICR; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PARAQUAT; SIRTUIN 1; UP-REGULATION;

EID: 84960510809     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2016.2503     Document Type: Article

References (40)

1. Gawarammana IB and Buckley NA: Medical management of paraquat ingestion. Br J Clin Pharmacol 72: 745-757, 2011.
2. Shao X and Chen JH: Progress on pathogenesis and treatment of paraquat-induced pulmonary fibrosis. Zhejiang Da Xue Xue Bao Yi Xue Ban 43: 717-727, 2014 (In Chinese).
3. He X, Wang L, Szklarz G, Bi Y and Ma Q: Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway. J Pharmacol Exp Ther 342: 81-90, 2012.
4. Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS and Rahman I: SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J 24: 3145-3159, 2010.
5. Salminen A, Kaarniranta K and Kauppinen A: Crosstalk between oxidative stress and SIRT1: impact on the aging process. Int J Mol Sci 14: 3834-3859, 2013.
6. Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ and Rahman I: Disruption of sirtuin 1-mediated control of circadian molecular clock and inflammation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 53: 782-792, 2015.
7. Chun P: Role of sirtuins in chronic obstructive pulmonary disease. Arch Pharm Res 38: 1-10, 2015.
8. Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL and Rahman I: SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol 305: L615-L624, 2013.
9. Hong GL, Cai QQ, Tan JP, Jiang XZ, Zhao GJ, Wu B, Li MF, Qiu QM and Lu ZQ: Mifepristone-inducible recombinant adenovirus attenuates paraquat-induced lung injury in rats. Hum Exp Toxicol 34: 32-43, 2015.
10. Hong GL, Liu JM, Zhao GJ, Wang L, Liang G, Wu B, Li MF, Qiu QM and Lu ZQ: The reversal of paraquat-induced mitochondria-mediated apoptosis by cycloartenyl ferulate, the important role of Nrf2 pathway. Exp Cell Res 319: 2845-2855, 2013.
11. Dinkova-Kostova AT: The role of sulfhydryl reactivity of small molecules for the activation of the KEAP1/NRF2 pathway and the heat shock response. Scientifica (Cairo) 2012: 606104, 2012.
12. Giudice A, Arra C and Turco MC: Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents. Methods Mol Biol 647: 37-74, 2010.
13. Motohashi H and Yamamoto M: Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10: 549-557, 2004.
14. Huang K, Huang J, Xie X, Wang S, Chen C, Shen X, Liu P and Huang H: Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells. Free Radic Biol Med 65: 528-540, 2013.
15. Huang K, Chen C, Hao J, Huang J, Wang S, Liu P and Huang H: Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells. Mol Cell Endocrinol 399: 178-189, 2015.
16. Potteti HR, Rajasekaran S, Rajamohan SB, Tamatam CR, Machireddy N and Reddy SP: Sirtuin 1 promotes hyperoxia-induced lung epithelial death independent of NRF2 activation. Am J Respir Cell Mol Biol: Oct 14, 2015 (Epub ahead of print).
17. Cai Q, Lu Z, Hong G, Jiang X, Wu Z, Zheng J, Song Q and Chang Z: Recombinant adenovirus Ad-RUNrf2 reduces paraquat-induced A549 injury. Hum Exp Toxicol 31: 1102-1112, 2012.
18. Lu H, Chang Z, Han W, Wang L and Hong G: Curcumin reduces paraquat-induced oxidative injury in A549 cells by activation of the Nrf2-ARE pathway. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 32: 44-49, 2014.
19. Dinis-Oliveira RJ, Pontes H, Bastos ML, Remião F, Duarte JA and Carvalho F: An effective antidote for paraquat poisonings: the treatment with lysine acetylsalicylate. Toxicology 255: 187-193, 2009.
20. Kim YS, Zerin T and Song HY: Antioxidant action of ellagic acid ameliorates paraquat-induced A549 cytotoxicity. Biol Pharm Bull 36: 609-615, 2013.
21. Yang SR, Park JR and Kang KS: Reactive oxygen species in mesenchymal stem cell aging: implication to lung diseases. Oxid Med Cell Longev 2015: p486263, 2015.
22. Toygar M, Aydin I, Agilli M, Aydin FN, Oztosun M, Gul H, Macit E, Karslioglu Y, Topal T, Uysal B and Honca M: The relation between oxidative stress, inflammation, and neopterin in the paraquat-induced lung toxicity. Hum Exp Toxicol 34: 198-204, 2015.
23. Wang X, Luo F and Zhao H: Paraquat-induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK/NF-κB-IL-6/TNF-α positive-feedback circuit. PLoS One 9: e93837, 2014.
24. Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, Remião F, Bastos ML and Carvalho F: Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol 38: 13-71, 2008.
25. Senator A, Rachidi W, Lehmann S, Favier A and Benboubetra M: Prion protein protects against DNA damage induced by paraquat in cultured cells. Free Radic Biol Med 37: 1224-1230, 2004.
26. Zhang S, Zhang Y, Li H, Xu W, Chu K, Chen L and Chen X: Antioxidant and anti-excitotoxicity effect of Gualou Guizhi decoction on cerebral ischemia/reperfusion injury in rats. Exp Ther Med 9: 2121-2126, 2015.
27. Jiang XZ, Song Q, Xu XP, Cai QQ, Hong GL, Liang H and Lu ZQ: The effects of Nrf2 gene expression induced by RU486 at different doses on A549 cell damage induced by paraquat. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 30: 268-272, 2012 (In Chinese).
28. Lee HJ, Han J, Jang Y, Kim SJ, Park JH, Seo KS, Jeong S, Shin S, Lim K, Heo JY and Kweon GR: Docosahexaenoic acid prevents paraquat-induced reactive oxygen species production in dopaminergic neurons via enhancement of glutathione homeostasis. Biochem Biophys Res Commun 457: 95-100, 2015.
29. Giudice A and Montella M: Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention. Bioessays 28: 169-181, 2006.
30. Varì R, Scazzocchio B, Santangelo C, Filesi C, Galvano F, D'Archivio M, Masella R and Giovannini C: Protocatechuic acid prevents oxLDL-induced apoptosis by activating JNK/Nrf2 survival signals in macrophages. Oxid Med Cell Longev, p351827, 2015.
31. Ci X, Lv H, Wang L, Wang X, Peng L, Qin FX and Cheng G: The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells. Chem Biol Interact 239: 192-199, 2015.
32. He XY, Zhao GJ, Lu ZQ, Hong GL, He F, Liang H, Qiu QM and Li JR: Oxidative stress of acute paraquat poisoned rats and sodium dimercaptopropane sulfonate intervention. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 27: 476-479, 2009 (In Chinese).
33. Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M and Kensler TW: Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 278: 8135-8145, 2003.
34. Baird L, Llères D, Swift S and Dinkova-Kostova AT: Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex. Proc Natl Acad Sci USA 110: 15259-15264, 2013.
35. Sun Z, Chin YE and Zhang DD: Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol 29: 2658-2672, 2009.
36. Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K and Barnes PJ: Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun 406: 292-298, 2011.
37. Yang WJ, Wang DL and Zhu WG: Mechanism of regulating deacetylase SIRT1 expression and activity. Yi Chuan 32: 1003-1008, 2010 (In Chinese).
38. Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente L and Rahman I: SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 306: L816-L828, 2014.
39. Tyagi N, Kumari A, Dash D and Singh R: Protective effects of intranasal curcumin on paraquot-induced acute lung injury (ALI) in mice. Environ Toxicol Pharmacol 38: 913-921, 2014.
40. Li S, Zhao G, Chen L, Ding Y, Lian J, Hong G and Lu Z: Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways. Mol Med Rep 13: 1833-1838, 2016.