Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells

Molecular and Cellular Endocrinology

Volumn 399, Issue , 2015, Pages 178-189

  Huang, Kaipeng ^a,b   Chen, Cheng ^b   Hao, Jie ^b   Huang, Junying ^b   Wang, Shaogui ^b   Liu, Peiqing ^b   Huang, Heqing ^b  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Advanced glycation end products; Diabetic nephropathy; Nrf2 are pathway; Oxidative stress; Polydatin; Sirt1

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; COPPER ZINC SUPEROXIDE DISMUTASE; FIBRONECTIN; HEME OXYGENASE 1; HISTONE DEACETYLASE; NATURAL PRODUCT; POLYDATIN; SIRTUIN 1; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; GLUCOSIDE; IMMUNOGLOBULIN RECEPTOR; NFE2L2 PROTEIN, RAT; SIRT1 PROTEIN, RAT; STILBENE DERIVATIVE; TGFB1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HO 1 GENE; MALE; MESANGIUM CELL; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SOD1 GENE; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DIABETIC NEPHROPATHY; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; FIBRONECTINS; GENE SILENCING; GLUCOSIDES; GLYCOSYLATION END PRODUCTS, ADVANCED; MESANGIAL CELLS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; RESPONSE ELEMENTS; SIRTUIN 1; STILBENES; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84908571333     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2014.08.014     Document Type: Article

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