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Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 8, 2016, Pages 1901-1904

Identification of nonabsorbable inhibitors of the scavenger receptor-BI (SR-BI) for tissue-specific administration

(9) Sparks, Steven M a,b Zhou, Huiqiang a Generaux, Claudia a Harston, Lindsey a Moncol, David a Jayawickreme, Channa a Parham, Janet a Condreay, Patrick a Rimele, Thomas a

a GLAXOSMITHKLINE (United States)

b Viamet Pharmaceuticals (United States)

Author keywords

Intestinal SR BI; Nonabsorbed SR BI inhibitor; Scavenger receptor class B type I; SR BI inhibitor

Indexed keywords

ITX 5061; RECEPTOR BLOCKING AGENT; SCAVENGER RECEPTOR BI; UNCLASSIFIED DRUG; ITX-5061; PHENYLENEDIAMINE DERIVATIVE; SCARB1 PROTEIN, HUMAN; SCARB1 PROTEIN, RAT; SCAVENGER RECEPTOR B; SULFONAMIDE;

ARTICLE; DRUG IDENTIFICATION; DRUG POTENCY; HUMAN; HUMAN CELL; INHIBITION KINETICS; NONHUMAN; PERMEABILITY; RAT; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; TISSUE SPECIFICITY; U2OS CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; CHEMICAL STRUCTURE; CHEMISTRY; DOG; DOSE RESPONSE; MDCK CELL LINE;

ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MOLECULAR STRUCTURE; ORGAN SPECIFICITY; PHENYLENEDIAMINES; RATS; SCAVENGER RECEPTORS, CLASS B; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84960510698 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2016.03.025 Document Type: Article

Times cited : (5)

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