Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes

Journal of Medicinal Chemistry

Volumn 56, Issue 12, 2013, Pages 5094-5114

  Wu, Yulin ^a   Aquino, Christopher J ^a   Cowan, David J ^a   Anderson, Don L ^a   Ambroso, Jeff L ^a   Bishop, Michael J ^a   Boros, Eric E ^a   Chen, Lihong ^a   Cunningham, Alan ^a   Dobbins, Robert L ^a   Feldman, Paul L ^a   Harston, Lindsey T ^a   Kaldor, Istvan W ^a   Klein, Ryan ^a   Liang, Xi ^a   McIntyre, Maggie S ^a   Merrill, Christine L ^a   Patterson, Kristin M ^a   Prescott, Judith S ^a   Ray, John S ^a   Roller, Shane G ^a   Yao, Xiaozhou ^a   Young, Andrew ^a   Yuen, Josephine ^a   Collins, Jon L ^a   more..

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; GSK 2330672; HEMOGLOBIN A1C; INSULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CARBONYLATION; CELL MEMBRANE PERMEABILITY; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DRUG ABSORPTION; DRUG INDUSTRY; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IONIZATION; LIPOPHILICITY; MALE; MOLECULAR SIZE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PORTAL VEIN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BILE ACIDS AND SALTS; DIABETES MELLITUS, TYPE 2; DOGS; DRUG DISCOVERY; DRUG STABILITY; HEK293 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METHYLAMINES; MICE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RATS; SOLUBILITY; SYMPORTERS; THIAZEPINES;

EID: 84879570980     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400459m     Document Type: Article

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