Intestinal SR-BI is upregulated in insulin-resistant states and is associated with overproduction of intestinal apoB48-containing lipoproteins

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 2, 2011, Pages

  Hayashi, Amanda A ^a   Webb, Jennifer ^a   Choi, Joanna ^a   Baker, Chris ^a   Lino, Marsel ^a   Trigatti, Bernardo ^b   Trajcevski, Karin E ^b   Hawke, Thomas J ^b   Adeli, Khosrow ^a  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Apolipoprotein; Apolipoprotein B; Chylomicron; Hamster; Insulin resistance; Intestine; ; Scavenger receptor class B type I

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; ADENOSINE TRIPHOSPHATE; APOLIPOPROTEIN B48; CARBOHYDRATE; CHOLESTEROL; CHYLOMICRON; FATTY ACID TRANSPORTER 4; GLUCOSE; INSULIN; KETAMINE; LIPID; LIPOPROTEIN; MESSENGER RNA; OLEIC ACID; SCAVENGER RECEPTOR BI; TRIACYLGLYCEROL; XYLAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DUODENUM; DYSLIPIDEMIA; FAT INTAKE; FOOD INTAKE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GLUCOSE BLOOD LEVEL; HAMSTER; HUMAN; HUMAN CELL; ILEUM; INSULIN RESISTANCE; JEJUNUM; LIPID ABSORPTION; LIPID ANALYSIS; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA INTERFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

ANIMALS; ANTIGENS, CD36; APOLIPOPROTEIN B-48; ATP-BINDING CASSETTE TRANSPORTERS; CRICETINAE; DIETARY FATS; DUODENUM; DYSLIPIDEMIAS; FASTING; FATTY ACID TRANSPORT PROTEINS; FRUCTOSE; GENE EXPRESSION; ILEUM; INSULIN; INSULIN RESISTANCE; INTESTINAL MUCOSA; JEJUNUM; LIPOPROTEINS; MALE; MEMBRANE TRANSPORT PROTEINS; MESOCRICETUS; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; POSTPRANDIAL PERIOD; RNA, MESSENGER; UP-REGULATION;

EID: 79960976746     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00425.2010     Document Type: Article

References (29)

1. Adeli K, Lewis GF. Intestinal lipoprotein overproduction in insulinresistant states. Curr Opin Lipidol 19: 221-228, 2008.
2. Ahmed RA, Murao K, Imachi H, Yu X, Li J, Wong NC, Ishida T. Human scavenger receptor class B type 1 is regulated by activators of peroxisome proliferators-activated receptor-gamma in hepatocytes. Endocrine 35: 233-242, 2009.
3. Beaslas O, Cueille C, Delers F, Chateau D, Chambaz J, Rousset M, Carriere V. Sensing of dietary lipids by enterocytes: a new role for SR-BI/CLA-1. PLoS One 4: e4278, 2009.
4. Bietrix F, Yan D, Nauze M, Rolland C, Bertrand-Michel J, Comera C, Schaak S, Barbaras R, Groen AK, Perret B, Terce F, Collet X. Accelerated lipid absorption in mice overexpressing intestinal SR-BI. J Biol Chem 281: 7214-7219, 2006.
5. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
6. Cai L, Eckhardt ER, Shi W, Zhao Z, Nasser M, de Villiers WJ, van der Westhuyzen DR. Scavenger receptor class B type I reduces cholesterol absorption in cultured enterocyte CaCo-2 cells. J Lipid Res 45: 253-262, 2004.
7. Cai SF, Kirby RJ, Howles PN, Hui DY. Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine. J Lipid Res 42: 902-909, 2001.
8. Connelly MA, Williams DL. SR-BI and HDL cholesteryl ester metabolism. Endocr Res 30: 697-703, 2004.
9. Federico LM, Naples M, Taylor D, Adeli K. Intestinal insulin resistance and aberrant production of apolipoprotein B48 lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia: evidence for activation of protein tyrosine phosphatase-1B, extracellular signal-related kinase, and sterol regulatory element-binding protein-1c in the fructosefed hamster intestine. Diabetes 55: 1316-1326, 2006.
10. Guo Q, Avramoglu RK, Adeli K. Intestinal assembly and secretion of highly dense/lipid-poor apolipoprotein B48-containing lipoprotein particles in the fasting state: evidence for induction by insulin resistance and exogenous fatty acids. Metabolism 54: 689-697, 2005.
11. Haidari M, Leung N, Mahbub F, Uffelman KD, Kohen-Avramoglu R, Lewis GF, Adeli K. Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance. Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and ApoB48-containing lipoprotein overproduction. J Biol Chem 277: 31646-31655, 2002.
12. Hansen GH, Niels-Christiansen LL, Immerdal L, Danielsen EM. Scavenger receptor class B type I (SR-BI) in pig enterocytes: trafficking from the brush border to lipid droplets during fat absorption. Gut 52: 1424-1431, 2003.
13. Hussain MM. A proposed model for the assembly of chylomicrons. Atherosclerosis 148: 1-15, 2000.
14. Hussain MM, Kancha RK, Zhou Z, Luchoomun J, Zu H, Bakillah A. Chylomicron assembly and catabolism: role of apolipoproteins and receptors. Biochim Biophys Acta 1300: 151-170, 1996.
15. Levy E, Lalonde G, Delvin E, Elchebly M, Precourt LP, Seidah NG, Spahis S, Rabasa-Lhoret R, Ziv E. Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus. Endocrinology 151: 958-970, 2010.
16. Lewis GF, Uffelman K, Naples M, Szeto L, Haidari M, Adeli K. Intestinal lipoprotein overproduction, a newly recognized component of insulin resistance, is ameliorated by the insulin sensitizer rosiglitazone: studies in the fructose-fed Syrian golden hamster. Endocrinology 146: 247-255, 2005.
17. Masuda D, Nakagawa-Toyama Y, Nakatani K, Inagaki M, Tsubakio- Yamamoto K, Sandoval JC, Ohama T, Nishida M, Ishigami M, Yamashita S. Ezetimibe improves postprandial hyperlipidaemia in patients with type IIb hyperlipidaemia. Eur J Clin Invest 39: 689-698, 2009.
18. McCarthy JJ, Somji A, Weiss LA, Steffy B, Vega R, Barrett-Connor E, Talavera G, Glynne R. Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction. J Clin Endocrinol Metab 94: 1789-1796, 2009.
19. Nguyen DV, Drover VA, Knopfel M, Dhanasekaran P, Hauser H, Phillips MC. Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption. J Lipid Res 50: 2235-2244, 2009.
20. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36, 2002.
21. Qin B, Qiu W, Avramoglu RK, Adeli K. Tumor necrosis factor-alpha induces intestinal insulin resistance and stimulates the overproduction of intestinal apolipoprotein B48-containing lipoproteins. Diabetes 56: 450-461, 2007.
22. Rozen S, Skaletsky H. Primer3 on the for general users and for biologist programmers. Methods Mol Biol 132: 365-386, 2000.
23. Sandoval JC, Nakagawa-Toyama Y, Masuda D, Tochino Y, Nakaoka H, Kawase R, Yuasa-Kawase M, Nakatani K, Inagaki M, Tsubakio- Yamamoto K, Ohama T, Matsuyama A, Nishida M, Ishigami M, Komuro I, Yamashita S. Molecular mechanisms of ezetimibe-induced attenuation of postprandial hypertriglyceridemia. J Atheroscler Thromb 17: 914-924, 2010.
24. Shetty S, Eckhardt ER, Post SR, van der Westhuyzen DR. Phosphatidylinositol- 3-kinase regulates scavenger receptor class B type I subcellular localization and selective lipid uptake in hepatocytes. Arterioscler Thromb Vasc Biol 26: 2125-2131, 2006.
25. Shortreed KE, Krause MP, Huang JH, Dhanani D, Moradi J, Ceddia RB, Hawke TJ. Muscle-specific adaptations, impaired oxidative capacity and maintenance of contractile function characterize diet-induced obese mouse skeletal muscle. PLoS One 4: e7293, 2009.
26. Taghibiglou C, Rudy D, Van Iderstine SC, Aiton A, Cavallo D, Cheung R, Adeli K. Intracellular mechanisms regulating apoB-containing lipoprotein assembly and secretion in primary hamster hepatocytes. J Lipid Res 41: 499-513, 2000.
27. Tancevski I, Frank S, Massoner P, Stanzl U, Schgoer W, Wehinger A, Fievet C, Eller P, Patsch JR, Ritsch A. Increased plasma levels of LDL cholesterol in rabbits after adenoviral overexpression of human scavenger receptor class B type I. J Mol Med 83: 927-932, 2005.
28. Tondu AL, Robichon C, Yvan-Charvet L, Donne N, Le L, Hajduch E, Ferre P, Dugail I, Dagher G. Insulin and angiotensin II induce the translocation of scavenger receptor class B, type I from intracellular sites to the plasma membrane of adipocytes. J Biol Chem 280: 33536-33540, 2005.
29. van der Velde AE, Vrins CL, van den OK, Seemann I, Oude Elferink RP, van Eck M, Kuipers F, Groen AK. Regulation of direct transintestinal cholesterol excretion in mice. Am J Physiol Gastrointest Liver Physiol 295: G203-G208, 2008.