Uric acid enhances PKC-dependent eNOS phosphorylationand mediates cellular ER stress: A mechanism for uric acid-induced endothelial dysfunction

International Journal of Molecular Medicine

Volumn 37, Issue 4, 2016, Pages 989-997

  Li, Peng ^a,b   Zhang, Lina ^b   Zhang, Mei ^a   Zhou, Changyong ^b   Lin, Nan ^b  

^a SHANDONG UNIVERSITY   (China)

^b QINGDAO UNIVERSITY   (China)

Author keywords

Endoplasmic reticulum stress; Endothelial cells; Endothelial nitric oxide synthase; Protein kinase C; Reactive oxygen species; Uric acid

Indexed keywords

CALMODULIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LIPOCORTIN 5; MACROGOL; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; URIC ACID; MACROGOL DERIVATIVE; NITRIC OXIDE; POLYETHYLENE GLYCOL-SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL INTERACTION; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; ENDOTHELIUM CELL; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

APOPTOSIS; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHORYLATION; POLYETHYLENE GLYCOLS; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; URIC ACID;

EID: 84960493690     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2016.2491     Document Type: Article

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