Activation of ERK1/2 by NADPH oxidase-originated reactive oxygen species mediates uric acid-induced mesangial cell proliferation

American Journal of Physiology - Renal Physiology

Volumn 307, Issue 4, 2014, Pages

  Zhuang, Yibo ^a   Feng, Quancheng ^a   Ding, Guixia ^a   Zhao, Min ^a   Che, Ruochen ^a   Bai, Mi ^a   Bao, Huaying ^a   Zhang, Aihua ^a   Huang, Songming ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Cell proliferation; ERK1 2; Mesangial cells; Reactive oxygen species; Uric acid

Indexed keywords

APOCYNIN; CYCLIN A2; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; URIC ACID;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL COUNTING; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MESANGIUM CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; UPREGULATION; WESTERN BLOTTING;

CELL PROLIFERATION; ERK1/2; MESANGIAL CELLS; REACTIVE OXYGEN SPECIES; URIC ACID;

ACETOPHENONES; ANIMALS; BUTADIENES; CELL PROLIFERATION; CYCLIN A2; CYCLIN D1; FLAVONOIDS; MESANGIAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NADPH OXIDASE; NITRILES; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; URIC ACID;

EID: 84906066493     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00565.2013     Document Type: Article

References (36)

1. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489-27494, 1995.
2. Bellomo G. Uric acid and chronic kidney disease: a time to act? World J Nephrol 2: 17-25, 2013.
3. Bokemeyer D, Sorokin A, Dunn MJ. Multiple intracellular MAP kinase signaling cascades. Kidney Int 49: 1187-1198, 1996.
4. Causevic A, Semiz S, Macic Dzankovic A, Cico B, Dujic T, Malenica M, Bego T. Relevance of uric acid in progression of type 2 diabetes mellitus. Bosn J Basic Med Sci 10: 54-59, 2010.
5. Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J Hypertens 26: 269-275, 2008.
6. Dichtl W, Dulak J, Frick M, Alber HF, Schwarzacher SP, Ares MP, Nilsson J, Pachinger O, Weidinger F. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 23: 58-63, 2003.
7. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95, 2002.
8. Duann P, Ho TY, Desai BD, Kapoian T, Cowen DS, Lianos EA. Mesangial cell apoptosis induced by stimulation of the adenosine A3 receptor: signaling and apoptotic events. J Investig Med 53: 37-43, 2005.
9. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632, 1998.
10. Foresti R, Sarathchandra P, Clark JE, Green CJ, Motterlini R. Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis. Biochem J 339: 729-736, 1999.
11. Girard F, Strausfeld U, Fernandez A, Lamb NJ. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67: 1169-1179, 1991.
12. Hayden MR, Tyagi SC. Uric acid: a new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: the urate redox shuttle. Nutr Metab (Lond) 1: 10, 2004.
13. Ingram AJ, Krepinsky JC, James L, Austin RC, Tang D, Salapatek AM, Thai K, Scholey JW. Activation of mesangial cell MAPK in response to homocysteine. Kidney Int 66: 733-745, 2004.
14. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, Truong L, Harris R, Johnson RJ. A role for uric acid in the progression of renal disease. J Am Soc Nephrol 13: 2888-2897, 2002.
15. Kean RB, Spitsin SV, Mikheeva T, Scott GS, Hooper DC. The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity. J Immunol 165: 6511-6518, 2000.
16. Kim JS, Yeo S, Shin DG, Bae YS, Lee JJ, Chin BR, Lee CH, Baek SH. Glycogen synthase kinase 3beta and beta-catenin pathway is involved in toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages. FEBS J 277: 2830-2837, 2010.
17. Kosugi T, Nakayama T, Heinig M, Zhang L, Yuzawa Y, Sanchez-Lozada LG, Roncal C, Johnson RJ, Nakagawa T. Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol 297: F481-F488, 2009.
18. LeBel CP, Ischiropoulos H, Bondy SC. Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5: 227-231, 1992.
19. Lee JH, Joo JH, Kim J, Lim HJ, Kim S, Curtiss L, Seong JK, Cui W, Yabe-Nishimura C, Bae YS. Interaction of NADPH oxidase 1 with Toll-like receptor 2 induces migration of smooth muscle cells. Cardiovasc Res 99: 483-493, 2013.
20. Liang CF, Liu JT, Wang Y, Xu A, Vanhoutte PM. Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. Arterioscler Thromb Vasc Biol 33: 777-784, 2013.
21. Lim H, Kim D, Lee SJ. Toll-like receptor 2 mediates peripheral nerve injury-induced NADPH oxidase 2 expression in spinal cord microglia. J Biol Chem 288: 7572-7579, 2013.
22. Liu-Bryan R, Scott P, Sydlaske A, Rose DM, Terkeltaub R. Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum 52: 2936-2946, 2005.
23. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Goutassociated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237-241, 2006.
24. Mesquita FS, Dyer SN, Heinrich DA, Bulun SE, Marsh EE, Nowak RA. Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells. Biol Reprod 82: 341-351, 2010.
25. Miyaoka T, Mochizuki T, Takei T, Tsuchiya K, Nitta K. Serum uric acid levels and long-term outcomes in chronic kidney disease. Heart Vessels 2013.
26. Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, Ouyang X, Feig DI, Block ER, Herrera-Acosta J, Patel JM, Johnson RJ. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 290: F625-F631, 2006.
27. Nakagawa T, Mazzali M, Kang DH, Kanellis J, Watanabe S, Sanchez-Lozada LG, Rodriguez-Iturbe B, Herrera-Acosta J, Johnson RJ. Hyperuricemia causes glomerular hypertrophy in the rat. Am J Nephrol 23: 2-7, 2003.
28. Pardo FS, Su M, Borek C. Cyclin D1 induced apoptosis maintains the integrity of the G1/S checkpoint following ionizing radiation irradiation. Somat Cell Mol Genet 22: 135-144, 1996.
29. Ryu ES, Kim MJ, Shin HS, Jang YH, Choi HS, Jo I, Johnson RJ, Kang DH. Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease. Am J Physiol Renal Physiol 304: F471-F480, 2013.
30. Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol 293: C584-C596, 2007.
31. Schocklmann HO, Lang S, Sterzel RB. Regulation of mesangial cell proliferation. Kidney Int 56: 1199-1207, 1999.
32. Shi Y, Evans JE, Rock KL. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425: 516-521, 2003.
33. Shimada M, Johnson RJ, May WS Jr, Lingegowda V, Sood P, Nakagawa T, Van QC, Dass B, Ejaz AA. A novel role for uric acid in acute kidney injury associated with tumour lysis syndrome. Nephrol Dial Transplant 24: 2960-2964, 2009.
34. Stockand JD, Meszaros JG. Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling. Am J Physiol Heart Circ Physiol 284: H176-H184, 2003.
35. Wang Y, Bao X. Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms. Eur J Med Res 18: 26, 2013.
36. Wu XW, Muzny DM, Lee CC, Caskey CT. Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol 34: 78-84, 1992.