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Volumn 36, Issue 10, 2016, Pages 3049-3063

Ghrelin-AMPK signaling mediates the neuroprotective effects of calorie restriction in Parkinson’s disease

Author keywords

AMPK; Calorie restriction; Ghrelin; Stereology; Substantia nigra

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; GHRELIN; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; CALCIUM BINDING PROTEIN; DOPAMINE TRANSPORTER; GLIAL FIBRILLARY ACIDIC PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; TYROSINE 3 MONOOXYGENASE;

EID: 84960390578     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4373-15.2016     Document Type: Article
Times cited : (134)

References (54)
  • 2
    • 77953749940 scopus 로고    scopus 로고
    • Uncoupling protein-2 and the potential link between metabolism and longevity
    • CrossRef Medline
    • Andrews ZB (2010) Uncoupling protein-2 and the potential link between metabolism and longevity. Curr Aging Sci 3:102–112. CrossRef Medline
    • (2010) Curr Aging Sci , vol.3 , pp. 102-112
    • Andrews, Z.B.1
  • 8
    • 0030926890 scopus 로고    scopus 로고
    • Dietary, anthropometric, hematological and biochemical assessment of the nutritional status of centenarians and elderly people in Okinawa, Japan
    • CrossRef Medline
    • Chan YC, Suzuki M, Yamamoto S (1997) Dietary, anthropometric, hematological and biochemical assessment of the nutritional status of centenarians and elderly people in Okinawa, Japan. J Am Coll Nutr 16: 229–235. CrossRef Medline
    • (1997) J am Coll Nutr , vol.16 , pp. 229-235
    • Chan, Y.C.1    Suzuki, M.2    Yamamoto, S.3
  • 10
    • 84895119109 scopus 로고    scopus 로고
    • Meta-analysis: Overweight, obesity, and Parkinson’s disease
    • CrossRef Medline
    • Chen J, Guan Z, Wang L, Song G, Ma B, Wang Y (2014b) Meta-analysis: overweight, obesity, and Parkinson’s disease. Int J Endocrinol 2014: 203930. CrossRef Medline
    • (2014) Int J Endocrinol , vol.2014
    • Chen, J.1    Guan, Z.2    Wang, L.3    Song, G.4    Ma, B.5    Wang, Y.6
  • 11
    • 72949122084 scopus 로고    scopus 로고
    • AMP-activated protein kinase is activated in Parkinson’s disease models mediated by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine
    • CrossRef Medline
    • Choi JS, Park C, Jeong JW (2010) AMP-activated protein kinase is activated in Parkinson’s disease models mediated by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine. Biochem Biophys Res Commun 391:147–151. CrossRef Medline
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 147-151
    • Choi, J.S.1    Park, C.2    Jeong, J.W.3
  • 12
    • 13844275515 scopus 로고    scopus 로고
    • Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity
    • CrossRef Medline
    • Choi JY, Jang EH, Park CS, Kang JH (2005) Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity. Free Radic Biol Med 38:806–816. CrossRef Medline
    • (2005) Free Radic Biol Med , vol.38 , pp. 806-816
    • Choi, J.Y.1    Jang, E.H.2    Park, C.S.3    Kang, J.H.4
  • 14
    • 61549095546 scopus 로고    scopus 로고
    • Ghrelin antagonized 1-methyl-4- phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells
    • CrossRef Medline
    • Dong J, Song N, Xie J, Jiang H (2009) Ghrelin antagonized 1-methyl-4- phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells. J Mol Neurosci 37:182–189. CrossRef Medline
    • (2009) J Mol Neurosci , vol.37 , pp. 182-189
    • Dong, J.1    Song, N.2    Xie, J.3    Jiang, H.4
  • 15
    • 0033566286 scopus 로고    scopus 로고
    • Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson’s disease
    • CrossRef Medline
    • Duan W, Mattson MP (1999) Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson’s disease. J Neurosci Res 57:195–206. CrossRef Medline
    • (1999) J Neurosci Res , vol.57 , pp. 195-206
    • Duan, W.1    Mattson, M.P.2
  • 17
    • 9644288053 scopus 로고    scopus 로고
    • Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat
    • CrossRef Medline
    • Englander EW, Gomez GA, Greeley GH Jr (2004) Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat. Mech Ageing Dev 125:871–875. CrossRef Medline
    • (2004) Mech Ageing Dev , vol.125 , pp. 871-875
    • Englander, E.W.1    Gomez, G.A.2    Greeley, G.H.3
  • 18
    • 0034883429 scopus 로고    scopus 로고
    • Astrocytic factors protect neuronal integrity and reduce microglial activation in an in vitro model of N-methyl-D-aspartate-induced excitotoxic injury in organotypic hippocampal slice cultures
    • CrossRef Medline
    • Hailer NP, Wirjatijasa F, Roser N, Hischebeth GT, Korf HW, Dehghani F (2001) Astrocytic factors protect neuronal integrity and reduce microglial activation in an in vitro model of N-methyl-D-aspartate-induced excitotoxic injury in organotypic hippocampal slice cultures. Eur J Neurosci 14:315–326. CrossRef Medline
    • (2001) Eur J Neurosci , vol.14 , pp. 315-326
    • Hailer, N.P.1    Wirjatijasa, F.2    Roser, N.3    Hischebeth, G.T.4    Korf, H.W.5    Dehghani, F.6
  • 19
    • 84908488977 scopus 로고    scopus 로고
    • Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling
    • CrossRef Medline
    • Han Y, Jiang C, Tang J, Wang C, Wu P, Zhang G, Liu W, Jamangulova N, Wu X, Song X (2014) Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling. Eur J Pain 18:1458–1470. CrossRef Medline
    • (2014) Eur J Pain , vol.18 , pp. 1458-1470
    • Han, Y.1    Jiang, C.2    Tang, J.3    Wang, C.4    Wu, P.5    Zhang, G.6    Liu, W.7    Jamangulova, N.8    Wu, X.9    Song, X.10
  • 21
    • 21344469043 scopus 로고    scopus 로고
    • Dietary restriction affects striatal glutamate in the MPTP-induced mouse model of nigrostriatal degeneration
    • CrossRef Medline
    • Holmer HK, Keyghobadi M, Moore C, Menashe RA, Meshul CK (2005) Dietary restriction affects striatal glutamate in the MPTP-induced mouse model of nigrostriatal degeneration. Synapse 57:100–112. CrossRef Medline
    • (2005) Synapse , vol.57 , pp. 100-112
    • Holmer, H.K.1    Keyghobadi, M.2    Moore, C.3    Menashe, R.A.4    Meshul, C.K.5
  • 23
    • 79955958928 scopus 로고    scopus 로고
    • GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function
    • CrossRef Medline
    • Horvath TL, Erion DM, Elsworth JD, Roth RH, Shulman GI, Andrews ZB (2011) GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function. Neurobiol Dis 43:152–162. CrossRef Medline
    • (2011) Neurobiol Dis , vol.43 , pp. 152-162
    • Horvath, T.L.1    Erion, D.M.2    Elsworth, J.D.3    Roth, R.H.4    Shulman, G.I.5    Rews, Z.B.6
  • 24
    • 47349087292 scopus 로고    scopus 로고
    • Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra
    • CrossRef Medline
    • Jiang H, Li LJ, Wang J, Xie JX (2008) Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. Exp Neurol 212:532–537. CrossRef Medline
    • (2008) Exp Neurol , vol.212 , pp. 532-537
    • Jiang, H.1    Li, L.J.2    Wang, J.3    Xie, J.X.4
  • 25
    • 84873462892 scopus 로고    scopus 로고
    • Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of alpha-synuclein oligomers and decrease of neurites
    • CrossRef Medline
    • Jiang P, Gan M, Ebrahim AS, Castanedes-Casey M, Dickson DW, Yen SH (2013) Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of alpha-synuclein oligomers and decrease of neurites. Neurobiol Aging 34:1504–1515. CrossRef Medline
    • (2013) Neurobiol Aging , vol.34 , pp. 1504-1515
    • Jiang, P.1    Gan, M.2    Ebrahim, A.S.3    Castanedes-Casey, M.4    Dickson, D.W.5    Yen, S.H.6
  • 26
    • 56149119401 scopus 로고    scopus 로고
    • Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson’s disease in rats
    • CrossRef Medline
    • Jin F, Wu Q, Lu YF, Gong QH, Shi JS (2008) Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson’s disease in rats. Eur J Pharmacol 600:78–82. CrossRef Medline
    • (2008) Eur J Pharmacol , vol.600 , pp. 78-82
    • Jin, F.1    Wu, Q.2    Lu, Y.F.3    Gong, Q.H.4    Shi, J.S.5
  • 27
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescenttagged LC3
    • CrossRef Medline
    • Kimura S, Noda T, Yoshimori T (2007) Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescenttagged LC3. Autophagy 3:452–460. CrossRef Medline
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 29
    • 84926663796 scopus 로고    scopus 로고
    • Ghrelin inhibits oligodendrocyte cell death by attenuating microglial activation
    • CrossRef Medline
    • Lee JY, Yune TY (2014) Ghrelin inhibits oligodendrocyte cell death by attenuating microglial activation. Endocrinol Metab (Seoul) 29:371–378. CrossRef Medline
    • (2014) Endocrinol Metab (Seoul) , vol.29 , pp. 371-378
    • Lee, J.Y.1    Yune, T.Y.2
  • 31
    • 77952700957 scopus 로고    scopus 로고
    • Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia
    • CrossRef Medline
    • Lu DY, Tang CH, Chen YH, Wei IH (2010) Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia. J Cell Biochem 110:697–705. CrossRef Medline
    • (2010) J Cell Biochem , vol.110 , pp. 697-705
    • Lu, D.Y.1    Tang, C.H.2    Chen, Y.H.3    Wei, I.H.4
  • 34
    • 84903994698 scopus 로고    scopus 로고
    • Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet
    • CrossRef Medline
    • McFarlane MR, Brown MS, Goldstein JL, Zhao TJ (2014) Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet. Cell Metab 20:54–60. CrossRef Medline
    • (2014) Cell Metab , vol.20 , pp. 54-60
    • McFarlane, M.R.1    Brown, M.S.2    Goldstein, J.L.3    Zhao, T.J.4
  • 35
    • 80052511813 scopus 로고    scopus 로고
    • TheAMPKsignalling pathway coordinates cell growth, autophagy and metabolism
    • CrossRef Medline
    • Mihaylova MM, Shaw RJ (2011) TheAMPKsignalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 13:1016–1023. CrossRef Medline
    • (2011) Nat Cell Biol , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 36
    • 70449527787 scopus 로고    scopus 로고
    • Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease by blocking microglial activation
    • CrossRef Medline
    • Moon M, Kim HG, Hwang L, Seo JH, Kim S, Hwang S, Kim S, Lee D, Chung H, Oh MS, Lee KT, Park S (2009) Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease by blocking microglial activation. Neurotox Res 15: 332–347. CrossRef Medline
    • (2009) Neurotox Res , vol.15 , pp. 332-347
    • Moon, M.1    Kim, H.G.2    Hwang, L.3    Seo, J.H.4    Kim, S.5    Hwang, S.6    Kim, S.7    Lee, D.8    Chung, H.9    Oh, M.S.10    Lee, K.T.11    Park, S.12
  • 37
    • 0028302235 scopus 로고
    • Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1 mice
    • CrossRef Medline
    • Muthane U, Ramsay KA, Jiang H, Jackson-Lewis V, Donaldson D, Fernando S, Ferreira M, Przedborski S (1994) Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1 mice. Exp Neurol 126:195–204. CrossRef Medline
    • (1994) Exp Neurol , vol.126 , pp. 195-204
    • Muthane, U.1    Ramsay, K.A.2    Jiang, H.3    Jackson-Lewis, V.4    Donaldson, D.5    Fernando, S.6    Ferreira, M.7    Przedborski, S.8
  • 38
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: An essential link between degeneration and regeneration
    • CrossRef Medline
    • Neumann H, Kotter MR, Franklin RJ (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132: 288–295. CrossRef Medline
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.3
  • 39
    • 84867269951 scopus 로고    scopus 로고
    • AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson’s disease
    • CrossRef Medline
    • Ng CH, Guan MS, Koh C, Ouyang X, Yu F, Tan EK, O’Neill SP, Zhang X, Chung J, Lim KL (2012) AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson’s disease. J Neurosci 32:14311–14317. CrossRef Medline
    • (2012) J Neurosci , vol.32 , pp. 14311-14317
    • Ng, C.H.1    Guan, M.S.2    Koh, C.3    Ouyang, X.4    Yu, F.5    Tan, E.K.6    O’Neill, S.P.7    Zhang, X.8    Chung, J.9    Lim, K.L.10
  • 41
    • 33745215883 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in mitochondrial biogenesis
    • CrossRef Medline
    • Reznick RM, Shulman GI (2006) The role of AMP-activated protein kinase in mitochondrial biogenesis. J Physiol 574:33–39. CrossRef Medline
    • (2006) J Physiol , vol.574 , pp. 33-39
    • Reznick, R.M.1    Shulman, G.I.2
  • 43
    • 0025074518 scopus 로고
    • Dose-dependent destruction of the coeruleus-cortical and nigral-striatal projections by MPTP
    • CrossRef Medline
    • Seniuk NA, Tatton WG, Greenwood CE (1990) Dose-dependent destruction of the coeruleus-cortical and nigral-striatal projections by MPTP. Brain Res 527:7–20. CrossRef Medline
    • (1990) Brain Res , vol.527 , pp. 7-20
    • Seniuk, N.A.1    Tatton, W.G.2    Greenwood, C.E.3
  • 44
    • 36549050805 scopus 로고    scopus 로고
    • Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging
    • CrossRef Medline
    • Smith RG, Sun Y, Jiang H, Albarran-Zeckler R, Timchenko N (2007) Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Ann N Y Acad Sci 1119:147–164. CrossRef Medline
    • (2007) Ann N Y Acad Sci , vol.1119 , pp. 147-164
    • Smith, R.G.1    Sun, Y.2    Jiang, H.3    Albarran-Zeckler, R.4    Timchenko, N.5
  • 46
    • 33847081784 scopus 로고    scopus 로고
    • Ghrelin and growth hormone secretagogue receptor expression in mice during aging
    • CrossRef Medline
    • Sun Y, Garcia JM, Smith RG (2007) Ghrelin and growth hormone secretagogue receptor expression in mice during aging. Endocrinology 148: 1323–1329. CrossRef Medline
    • (2007) Endocrinology , vol.148 , pp. 1323-1329
    • Sun, Y.1    Garcia, J.M.2    Smith, R.G.3
  • 47
    • 73649123558 scopus 로고    scopus 로고
    • Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition
    • CrossRef Medline
    • Takeda H, Muto S, Hattori T, Sadakane C, Tsuchiya K, Katsurada T, Ohkawara T, Oridate N, Asaka M (2010) Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition. Endocrinology 151:244–252. CrossRef Medline
    • (2010) Endocrinology , vol.151 , pp. 244-252
    • Takeda, H.1    Muto, S.2    Hattori, T.3    Sadakane, C.4    Tsuchiya, K.5    Katsurada, T.6    Ohkawara, T.7    Oridate, N.8    Asaka, M.9
  • 48
    • 79959846783 scopus 로고    scopus 로고
    • Postprandial ghrelin response is reduced in patients with Parkinson’s disease and idiopathic REM sleep behaviour disorder: A peripheral biomarker for early Parkinson’s disease?
    • CrossRef Medline
    • Unger MM, Möller JC, Mankel K, Eggert KM, Bohne K, Bodden M, Stiasny- Kolster K, Kann PH, Mayer G, Tebbe JJ, Oertel WH (2011) Postprandial ghrelin response is reduced in patients with Parkinson’s disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson’s disease? J Neurol 258:982–990. CrossRef Medline
    • (2011) J Neurol , vol.258 , pp. 982-990
    • Unger, M.M.1    Möller, J.C.2    Mankel, K.3    Eggert, K.M.4    Bohne, K.5    Bodden, M.6    Stiasny-Kolster, K.7    Kann, P.H.8    Mayer, G.9    Tebbe, J.J.10    Oertel, W.H.11
  • 50
    • 34548689861 scopus 로고    scopus 로고
    • Chronic caloric restriction induces forestomach hypertrophy with enhanced ghrelin levels during aging
    • CrossRef Medline
    • Yang H, Youm YH, Nakata C, Dixit VD (2007) Chronic caloric restriction induces forestomach hypertrophy with enhanced ghrelin levels during aging. Peptides 28:1931–1936. CrossRef Medline
    • (2007) Peptides , vol.28 , pp. 1931-1936
    • Yang, H.1    Youm, Y.H.2    Nakata, C.3    Dixit, V.D.4
  • 53
    • 84906939797 scopus 로고    scopus 로고
    • CaMKKbeta-dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation
    • CrossRef Medline
    • Zhou X, Cao Y, Ao G, Hu L, Liu H, Wu J, Wang X, Jin M, Zheng S, Zhen X, Alkayed NJ, Jia J, Cheng J (2014) CaMKKbeta-dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation. Antioxid Redox Signal 21:1741–1758. CrossRef Medline
    • (2014) Antioxid Redox Signal , vol.21 , pp. 1741-1758
    • Zhou, X.1    Cao, Y.2    Ao, G.3    Hu, L.4    Liu, H.5    Wu, J.6    Wang, X.7    Jin, M.8    Zheng, S.9    Zhen, X.10    Alkayed, N.J.11    Jia, J.12    Cheng, J.13
  • 54
    • 29044434688 scopus 로고    scopus 로고
    • Expression of ghrelin receptor mRNA in the rat and the mouse brain
    • CrossRef Medline
    • Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK (2006) Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 494:528–548. CrossRef Medline
    • (2006) J Comp Neurol , vol.494 , pp. 528-548
    • Zigman, J.M.1    Jones, J.E.2    Lee, C.E.3    Saper, C.B.4    Elmquist, J.K.5


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