Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet

Cell Metabolism

Volumn 20, Issue 1, 2014, Pages 54-60

  McFarlane, Matthew R ^a   Brown, Michael S ^a   Goldstein, Joseph L ^a   Zhao, Tong Jin ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; GHRELIN; GLUCOSE; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CALORIC RESTRICTION; CONTROLLED STUDY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HISTOLOGY; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HYPOGLYCEMIA; INJECTION; LIPID DIET; MOUSE; NONHUMAN; PRIORITY JOURNAL; SECRETORY CELL; TRANSGENIC MOUSE; ANIMAL; BLOOD; DRUG EFFECTS; EATING; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; ADULT; ANIMAL CELL; ANIMAL TISSUE; LOSS OF APPETITE;

MUS; MUS MUSCULUS;

ANIMALS; BODY WEIGHT; CALORIC RESTRICTION; DIET, HIGH-FAT; DIPHTHERIA TOXIN; EATING; GHRELIN; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; HYPOGLYCEMIA; MICE; MICE, TRANSGENIC; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84903994698     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.04.007     Document Type: Article

References (32)

1. T. Buch, F.L. Heppner, C. Tertilt, T.J.A.J. Heinen, M. Kremer, F.T. Wunderlich, S. Jung, and A. Waisman A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration Nat. Methods 2 2005 419 426
2. J.-C. Chuang, M. Perello, I. Sakata, S. Osborne-Lawrence, J.M. Savitt, M. Lutter, and J.M. Zigman Ghrelin mediates stress-induced food-reward behavior in mice J. Clin. Invest. 121 2011 2684 2692
3. M.A. Cowley, R.G. Smith, S. Diano, M. Tschöp, N. Pronchuk, K.L. Grove, C.J. Strasburger, M. Bidlingmaier, M. Esterman, and M.L. Heiman et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis Neuron 37 2003 649 661
4. C.R.Y. Cruz, and R.G. Smith The growth hormone secretagogue receptor Vitam. Horm. 77 2008 47 88
5. D.E. Cummings Ghrelin and the short- and long-term regulation of appetite and body weight Physiol. Behav. 89 2006 71 84
6. D.E. Cummings, J.Q. Purnell, R.S. Frayo, K. Schmidova, B.E. Wisse, and D.S. Weigle A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 50 2001 1714 1719
7. D.E. Cummings, D.S. Weigle, R.S. Frayo, P.A. Breen, M.K. Ma, E.P. Dellinger, and J.Q. Purnell Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery N. Engl. J. Med. 346 2002 1623 1630
8. Y. Date, M. Kojima, H. Hosoda, A. Sawaguchi, M.S. Mondal, T. Suganuma, S. Matsukura, K. Kangawa, and M. Nakazato Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans Endocrinology 141 2000 4255 4261
9. M.S. Engelstoft, W.-M. Park, I. Sakata, L.V. Kristensen, A.S. Husted, S. Osborne-Lawrence, P.K. Piper, A.K. Walker, M.H. Pedersen, and M.K. Nøhr et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells Mol Metab 2 2013 376 392
10. J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 1998 763 770
11. J.L. Goldstein, T.-J. Zhao, R.L. Li, D.P. Sherbet, G. Liang, and M.S. Brown Surviving starvation: essential role of the ghrelin-growth hormone axis Cold Spring Harb. Symp. Quant. Biol. 76 2011 121 127
12. J.A. Gutierrez, P.J. Solenberg, D.R. Perkins, J.A. Willency, M.D. Knierman, Z. Jin, D.R. Witcher, S. Luo, J.E. Onyia, and J.E. Hale Ghrelin octanoylation mediated by an orphan lipid transferase Proc. Natl. Acad. Sci. USA 105 2008 6320 6325
13. M. Kojima, and K. Kangawa Ghrelin: structure and function Physiol. Rev. 85 2005 495 522
14. R.L. Li, D.P. Sherbet, B.L. Elsbernd, J.L. Goldstein, M.S. Brown, and T.-J. Zhao Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids J. Biol. Chem. 287 2012 17942 17950
15. F. Lippl, J. Erdmann, A. Steiger, N. Lichter, C. Czogalla-Peter, M. Bidlingmaier, S. Tholl, and V. Schusdziarra Low-dose ghrelin infusion - evidence against a hormonal role in food intake Regul. Pept. 174 2012 26 31
16. S. Luquet, F.A. Perez, T.S. Hnasko, and R.D. Palmiter NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates Science 310 2005 683 685
17. M. Lutter, I. Sakata, S. Osborne-Lawrence, S.A. Rovinsky, J.G. Anderson, S. Jung, S. Birnbaum, M. Yanagisawa, J.K. Elmquist, E.J. Nestler, and J.M. Zigman The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress Nat. Neurosci. 11 2008 752 753
18. R. Nass, L.S. Farhy, J. Liu, C.E. Prudom, M.L. Johnson, P. Veldhuis, S.S. Pezzoli, M.C. Oliveri, B.D. Gaylinn, H.M. Geysen, and M.O. Thorner Evidence for acyl-ghrelin modulation of growth hormone release in the fed state J. Clin. Endocrinol. Metab. 93 2008 1988 1994
19. R. Nass, B.D. Gaylinn, and M.O. Thorner The ghrelin axis in disease: potential therapeutic indications Mol. Cell. Endocrinol. 340 2011 106 110
20. J. Saliba, J. Wattacheril, and N.N. Abumrad Endocrine and metabolic response to gastric bypass Curr. Opin. Clin. Nutr. Metab. Care 12 2009 515 521
21. T. Shiiya, M. Nakazato, M. Mizuta, Y. Date, M.S. Mondal, M. Tanaka, S.-I. Nozoe, H. Hosoda, K. Kangawa, and S. Matsukura Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion J. Clin. Endocrinol. Metab. 87 2002 240 244
22. Y. Sun, S. Ahmed, and R.G. Smith Deletion of ghrelin impairs neither growth nor appetite Mol. Cell. Biol. 23 2003 7973 7981
23. Y. Sun, P. Wang, H. Zheng, and R.G. Smith Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor Proc. Natl. Acad. Sci. USA 101 2004 4679 4684
24. Y. Sun, M. Asnicar, P.K. Saha, L. Chan, and R.G. Smith Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice Cell Metab. 3 2006 379 386
25. M. Tschöp, D.L. Smiley, and M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
26. M. Tschöp, R. Wawarta, R.L. Riepl, S. Friedrich, M. Bidlingmaier, R. Landgraf, and C. Folwaczny Post-prandial decrease of circulating human ghrelin levels J. Endocrinol. Invest. 24 2001 RC19 RC21
27. K.E. Wortley, K.D. Anderson, K. Garcia, J.D. Murray, L. Malinova, R. Liu, M. Moncrieffe, K. Thabet, H.J. Cox, and G.D. Yancopoulos et al. Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference Proc. Natl. Acad. Sci. USA 101 2004 8227 8232
28. A.M. Wren, L.J. Seal, M.A. Cohen, A.E. Brynes, G.S. Frost, K.G. Murphy, W.S. Dhillo, M.A. Ghatei, and S.R. Bloom Ghrelin enhances appetite and increases food intake in humans J. Clin. Endocrinol. Metab. 86 2001 5992 5995
29. J. Yang, M.S. Brown, G. Liang, N.V. Grishin, and J.L. Goldstein Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone Cell 132 2008 387 396
30. C.-X. Yi, K.M. Heppner, H. Kirchner, J. Tong, M. Bielohuby, B.D. Gaylinn, T.D. Müller, E. Bartley, H.W. Davis, and Y. Zhao et al. The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction PLoS ONE 7 2012 e32100
31. T.-J. Zhao, G. Liang, R.L. Li, X. Xie, M.W. Sleeman, A.J. Murphy, D.M. Valenzuela, G.D. Yancopoulos, J.L. Goldstein, and M.S. Brown Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice Proc. Natl. Acad. Sci. USA 107 2010 7467 7472
32. 1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice Proc. Natl. Acad. Sci. USA 107 2010 15868 15873