HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus-6A from the telomere of chromosome 19q

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Zhang, Enjie ^a   Cotton, Victoria E ^a   Hidalgo Bravo, Alberto ^a   Huang, Yan ^a   Bell, Adam J ^b   Jarrett, Ruth F ^b   Wilkie, Gavin S ^b   Davison, Andrew J ^b   Nacheva, Ellie P ^c   Siebert, Reiner ^d   Majid, Aneela ^a   Kelpanides, Inga ^a   Jayne, Sandrine ^a   Dyer, Martin J ^a   Royle, Nicola J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; CASE REPORT; CHROMOSOME 19; COMPLICATION; DNA SEQUENCE; EXANTHEMA SUBITUM; FEMALE; GENE DELETION; GENETICS; HUMAN; HUMAN HERPESVIRUS 6; LYMPHOMA, PRIMARY EFFUSION; MALE; PATHOLOGY; PROVIRUS; TELOMERE; VIROLOGY; VIRUS DNA CELL DNA INTERACTION;

AGED; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; HERPESVIRUS 6, HUMAN; HUMANS; LYMPHOMA, PRIMARY EFFUSION; MALE; PROVIRUSES; ROSEOLOVIRUS INFECTIONS; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; TELOMERE; VIRUS INTEGRATION;

EID: 84960381280     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep22730     Document Type: Article

References (56)

1. Sabattini, E., Bacci, F., Sagramoso, C. & Pileri, S. A. WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview. Pathologica 102, 83-87 (2010).
2. Kaplan, L. D. Human herpesvirus-8: Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma. Hematology Am Soc Hematol Educ Program 2013, 103-108 (2013).
3. Kobayashi, Y. et al. Comparison of human herpes virus 8 related primary effusion lymphoma with human herpes virus 8 unrelated primary effusion lymphoma-like lymphoma on the basis of HIV: report of 2 cases and review of 212 cases in the literature. Acta Haematol 117, 132-144 (2007).
4. Carbone, A. & Gloghini, A. PEL and HHV8-unrelated effusion lymphomas: classification and diagnosis. Cancer 114, 225-227 (2008).
5. Saini, N. et al. HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature. Case Rep Oncol Med 2013, 292301 (2013).
6. Wu, W., Youm, W., Rezk, S. A. & Zhao, X. Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma: report of a rare case and review of 54 cases in the literature. Am J Clin Pathol 140, 258-273 (2013).
7. Ablashi, D. et al. Classification of HHV-6A and HHV-6B as distinct viruses. Arch Virol 159, 863-870 (2014).
8. Smith, C. & Khanna, R. Immune regulation of human herpesviruses and its implications for human transplantation. Am J Transplant 13 Suppl 3, 9-23 quiz 23 (2013).
9. Dominguez, G. et al. Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J Virol 73, 8040-8052 (1999).
10. De Bolle, L., Naesens, L. & De Clercq, E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev 18, 217-245 (2005).
11. Tsao, E. H. et al. Microarray-based determination of the lytic cascade of human herpesvirus 6B. J Gen Virol 90, 2581-2591 (2009).
12. Flamand, L. et al. Review, part 1: Human herpesvirus-6-basic biology, diagnostic testing, and antiviral efficacy. J Med Virol 82, 1560-1568 (2010).
13. Kashanchi, F. et al. Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53. Oncogene 14, 359-367 (1997).
14. Takemoto, M. et al. Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion. J Virol 79, 13037-13046 (2005).
15. Schleimann, M. H. et al. The DR6 protein from human herpesvirus-6B induces p53-independent cell cycle arrest in G2/M. Virology 452-453, 254-263 (2014).
16. Kofod-Olsen, E. et al. Human herpesvirus-6B protein U19 contains a p53 BOX I homology motif for HDM2 binding and p53 stabilization. Virology 448, 33-42 (2014).
17. Mori, J. et al. Human Herpesvirus-6 U14 Induces Cell-Cycle Arrest in G2/M Phase by Associating with a Cellular Protein, EDD. Plos One 10, e0137420; doi: 10.1371/journal.pone.0137420 (2015).
18. Mori, J. et al. Human herpesvirus 6A U14 is important for virus maturation. J Virol 90, 1677-1681 (2015).
19. Razzaque, A. Oncogenic potential of human herpesvirus-6 DNA. Oncogene 5, 1365-1370 (1990).
20. Ogata, M. Human herpesvirus 6 in hematological malignancies. J Clin Exp Hematop 49, 57-67 (2009).
21. Ablashi, D. V. et al. Review Part 3: Human herpesvirus-6 in multiple non-neurological diseases. J Med Virol 82, 1903-1910 (2010).
22. Armanios, M. & Blackburn, E. H. The telomere syndromes. Nat Rev Genet 13, 693-704 (2012).
23. Leong, H. N. et al. The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors. J Med Virol 79, 45-51 (2007).
24. Arbuckle, J. H. et al. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc Natl Acad Sci USA 107, 5563-5568 (2010).
25. Huang, Y. et al. Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome. Nucleic Acids Res 42, 315-327 (2014).
26. Ohye, T. et al. Dual roles for the telomeric repeats in chromosomally integrated human herpesvirus-6. Sci Rep 4, 4559 (2014).
27. Endo, A. et al. Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency. Clin Infect Dis 59, 545-548 (2014).
28. Gravel, A., Hall, C. B. & Flamand, L. Sequence analysis of transplacentally acquired human herpesvirus 6 DNA is consistent with transmission of a chromosomally integrated reactivated virus. J Infect Dis 207, 1585-1589 (2013).
29. Wang, R. C., Smogorzewska, A. & de Lange, T. Homologous recombination generates T-loop-sized deletions at human telomeres. Cell 119, 355-368 (2004).
30. Vannier, J. B. et al. RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity. Cell 149, 795-806 (2012).
31. Sanchez-Izquierdo, D. et al. Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin's lymphoma by interphase fluorescence in situ hybridization. Leukemia 15, 1475-1484 (2001).
32. Martin-Subero, J. I. et al. Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci. Int J Cancer 98, 470-474 (2002).
33. Jeyapalan, J. N. et al. Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome. Hum Mol Genet 14, 1785-1794 (2005).
34. Mendez-Bermudez, A. et al. The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres. Nucleic Acids Res 40, 10809-10820 (2012).
35. Tweedy, J. et al. Analyses of germline, chromosomally integrated human herpesvirus 6A and B genomes indicate emergent infection and new inflammatory mediators. J Gen Virol 96, 370-389 (2015).
36. Kondo, K. et al. Identification of human herpesvirus 6 latency-associated transcripts. J Virol 76, 4145-4151 (2002).
37. Gompels, U. A. et al. The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology 209, 29-51 (1995).
38. Tweedy, J. et al. Complete Genome Sequence of the Human Herpesvirus 6A Strain AJ from Africa Resembles Strain GS from North America. Genome Announc 3, e01498-14; doi: 10.1128/genomeA.01498-14 (2015).
39. Cesare, A. J. & Reddel, R. R. Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet 11, 319-330 (2010).
40. Bell, A. J. et al. Germ-line transmitted, chromosomally integrated HHV-6 and classical Hodgkin lymphoma. Plos One 9, e112642 (2014).
41. Hubacek, P. et al. Prevalence of HHV-6 integrated chromosomally among children treated for acute lymphoblastic or myeloid leukemia in the Czech Republic. J Med Virol 81, 258-263 (2009).
42. Gravel, A., Sinnett, D. & Flamand, L. Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia. PLoS One 8, e84322 (2013).
43. Robin, J. D. et al. Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes Dev 28, 2464-2476 (2014).
44. Nacheva, E. P. et al. Human herpesvirus 6 integrates within telomeric regions as evidenced by five different chromosomal sites. J Med Virol 80, 1952-1958 (2008).
45. Ventura, R. A. et al. FISH analysis for the detection of lymphoma-associated chromosomal abnormalities in routine paraffinembedded tissue. J Mol Diagn 8, 141-151 (2006).
46. Neipel, F., Ellinger, K. & Fleckenstein, B. The unique region of the human herpesvirus 6 genome is essentially collinear with the UL segment of human cytomegalovirus. J Gen Virol 72(Pt 9), 2293-2297 (1991).
47. Jeyapalan, J. N. et al. Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies. Int J Cancer 122, 2414-2421 (2008).
48. Mendez-Bermudez, A. & Royle, N. J. Deficiency in DNA mismatch repair increases the rate of telomere shortening in normal human cells. Hum Mutat 32, 939-946 (2011).
49. Simpson, J. T. et al. ABySS: a parallel assembler for short read sequence data. Genome Res 19, 1117-1123 (2009).
50. Silva, G. G. et al. Combining de novo and reference-guided assembly with scaffold-builder. Source Code Biol Med 8, 23 (2013).
51. Rice, P., Longden, I. & Bleasby, A. EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet 16, 276-277 (2000).
52. Boetzer, M. & Pirovano, W. Toward almost closed genomes with GapFiller. Genome Biol 13, R56 (2012).
53. Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26, 589-595 (2010).
54. Milne, I. et al. Tabletnext generation sequence assembly visualization. Bioinformatics 26, 401-402 (2010).
55. Weber, J. L. et al. Evidence for human meiotic recombination interference obtained through construction of a short tandem repeatpolymorphism linkage map of chromosome-19. Am. J. Hum. Genet. 53, 1079-1095 (1993).
56. Baird, D. M., Rowson, J., Wynford-Thomas, D. & Kipling, D. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet 33, 203-207 (2003).