Germ-line transmitted, chromosomally integrated HHV-6 and classical hodgkin lymphoma

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Bell, Adam J ^a   Gallagher, Alice ^a   Mottram, Timothy ^a   Lake, Annette ^a   Kane, Eleanor V ^b   Lightfoot, Tracy ^b   Roman, Eve ^b   Jarrett, Ruth F ^a  

^a MRC UNIVERSITY OF GLASGOW CENTRE FOR VIRUS RESEARCH   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Data collection and analysis; Decision to publish; Or preparation of the manuscript.; Role in study design

Indexed keywords

HEMOGLOBIN BETA CHAIN; VIRUS DNA;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; BETA GLOBIN GENE; BIOASSAY; CANCER RISK; CARCINOGENESIS; CHROMOSOME; CLASSICAL HODGKIN LYMPHOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; DROPLET DIGITAL POLYMERASE CHAIN REACTION; DUPLEX TAQMAN ASSAY; FEMALE; GERM LINE; HEALTH STATUS; HISTOPATHOLOGY; HUMAN; HUMAN HERPESVIRUS 6; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; QUANTITATIVE STUDY; STRUCTURAL GENE; VIRUS DNA CELL DNA INTERACTION; VIRUS TRANSMISSION; CASE CONTROL STUDY; EXANTHEMA SUBITUM; GENETICS; GERM CELL; HODGKIN DISEASE; HUMAN CHROMOSOME; PHYSIOLOGY; PROCEDURES; TELOMERE; VIROLOGY;

HUMAN HERPESVIRUS 6;

CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN; DNA, VIRAL; FEMALE; GERM CELLS; HERPESVIRUS 6, HUMAN; HODGKIN DISEASE; HUMANS; MALE; POLYMERASE CHAIN REACTION; ROSEOLOVIRUS INFECTIONS; TELOMERE; VIRUS INTEGRATION;

EID: 84911437441     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112642     Document Type: Article

References (34)

1. Siddon A, Lozovatsky L, Mohamed A, Hudnall SD (2012) Human herpesvirus 6positive Reed-Sternberg cells in nodular sclerosis Hodgkin lymphoma.Br J Haematol 158: 635-643.
2. Strenger V, Aberle SW, Nacheva EP, Urban C (2013) Chromosomal integrationof the HHV-6 genome in a patient with nodular sclerosis Hodgkin lymphoma.Br J Haematol 161: 594-595.
3. Chang ET, Zheng T, Weir EG, Borowitz M, Mann RB, et al. (2004) Childhoodsocial environment and Hodgkin's lymphoma: new findings from a populationbasedcase-control study. Cancer Epidemiol Biomarkers Prev 13: 1361-1370.
4. Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, et al. (2013)Classification of HHV-6A and HHV-6B as distinct viruses. Arch Virol 159: 863-870.
5. Nacheva EP, Ward KN, Brazma D, Virgili A, Howard J, et al. (2008) Humanherpesvirus 6 integrates within telomeric regions as evidenced by five differentchromosomal sites. J Med Virol 80: 1952-1958.
6. Arbuckle JH, Medveczky MM, Luka J, Hadley SH, Luegmayr A, et al. (2010)The latent human herpesvirus-6A genome specifically integrates in telomeres ofhuman chromosomes in vivo and in vitro. Proc Natl Acad Sci U S A 107:5563-5568.
7. Daibata M, Taguchi T, Miyoshi K, Taguchi H, Miyoshi I (2000) Presence ofhuman herpesvirus 6 DNA in somatic cells. Blood 95: 1108-1109.
8. Daibata M, Taguchi T, Nemoto Y, Taguchi H, Miyoshi I (1999) Inheritance ofchromosomally integrated human herpesvirus 6 DNA. Blood 94: 1545-1549.
9. Leong HN, Tuke PW, Tedder RS, Khanom AB, Eglin RP, et al. (2007) Theprevalence of chromosomally integrated human herpesvirus 6 genomes in theblood of UK blood donors. J Med Virol 79: 45-51.
10. Luppi M, Marasca R, Barozzi P, Ferrari S, Ceccherini-Nelli L, et al. (1993)Three cases of human herpesvirus-6 latent infection: integration of viral genomein peripheral blood mononuclear cell DNA. J Med Virol 40: 44-52.
11. Hubacek P, Hrdlickova A, Spacek M, Zajac M, Muzikova K, et al. (2013)Prevalence of chromosomally integrated HHV-6 in patients with malignantdisease and healthy donors in the Czech Republic. Folia Microbiol (Praha) 58:87-90.
12. Alexander FE, Lawrence DJ, Freeland J, Krajewski AS, Angus B, et al. (2003)An epidemiologic study of index and family infectious mononucleosis and adultHodgkin's disease (HD): evidence for a specific association with EBV+ve HD inyoung adults. Int J Cancer 107: 298-302.
13. Alexander FE, Jarrett RF, Lawrence D, Armstrong AA, Freeland J, et al. (2000)Risk factors for Hodgkin's disease by Epstein-Barr virus (EBV) status: priorinfection by EBV and other agents. Br J Cancer 82: 1117-1121.
14. Willett EV, O'Connor S, Smith AG, Roman E (2007) Does smoking or alcoholmodify the risk of Epstein-Barr virus-positive or -negative Hodgkin lymphoma?Epidemiology 18: 130-136.
15. Gallagher A, Perry J, Freeland J, Alexander FE, Carman WF, et al. (2003)Hodgkin lymphoma and Epstein-Barr virus (EBV): no evidence to support hit-and-run mechanism in cases classified as non-EBV-associated. Int J Cancer 104:624-630.
16. Tavakoli NP, Nattanmai S, Hull R, Fusco H, Dzigua L, et al. (2007) Detectionand typing of human herpesvirus 6 by molecular methods in specimens frompatients diagnosed with encephalitis or meningitis. J Clin Microbiol 45: 3972-3978.
17. Gallagher A, Perry J, Shield L, Freeland J, MacKenzie J, et al. (2002) Virusesand Hodgkin disease: no evidence of novel herpesviruses in non-EBV-associatedlesions. Int J Cancer 101: 259-264.
18. Hindson BJ, Ness KD, Masquelier DA, Belgrader P, Heredia NJ, et al. (2011)High-throughput droplet digital PCR system for absolute quantitation of DNAcopy number. Anal Chem 83: 8604-8610.
19. Sedlak RH, Cook L, Huang ML, Magaret A, Zerr DM, et al. (2014)Identification of chromosomally integrated human herpesvirus 6 by dropletdigital PCR. Clin Chem 60: 765-772.
20. Leibovitch EC, Brunetto GS, Caruso B, Fenton K, Ohayon J, et al. (2014)Coinfection of human herpesviruses 6A (HHV-6A) and HHV-6B as demonstratedby novel digital droplet PCR assay. PLoS One 9: e92328.
21. Torelli G, Barozzi P, Marasca R, Cocconcelli P, Merelli E, et al. (1995) Targetedintegration of human herpesvirus 6 in the p arm of chromosome 17 of humanperipheral blood mononuclear cells in vivo. J Med Virol 46: 178-188.
22. Ward KN, Thiruchelvam AD, Couto-Parada X (2005) Unexpected occasionalpersistence of high levels of HHV-6 DNA in sera: detection of variants A and B.J Med Virol 76: 563-570.
23. Huang Y, Hidalgo-Bravo A, Zhang E, Cotton VE, Mendez-Bermudez A, et al.(2013) Human telomeres that carry an integrated copy of human herpesvirus 6are often short and unstable, facilitating release of the viral genome from thechromosome. Nucleic Acids Res 42: 315-327.
24. Geraudie B, Charrier M, Bonnafous P, Heurte D, Desmonet M, et al. (2012)Quantitation of human herpesvirus-6A, -6B and -7 DNAs in whole blood,mononuclear and polymorphonuclear cell fractions from healthy blood donors.J Clin Virol 53: 151-155.
25. Artandi SE, DePinho RA (2010) Telomeres and telomerase in cancer.Carcinogenesis 31: 9-18.
26. Roberts CH, Jiang W, Jayaraman J, Trowsdale J, Holland MJ, et al. (2014)Killer-cell Immunoglobulin-like Receptor gene linkage and copy numbervariation analysis by droplet digital PCR. Genome Med 6: e-pub ahead ofprint March 2014; doi:10.1186/gm537
27. Dewhurst S, McIntyre K, Schnabel K, Hall CB (1993) Human herpesvirus 6(HHV-6) variant B accounts for the majority of symptomatic primary HHV-6infections in a population of U.S. infants. J Clin Microbiol 31: 416-418.
28. Hall CB, Caserta MT, Schnabel KC, McDermott MP, Lofthus GK, et al. (2006)Characteristics and acquisition of human herpesvirus (HHV) 7 infections inrelation to infection with HHV-6. J Infect Dis 193: 1063-1069.
29. Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, et al. (2005) Apopulation-based study of primary human herpesvirus 6 infection.N Engl J Med 352: 768-776.
30. Boutolleau D, Duros C, Bonnafous P, Caiola D, Karras A, et al. (2006)Identification of human herpesvirus 6 variants A and B by primer-specific realtimePCR may help to revisit their respective role in pathology. J Clin Virol 35:257-263..
31. Aberle SW, Mandl CW, Kunz C, Popow-Kraupp T (1996) Presence of humanherpesvirus 6 variants A and B in saliva and peripheral blood mononuclear cellsof healthy adults. J Clin Microbiol 34: 3223-3225.
32. Bates M, Monze M, Bima H, Kapambwe M, Clark D, et al. (2009) Predominanthuman herpesvirus 6 variant A infant infections in an HIV-1 endemic region ofSub-Saharan Africa. J Med Virol 81: 779-789.
33. Clark DA, Ward KN (2008) Importance of chromosomally integrated HHV-6Aand -6B in the diagnosis of active HHV-6 infection. Herpes 15: 28-32.
34. Hall CB, Caserta MT, Schnabel KC, Boettrich C, McDermott MP, et al. (2004)Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus7 (HHV7). J Pediatr 145: 472-477.