Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies

International Journal of Cancer

Volumn 122, Issue 11, 2008, Pages 2414-2421

  Jeyapalan, Jennie N ^a   Mendez Bermudez, Aaron ^a   Zaffaroni, Nadia ^b   Dubrova, Yuri E ^a   Royle, Nicola J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

ALT; Minisatellite; PML bodies; Recombination; Telomere

Indexed keywords

DNA MINISATELLITE;

ARTICLE; CANCER GENETICS; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; LIPOSARCOMA; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SISTER CHROMATID EXCHANGE; TELOMERE;

CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; LIPOSARCOMA; MICROSATELLITE INSTABILITY; MINISATELLITE REPEATS; MUTATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; SEQUENCE ANALYSIS, DNA; TELOMERASE; TELOMERE; TELOMERE-BINDING PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 42549121200     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23412     Document Type: Article

References (36)

1. Baird DM, Jeffreys AJ, Royle NJ. Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere. EMBO J 1995;14:5433-43.
2. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature (London) 1990;345:458-60.
3. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995;14:4240-48.
4. Henson JD, Neumann AA, Yeager TR, Reddel RR. Alternative lengthening of telomeres in mammalian cells. Oncogene 2002;21:598-610.
5. Cesare AJ, Griffith JD. Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops. Mol Cell Biol 2004;24:9948-57.
6. Yeager TR, Neumann AA, Englezou A, Huschtscha LI, Noble JR, Reddel RR. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res 1999;59:4175-9.
7. Wu G, Lee WH, Chen PL. NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres. J Biol Chem 2000;275:30618-22.
8. Nabetani A, Yokoyama O, Ishikawa F. Localization of hRad9, hHus1, hRad1 and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body. J Biol Chem 2004;279:25849-57.
9. Henson JD, Hannay JA, McCarthy SW, Royds JA, Yeager TR, Robinson RA, Wharton SB, Jellinek DA, Arbuckle SM, Yoo J, Robinson BG, Learoyd DL, et al. A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clin Cancer Res 2005;11:217-25.
10. Londono-Vallejo JA, Der-Sarkissian H, Cazes L, Bacchetti S, Reddel RR. Alternative lengthening of telomeres is characterized by high rates of telomeric exchange. Cancer Res 2004;64:2324-7.
11. Bailey SM, Brenneman MA, Goodwin EH. Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res 2004;32:3743-51.
12. Varley H, Pickett HA, Foxon JL, Reddel RR, Royle NJ. Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Nat Genet 2002;30:301-5.
13. Jeyapalan JN, Varley H, Foxon JL, Pollock RE, Jeffreys AJ, Henson JD, Reddel RR, Royle NJ. Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome. Hum Mol Genet 2005;14:1785-94.
14. Ulaner GA, Huang HY, Otero J, Zhao Z, Ben-Porat L, Satagopan JM, Gorlick R, Meyers P, Healey JH, Huvos AG, Hoffman AR, Ladanyi M. Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma. Cancer Res 2003;63:1759-63.
15. Hakin-Smith V, Jellinek DA, Levy D, Carroll T, Teo M, Timperley WR, McKay MJ, Reddel RR, Royds JA. Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme. Lancet 2003;361:836-8.
16. Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D. Multiple mechanisms of telomere maintenance exist in liposarcomas. Clin Cancer Res 2005;11:5347-55.
17. Costa A, Daidone MG, Daprai L, Villa R, Cantu S, Pilotti S, Mariani L, Gronchi A, Henson JD, Reddel RR, Zaffaroni N. Telomere maintenance mechanisms in liposarcomas: association with histologic subtypes and disease progression. Cancer Res 2006;66:8918-24.
18. Jeffreys AJ, Neumann R. Somatic mutation processes at a human minisatellite. Hum Mol Genet 1997;6:129-36.
19. Jeffreys AJ, Tamaki K, MacLeod A, Monckton DG, Neil DL, Armour JA. Complex gene conversion events in germline mutation at human minisatellites. Nat Genet 1994;6:136-45.
20. Wong Z, Wilson V, Patel I, Povey S, Jeffreys AJ. Characterization of a panel of highly variable minisatellites cloned from human DNA. Ann Hum Genet 1987;51:269-88.
21. Baird DM, Rowson J, Wynford-Thomas D, Kipling D. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet 2003;33:203-7.
22. Jeffreys AJ, MacLeod A, Tamaki K, Neil DL, Monckton DG. Minisatellite repeat coding as a digital approach to DNA typing. Nature 1991;354:204-9.
23. Jeffreys AJ, Murray J, Neumann R. High-resolution mapping of cross-overs in human sperm defines a minisatellite-associated recombination hotspot. Mol Cell 1998;2:267-73.
24. Hogendoorn PC, Collin F, Daugaard S, Dei Tos AP, Fisher C, Schneider U, Sciot R. Changing concepts in the pathological basis of soft tissue and bone sarcoma treatment. Eur J Cancer 2004;40:1644-54.
25. Knight JC, Renwick PJ, Cin PD, Van den Berghe H, Fletcher CD. Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. Cancer Res 1995;55:24-7.
26. Schneider-Stock R, Boltze C, Jager V, Epplen J, Landt O, Peters B, Rys J, Roessner A. Elevated telomerase activity, c-MYC-, and hTERT mRNA expression: association with tumour progression in malignant lipomatous tumours. J Pathol 2003;199:517-25.
27. Pedeutour F, Suijkerbuijk RF, Forus A, Van Gaal J, Van de Klundert W, Coindre JM, Nicolo G, Collin F, Van Haelst U, Huffermann K, et al. Complex composition and co-amplification of SAS and MDM2 in ring and giant rod marker chromosomes in well-differentiated liposarcoma. Genes Chromosomes Cancer 1994;10:85-94.
28. Pedeutour F, Forus A, Coindre JM, Berner JM, Nicolo G, Michiels JF, Terrier P, Ranchere-Vince D, Collin F, Myklebost O, Turc-Carel C. Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors. Genes Chromosomes Cancer 1999;24:30-41.
29. Seger YR, Garcia-Cao M, Piccinin S, Cunsolo CL, Doglioni C, Blasco MA, Hannon GJ, Maestro R. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2002;2:401-13.
30. Fasching CL, Bower K, Reddel RR. Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies. Cancer Res 2005;65:2722-9.
31. Marciniak RA, Cavazos D, Montellano R, Chen Q, Guarente L, Johnson FB. A novel telomere structure in a human alternative lengthening of telomeres cell line. Cancer Res 2005;65:2730-7.
32. Cerone MA, Autexier C, Londono-Vallejo JA, Bacchetti S. A human cell line that maintains telomeres in the absence of telomerase and of key markers of ALT. Oncogene 2005;24:7893-901.
33. Wang RC, Smogorzewska A, de Lange T. Homologous recombination generates T-loop-sized deletions at human telomeres. Cell 2004;119:355-68.
34. McEachern MJ, Haber JE. Break-induced replication and recombinational telomere elongation in yeast. Annu Rev Biochem 2006;75:111-35.
35. Murnane JP, Sabatier L, Marder BA, Morgan WF. Telomere dynamics in an immortal human cell-line. EMBO J 1994;13:4953-62.
36. Rizki A, Lundblad V. Detects in mismatch repair promote telomerase-independent proliferation. Nature 2001;411:713-16.