Prevalence of HHV-6 integrated chromosomally among children treated for acute lymphoblastic or myeloid leukemia in the Czech Republic

Journal of Medical Virology

Volumn 81, Issue 2, 2009, Pages 258-263

  Hubacek, Petr ^a   Muzikova, Katerina ^a   Hrdlickova, Alena ^a   Cinek, Ondrej ^a   Hyncicova, Katerina ^a   Hrstkova, Hana ^b   Sedlacek, Petr ^a   Stary, Jan ^a  

^a UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^b UNIVERSITY HOSPITAL BRNO   (Czech Republic)

Author keywords

Chromosomal integration; Human herpesvirus 6; Leukemia

Indexed keywords

ANTIVIRUS AGENT; VIRUS DNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; CZECH REPUBLIC; DRUG WITHDRAWAL; HAIR FOLLICLE; HERPES SIMPLEX; HUMAN; HUMAN HERPESVIRUS 6; INFANT; MAJOR CLINICAL STUDY; MYELOID LEUKEMIA; NEWBORN; PREVALENCE; RETROSPECTIVE STUDY; TREATMENT WITHDRAWAL; ADOLESCENT; BLOOD; CHROMOSOME; FEMALE; GENETICS; HERPES VIRUS INFECTION; ISOLATION AND PURIFICATION; MALE; PRESCHOOL CHILD; VIROLOGY; VIRUS DNA CELL DNA INTERACTION;

ADOLESCENT; BLOOD; CHILD; CHILD, PRESCHOOL; CHROMOSOMES; CZECH REPUBLIC; DNA, VIRAL; FEMALE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 6, HUMAN; HUMANS; INFANT; INFANT, NEWBORN; LEUKEMIA, MYELOID; MALE; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PREVALENCE; RETROSPECTIVE STUDIES; VIRUS INTEGRATION;

HUMAN HERPESVIRUS 6;

EID: 61749100072     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21371     Document Type: Article

References (34)

1. Asano Y, Yoshikawa T, Kajita Y, Ogura R, Suga S, Yazaki T, Nakashima T, Yamada A, Kurata T. 1992. Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection. Arch Dis Child 67:1484-1485.
2. Bethge W, Beck R, Jahn G, Mundinger P, Kanz L, Einsele H. 1999. Successful treatment of human herpesvirus-6 encephalitis after bone marrow transplantation. Bone Marrow Transplant 24:1245-1248.
3. Caserta MT, Mock DJ, Dewhurst S. 2001. Human herpesvirus 6. Clin Infect Dis 33:829-833.
4. Chemaly RF, Torres HA, Hachem R, Kontoyiannis DP, Safdar A, Raad II. 2008. Human herpesvirus-6 DNAemia in immunosuppressed adult patients with leukemia at risk for mold infection. Haematologica 93:157-158.
5. Clark DA, Nacheva EP, Leong HN, Brazma D, Li YT, Tsao EH, Buyck HC, Atkinson CE, Lawson HM, Potter MN, Griffiths PD. 2006a. Transmission of integrated human herpesvirus 6 through stem cell transplantation: Implications for laboratory diagnosis. J Infect Dis 193:912-916.
6. Clark DA, Tsao EH, Leong HN, Ward KN, Nacheva EP, Griffiths PD. 2006b. Reply to Boutolleau et al. and Luppi et al. J Infect Dis 194:1021-1023.
7. Daibata M, Taguchi T, Taguchi H, Miyoshi I. 1998. Integration of human herpesvirus 6 in a Burkitt's lymphoma cell line. Br J Haematol 102:1307-1313.
8. Daibata M, Taguchi T, Nemoto Y, Taguchi H, Miyoshi I. 1999. Inheritance of chromosomally integrated human herpesvirus 6 DNA. Blood 94:1545-1549.
9. Daibata M, Taguchi T, Miyoshi K, Taguchi H, Miyoshi I. 2000. Presence of human herpesvirus 6 DNAin somatic cells. Blood 95:1108-1109.
10. De Bolle L, Naesens L, De Clercq E. 2005. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev 18:217-245.
11. Gautheret-Dejean A, Manichanh C, Thien-Ah-Koon F, Fillet AM, Mangeney N, Vidaud M, Dhedin N, Vernant JP, Agut H. 2002. Development of a real-time polymerase chain reaction assay for the diagnosis of human herpesvirus-6 infection and application to bone marrow transplant patients. J Virol Methods 100:27-35.
12. Hubacek P, Hyncicova K, Muzikova K, Cinek O, Zajac M, Sedlacek P. 2007a. Disappearance of pre-existing high HHV-6 DNA load in blood after allogeneic SCT. Bone Marrow Transplant 40:805-806.
13. Hubacek P, Maalouf J, Zajickova M, Kouba M, Cinek O, Hyncicova K, Fales I, Cetkovsky P. 2007b. Failure of multiple antivirals to affect high HHV-6 DNAaemia resulting from viral chromosomal integration in case of severe aplastic anaemia. Haematologica 92:e98-e100.
14. Ishikawa K, Hasegawa K, Naritomi T, Kanai N, Ogawa M, Kato Y, Kobayashi M, Torii N, Hayashi N. 2002. Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan. J Gastroenterol 37:523-530.
15. Jones CM, Dunn HG, Thomas EE, Cone RW, Weber JM. 1994. Acute encephalopathy and status epilepticus associated with human herpes virus 6 infection. Dev Med Child Neurol 36:646-650.
16. Leong HN, Tuke PW, Tedder RS, Khanom AB, Eglin RP, Atkinson CE, Ward KN, Griffiths PD, Clark DA. 2007. The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors. J Med Virol 79:45-51.
17. Ljungman P, Wang FZ, Clark DA, Emery VC, Remberger M, Ringden O, Linde A. 2000. High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients. Br J Haematol 111:774-781.
18. Luppi M, Marasca R, Barozzi P, Ferrari S, Ceccherini-Nelli L, Batoni G, Merelli E, Torelli G. 1993. Three cases of human herpesvirus-6 latent infection: Integration of viral genome in peripheral blood mononuclear cell DNA. J Med Virol 40:44-52.
19. Ma XT, Song YH, Lu DM, Mu GF, Li G, Ji LX, Yang RC, Wu KF. 2000. Human herpesvirus 6 in hematologic diseases in China. Haematologica 85:458-463.
20. Nitsche A, Muller CW, Radonic A, Landt O, Ellerbrok H, Pauli G, Siegert W. 2001. Human herpesvirus 6A DNA Is detected frequently in plasma but rarely in peripheral blood leukocytes of patients after bone marrow transplantation. J Infect Dis 183:130-133.
21. Oki J, Yoshida H, Tokumitsu A, Takahashi S, Miyamoto A, Yoda M, Miura J. 1995. Serial neuroimages of acute necrotizing encephalopathy associated with human herpesvirus 6 infection. Brain Dev 17:356-359.
22. Pongers-Willemse MJ, Verhagen OJ, Tibbe GJ, Wijkhuijs AJ, de Haas V, Roovers E, van der Schoot CE, van Dongen JJ. 1998. Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes. Leukemia 12:2006-2014.
23. Sashihara J, Tanaka-Taya K, Tanaka S, Amo K, Miyagawa H, Hosoi G, Taniguchi T, Fukui T, Kasuga N, Aono T, Sako M, Hara J, Yamanishi K, Okada S. 2002. High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients. Blood 100:2005-2011.
24. Suga S, Yoshikawa T, Asano Y, Kozawa T, Nakashima T, Kobayashi I, Yazaki T, Yamamoto H, Kajita Y, Ozaki T, Nishimura Y, Yamanaka T, Yamada A, Imamshi J. 1993. Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications. Ann Neurol 33:597-603.
25. Tanaka-Taya K, Sashihara J, Kurahashi H, Amo K, Miyagawa H, Kondo K, Okada S, Yamanishi K. 2004. Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA. J Med Virol 73:465-473.
26. Uchida S, Wang L, Yahagi Y, Tokunaga K, Tadokoro K, Juji T. 1996. Utility of fingernail DNA for evaluation of chimerism after bone marrow transplantation and for diagnostic testing for transfusion-associated graft-versus-host disease. Blood 87:4015-4016.
27. Ward KN. 2005. The natural history and laboratory diagnosis of human herpesviruses-6 and -7 infections in the immunocompetent. J Clin Virol 32:183-193.
28. Ward KN, Leong HN, Nacheva EP, Howard J, Atkinson CE, Davies NW, Griffiths PD, Clark DA. 2006. Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. J Clin Microbiol 44:1571-1574.
29. Ward KN, Leong HN, Thiruchelvam AD, Atkinson CE, Clark DA. 2007. HHV-6 DNA level in CSF due to primary infection differs from that in chromosomal viral integration and has implications for the diagnosis of encephalitis. J Clin Microbiol 45:1298-1304.
30. Yoshihara S, Kato R, Inoue T, Miyagawa H, Sashihara J, Kawakami M, Ikegame K, Oka Y, Sugiyama H, Kawase I, Ogawa H. 2004. Successful treatment of life-threatening human herpesvirus-6 encephalitis with donor lymphocyte infusion in a patient who had undergone human leukocyte antigen-haploidentical nonmyeloablative stem cell transplantation. Transplantation 77:835-838.
31. Yoshikawa T. 2004. Human herpesvirus 6 infection in hematopoietic stem cell transplant patients. Br J Haematol 124:421-432.
32. Yoshikawa T, Asano Y, Kobayashi I, Nakashima T, Yazaki T. 1993. Exacerbation of idiopathic thrombocytopenic purpura by primary human herpesvirus 6 infection. Pediatr Infect Dis J 12:409-410.
33. Yoshikawa T, Ihira M, Suzuki K, Suga S, Kito H, Iwasaki T, Kurata T, Tanaka T, Saito Y, Asano Y. 2001. Fatal acute myocarditis in an infant with human herpesvirus 6 infection. J Clin Pathol 54:792-795.
34. Zerr DM, Corey L, Kim HW, Huang ML, Nguy L, Boeckh M. 2005. Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation. Clin Infect Dis 40:932-940.