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Volumn 21, Issue 1, 2016, Pages 150-156

Phenotypic screening: The future of antibody discovery

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; HYBRIDOMA DERIVED ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; ANTIBODY;

EID: 84960355587     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2015.09.014     Document Type: Review
Times cited : (19)

References (60)
  • 1
    • 84921345093 scopus 로고    scopus 로고
    • Antibodies to watch in 2015
    • J.M. Reichert Antibodies to watch in 2015 MAbs 7 2015 1 8
    • (2015) MAbs , vol.7 , pp. 1-8
    • Reichert, J.M.1
  • 2
    • 77957361348 scopus 로고    scopus 로고
    • Development trends for human monoclonal antibody therapeutics
    • A.L. Nelson, and et al. Development trends for human monoclonal antibody therapeutics Nat. Rev. Drug Discov. 9 2010 767 774
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 767-774
    • Nelson, A.L.1
  • 3
    • 27144431943 scopus 로고    scopus 로고
    • Selecting and screening recombinant antibody libraries
    • H.R. Hoogenboom Selecting and screening recombinant antibody libraries Nat. Biotechnol. 23 2005 1105 1116
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1105-1116
    • Hoogenboom, H.R.1
  • 4
    • 84900846071 scopus 로고    scopus 로고
    • Different approaches for obtaining antibodies from human B cells
    • M.R. Duvall, and R.N. Fiorini Different approaches for obtaining antibodies from human B cells Curr. Drug Discov. Technol. 11 2014 41 47
    • (2014) Curr. Drug Discov. Technol. , vol.11 , pp. 41-47
    • Duvall, M.R.1    Fiorini, R.N.2
  • 5
    • 84925832282 scopus 로고    scopus 로고
    • New horizons in therapeutic antibody discovery: Opportunities and challenges versus small molecule therapeutics
    • A.J. Smith New horizons in therapeutic antibody discovery: opportunities and challenges versus small molecule therapeutics J. Biomol. Screen. 20 2014 437 453
    • (2014) J. Biomol. Screen. , vol.20 , pp. 437-453
    • Smith, A.J.1
  • 6
    • 79952715351 scopus 로고    scopus 로고
    • Biosimilar, biobetter and next generation therapeutic antibodies
    • A. Beck Biosimilar, biobetter and next generation therapeutic antibodies MAbs 3 2011 107 110
    • (2011) MAbs , vol.3 , pp. 107-110
    • Beck, A.1
  • 8
    • 54849438869 scopus 로고    scopus 로고
    • Antibody-based identification of cell surface antigens: Targets for cancer therapy
    • D.T. Loo, and J.P. Mather Antibody-based identification of cell surface antigens: targets for cancer therapy Curr. Opin. Pharmacol. 8 2008 627 631
    • (2008) Curr. Opin. Pharmacol. , vol.8 , pp. 627-631
    • Loo, D.T.1    Mather, J.P.2
  • 9
    • 84928049044 scopus 로고    scopus 로고
    • Selection strategies for anticancer antibody discovery: Searching off the beaten path
    • D. Sánchez-Martín, and et al. Selection strategies for anticancer antibody discovery: searching off the beaten path Trends Biotechnol. 33 2015 292 301
    • (2015) Trends Biotechnol. , vol.33 , pp. 292-301
    • Sánchez-Martín, D.1
  • 10
    • 84958825022 scopus 로고    scopus 로고
    • Efficient methods to isolate human monoclonal antibodies from memory B cells and plasma cells
    • D. Corti, and A. Lanzavecchia Efficient methods to isolate human monoclonal antibodies from memory B cells and plasma cells Microbiol. Spectrum 2 2014 1 9
    • (2014) Microbiol. Spectrum , vol.2 , pp. 1-9
    • Corti, D.1    Lanzavecchia, A.2
  • 11
    • 0029008062 scopus 로고
    • Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library
    • J. de Kruif, and et al. Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library Proc. Natl. Acad. Sci. U. S. A. 92 1995 3938 3942
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 3938-3942
    • De Kruif, J.1
  • 12
    • 35148840552 scopus 로고    scopus 로고
    • Phage display derived human monoclonal antibodies isolated by binding to the surface of live primary breast cancer cells recognize GRP78
    • C.G. Jakobsen, and et al. Phage display derived human monoclonal antibodies isolated by binding to the surface of live primary breast cancer cells recognize GRP78 Cancer Res. 67 2007 9507 9517
    • (2007) Cancer Res. , vol.67 , pp. 9507-9517
    • Jakobsen, C.G.1
  • 13
    • 78650209114 scopus 로고    scopus 로고
    • Selection and analysis of anti-cancer antibodies for cancer therapy obtained from antibody phage library
    • G. Kurosawa, and et al. Selection and analysis of anti-cancer antibodies for cancer therapy obtained from antibody phage library Cancer Sci. 102 2011 175 181
    • (2011) Cancer Sci. , vol.102 , pp. 175-181
    • Kurosawa, G.1
  • 14
    • 84876683956 scopus 로고    scopus 로고
    • A novel human anti-syndecan-1 antibody inhibits vascular maturation and tumour growth in melanoma
    • P. Orecchia, and et al. A novel human anti-syndecan-1 antibody inhibits vascular maturation and tumour growth in melanoma Eur. J. Cancer 49 2013 2022 2033
    • (2013) Eur. J. Cancer , vol.49 , pp. 2022-2033
    • Orecchia, P.1
  • 15
    • 33745220111 scopus 로고    scopus 로고
    • Rapid induction of apoptosis in B-cell lymphoma by functionally isolated human antibodies
    • J. Fransson, and et al. Rapid induction of apoptosis in B-cell lymphoma by functionally isolated human antibodies Int. J. Cancer 119 2006 349 358
    • (2006) Int. J. Cancer , vol.119 , pp. 349-358
    • Fransson, J.1
  • 16
    • 84907899169 scopus 로고    scopus 로고
    • A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies
    • D.T. Dudley, and et al. A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies Proc. Natl. Acad. Sci. U. S. A. 111 2014 14882 14887
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 14882-14887
    • Dudley, D.T.1
  • 17
    • 0034283551 scopus 로고    scopus 로고
    • Selection of tumor-specific internalizing human antibodies from phage libraries
    • M.A. Poul, and et al. Selection of tumor-specific internalizing human antibodies from phage libraries J. Mol. Biol. 301 2000 1149 1161
    • (2000) J. Mol. Biol. , vol.301 , pp. 1149-1161
    • Poul, M.A.1
  • 18
    • 84874283227 scopus 로고    scopus 로고
    • Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type
    • S. Rust, and et al. Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type Mol. Cancer 12 2013 11
    • (2013) Mol. Cancer , vol.12 , pp. 11
    • Rust, S.1
  • 20
    • 84872204344 scopus 로고    scopus 로고
    • Anti-CD44 antibody, ARH460-16-2, binds to human AML CD34+CD38- cancer stem cells and shows anti-tumor activity in an AML xenograft model
    • L. da Cruz, and et al. Anti-CD44 antibody, ARH460-16-2, binds to human AML CD34+CD38- cancer stem cells and shows anti-tumor activity in an AML xenograft model AACR Meeting Abstracts 3976 2008
    • (2008) AACR Meeting Abstracts 3976
    • Da Cruz, L.1
  • 21
    • 84941985213 scopus 로고    scopus 로고
    • CD44 isoform status predicts response to treatment with anti-CD44 antibody in cancer patients
    • F. Birzele, and et al. CD44 isoform status predicts response to treatment with anti-CD44 antibody in cancer patients Clin. Cancer Res. 21 2015 2753 2762
    • (2015) Clin. Cancer Res. , vol.21 , pp. 2753-2762
    • Birzele, F.1
  • 22
    • 84876037294 scopus 로고    scopus 로고
    • Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44
    • S. Zhang, and et al. Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44 Proc. Natl. Acad. Sci. U. S. A. 110 2013 6127 6132
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 6127-6132
    • Zhang, S.1
  • 24
    • 34147140962 scopus 로고    scopus 로고
    • The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo
    • D. Loo, and et al. The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo Mol. Cancer Ther. 6 2007 856 865
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 856-865
    • Loo, D.1
  • 25
    • 69749108893 scopus 로고    scopus 로고
    • The RAV12 monoclonal antibody recognizes the N-linked glycotope RAAG12: Expression in human normal and tumor tissues
    • S.K. Coberly, and et al. The RAV12 monoclonal antibody recognizes the N-linked glycotope RAAG12: expression in human normal and tumor tissues Arch. Pathol. Lab. Med. 133 2009 1403 1412
    • (2009) Arch. Pathol. Lab. Med. , vol.133 , pp. 1403-1412
    • Coberly, S.K.1
  • 26
    • 84892153139 scopus 로고    scopus 로고
    • Clinical development success rates for investigational drugs
    • M. Hay, and et al. Clinical development success rates for investigational drugs Nat. Biotechnol. 32 2014 40 51
    • (2014) Nat. Biotechnol. , vol.32 , pp. 40-51
    • Hay, M.1
  • 27
    • 84875448716 scopus 로고    scopus 로고
    • Phenotypic vs. Target-based drug discovery for first-in-class medicines
    • D.C. Swinney Phenotypic vs. target-based drug discovery for first-in-class medicines Clin. Pharmacol. Ther. 93 2013 299 301
    • (2013) Clin. Pharmacol. Ther. , vol.93 , pp. 299-301
    • Swinney, D.C.1
  • 28
    • 9344223986 scopus 로고    scopus 로고
    • Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library
    • T.J. Vaughan, and et al. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library Nat. Biotechnol. 14 1996 309 314
    • (1996) Nat. Biotechnol. , vol.14 , pp. 309-314
    • Vaughan, T.J.1
  • 29
    • 0034635335 scopus 로고    scopus 로고
    • Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides
    • A. Knappik, and et al. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides J. Mol. Biol. 11 2000 57 86
    • (2000) J. Mol. Biol. , vol.11 , pp. 57-86
    • Knappik, A.1
  • 30
    • 84876385896 scopus 로고    scopus 로고
    • A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo
    • N. Veitonmaki, and et al. A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo Cancer Cell 23 2013 502 515
    • (2013) Cancer Cell , vol.23 , pp. 502-515
    • Veitonmaki, N.1
  • 31
    • 84885794229 scopus 로고    scopus 로고
    • Function-first antibody discovery: Embracing the unpredictable biology of antibodies
    • B. Frendéus Function-first antibody discovery: embracing the unpredictable biology of antibodies OncoOmmunology 2 2013 e25047
    • (2013) OncoOmmunology , vol.2 , pp. e25047
    • Frendéus, B.1
  • 32
    • 84941955989 scopus 로고    scopus 로고
    • A Phase I dose-escalation study of antibody BI-505 in relapsed/refractory multiple myeloma
    • M. Hansson, and et al. A Phase I dose-escalation study of antibody BI-505 in relapsed/refractory multiple myeloma Clin. Cancer Res. 21 2015 2730 2736
    • (2015) Clin. Cancer Res. , vol.21 , pp. 2730-2736
    • Hansson, M.1
  • 33
    • 84864291211 scopus 로고    scopus 로고
    • Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening
    • A. DiGiandomenico, and et al. Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening J. Exp. Med. 209 2012 1273 1287
    • (2012) J. Exp. Med. , vol.209 , pp. 1273-1287
    • DiGiandomenico, A.1
  • 34
    • 84910673427 scopus 로고    scopus 로고
    • A multifunctional bispecific antibody protects against Pseudomonas aeruginosa
    • A. DiGiandomenico, and et al. A multifunctional bispecific antibody protects against Pseudomonas aeruginosa Sci. Transl. Med. 6 2014 262ra155
    • (2014) Sci. Transl. Med. , vol.6 , pp. 262ra155
    • DiGiandomenico, A.1
  • 35
    • 84878349946 scopus 로고    scopus 로고
    • Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody
    • J.S. McLellan, and et al. Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody Science 340 2013 1113 1117
    • (2013) Science , vol.340 , pp. 1113-1117
    • McLellan, J.S.1
  • 36
    • 73849089855 scopus 로고    scopus 로고
    • Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex
    • A. Macagno, and et al. Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex J. Virol. 84 2010 1005 1013
    • (2010) J. Virol. , vol.84 , pp. 1005-1013
    • MacAgno, A.1
  • 37
    • 84875833320 scopus 로고    scopus 로고
    • Targeted anti-leukemic therapy as disease-stabilizing treatment for acute myeloid leukemia relapse after allogeneic stem cell transplantation: Will it be possible to combine these strategies with retransplantation or donor lymphocyte infusions?
    • H. Reikvam, and et al. Targeted anti-leukemic therapy as disease-stabilizing treatment for acute myeloid leukemia relapse after allogeneic stem cell transplantation: Will it be possible to combine these strategies with retransplantation or donor lymphocyte infusions? Curr. Cancer. Drug Targets 13 2013 30 47
    • (2013) Curr. Cancer. Drug Targets , vol.13 , pp. 30-47
    • Reikvam, H.1
  • 38
    • 84881552515 scopus 로고    scopus 로고
    • A mammalian expression system for high throughput antibody screening
    • L. Xu, and et al. A mammalian expression system for high throughput antibody screening J. Immunol. Methods 395 2013 45 53
    • (2013) J. Immunol. Methods , vol.395 , pp. 45-53
    • Xu, L.1
  • 39
    • 84866847222 scopus 로고    scopus 로고
    • Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries
    • H. Zhang, and et al. Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries Proc. Natl. Acad. Sci. U. S. A. 109 2012 15728 15733
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 15728-15733
    • Zhang, H.1
  • 40
    • 84877871396 scopus 로고    scopus 로고
    • Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells
    • J. Xie, and et al. Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells Proc. Natl. Acad. Sci. U. S. A. 110 2013 8099 8104
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 8099-8104
    • Xie, J.1
  • 41
    • 84878241266 scopus 로고    scopus 로고
    • Selecting agonists from single cells infected with combinatorial antibody libraries
    • H. Zhang, and et al. Selecting agonists from single cells infected with combinatorial antibody libraries Chem. Biol. 20 2013 734 7341
    • (2013) Chem. Biol. , vol.20 , pp. 734-7341
    • Zhang, H.1
  • 42
    • 84887037302 scopus 로고    scopus 로고
    • Selecting antagonistic antibodies that control differentiation through inducible expression in embryonic stem cells
    • A.N. Melidoni, and et al. Selecting antagonistic antibodies that control differentiation through inducible expression in embryonic stem cells Proc. Natl. Acad. Sci. U. S. A. 110 2013 17802 17807
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 17802-17807
    • Melidoni, A.N.1
  • 43
    • 84950152263 scopus 로고    scopus 로고
    • Selection of antibodies interfering with cell surface receptor signalling using embryonic stem cell differentiation
    • A.N. Melidoni, and et al. Selection of antibodies interfering with cell surface receptor signalling using embryonic stem cell differentiation Methods Mol. Biol. 2015 10.1007/7651-2015-270
    • (2015) Methods Mol. Biol.
    • Melidoni, A.N.1
  • 44
    • 84894499829 scopus 로고    scopus 로고
    • Prevention of cell death by antibodies selected from intracellular combinatorial libraries
    • J. Xie, and et al. Prevention of cell death by antibodies selected from intracellular combinatorial libraries Chem. Biol. 21 2014 274 283
    • (2014) Chem. Biol. , vol.21 , pp. 274-283
    • Xie, J.1
  • 45
    • 84883822712 scopus 로고    scopus 로고
    • Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections
    • K. Yea, and et al. Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections Proc. Natl. Acad. Sci. U. S. A. 110 2013 14966 14971
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 14966-14971
    • Yea, K.1
  • 46
    • 84905985710 scopus 로고    scopus 로고
    • In-cell intrabody selection from a diverse human library identifies C12orf4 protein as a new player in rodent mast cell degranulation
    • E. Mazuc, and et al. In-cell intrabody selection from a diverse human library identifies C12orf4 protein as a new player in rodent mast cell degranulation PLOS ONE 9 2014 e104998
    • (2014) PLOS ONE , vol.9 , pp. e104998
    • Mazuc, E.1
  • 47
    • 84925759142 scopus 로고    scopus 로고
    • Discovery of functional antibodies targeting ion channels
    • T.C. Wilkinson, and et al. Discovery of functional antibodies targeting ion channels J. Biomol. Screen. 20 2015 454 467
    • (2015) J. Biomol. Screen. , vol.20 , pp. 454-467
    • Wilkinson, T.C.1
  • 48
    • 84873538403 scopus 로고    scopus 로고
    • Antibody therapeutics targeting ion channels: Are we there yet?
    • H. Sun, and M. Li Antibody therapeutics targeting ion channels: are we there yet? Acta Pharmacol. Sin. 34 2013 199 204
    • (2013) Acta Pharmacol. Sin. , vol.34 , pp. 199-204
    • Sun, H.1    Li, M.2
  • 49
    • 84862490558 scopus 로고    scopus 로고
    • Zebrafish screen identifies novel compound with selective toxicity against leukemia
    • S. Ridges, and et al. Zebrafish screen identifies novel compound with selective toxicity against leukemia Blood 119 2012 5621 5631
    • (2012) Blood , vol.119 , pp. 5621-5631
    • Ridges, S.1
  • 50
    • 84930181142 scopus 로고    scopus 로고
    • Rapid reverse genetic screening using CRISPR in zebrafish
    • A.N. Shah, and et al. Rapid reverse genetic screening using CRISPR in zebrafish Nat. Methods 12 2015 535 540
    • (2015) Nat. Methods , vol.12 , pp. 535-540
    • Shah, A.N.1
  • 51
    • 84930579751 scopus 로고    scopus 로고
    • Phenotype-driven chemical screening in zebrafish for collective cell migration inhibitors identifies multiple potential pathways for targeting metastasis
    • V.E. Gallardo, and et al. Phenotype-driven chemical screening in zebrafish for collective cell migration inhibitors identifies multiple potential pathways for targeting metastasis Dis. Model. Mech. 8 2015 565 576
    • (2015) Dis. Model. Mech. , vol.8 , pp. 565-576
    • Gallardo, V.E.1
  • 53
    • 0344845001 scopus 로고    scopus 로고
    • Tissue architecture: The ultimate regulator of breast epithelial function
    • M.J. Bissell, and et al. Tissue architecture: the ultimate regulator of breast epithelial function Curr. Opin. Cell Biol. 15 2003 753 762
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 753-762
    • Bissell, M.J.1
  • 54
    • 84938059590 scopus 로고    scopus 로고
    • Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling
    • A. Sandercock, and et al. Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling Mol. Cancer 14 2015 147
    • (2015) Mol. Cancer , vol.14 , pp. 147
    • Sandercock, A.1
  • 55
    • 84869126274 scopus 로고    scopus 로고
    • A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice
    • D. Huh, and et al. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice Sci. Transl. Med. 4 2012 159ra147
    • (2012) Sci. Transl. Med. , vol.4 , pp. 159ra147
    • Huh, D.1
  • 56
    • 84873309547 scopus 로고    scopus 로고
    • Screening therapeutic EMT blocking agents in a three-dimensional microenvironment
    • A.R. Aref, and et al. Screening therapeutic EMT blocking agents in a three-dimensional microenvironment Integr. Biol. 5 2013 381 389
    • (2013) Integr. Biol. , vol.5 , pp. 381-389
    • Aref, A.R.1
  • 58
    • 0024566393 scopus 로고
    • Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype
    • M.J. Dyer, and et al. Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype Blood 73 1989 1431 1439
    • (1989) Blood , vol.73 , pp. 1431-1439
    • Dyer, M.J.1
  • 59
    • 0021227678 scopus 로고
    • Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1)
    • H. Waldmann, and et al. Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1) Lancet 2 1984 483 486
    • (1984) Lancet , vol.2 , pp. 483-486
    • Waldmann, H.1
  • 60
    • 0025878925 scopus 로고
    • Characterization of the CAMPATH-1 (CDw52) antigen: Biochemical analysis and cDNA cloning reveal an unusually small peptide backbone
    • M.Q. Xia, and et al. Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone Eur. J. Immunol. 21 1991 1677 1684
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1677-1684
    • Xia, M.Q.1


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