Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion

DMM Disease Models and Mechanisms

Volumn 8, Issue 6, 2015, Pages 565-576

  Gallardo, Viviana E ^a   Varshney, Gaurav K ^a   Lee, Minnkyong ^a   Bupp, Sujata ^a   Xu, Lisha ^a   Shinn, Paul ^b   Crawford, Nigel P ^a   Inglese, James ^a,b   Burgess, Shawn M ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Drug screening; Metastasis; Orthotopic implantation; Src; Tks5; Zebrafish

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; ANTIMETASTATIC AGENT; GREEN FLUORESCENT PROTEIN; NATURAL PRODUCT; INDOLE DERIVATIVE; MESSENGER RNA; MOLECULAR LIBRARY; PROTEIN TYROSINE KINASE; SULFONAMIDE; ZEBRAFISH PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CANCER TRANSPLANTATION; CELL MIGRATION; CONTROLLED STUDY; CRISPR CAS SYSTEM; EMBRYO; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; METASTASIS INHIBITION; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIMORDIUM; PRIORITY JOURNAL; TRANSGENIC ZEBRAFISH; TUMOR INVASION; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOLOGICAL MODEL; CELL MOTION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EMBRYOLOGY; GENETICS; LATERAL LINE SYSTEM; METABOLISM; METASTASIS; MOLECULAR GENETICS; MOLECULAR LIBRARY; NEOPLASM; NONMAMMALIAN EMBRYO; PATHOLOGY; PHARMACOLOGY; PRECLINICAL STUDY; REPRODUCIBILITY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; ZEBRA FISH;

DANIO RERIO; MUS;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CRISPR-CAS SYSTEMS; DRUG EVALUATION, PRECLINICAL; EMBRYO, NONMAMMALIAN; FEMALE; HUMANS; INDOLES; LATERAL LINE SYSTEM; MICE, INBRED BALB C; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; NEOPLASMS; PHENOTYPE; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; SRC-FAMILY KINASES; SULFONAMIDES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84930579751     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.018689     Document Type: Article

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