Can residence time offer a useful strategy to target agonist drugs for sustained GPCR responses?

Drug Discovery Today

Volumn 21, Issue 1, 2016, Pages 90-96

  Hothersall, J Daniel ^a   Brown, Alastair J ^b   Dale, Ian ^a   Rawlins, Philip ^a  

^a ASTRAZENECA   (United Kingdom)

^b Heptares Therapeutics Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2A RECEPTOR; ANGIOTENSIN 2 RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CALCITONIN RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE RECEPTOR; MELANOCORTIN 1 RECEPTOR; MELATONIN 1 RECEPTOR; MUSCARINIC M1 RECEPTOR; PARATHYROID HORMONE RECEPTOR; SEROTONIN RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR; THYROTROPIN RECEPTOR; VASOPRESSIN V2 RECEPTOR; LIGAND; PROTEIN BINDING;

AGONIST; CELL MEMBRANE; DRUG BINDING; DRUG EFFICACY; DRUG TARGETING; INTERNALIZATION; LIGAND BINDING; REVIEW; SIGNAL TRANSDUCTION; AGONISTS; DRUG DEVELOPMENT; KINETICS; PHYSIOLOGY; PROCEDURES;

DRUG DISCOVERY; KINETICS; LIGANDS; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84960296371     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2015.07.015     Document Type: Review

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