-
1
-
-
0009644628
-
Some quantitative uses of drug antagonists
-
Arunlakshana O and Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol 14:48-58.
-
(1959)
Br J Pharmacol
, vol.14
, pp. 48-58
-
-
Arunlakshana, O.1
Schild, H.O.2
-
2
-
-
0030902127
-
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioural symptoms in Alzheimer's disease
-
Bodick NC, Offen WW, Levey AI, Cutler NC, Gauthier SG, Satlin A, Shannon HE, Tollefson GD, Rasmussen K, Bymaster FP, Hurley DJ, Potter WZ, and Paul SM (1997) Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioural symptoms in Alzheimer's disease. Arch Neurol 54:465-473.
-
(1997)
Arch Neurol
, vol.54
, pp. 465-473
-
-
Bodick, N.C.1
Offen, W.W.2
Levey, A.I.3
Cutler, N.C.4
Gauthier, S.G.5
Satlin, A.6
Shannon, H.E.7
Tollefson, G.D.8
Rasmussen, K.9
Bymaster, F.P.10
Hurley, D.J.11
Potter, W.Z.12
Paul, S.M.13
-
3
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Annal Biochem 72:248-254.
-
(1976)
Annal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.1
-
4
-
-
0024378999
-
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum
-
Bredt DS and Snyder SH (1989) Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86:9030-9033.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 9030-9033
-
-
Bredt, D.S.1
Snyder, S.H.2
-
5
-
-
0030927142
-
Xanomeline: A selective muscarinic agonist for the treatment of Alzheimer's disease
-
Bymaster FP, Whitesitt CA, Shannon HE, DeLapp N, Ward JS, Calligaro DO, Shipley LA, Buelke-Sam JL, Bodick NC, Farde L, Sheardown MJ, Olesen PH, Hansen KT, Suzdak PD, Swedberg MDB, Sauerberg P, and Mitch CH (1997) Xanomeline: a selective muscarinic agonist for the treatment of Alzheimer's disease. Drug Dev Res 40:158-170.
-
(1997)
Drug Dev Res
, vol.40
, pp. 158-170
-
-
Bymaster, F.P.1
Whitesitt, C.A.2
Shannon, H.E.3
DeLapp, N.4
Ward, J.S.5
Calligaro, D.O.6
Shipley, L.A.7
Buelke-Sam, J.L.8
Bodick, N.C.9
Farde, L.10
Sheardown, M.J.11
Olesen, P.H.12
Hansen, K.T.13
Suzdak, P.D.14
Swedberg, M.D.B.15
Sauerberg, P.16
Mitch, C.H.17
-
7
-
-
0030024180
-
2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: Evidence for a quasi-irreversible binding to an exosite
-
2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: evidence for a quasi-irreversible binding to an exosite. Mol Pharmacol 49:182-189.
-
(1996)
Mol Pharmacol
, vol.49
, pp. 182-189
-
-
Clark, R.B.1
Allal, C.2
Friedman, J.3
Johnson, M.4
Barber, R.5
-
8
-
-
0030247623
-
Exosites: Their current status, and their relevance to the duration of action of long-acting β2-adrenoceptor agonists
-
Coleman RA, Johnson M, Nials AT, and Vardey CJ (1996) Exosites: their current status, and their relevance to the duration of action of long-acting β2-adrenoceptor agonists. Trends Pharmacol Sci 17:324-330.
-
(1996)
Trends Pharmacol Sci
, vol.17
, pp. 324-330
-
-
Coleman, R.A.1
Johnson, M.2
Nials, A.T.3
Vardey, C.J.4
-
9
-
-
0028919316
-
Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease
-
Ferrari-Dileo G, Mash DC, and Flynn, DD (1995) Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease. Mol Chem Neuropathol 24:69-91.
-
(1995)
Mol Chem Neuropathol
, vol.24
, pp. 69-91
-
-
Ferrari-Dileo, G.1
Mash, D.C.2
Flynn, D.D.3
-
10
-
-
0002361315
-
Cholinomimetic replacement of cholinergic function in Alzheimer's disease
-
Meyer EM, Simpkins JW, Yamamoto J, and Crews FT, eds, Plenum Press, NY
-
Giacobini E (1992) Cholinomimetic replacement of cholinergic function in Alzheimer's disease, in Treatment of Dementias (Meyer EM, Simpkins JW, Yamamoto J, and Crews FT, eds) pp 19-34, Plenum Press, NY.
-
(1992)
Treatment of Dementias
, pp. 19-34
-
-
Giacobini, E.1
-
12
-
-
0025856977
-
Effects of agonist efficacy on desensitization of phosphoinositide hydrolysis mediated by m1 and m3 muscarinic receptors expressed in Chinese hamster ovary cells
-
Hu J, Wang SZ, and El-Fakahany EE (1991) Effects of agonist efficacy on desensitization of phosphoinositide hydrolysis mediated by m1 and m3 muscarinic receptors expressed in Chinese hamster ovary cells J Pharmacol Exp Ther 257:938-945.
-
(1991)
J Pharmacol Exp Ther
, vol.257
, pp. 938-945
-
-
Hu, J.1
Wang, S.Z.2
El-Fakahany, E.E.3
-
13
-
-
0030612652
-
2-Adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists
-
2-Adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists. J Biol Chem 272:23871-23879.
-
(1997)
J Biol Chem
, vol.272
, pp. 23871-23879
-
-
January, B.1
Seibold, A.2
Whaley, B.3
Hipkin, R.W.4
Lin, D.5
Schonbrunn, A.6
Barber, R.7
Clark, R.B.8
-
15
-
-
0030218059
-
Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation
-
Kostenis E and Mohr K (1996) Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation. Trends Pharmacol Sci 17:280-283.
-
(1996)
Trends Pharmacol Sci
, vol.17
, pp. 280-283
-
-
Kostenis, E.1
Mohr, K.2
-
17
-
-
0029126526
-
Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: Interactions of strychnine and acetyicholine at muscarinic receptors
-
Lazareno S and Birdsall NJM (1995) Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetyicholine at muscarinic receptors. Mol Pharmacol 48:362-378.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 362-378
-
-
Lazareno, S.1
Birdsall, N.J.M.2
-
18
-
-
0025875643
-
Allosteric antagonists of the muscarinic acetylcholine receptor
-
Lee NH and El-Fakahany EE (1991) Allosteric antagonists of the muscarinic acetylcholine receptor. Biochem Pharmacol 42:199-205.
-
(1991)
Biochem Pharmacol
, vol.42
, pp. 199-205
-
-
Lee, N.H.1
El-Fakahany, E.E.2
-
19
-
-
0025212261
-
Estimation of agonist affinity and efficacy by direct, operational model fitting
-
Leff P, Prentice DJ, Giles H, Martin GR, and Wood J (1990) Estimation of agonist affinity and efficacy by direct, operational model fitting. J Pharmacol Methods 23:225-237.
-
(1990)
J Pharmacol Methods
, vol.23
, pp. 225-237
-
-
Leff, P.1
Prentice, D.J.2
Giles, H.3
Martin, G.R.4
Wood, J.5
-
20
-
-
0027375964
-
Molecular mechanisms of membrane receptor desensitization
-
Lohse MJ (1993) Molecular mechanisms of membrane receptor desensitization. Biochim Biophys Acta 1179:171-188.
-
(1993)
Biochim Biophys Acta
, vol.1179
, pp. 171-188
-
-
Lohse, M.J.1
-
21
-
-
0021962590
-
Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation
-
Mash DC, Flynn DD, and Potter LT (1985) Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. Science (Washington D C) 228:1115-1117.
-
(1985)
Science (Washington D C)
, vol.228
, pp. 1115-1117
-
-
Mash, D.C.1
Flynn, D.D.2
Potter, L.T.3
-
22
-
-
0002704168
-
Regulation and development of muscarinic receptor number and function
-
Brown JH, ed, Humana Press, NJ
-
Nathanson NM (1989) Regulation and development of muscarinic receptor number and function, in The Muscarinic Receptors (Brown JH, ed) pp 419-454, Humana Press, NJ.
-
(1989)
The Muscarinic Receptors
, pp. 419-454
-
-
Nathanson, N.M.1
-
24
-
-
0028231689
-
Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic receptors
-
Proška J and Tucek S (1994) Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic receptors. Mol Pharmacol 45:709-717.
-
(1994)
Mol Pharmacol
, vol.45
, pp. 709-717
-
-
Proška, J.1
Tucek, S.2
-
25
-
-
0024472079
-
Muscarinic receptor subtypes in human neurodegenerative disorders: Focus on Alzheimer's disease
-
Quirion R, Aubert I, Lapchak PA, Schaum RP, Teolis S, Gauthier S, and Araujo DM (1989) Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease. Trends Pharmacol Sci 10(suppl.):80-84.
-
(1989)
Trends Pharmacol Sci
, vol.10
, Issue.SUPPL.
, pp. 80-84
-
-
Quirion, R.1
Aubert, I.2
Lapchak, P.A.3
Schaum, R.P.4
Teolis, S.5
Gauthier, S.6
Araujo, D.M.7
-
26
-
-
0028344181
-
1 receptors
-
1 receptors. J Pharmacol Exp Ther 269:271-281.
-
(1994)
J Pharmacol Exp Ther
, vol.269
, pp. 271-281
-
-
Shannon, H.E.1
Bymaster, F.P.2
Calligaro, D.O.3
Greenwood, B.4
Mitch, C.H.5
Sawyer, B.D.6
Ward, J.S.7
Wong, D.T.8
Olesen, P.H.9
Sheardown, M.J.10
Swedberg, M.D.B.11
Suzdak, P.D.12
Sauerberg, P.13
-
27
-
-
0028297202
-
Efficient coupling of m5 muscarinic acetyicholine receptors to activation of nitric oxide synthase
-
Wang SZ, Zhu SZ, and El-Fakahany EE (1994) Efficient coupling of m5 muscarinic acetyicholine receptors to activation of nitric oxide synthase. J Pharmacol Exp Ther 268:552-557.
-
(1994)
J Pharmacol Exp Ther
, vol.268
, pp. 552-557
-
-
Wang, S.Z.1
Zhu, S.Z.2
El-Fakahany, E.E.3
-
28
-
-
0009603660
-
An arginine residue conserved in most G protein-coupled receptors is essential for the function of the m1 muscarinic receptor
-
Zhu SZ, Wang SZ, Hu J, and El-Fakahany EE (1994) An arginine residue conserved in most G protein-coupled receptors is essential for the function of the m1 muscarinic receptor. Mol Pharmacol 45:517-523.
-
(1994)
Mol Pharmacol
, vol.45
, pp. 517-523
-
-
Zhu, S.Z.1
Wang, S.Z.2
Hu, J.3
El-Fakahany, E.E.4
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