Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer

ACS Nano

Volumn 10, Issue 2, 2016, Pages 2702-2715

  Liu, Xiangsheng ^a   Situ, Allen ^a   Kang, Yanan ^a   Villabroza, Katie Rose ^a   Liao, Yupei ^a   Chang, Chong Hyun ^a   Donahue, Timothy ^b   Nel, Andre E ^a   Meng, Huan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

FOLFIRINOX; irinotecan; lipid bilayer; mesoporous silica nanoparticle; pancreatic cancer; proton gradient; toxicity reduction

Indexed keywords

BONE; DISEASES; DRUG DOSAGE; ENZYME INHIBITION; LIPID BILAYERS; LIPOSOMES; MESOPOROUS MATERIALS; NANOPARTICLES; PATIENT TREATMENT; SILICA; TOXICITY; TUMORS;

FOLFIRINOX; IRINOTECAN; MESOPOROUS SILICA NANOPARTICLES; PANCREATIC CANCERS; PROTON GRADIENT; TOXICITY REDUCTION;

DRUG PRODUCTS;

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; IRINOTECAN; LIPID BILAYER; LIPOSOME; NANOPARTICLE; SILICON DIOXIDE;

ADENOCARCINOMA; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG RELEASE; FEMALE; LIPID BILAYER; MOUSE; PANCREATIC NEOPLASMS; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL LINE, TUMOR; DRUG LIBERATION; FEMALE; LIPID BILAYERS; LIPOSOMES; MICE; NANOPARTICLES; PANCREATIC NEOPLASMS; SILICON DIOXIDE;

EID: 84960192514     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b07781     Document Type: Article

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