Image-guided and tumor-targeted drug delivery with radiolabeled unimolecular micelles

Biomaterials

Volumn 34, Issue 33, 2013, Pages 8323-8332

  Guo, Jintang ^a,b,c   Hong, Hao ^c,d   Chen, Guojun ^b,c   Shi, Sixiang ^b,c   Zheng, Qifeng ^b,c   Zhang, Yin ^d   Theuer, Charles P ^e   Barnhart, Todd E ^d   Cai, Weibo ^b,c,d   Gong, Shaoqin ^b,c  

^a TIANJIN UNIVERSITY   (China)

^b University of Wisconsin Madison   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e TRACON Pharmaceuticals Inc   (United States)

Author keywords

CD105 (endoglin); Dendritic amphiphilic block copolymer; Molecular imaging; Nanocarriers; Positron emission tomography (PET); Unimolecular micelles

Indexed keywords

AMPHIPHILIC BLOCK COPOLYMERS; CD105 (ENDOGLIN); NANO-CARRIERS; POSITRON EMISSION TOMOGRAPHY (PET); UNIMOLECULAR MICELLES;

BLOCK COPOLYMERS; DRUG DELIVERY; ENDOTHELIAL CELLS; MOLECULAR IMAGING; MONOCLONAL ANTIBODIES; ORGANIC POLYMERS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POSITRON EMISSION TOMOGRAPHY; TUMORS;

MICELLES;

COPOLYMER; COPPER 64; DOXORUBICIN; MACROGOL; MONOCLONAL ANTIBODY; POLY(AMIDOAMINE) POLY(LEVO LACTIDE) POLY(ETHYLENE GLYCOL); POLYAMIDOAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG UPTAKE; ENCAPSULATION; HUMAN; HUMAN CELL; ISOTOPE LABELING; MICELLE; MOLECULARLY TARGETED THERAPY; MOUSE; NON INVASIVE PROCEDURE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

MURINAE; MUS;

CD105 (ENDOGLIN); DENDRITIC AMPHIPHILIC BLOCK COPOLYMER; MOLECULAR IMAGING; NANOCARRIERS; POSITRON EMISSION TOMOGRAPHY (PET); UNIMOLECULAR MICELLES;

ANIMALS; ANTIGENS, CD; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; FEMALE; MCF-7 CELLS; MICE; MICE, INBRED BALB C; MICELLES; MICROSCOPY, FLUORESCENCE; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, CELL SURFACE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84881662751     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.07.085     Document Type: Article

References (39)

1. Luo K., Li C., Li L., She W., Wang G., Gu Z. Arginine functionalized peptide dendrimers as potential gene delivery vehicles. Biomaterials 2012, 33:4917-4927.
2. Cao W., Zhu L. Synthesis and unimolecular micelles of amphiphilic dendrimer-like star polymer with various functional surface groups. Macromolecules 2011, 44:1500-1512.
3. Iezzi R., Guru B.R., Glybina I.V., Mishra M.K., Kennedy A., Kannan R.M. Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration. Biomaterials 2012, 33:979-988.
4. Chang Y., Liu N., Chen L., Meng X., Liu Y., Li Y., et al. Synthesis and characterization of DOX-conjugated dendrimer-modified magnetic iron oxide conjugates for magnetic resonance imaging, targeting, and drug delivery. JMater Chem 2012, 22:9594-9601.
5. Kontoyianni C., Sideratou Z., Theodossiou T., Tziveleka L.A., Tsiourvas D., Paleos C.M. Anovel micellar PEGylated hyperbranched polyester as a prospective drug delivery system for paclitaxel. Macromol Biosci 2008, 8:871-881.
6. van Hest J.C., Delnoye D.A., Baars M.W., van Genderen M.H., Meijer E.W. Polystyrene-dendrimer amphiphilic block copolymers with a generation-dependent aggregation. Science 1995, 268:1592-1595.
7. Cho B.-K., Jain A., Nieberle J., Mahajan S., Wiesner U., Gruner S.M., et al. Synthesis and self-assembly of amphiphilic dendrimers based on aliphatic polyether-type dendritic cores. Macromolecules 2004, 37:4227-4234.
8. Tao L., Uhrich K.E. Novel amphiphilic macromolecules and their invitro characterization as stabilized micellar drug delivery systems. JColloid Interface Sci 2006, 298:102-110.
9. Kataoka K., Harada A., Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 2001, 47:113-131.
10. Torchilin V.P. Multifunctional nanocarriers. Adv Drug Deliv Rev 2006, 58:1532-1555.
11. Kim K., Kim J.H., Park H., Kim Y.S., Park K., Nam H., et al. Tumor-homing multifunctional nanoparticles for cancer theragnosis: simultaneous diagnosis, drug delivery, and therapeutic monitoring. JControl Release 2010, 146:219-227.
12. Chen G., Guan Z. Transition metal-catalyzed one-pot synthesis of water-soluble dendritic molecular nanocarriers. JAm Chem Soc 2004, 126:2662-2663.
13. Wang F., Bronich T.K., Kabanov A.V., Rauh R.D., Roovers J. Synthesis and evaluation of a star amphiphilic block copolymer from poly(epsilon-caprolactone) and poly(ethylene glycol) as a potential drug delivery carrier. Bioconjug Chem 2005, 16:397-405.
14. Heise A., Hedrick J.L., Frank C.W., Miller R.D. Starlike block copolymers with amphiphilic arms as models for unimolecular micelles. JAm Chem Soc 1999, 121:8647-8648.
15. Li X., Qian Y., Liu T., Hu X., Zhang G., You Y., et al. Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging. Biomaterials 2011, 32:6595-6605.
16. Zhou Y., Huang W., Liu J., Zhu X., Yan D. Self-assembly of hyperbranched polymers and its biomedical applications. Adv Mater 2010, 22:4567-4590.
17. Prabaharan M., Grailer J.J., Pilla S., Steeber D.A., Gong S. Amphiphilic multi-arm block copolymer based on hyperbranched polyester, poly(L-lactide) and poly(ethylene glycol) as a drug delivery carrier. Macromol Biosci 2009, 9:515-524.
18. Xiao Y., Hong H., Javadi A., Engle J.W., Xu W., Yang Y., et al. Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging. Biomaterials 2012, 33:3071-3082.
19. Liu J., Huang W., Pang Y., Zhu X., Zhou Y., Yan D. Self-assembled micelles from an amphiphilic hyperbranched copolymer with polyphosphate arms for drug delivery. Langmuir 2010, 26:10585-10592.
20. Radowski M.R., Shukla A., von Berlepsch H., Bottcher C., Pickaert G., Rehage H., et al. Supramolecular aggregates of dendritic multishell architectures as universal nanocarriers. Angew Chem Int Ed Engl 2007, 46:1265-1269.
21. Sheng Y.J., Nung C.H., Tsao H.K. Morphologies of star-block copolymers in dilute solutions. JPhys Chem B 2006, 110:21643-21650.
22. Seon B.K., Haba A., Matsuno F., Takahashi N., Tsujie M., She X., et al. Endoglin-targeted cancer therapy. Curr Drug Deliv 2011, 8:135-143.
23. Dallas N.A., Samuel S., Xia L., Fan F., Gray M.J., Lim S.J., et al. Endoglin (CD105): a marker of tumor vasculature and potential target for therapy. Clin Cancer Res 2008, 14:1931-1937.
24. Fonsatti E., Nicolay H.J., Altomonte M., Covre A., Maio M. Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours. Cardiovasc Res 2010, 86:12-19.
25. Zhang Y., Yang Y., Hong H., Cai W. Multimodality molecular imaging of CD105 (endoglin) expression. Int J Clin Exp Med 2011, 4:32-42.
26. Rosen L.S., Hurwitz H.I., Wong M.K., Goldman J., Mendelson D.S., Figg W.D., et al. Aphase I first-in-human study of TRC105 (anti-endoglin antibody) in patients with advanced cancer. Clin Cancer Res 2012, 18:4820-4829.
27. Hong H., Yang Y., Zhang Y., Engle J.W., Barnhart T.E., Nickles R.J., et al. Positron emission tomography imaging of CD105 expression during tumor angiogenesis. Eur J Nucl Med Mol Imaging 2011, 38:1335-1343.
28. 89Zr and IRDye 800CW. Mol Pharm 2012, 9:2339-2349.
29. James M.L., Gambhir S.S. Amolecular imaging primer: modalities, imaging agents, and applications. Physiol Rev 2012, 92:897-965.
30. Hong H., Yang K., Zhang Y., Engle J.W., Feng L., Yang Y., et al. Invivo targeting and imaging of tumor vasculature with radiolabeled, antibody-conjugated nanographene. ACS Nano 2012, 6:2361-2370.
31. 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials 2011, 32:4151-4160.
32. Wang F., Bronich T.K., Kabanov A.V., Rauh R.D., Roovers J. Synthesis and characterization of star poly(epsilon-caprolactone)-b-poly(ethylene glycol) and poly(L-lactide)-b-poly(ethylene glycol) copolymers: evaluation as drug delivery carriers. Bioconjug Chem 2008, 19:1423-1429.
33. Miao Z.M., Cheng S.X., Zhang X.Z., Wang Q.R., Zhuo R.X. Degradation and drug release property of star poly(epsilon-caprolactone)s with dendritic cores. JBiomed Mater Res B Appl Biomater 2007, 81:40-49.
34. Zhao Y., Shuai X., Chen C., Xi F. Synthesis and characterization of star-shaped poly(l-lactide)s initiated with hydroxyl-terminated poly(amidoamine) (PAMAM-OH) dendrimers. Chem Mater 2003, 15:2836-2843.
35. Tian H., Chen X., Lin H., Deng C., Zhang P., Wei Y., et al. Micellization and reversible pH-sensitive phase transfer of the hyperbranched multiarm PEI-PBLG copolymer. Chemistry 2006, 12:4305-4312.
36. Prabaharan M., Grailer J.J., Pilla S., Steeber D.A., Gong S. Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn H40, poly(L-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery. Biomaterials 2009, 30:3009-3019.
37. Bareford L.M., Swaan P.W. Endocytic mechanisms for targeted drug delivery. Adv Drug Deliv Rev 2007, 59:748-758.
38. Soppimath K.S., Liu L.H., Seow W.Y., Liu S.Q., Powell R., Chan P., et al. Multifunctional core/shell nanoparticles self-assembled from pH-induced thermosensitive polymers for targeted intracellular anticancer drug delivery. Adv Funct Mater 2007, 17:355-362.
39. Shi S., Yang K., Hong H., Valdovinos H.F., Nayak T.R., Zhang Y., et al. Tumor vasculature targeting and imaging in living mice with reduced graphene oxide. Biomaterials 2013, 34:3002-3009.