Factors influencing uptake and retention of amino-containing drugs in large unilamellar vesicles exhibiting transmembrane pH gradients

Biochimica et Biophysica Acta - Biomembranes

Volumn 1416, Issue 1-2, 1999, Pages 1-10

  Maurer Spurej, Elisabeth ^a   Wong, Kim F ^a   Maurer, Norbert ^a   Fenske, David B ^a   Cullis, Pieter R ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Inex Pharmaceuticals Corporation   (Canada)

Author keywords

Liposome; Membrane partitioning; Transmembrane pH gradient

Indexed keywords

ALIPHATIC AMINE; AMINE; AMMONIUM SULFATE; CHOLESTEROL; CIPROFLOXACIN; DIAMINE; DISTEAROYLPHOSPHATIDIC ACID; DISTEAROYLPHOSPHATIDYLCHOLINE; DOXORUBICIN; EPIRUBICIN; LIPOSOME; METHYLAMINE; VINCRISTINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RELEASE; DRUG RETENTION; DRUG UPTAKE; HYDROPHOBICITY; IN VITRO STUDY; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PH; PRIORITY JOURNAL; SERUM;

AMINES; AMMONIUM SULFATE; CIPROFLOXACIN; DOXORUBICIN; DRUG CARRIERS; EPIRUBICIN; HYDROGEN-ION CONCENTRATION; LIPOSOMES; PHARMACEUTICAL PREPARATIONS; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS; SOLUBILITY; VINCRISTINE;

EID: 0032898738     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2736(98)00204-1     Document Type: Article

References (20)

1. A. Chonn, P.R. Cullis, Recent advances in liposomal drug delivery systems, Curr. Opin. Biotechnol. 6 (1995) 698-708.
2. P.R. Harrigan, K.F. Wong, T.E. Redelmeier, J.J. Wheeler, P.R. Cullis, Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients, Biochim. Biophys. Acta 1149 (1993) 329-338.
3. N.L. Boman, L.D. Mayer, P.R. Cullis, Optimization of the retention properties of vincristine in liposomal systems, Biochim. Biophys. Acta 1152 (1993) 253-258.
4. G. Haran, R. Cohen, L.K. Bar, Y. Barenholz, Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases, Biochim. Biophys. Acta 1151 (1993) 201-215.
5. M.J. Hope, K.W. Wong, Liposomal formulation of ciprofloxacin, in: P.N. Shek, (Ed.), Liposomes in Biomedical Applications, Harwood Academic, Singapore, 1995, pp. 121-134.
6. P.R. Cullis, M.J. Hope, M.B. Bally, T.D. Madden, L.D. Mayer, D.B. Fenske, Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles, Biochim. Biophys. Acta 1331 (1997) 187-211.
7. M.J. Hope, M.B. Bally, M.S. Webb, P.R. Cullis, Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential, Biochim. Biophys. Acta 812 (1985) 5565.
8. E.A. Werner, The isomeric transformation of ammonium methyl sulphate, and of substituted ammonium methyl sulphates; the interaction of amine and methyl sulphate, J. Chem. Soc. 105 (1914) 2762-2769.
9. U. Pick, Liposomes with a large trapping capacity prepared by freezing and thawing of sonicated phospholipid mixtures, Arch. Biochem. Biophys. 212 (1991) 186-194.
10. J.V. Castell, M. Cervera, R. Marco, A convenient micromethod for the assay of primary amines and proteins with flourescamine. A reexamination of the conditions of reaction, Anal. Biochem. 99 (1979) 379-391.
11. Beilstein, Ergaenzungswerk III, Band 4, 250-480 and Ergaenzungswerk IV, Band 4, 119-675.
12. Beilstein, Ergaenzungswerk III, Band 4, 250-480 and Ergaenzungswerk IV, Band 4, 119-675.
13. T.E. Redelmeier, L.D. Mayer, K.F. Wong, M.B. Bally, P.R. Cullis, Proton flux in large unilamellar vesicles in response to membrane potentials and pH gradients, Biophys. J. 56 (1989) 385-393.
14. E.G. Bligh, W.J. Dyer, A rapid method of total lipid extraction and purification, Can. J. Biochem. Physiol. 37 (1959) 911-917.
15. T.M. Allen, L.G. Cleland, Serum-induced leakage of liposome contents, Biochim. Biophys. Acta 597 (1980) 418-426.
16. Y.-K. Oh, D.E. Nix, R.M. Straubinger, Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular Mycrobacterium avium infection, Antimicrob. Agents Chemother. 39 (1995) 2104-2111.
17. J.-F. Tocanne, J. Teissie, Ionization of phospholipids and phospholipid-supported interfacial lateral diffusion of protons in membrane model systems, Biochim. Biophys. Acta 1031 (1990) 111-142.
18. R.B. Gennis, Interactions of small molecules with membranes: partitioning, permeability, and electrical effects, in: C.R. Cantor (Ed.), Biomembranes, Springer-Verlag, New York, 1989, pp. 235-269.
19. A. Chonn, S.C. Semple, P.R. Cullis, Separation of large unilamellar liposomes from blood components by a spin column procedure: towards identifying plasma proteins which mediate liposome clearance in vivo, Biochim. Biophys. Acta 1070 (1991) 215-222.
20. N.L. Boman, D. Masin, L.D. Mayer, P.R. Cullis, M.B. Bally, Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumours, Cancer Res. 54 (1994) 2830-2833.