Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice

ACS Nano

Volumn 7, Issue 11, 2013, Pages 10048-10065

  Meng, Huan ^a   Zhao, Yang ^a   Dong, Juyao ^a   Xue, Min ^a   Lin, Yu Shen ^c   Ji, Zhaoxia ^a   Mai, Wilson X ^a   Zhang, Haiyuan ^a   Chang, Chong Hyun ^a   Brinker, C Jeffrey ^b,d   Zink, Jeffrey I ^a   Nel, Andre E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SANDIA NATIONAL LABORATORIES   (United States)

^c UNIVERSITY OF NEW MEXICO   (United States)

^d University of New Mexico   (United States)

Author keywords

gemcitabine; liposome; mesoporous silica nanoparticles; nano engineered approach; pancreatic cancer; pericyte and stroma; TGF ; two wave

Indexed keywords

GEMCITABINE; MESOPOROUS SILICA NANOPARTICLES; NANO-ENGINEERED APPROACH; PANCREATIC CANCERS; PERICYTE AND STROMA; TWO-WAVE;

BIOLOGICAL MATERIALS; BLOOD VESSELS; CHEMOTHERAPY; DISEASES; DRUG DELIVERY; LIPOSOMES; TUMORS;

DRUG PRODUCTS;

COLLAGEN; DEOXYCYTIDINE; DRUG CARRIER; DRUG DERIVATIVE; GEMCITABINE; LAMININ; LIPOSOME; MACROGOL DERIVATIVE; MATRIGEL; NANOPARTICLE; POLYETHYLENEIMINE; PROTEOGLYCAN; SILICON DIOXIDE; SMAD2 PROTEIN; SMAD2 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG COMBINATION; ENDOTHELIUM CELL; FEMALE; HUMAN; METABOLISM; METHODOLOGY; MOUSE; NANOMEDICINE; PANCREAS TUMOR; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; COLLAGEN; DEOXYCYTIDINE; DRUG CARRIERS; DRUG COMBINATIONS; ENDOTHELIAL CELLS; FEMALE; HUMANS; LAMININ; LIPOSOMES; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; NANOMEDICINE; NANOPARTICLES; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; PROTEOGLYCANS; SIGNAL TRANSDUCTION; SILICON DIOXIDE; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84888868397     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn404083m     Document Type: Article

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