Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  LeJeune, Timothy M ^a   Tsui, Hei Yin ^a   Parsons, Laura B ^a   Miller, Gerald E ^a   Whitted, Crystal ^a   Lynch, Kayla E ^a   Ramsauer, Robert E ^a   Patel, Jasmine U ^a   Wyatt, Jarrett E ^a   Street, Doris S ^a   Adams, Carolyn B ^a   McPherson, Brian ^a   Tsui, Hei Man ^a   Evans, Julie A ^a   Livesay, Christopher ^a   Torrenegra, Ruben D ^b   Palau, Victoria E ^a,c  

^a EAST TENNESSEE STATE UNIVERSITY   (United States)

^b UNIVERSIDAD DE CIENCIAS APLICADAS Y AMBIENTALES   (Colombia)

^c East Tennessee State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 10; CASPASE 8; CASPASE 9; FLAVONE A; FLAVONE B; FLAVONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAD; PROTEIN C JUN; PROTEIN KINASE B; S6 KINASE; SERINE; THREONINE; UNCLASSIFIED DRUG; FLAVONE; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL LINE; CELL CYCLE; CELL DIFFERENTIATION; COLON CARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG PURIFICATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; PANCREAS CARCINOMA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CASPASE 10; CASPASE 8; CASPASE 9; CELL CYCLE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONES; HUMANS; PHOSPHORYLATION; PLANT EXTRACTS; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION;

EID: 84960156975     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0142928     Document Type: Article

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