Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030

British Journal of Cancer

Volumn 105, Issue 2, 2011, Pages 212-220

  Lin, L ^a,b   Liu, Y ^a   Li, H ^c   Li, P K ^c   Fuchs, J ^c   Shibata, H ^d   Iwabuchi, Y ^e   Lin, J ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c OHIO STATE UNIVERSITY   (United States)

^d AKITA UNIVERSITY   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

Author keywords

ALDH; cancer stem cells; CD133; colon cancer; curcumin analogue; STAT3

Indexed keywords

ALDEHYDE DEHYDROGENASE; CD133 ANTIGEN; CURCUMIN; GOY 030; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER STEM CELL; CELL ISOLATION; CELL STRAIN HCT116; CELL SUBPOPULATION; CELL VIABILITY; COLON CANCER; COLORECTAL CANCER; CONTROLLED STUDY; DRUG TARGETING; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; CARCINOMA; CELL LINE, TUMOR; COLONIC NEOPLASMS; CURCUMIN; DRUG DELIVERY SYSTEMS; FEMALE; HCT116 CELLS; HT29 CELLS; HUMANS; KETONES; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79960276970     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.200     Document Type: Article

References (45)

1. Aggarwal B, Shishodia S (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421
2. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449(7165): 1003-1007 (Pubitemid 350014593)
3. Bharti A, Donato N, Aggarwal B (2003) Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol 171: 3863-3871 (Pubitemid 37254592)
4. Boman BM, Huang E (2008) Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J Clin Oncol 26(17): 2828-2838
5. Bromberg J, Wrzeszczynska M, Devgan G, Zhao Y, Pestell R, Albanese C, Darnell JJ (1999) Stat3 as an oncogene. Cell 98(3): 295-303 (Pubitemid 29380565)
6. Calo VV, Migliavacca M, Bazan V, Macaluso M, Buscemi M, Gebbia N, Russo A (2003) STAT proteins: from normal control of cellular events to tumorigenesis. J Cell Physiol 197: 157-168 (Pubitemid 37485244)
7. Catlett-Falcone R, Landowski TH, Oshiro MM, Turkson J, Levitzki A, Savino R, Ciliberto G, Moscinski L, Fernandez-Luna JL, Nunez G, Dalton WS, Jove R (1999) Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10(1): 105-115 (Pubitemid 29077388)
8. Cen L, Hutzen B, Ball S, DeAngelis S, Chen CL, Fuchs JR, Li C, Li PK, Lin J (2009) New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. BMC Cancer 9: 99
9. Chauhan DP (2002) Chemotherapeutic potential of curcumin for colorectal cancer. Curr Pharm Des 8(19): 1695-1706 (Pubitemid 34846196)
10. Corvinus FM, Orth C, Moriggl R, Tsareva SA, Wagner S, Pfitzner EB, Baus D, Kaufmann R, Huber LA, Zatloukal K, Beug H, Ohlschlager P, Schutz A, Halbhuber KJ, Friedrich K (2005) Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia 7(6): 545-555 (Pubitemid 40967755)
11. Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 104(24): 10158-10163 (Pubitemid 47175279)
12. Diaz N, Minton S, Cox C, Bowman T, Gritsko T, Garcia R, Eweis I, Wloch M, Livingston S, Seijo E, Cantor A, Lee JH, Beam CA, Sullivan D, Jove R, Muro-Cacho CA (2006) Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res 12(1): 20-28 (Pubitemid 43166171)
13. Dontu G, Jackson KW, McNicholas E, Kawamura MJ, Abdallah WM, Wicha MS (2004) Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res 6(6): R605-R615
14. Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y, Chen Q (2008) CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 14(21): 6751-6760
15. Faruqi T, Gomez D, Bustelo X, Bar-Sagi D, Reich N (2001) Rac1 mediates STAT3 activation by autocrine IL-6. Proc Natl Acad Sci USA 98: 9014-9019 (Pubitemid 32743861)
16. Frank DA (2007) STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett 251(2): 199-210 (Pubitemid 46680370)
17. Germain D, Frank DA (2007) Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res 13(19): 5665-5669 (Pubitemid 47583890)
18. Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G (2007) ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1(5): 555-567 (Pubitemid 350056407)
19. Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee J, Beam C, Cheng J, Minton S, Muro-Cacho C, Jove R (2006) Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res 12: 11-19 (Pubitemid 43166170)
20. Grivennikov S, Karin M (2008) Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell 13(1): 7-9 (Pubitemid 350309747)
21. Hanif R, Qiao L, Shiff SJ, Rigas B (1997) Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway. J Lab Clin Med 130(6): 576-584 (Pubitemid 28029226)
22. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV (2008) Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65(11): 1631-1652
23. Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, Fields JZ, Wicha MS, Boman BM (2009) Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 69(8): 3382-3389
24. Huey R, Morris GM, Olson AJ, Goodsell DS (2007) An empirical free energy force field with charge-based desolvation and intramolecular evaluation. J Comp Chem 28: 1145-1152 (Pubitemid 46506716)
25. Johnson JJ, Mukhtar H (2007) Curcumin for chemoprevention of colon cancer. Cancer Lett 255(2): 170-181 (Pubitemid 47268637)
26. Kaptein A, Paillard V, Saunders M (1996) Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction. J Biol Chem 271(11): 5961-5964 (Pubitemid 26095392)
27. Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, Rao CV, Reddy BS (1999) Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res 59(3): 597-601 (Pubitemid 29076056)
28. Kusaba T, Nakayama T, Yamazumi K, Yakata Y, Yoshizaki A, Nagayasu T, Sekine I (2005) Expression of p-STAT3 in human colorectal adenocarci-noma and adenoma; correlation with clinicopathological factors. J Clin Pathol 58: 833-838 (Pubitemid 41113390)
29. Li H, Li C (2010) Multiple ligand simultaneous docking: orchestrated dancing of ligands in binding sites of protein. J Comput Chem 31(10): 2014-2022
30. Lin Q, Lai R, Chirieac LR, Li C, Thomazy VA, Grammatikakis I, Rassidakis GZ, Zhang W, Fujio Y, Kunisada K, Hamilton SR, Amin HM (2005) Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol 167(4): 969-980 (Pubitemid 41416250)
31. Liu S, Wicha M (2010) Targeting breast cancer stem cells. J Clin Oncol 28(25): 4006-4012
32. Magni M, Shammah S, Schiro R, Mellado W, Dalla-Favera R, Gianni AM (1996) Induction of cyclophosphamide-resistance by aldehyde-dehydro-genase gene transfer. Blood 87(3): 1097-1103 (Pubitemid 26043537)
33. O'Brien CA, Pollett A, Gallinger S, Dick JE (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445(7123): 106-110 (Pubitemid 46067310)
34. Ohori H, Yamakoshi H, Tomizawa M, Shibuya M, Kakudo Y, Takahashi A, Takahashi S, Kato S, Suzuki T, Ishioka C, Iwabuchi Y, Shibata H (2006) Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Mol Cancer Ther 5(10): 2563-2571 (Pubitemid 44650921)
35. Real PJ, Sierra A, De Juan A, Segovia JC, Lopez-Vega JM, Fernandez-Luna JL (2002) Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene 21(50): 7611-7618 (Pubitemid 35398808)
36. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R (2007) Identification and expansion of human colon-cancer-initiating cells. Nature 445(7123): 111-115 (Pubitemid 46067311)
37. Schaefer T, Sanders L, Park O, Nathans D (1997) Functional Differences between STAT 3 and STAT 3. Mol Cell Biol 17: 5307-5316
38. Shibata H, Yamakoshi H, Sato A, Ohori H, Kakudo Y, Kudo C, Takahashi Y, Watanabe M, Takano H, Ishioka C, Noda T, Iwabuchi Y (2009) Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo. Cancer Sci 100(5): 956-960
39. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB (2004) Identification of human brain tumour initiating cells. Nature 432(7015): 396-401 (Pubitemid 39551674)
40. Todaro M, Francipane MG, Medema JP, Stassi G (2010) Colon cancer stem cells: promise of targeted therapy. Gastroenterology 138(6): 2151-2162
41. Tsareva S, Moriggl R, Corvinus F, Wiederanders B, Schütz A, Kovacic B, Friedrich K (2007) Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia 9: 279-291 (Pubitemid 46608295)
42. Turkson J, Jove R (2002) STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19: 6613-6626
43. Xiong H, Zhang Z, Tian X, Sun D, Liang Q, Zhang Y, Lu R, Chen Y, Fang J (2008) Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia 10: 287-297 (Pubitemid 351328587)
44. Yoshida A, Rzhetsky A, Hsu LC, Chang C (1998) Human aldehyde dehydrogenase gene family. Eur J Biochem 251(3): 549-557 (Pubitemid 28108946)
45. Yu H, Pardoll D, Jove R (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9(11): 798-809