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Volumn 40, Issue , 2016, Pages 152-157

Hedgehog signaling pathway as a therapeutic target for ovarian cancer

Author keywords

Hedgehog; Ovarian cancer; Targeted therapy

Indexed keywords

CYCLOPAMINE; PACLITAXEL; PATIDEGIB; SONIC HEDGEHOG PROTEIN; SONIDEGIB; VISMODEGIB; ANTINEOPLASTIC AGENT;

EID: 84960084793     PISSN: 18777821     EISSN: 1877783X     Source Type: Journal    
DOI: 10.1016/j.canep.2015.11.014     Document Type: Review
Times cited : (29)

References (66)
  • 1
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: functions and mechanisms
    • Varjosalo M., Taipale J. Hedgehog: functions and mechanisms. Genes Dev. 2008, 22:2454-2472.
    • (2008) Genes Dev. , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 2
    • 84906875879 scopus 로고    scopus 로고
    • Roles for hedgehog signaling in adult organ homeostasis and repair
    • Petrova R., Joyner A.L. Roles for hedgehog signaling in adult organ homeostasis and repair. Development 2014, 141:3445-3457.
    • (2014) Development , vol.141 , pp. 3445-3457
    • Petrova, R.1    Joyner, A.L.2
  • 4
  • 5
    • 84890572199 scopus 로고    scopus 로고
    • Gastric cancer (GC) patients with hedgehog pathway activation: PTCH1 and GLI2 as independent prognostic factors
    • Lee S.J., Do I.G., Lee J., Kim K.M., Jang J., Sohn I., et al. Gastric cancer (GC) patients with hedgehog pathway activation: PTCH1 and GLI2 as independent prognostic factors. Target Oncol. 2013, 8:271-280.
    • (2013) Target Oncol. , vol.8 , pp. 271-280
    • Lee, S.J.1    Do, I.G.2    Lee, J.3    Kim, K.M.4    Jang, J.5    Sohn, I.6
  • 6
    • 84905120618 scopus 로고    scopus 로고
    • Hedgehog signaling between cancer cells and hepatic stellate cells in promoting cholangiocarcinoma
    • Kim Y., Kim M.O., Shin J.S., Park S.H., Kim S.B., Kim J., et al. Hedgehog signaling between cancer cells and hepatic stellate cells in promoting cholangiocarcinoma. Ann. Surg. Oncol. 2014, 21:2684-2698.
    • (2014) Ann. Surg. Oncol. , vol.21 , pp. 2684-2698
    • Kim, Y.1    Kim, M.O.2    Shin, J.S.3    Park, S.H.4    Kim, S.B.5    Kim, J.6
  • 7
    • 79959482541 scopus 로고    scopus 로고
    • Hedgehog signaling and pancreatic tumor development
    • Lauth M., Toftgard R. Hedgehog signaling and pancreatic tumor development. Adv. Cancer Res. 2011, 110:1-17.
    • (2011) Adv. Cancer Res. , vol.110 , pp. 1-17
    • Lauth, M.1    Toftgard, R.2
  • 9
    • 84858009739 scopus 로고    scopus 로고
    • Targeting hedgehog in hematologic malignancy
    • Irvine D.A., Copland M. Targeting hedgehog in hematologic malignancy. Blood 2012, 119:2196-2204.
    • (2012) Blood , vol.119 , pp. 2196-2204
    • Irvine, D.A.1    Copland, M.2
  • 10
    • 84931088974 scopus 로고    scopus 로고
    • Targeting the hedgehog signaling pathway in cancer: beyond smoothened
    • Gonnissen A., Isebaert S., Haustermans K. Targeting the hedgehog signaling pathway in cancer: beyond smoothened. Oncotarget 2015, 6:13899-13913.
    • (2015) Oncotarget , vol.6 , pp. 13899-13913
    • Gonnissen, A.1    Isebaert, S.2    Haustermans, K.3
  • 11
    • 84856058700 scopus 로고    scopus 로고
    • The GLI genes as the molecular switch in disrupting hedgehog signaling in colon cancer
    • Mazumdar T., DeVecchio J., Agyeman A., Shi T., Houghton J.A. The GLI genes as the molecular switch in disrupting hedgehog signaling in colon cancer. Oncotarget 2011, 2:638-645.
    • (2011) Oncotarget , vol.2 , pp. 638-645
    • Mazumdar, T.1    DeVecchio, J.2    Agyeman, A.3    Shi, T.4    Houghton, J.A.5
  • 12
    • 0011102935 scopus 로고    scopus 로고
    • The tumour-suppressor gene patched encodes a candidate receptor for sonic hedgehog
    • Stone D.M., Hynes M., Armanini M., Swanson T.A., Gu Q., Johnson R.L., et al. The tumour-suppressor gene patched encodes a candidate receptor for sonic hedgehog. Nature 1996, 384:129-134.
    • (1996) Nature , vol.384 , pp. 129-134
    • Stone, D.M.1    Hynes, M.2    Armanini, M.3    Swanson, T.A.4    Gu, Q.5    Johnson, R.L.6
  • 13
    • 0037158748 scopus 로고    scopus 로고
    • Patched acts catalytically to suppress the activity of smoothened
    • Taipale J., Cooper M.K., Maiti T., Beachy P.A. Patched acts catalytically to suppress the activity of smoothened. Nature 2002, 418:892-897.
    • (2002) Nature , vol.418 , pp. 892-897
    • Taipale, J.1    Cooper, M.K.2    Maiti, T.3    Beachy, P.A.4
  • 14
    • 2942738996 scopus 로고    scopus 로고
    • The hedgehog response network: sensors, switches, and routers
    • Lum L., Beachy P.A. The hedgehog response network: sensors, switches, and routers. Science 2004, 304:1755-1759.
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 15
    • 77953316514 scopus 로고    scopus 로고
    • Mechanism and evolution of cytosolic hedgehog signal transduction
    • Wilson C.W., Chuang P.T. Mechanism and evolution of cytosolic hedgehog signal transduction. Development 2010, 137:2079-2094.
    • (2010) Development , vol.137 , pp. 2079-2094
    • Wilson, C.W.1    Chuang, P.T.2
  • 16
    • 77649337790 scopus 로고    scopus 로고
    • Hedgehog beyond medulloblastoma and basal cell carcinoma
    • Teglund S., Toftgard R. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim. Biophys. Acta 2010, 2:181-208.
    • (2010) Biochim. Biophys. Acta , vol.2 , pp. 181-208
    • Teglund, S.1    Toftgard, R.2
  • 17
    • 59149087474 scopus 로고    scopus 로고
    • Hedgehog signaling promotes the degradation of tumor suppressor sufu through the ubiquitin-proteasome pathway
    • Yue S., Chen Y., Cheng S.Y. Hedgehog signaling promotes the degradation of tumor suppressor sufu through the ubiquitin-proteasome pathway. Oncogene 2009, 28:492-499.
    • (2009) Oncogene , vol.28 , pp. 492-499
    • Yue, S.1    Chen, Y.2    Cheng, S.Y.3
  • 18
    • 84862775317 scopus 로고    scopus 로고
    • Crosstalk between TGF-beta and hedgehog signaling in cancer
    • Javelaud D., Pierrat M.J., Mauviel A. Crosstalk between TGF-beta and hedgehog signaling in cancer. FEBS Lett. 2012, 586:2016-2025.
    • (2012) FEBS Lett. , vol.586 , pp. 2016-2025
    • Javelaud, D.1    Pierrat, M.J.2    Mauviel, A.3
  • 19
    • 84899898581 scopus 로고    scopus 로고
    • Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer
    • Brechbiel J., Miller-Moslin K., Adjei A.A. Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer. Cancer Treat. Rev. 2014, 40:750-759.
    • (2014) Cancer Treat. Rev. , vol.40 , pp. 750-759
    • Brechbiel, J.1    Miller-Moslin, K.2    Adjei, A.A.3
  • 21
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996, 85:841-851.
    • (1996) Cell , vol.85 , pp. 841-851
    • Hahn, H.1    Wicking, C.2    Zaphiropoulous, P.G.3    Gailani, M.R.4    Shanley, S.5    Chidambaram, A.6
  • 22
    • 84864419974 scopus 로고    scopus 로고
    • Dissecting the genomic complexity underlying medulloblastoma
    • Jones D.T., Jager N., Kool M., Zichner T., Hutter B., Sultan M., et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 2012, 488:100-105.
    • (2012) Nature , vol.488 , pp. 100-105
    • Jones, D.T.1    Jager, N.2    Kool, M.3    Zichner, T.4    Hutter, B.5    Sultan, M.6
  • 23
    • 79251629946 scopus 로고    scopus 로고
    • The genetic landscape of the childhood cancer medulloblastoma
    • Parsons D.W., Li M., Zhang X., Jones S., Leary R.J., Lin J.C., et al. The genetic landscape of the childhood cancer medulloblastoma. Science 2011, 331:435-439.
    • (2011) Science , vol.331 , pp. 435-439
    • Parsons, D.W.1    Li, M.2    Zhang, X.3    Jones, S.4    Leary, R.J.5    Lin, J.C.6
  • 25
    • 34547683699 scopus 로고    scopus 로고
    • Essential role of stromally induced hedgehog signaling in B-cell malignancies
    • Dierks C., Grbic J., Zirlik K., Beigi R., Englund N.P., Guo G.R., et al. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nat. Med. 2007, 13:944-951.
    • (2007) Nat. Med. , vol.13 , pp. 944-951
    • Dierks, C.1    Grbic, J.2    Zirlik, K.3    Beigi, R.4    Englund, N.P.5    Guo, G.R.6
  • 26
    • 33751337806 scopus 로고    scopus 로고
    • Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis
    • Chen X., Horiuchi A., Kikuchi N., Osada R., Yoshida J., Shiozawa T., et al. Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis. Cancer Sci. 2007, 98:68-76.
    • (2007) Cancer Sci. , vol.98 , pp. 68-76
    • Chen, X.1    Horiuchi, A.2    Kikuchi, N.3    Osada, R.4    Yoshida, J.5    Shiozawa, T.6
  • 27
    • 58949100355 scopus 로고    scopus 로고
    • Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation
    • Liao X., Siu M.K., Au C.W., Wong E.S., Chan H.Y., Ip P.P., et al. Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 2009, 30:131-140.
    • (2009) Carcinogenesis , vol.30 , pp. 131-140
    • Liao, X.1    Siu, M.K.2    Au, C.W.3    Wong, E.S.4    Chan, H.Y.5    Ip, P.P.6
  • 28
    • 71549129295 scopus 로고    scopus 로고
    • Activation of hedgehog signaling is not a frequent event in ovarian cancers
    • Yang L., He J., Huang S., Zhang X., Bian Y., He N., et al. Activation of hedgehog signaling is not a frequent event in ovarian cancers. Mol. Cancer 2009, 8:1476-4598.
    • (2009) Mol. Cancer , vol.8 , pp. 1476-4598
    • Yang, L.1    He, J.2    Huang, S.3    Zhang, X.4    Bian, Y.5    He, N.6
  • 29
    • 84875530284 scopus 로고    scopus 로고
    • Expression of the glioma-associated oncogene homolog 1 (gli1) in advanced serous ovarian cancer is associated with unfavorable overall survival
    • Ciucci A., De Stefano I., Vellone V.G., Lisi L., Bottoni C., Scambia G., et al. Expression of the glioma-associated oncogene homolog 1 (gli1) in advanced serous ovarian cancer is associated with unfavorable overall survival. PLoS One 2013, 8:e60145.
    • (2013) PLoS One , vol.8 , pp. e60145
    • Ciucci, A.1    De Stefano, I.2    Vellone, V.G.3    Lisi, L.4    Bottoni, C.5    Scambia, G.6
  • 30
    • 84938209433 scopus 로고    scopus 로고
    • Targeting notch, hedgehog, and Wnt pathways in cancer stem cells: clinical update
    • Takebe N., Miele L., Harris P.J., Jeong W., Bando H., Kahn M., et al. Targeting notch, hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat. Rev. Clin. Oncol. 2015, 12:445-464.
    • (2015) Nat. Rev. Clin. Oncol. , vol.12 , pp. 445-464
    • Takebe, N.1    Miele, L.2    Harris, P.J.3    Jeong, W.4    Bando, H.5    Kahn, M.6
  • 31
    • 84921797631 scopus 로고    scopus 로고
    • Hedgehog signaling in cancer stem cells: a focus on hematological cancers
    • Campbell V., Copland M. Hedgehog signaling in cancer stem cells: a focus on hematological cancers. Stem Cells Cloning 2015, 8:27-38.
    • (2015) Stem Cells Cloning , vol.8 , pp. 27-38
    • Campbell, V.1    Copland, M.2
  • 32
    • 84924219703 scopus 로고    scopus 로고
    • Genetic activation of hedgehog signaling unbalances the rate of neural stem cell renewal by increasing symmetric divisions
    • Ferent J., Cochard L., Faure H., Taddei M., Hahn H., Ruat M., et al. Genetic activation of hedgehog signaling unbalances the rate of neural stem cell renewal by increasing symmetric divisions. Stem Cell Rep. 2014, 3:312-323.
    • (2014) Stem Cell Rep. , vol.3 , pp. 312-323
    • Ferent, J.1    Cochard, L.2    Faure, H.3    Taddei, M.4    Hahn, H.5    Ruat, M.6
  • 33
    • 79960849567 scopus 로고    scopus 로고
    • Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells
    • Ray A., Meng E., Reed E., Shevde L.A., Rocconi R.P. Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells. Int. J. Oncol. 2011, 39:797-804.
    • (2011) Int. J. Oncol. , vol.39 , pp. 797-804
    • Ray, A.1    Meng, E.2    Reed, E.3    Shevde, L.A.4    Rocconi, R.P.5
  • 34
    • 84925661239 scopus 로고    scopus 로고
    • Twist1 and snail link hedgehog signaling to tumor-initiating cell-like properties and acquired chemoresistance independently of ABC transporters
    • Kong Y., Peng Y., Liu Y., Xin H., Zhan X., Tan W. Twist1 and snail link hedgehog signaling to tumor-initiating cell-like properties and acquired chemoresistance independently of ABC transporters. Stem Cells 2015, 33:1063-1074.
    • (2015) Stem Cells , vol.33 , pp. 1063-1074
    • Kong, Y.1    Peng, Y.2    Liu, Y.3    Xin, H.4    Zhan, X.5    Tan, W.6
  • 35
    • 84863111668 scopus 로고    scopus 로고
    • Chemoresistance in prostate cancer cells is regulated by miRNAs and hedgehog pathway
    • Singh S., Chitkara D., Mehrazin R., Behrman S., Wake R., Mahato R. Chemoresistance in prostate cancer cells is regulated by miRNAs and hedgehog pathway. PLoS One 2012, 7:e40021.
    • (2012) PLoS One , vol.7 , pp. e40021
    • Singh, S.1    Chitkara, D.2    Mehrazin, R.3    Behrman, S.4    Wake, R.5    Mahato, R.6
  • 36
    • 84909607973 scopus 로고    scopus 로고
    • Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors
    • Tripathi K., Mani C., Barnett R., Nalluri S., Bachaboina L., Rocconi R., et al. Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors. J. Biol. Chem. 2014, 289:31513-31525.
    • (2014) J. Biol. Chem. , vol.289 , pp. 31513-31525
    • Tripathi, K.1    Mani, C.2    Barnett, R.3    Nalluri, S.4    Bachaboina, L.5    Rocconi, R.6
  • 39
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B., Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat. Rev. Cancer 2013, 13:97-110.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 40
    • 84870176548 scopus 로고    scopus 로고
    • Targeting pathways contributing to epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer
    • Huang R.Y., Chung V.Y., Thiery J.P. Targeting pathways contributing to epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer. Curr. Drug Targets 2012, 13:1649-1653.
    • (2012) Curr. Drug Targets , vol.13 , pp. 1649-1653
    • Huang, R.Y.1    Chung, V.Y.2    Thiery, J.P.3
  • 42
    • 84973523728 scopus 로고    scopus 로고
    • Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer
    • (Epub ahead of print)
    • Islam S.S., Mokhtari R.B., Noman A.S., Uddin M., Rahman M.Z., Azadi M.A., et al. Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer. Mol. Carcinog. 2015, 1. (Epub ahead of print).
    • (2015) Mol. Carcinog. , vol.1
    • Islam, S.S.1    Mokhtari, R.B.2    Noman, A.S.3    Uddin, M.4    Rahman, M.Z.5    Azadi, M.A.6
  • 43
    • 84938699651 scopus 로고    scopus 로고
    • Gli1 promotes transforming growth factor-beta1- and epidermal growth factor-induced epithelial to mesenchymal transition in pancreatic cancer cells
    • Liu Q., Sheng W., Dong M., Dong X., Dong Q., Li F. Gli1 promotes transforming growth factor-beta1- and epidermal growth factor-induced epithelial to mesenchymal transition in pancreatic cancer cells. Surgery 2015, 158:211-224.
    • (2015) Surgery , vol.158 , pp. 211-224
    • Liu, Q.1    Sheng, W.2    Dong, M.3    Dong, X.4    Dong, Q.5    Li, F.6
  • 44
    • 84945550963 scopus 로고    scopus 로고
    • SMO gene amplification and activation of the hedgehog pathway as novel mechanisms of resistance to anti-epidermal growth factor receptor drugs in human lung cancer
    • (Epub ahead of print)
    • Della Corte C.M., Bellevicine C., Vicidomini G., Vitagliano D., Malapelle U., Accardo M., et al. SMO gene amplification and activation of the hedgehog pathway as novel mechanisms of resistance to anti-epidermal growth factor receptor drugs in human lung cancer. Clin. Cancer Res. 2015, 29. (Epub ahead of print).
    • (2015) Clin. Cancer Res. , vol.29
    • Della Corte, C.M.1    Bellevicine, C.2    Vicidomini, G.3    Vitagliano, D.4    Malapelle, U.5    Accardo, M.6
  • 45
    • 84919929884 scopus 로고    scopus 로고
    • Sonic hedgehog-Gli1 signals promote epithelial-mesenchymal transition in ovarian cancer by mediating PI3K/AKT pathway
    • Ke Z., Caiping S., Qing Z., Xiaojing W. Sonic hedgehog-Gli1 signals promote epithelial-mesenchymal transition in ovarian cancer by mediating PI3K/AKT pathway. Med. Oncol. 2015, 32:368.
    • (2015) Med. Oncol. , vol.32 , pp. 368
    • Ke, Z.1    Caiping, S.2    Qing, Z.3    Xiaojing, W.4
  • 46
    • 82755190844 scopus 로고    scopus 로고
    • Anoikis an emerging hallmark in health and diseases
    • Taddei M.L., Giannoni E., Fiaschi T., Chiarugi P. Anoikis an emerging hallmark in health and diseases. J. Pathol. 2012, 226:380-393.
    • (2012) J. Pathol. , vol.226 , pp. 380-393
    • Taddei, M.L.1    Giannoni, E.2    Fiaschi, T.3    Chiarugi, P.4
  • 47
    • 77951480423 scopus 로고    scopus 로고
    • Targeting anoikis resistance in prostate cancer metastasis
    • Sakamoto S., Kyprianou N. Targeting anoikis resistance in prostate cancer metastasis. Mol. Aspects Med. 2010, 31:205-214.
    • (2010) Mol. Aspects Med. , vol.31 , pp. 205-214
    • Sakamoto, S.1    Kyprianou, N.2
  • 48
    • 84890856047 scopus 로고    scopus 로고
    • Cell cycle arrest or survival signaling through αv integrins, activation of PKC and ERK1/2 lead to anoikis resistance of ovarian cancer spheroids
    • Carduner L., Picot C., Leroy-Dudal J., Blay L., Kellouche S., Carreiras F. Cell cycle arrest or survival signaling through αv integrins, activation of PKC and ERK1/2 lead to anoikis resistance of ovarian cancer spheroids. Exp. Cell Res. 2014, 320:329-342.
    • (2014) Exp. Cell Res. , vol.320 , pp. 329-342
    • Carduner, L.1    Picot, C.2    Leroy-Dudal, J.3    Blay, L.4    Kellouche, S.5    Carreiras, F.6
  • 49
    • 73949160835 scopus 로고    scopus 로고
    • Elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells
    • Lui V.W., Yau D.M., Wong E.Y., Ng Y.K., Lau C.P., Ho Y., Cucurbitacin I., et al. Elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells. Carcinogenesis 2009, 30:2085-2094.
    • (2009) Carcinogenesis , vol.30 , pp. 2085-2094
    • Lui, V.W.1    Yau, D.M.2    Wong, E.Y.3    Ng, Y.K.4    Lau, C.P.5    Ho, Y.6    Cucurbitacin, I.7
  • 50
    • 84865217843 scopus 로고    scopus 로고
    • Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo
    • Kandala P.K., Srivastava S.K. Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo. J. Biol. Chem. 2012, 287:28745-28754.
    • (2012) J. Biol. Chem. , vol.287 , pp. 28745-28754
    • Kandala, P.K.1    Srivastava, S.K.2
  • 51
    • 84868143825 scopus 로고    scopus 로고
    • Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer
    • Yun J.I., Kim H.R., Park H., Kim S.K., Lee J. Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer. Arch. Pharm. Res. 2012, 35:1317-1333.
    • (2012) Arch. Pharm. Res. , vol.35 , pp. 1317-1333
    • Yun, J.I.1    Kim, H.R.2    Park, H.3    Kim, S.K.4    Lee, J.5
  • 53
    • 84878692279 scopus 로고    scopus 로고
    • Targeting sonic hedgehog signaling by compounds and derivatives from natural products
    • Huang Yu-Chuen, Clifford Chao K.S., Liao Hui-Fen, Chen Yu-Jen Targeting sonic hedgehog signaling by compounds and derivatives from natural products. Evid. Based Complement. Altern. Med. 2013, 2013:5. Article ID 748587. 10.1155/2013/748587.
    • (2013) Evid. Based Complement. Altern. Med. , vol.2013 , pp. 5
    • Huang, Y.-C.1    Clifford Chao, K.S.2    Liao, H.-F.3    Chen, Y.-J.4
  • 54
    • 84869176553 scopus 로고    scopus 로고
    • Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures
    • Eimer S., Dugay F., Airiau K., Avril T., Quillien V., Belaud-Rotureau M.A., et al. Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures. Neuro. Oncol. 2012, 14:1441-1451.
    • (2012) Neuro. Oncol. , vol.14 , pp. 1441-1451
    • Eimer, S.1    Dugay, F.2    Airiau, K.3    Avril, T.4    Quillien, V.5    Belaud-Rotureau, M.A.6
  • 56
    • 34249867843 scopus 로고    scopus 로고
    • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    • Lauth M., Bergstrom A., Shimokawa T., Toftgard R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:8455-8460.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 8455-8460
    • Lauth, M.1    Bergstrom, A.2    Shimokawa, T.3    Toftgard, R.4
  • 57
    • 84919969093 scopus 로고    scopus 로고
    • GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis
    • Srivastava R.K., Kaylani S.Z., Edrees N., Li C., Talwelkar S.S., Xu J., et al. GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis. Oncotarget 2014, 5:12151-12165.
    • (2014) Oncotarget , vol.5 , pp. 12151-12165
    • Srivastava, R.K.1    Kaylani, S.Z.2    Edrees, N.3    Li, C.4    Talwelkar, S.S.5    Xu, J.6
  • 58
    • 84896538817 scopus 로고    scopus 로고
    • Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer
    • Huang L., Walter V., Hayes D.N., Onaitis M. Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. Clin. Cancer Res. 2014, 20:1566-1575.
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1566-1575
    • Huang, L.1    Walter, V.2    Hayes, D.N.3    Onaitis, M.4
  • 59
    • 84868616969 scopus 로고    scopus 로고
    • Regulation of DNA damage following termination of hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer
    • Agyeman A., Mazumdar T., Houghton J.A. Regulation of DNA damage following termination of hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. Oncotarget 2012, 3:854-868.
    • (2012) Oncotarget , vol.3 , pp. 854-868
    • Agyeman, A.1    Mazumdar, T.2    Houghton, J.A.3
  • 60
    • 84895508853 scopus 로고    scopus 로고
    • Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin beta4-mediated FAK signaling
    • Chen Q., Xu R., Zeng C., Lu Q., Huang D., Shi C., et al. Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin beta4-mediated FAK signaling. PLoS One 2014, 9:e88386.
    • (2014) PLoS One , vol.9 , pp. e88386
    • Chen, Q.1    Xu, R.2    Zeng, C.3    Lu, Q.4    Huang, D.5    Shi, C.6
  • 61
    • 84926339483 scopus 로고    scopus 로고
    • A comprehensive review of the role of the hedgehog pathway and vismodegib in the management of basal cell carcinoma
    • Erdem G., Sendur M., Ozdemir N., Yazici O., Zengin N. A comprehensive review of the role of the hedgehog pathway and vismodegib in the management of basal cell carcinoma. Curr. Med. Res. Opin. 2015, 31:743-756.
    • (2015) Curr. Med. Res. Opin. , vol.31 , pp. 743-756
    • Erdem, G.1    Sendur, M.2    Ozdemir, N.3    Yazici, O.4    Zengin, N.5
  • 62
    • 84870366661 scopus 로고    scopus 로고
    • A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission
    • Kaye S., Fehrenbacher L., Holloway R., Amit A., Karlan B., Slomovitz B., et al. A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission. Clin. Cancer Res. 2012, 18:6509-6518.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 6509-6518
    • Kaye, S.1    Fehrenbacher, L.2    Holloway, R.3    Amit, A.4    Karlan, B.5    Slomovitz, B.6
  • 63
    • 84960186673 scopus 로고    scopus 로고
    • ClinicalTrials.gov.
    • ClinicalTrials.gov. Available from: http://www.clinicaltrials.gov.
  • 64
    • 84878037234 scopus 로고    scopus 로고
    • Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors
    • Jimeno A., Weiss G.J., Miller W.H., Gettinger S., Eigl B.J., Chang A.L., et al. Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors. Clin. Cancer Res. 2013, 19:2766-2774.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 2766-2774
    • Jimeno, A.1    Weiss, G.J.2    Miller, W.H.3    Gettinger, S.4    Eigl, B.J.5    Chang, A.L.6
  • 65
    • 84941166595 scopus 로고    scopus 로고
    • Sonidegib: first global approval
    • Burness C.B. Sonidegib: first global approval. Drugs 2015, 75:1559-1566.
    • (2015) Drugs , vol.75 , pp. 1559-1566
    • Burness, C.B.1
  • 66
    • 84907067520 scopus 로고    scopus 로고
    • Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer
    • Steg A.D., Burke M.R., Amm H.M., Katre A.A., Dobbin Z.C., Jeong D.H., et al. Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer. Oncotarget 2014, 5:7065-7080.
    • (2014) Oncotarget , vol.5 , pp. 7065-7080
    • Steg, A.D.1    Burke, M.R.2    Amm, H.M.3    Katre, A.A.4    Dobbin, Z.C.5    Jeong, D.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.