-
1
-
-
0345059765
-
Hedgehog signalling in cancer formation and maintenance
-
14737121 10.1038/nrc1229
-
Pasca Di Magliano M, Hebrok M (2003) Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 3:903-911
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 903-911
-
-
Pasca Di Magliano, M.1
Hebrok, M.2
-
2
-
-
0035902140
-
The Hedgehog and Wnt signalling pathways in cancer
-
11357142 10.1038/35077219 1:CAS:528:DC%2BD3MXktVSjsrw%3D
-
Taipale J, Beachy PA (2001) The Hedgehog and Wnt signalling pathways in cancer. Nature 411:349-354
-
(2001)
Nature
, vol.411
, pp. 349-354
-
-
Taipale, J.1
Beachy, P.A.2
-
3
-
-
50649088457
-
Pattern formation in the vertebrate neural tube: A sonic hedgehog morphogen-regulated transcriptional network
-
18621990 10.1242/dev.009324 1:CAS:528:DC%2BD1cXhtVGqt73E
-
Dessaud E, McMahon AP, Briscoe J (2008) Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 135:2489-2503
-
(2008)
Development
, vol.135
, pp. 2489-2503
-
-
Dessaud, E.1
McMahon, A.P.2
Briscoe, J.3
-
4
-
-
0033916281
-
Hedgehog signals regulate multiple aspects of gastrointestinal development
-
10821773 1:CAS:528:DC%2BD3cXkslOrs70%3D
-
Ramalho-Santos M, Melton DA, McMahon AP (2000) Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127:2763-2772
-
(2000)
Development
, vol.127
, pp. 2763-2772
-
-
Ramalho-Santos, M.1
Melton, D.A.2
McMahon, A.P.3
-
5
-
-
0029777408
-
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
-
8837770 10.1038/383407a0 1:CAS:528:DyaK28Xmt1ykt7k%3D
-
Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407-413
-
(1996)
Nature
, vol.383
, pp. 407-413
-
-
Chiang, C.1
Litingtung, Y.2
Lee, E.3
Young, K.E.4
Corden, J.L.5
Westphal, H.6
Beachy, P.A.7
-
6
-
-
0029948270
-
Biochemical evidence that patched is the Hedgehog receptor
-
8906794 10.1038/384176a0 1:CAS:528:DyaK28XmvFGgsrk%3D
-
Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ (1996) Biochemical evidence that patched is the Hedgehog receptor. Nature 384:176-179
-
(1996)
Nature
, vol.384
, pp. 176-179
-
-
Marigo, V.1
Davey, R.A.2
Zuo, Y.3
Cunningham, J.M.4
Tabin, C.J.5
-
7
-
-
0011102935
-
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
-
8906787 10.1038/384129a0 1:CAS:528:DyaK28XmvFGitLs%3D
-
Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper JE, De Sauvage F, Rosenthal A (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384:129-134
-
(1996)
Nature
, vol.384
, pp. 129-134
-
-
Stone, D.M.1
Hynes, M.2
Armanini, M.3
Swanson, T.A.4
Gu, Q.5
Johnson, R.L.6
Scott, M.P.7
Pennica, D.8
Goddard, A.9
Phillips, H.10
Noll, M.11
Hooper, J.E.12
De Sauvage, F.13
Rosenthal, A.14
-
8
-
-
0034721665
-
Transducing the hedgehog signal
-
11081624 10.1016/S0092-8674(00)00129-X 1:CAS:528:DC%2BD3cXnvF2ksrg%3D
-
Kalderon D (2000) Transducing the hedgehog signal. Cell 103:371-374
-
(2000)
Cell
, vol.103
, pp. 371-374
-
-
Kalderon, D.1
-
9
-
-
0031679850
-
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
-
9655799 1:CAS:528:DyaK1cXls1Sntbg%3D
-
Matise MP, Epstein DJ, Park HL, Platt KA, Joyner AL (1998) Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125:2759-2770
-
(1998)
Development
, vol.125
, pp. 2759-2770
-
-
Matise, M.P.1
Epstein, D.J.2
Park, H.L.3
Platt, K.A.4
Joyner, A.L.5
-
10
-
-
0031020221
-
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
-
9006072 1:CAS:528:DyaK2sXnsFCguw%3D%3D
-
Mo R, Freer AM, Zinyk DL, Crackower MA, Michaud J, Heng HH, Chik KW, Shi XM, Tsui LC, Cheng SH, Joyner AL, Hui C (1997) Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124:113-123
-
(1997)
Development
, vol.124
, pp. 113-123
-
-
Mo, R.1
Freer, A.M.2
Zinyk, D.L.3
Crackower, M.A.4
Michaud, J.5
Heng, H.H.6
Chik, K.W.7
Shi, X.M.8
Tsui, L.C.9
Cheng, S.H.10
Joyner, A.L.11
Hui, C.12
-
11
-
-
0037439152
-
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
-
12533516 10.1101/gad.1038103 1:CAS:528:DC%2BD3sXmtFyhtg%3D%3D
-
Mill P, Mo R, Fu H, Grachtchouk M, Kim PC, Dlugosz AA, Hui CC (2003) Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev 17:282-294
-
(2003)
Genes Dev
, vol.17
, pp. 282-294
-
-
Mill, P.1
Mo, R.2
Fu, H.3
Grachtchouk, M.4
Kim, P.C.5
Dlugosz, A.A.6
Hui, C.C.7
-
12
-
-
0031683165
-
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
-
9731531 10.1038/1711 1:CAS:528:DyaK1cXmtVOmtLg%3D
-
Motoyama J, Liu J, Mo R, Ding Q, Post M, Hui CC (1998) Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 20:54-57
-
(1998)
Nat Genet
, vol.20
, pp. 54-57
-
-
Motoyama, J.1
Liu, J.2
Mo, R.3
Ding, Q.4
Post, M.5
Hui, C.C.6
-
13
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
8681379 10.1016/S0092-8674(00)81268-4 1:CAS:528:DyaK28XjslSku74%3D
-
Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden AB, Gillies S, Negus K, Smyth I, Pressman C, Leffell DJ, Gerrard B, Goldstein AM, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale AE (1996) Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85:841-851
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
Gailani, M.R.4
Shanley, S.5
Chidambaram, A.6
Vorechovsky, I.7
Holmberg, E.8
Unden, A.B.9
Gillies, S.10
Negus, K.11
Smyth, I.12
Pressman, C.13
Leffell, D.J.14
Gerrard, B.15
Goldstein, A.M.16
Dean, M.17
Toftgard, R.18
Chenevix-Trench, G.19
Wainwright, B.20
Bale, A.E.21
more..
-
14
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
8658145 10.1126/science.272.5268.1668 1:CAS:528:DyaK28Xjs1eju78%3D
-
Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein EH Jr, Scott MP (1996) Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272:1668-1671
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein, Jr.E.H.10
Scott, M.P.11
-
15
-
-
0037200078
-
Medulloblastoma growth inhibition by hedgehog pathway blockade
-
12202832 10.1126/science.1073733 1:CAS:528:DC%2BD38XmslSjtLc%3D
-
Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA (2002) Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297:1559-1561
-
(2002)
Science
, vol.297
, pp. 1559-1561
-
-
Berman, D.M.1
Karhadkar, S.S.2
Hallahan, A.R.3
Pritchard, J.I.4
Eberhart, C.G.5
Watkins, D.N.6
Chen, J.K.7
Cooper, M.K.8
Taipale, J.9
Olson, J.M.10
Beachy, P.A.11
-
16
-
-
0030802458
-
Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog
-
9212109 10.1038/nm0797-788 1:CAS:528:DyaK2sXkt1Kqsbk%3D
-
Fan H, Oro AE, Scott MP, Khavari PA (1997) Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat Med 3:788-792
-
(1997)
Nat Med
, vol.3
, pp. 788-792
-
-
Fan, H.1
Oro, A.E.2
Scott, M.P.3
Khavari, P.A.4
-
17
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
15361885 10.1038/nature02962 1:CAS:528:DC%2BD2cXotFGru74%3D
-
Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, Beachy PA (2004) Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431:707-712
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
Dhara, S.4
Gardner, D.5
Maitra, A.6
Isaacs, J.T.7
Berman, D.M.8
Beachy, P.A.9
-
18
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
-
14520411 10.1038/nature01972 1:CAS:528:DC%2BD3sXotlWqsLc%3D
-
Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy PA (2003) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425:846-851
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
Montes De Oca, R.4
Gerstenblith, M.R.5
Briggs, K.6
Parker, A.R.7
Shimada, Y.8
Eshleman, J.R.9
Watkins, D.N.10
Beachy, P.A.11
-
19
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
14520413 10.1038/nature02009 1:CAS:528:DC%2BD3sXotlWqsb8%3D
-
Thayer SP, Di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernandez-Del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425:851-856
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
Qi, Y.P.7
Gysin, S.8
Fernandez-Del Castillo, C.9
Yajnik, V.10
Antoniu, B.11
McMahon, M.12
Warshaw, A.L.13
Hebrok, M.14
-
20
-
-
0242669237
-
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
-
12629553 10.1038/nature01493 1:CAS:528:DC%2BD3sXitFKmu7s%3D
-
Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB (2003) Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422:313-317
-
(2003)
Nature
, vol.422
, pp. 313-317
-
-
Watkins, D.N.1
Berman, D.M.2
Burkholder, S.G.3
Wang, B.4
Beachy, P.A.5
Baylin, S.B.6
-
21
-
-
27144541492
-
Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas
-
15905200 10.1093/carcin/bgi130 1:CAS:528:DC%2BD2MXhtVWnt7bO
-
Ma X, Chen K, Huang S, Zhang X, Adegboyega PA, Evers BM, Zhang H, Xie J (2005) Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 26:1698-1705
-
(2005)
Carcinogenesis
, vol.26
, pp. 1698-1705
-
-
Ma, X.1
Chen, K.2
Huang, S.3
Zhang, X.4
Adegboyega, P.A.5
Evers, B.M.6
Zhang, H.7
Xie, J.8
-
22
-
-
33745745896
-
Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer
-
16831586 10.1053/j.gastro.2006.05.008 1:CAS:528:DC%2BD28XnvF2gsL4%3D
-
Fukaya M, Isohata N, Ohta H, Aoyagi K, Ochiya T, Saeki N, Yanagihara K, Nakanishi Y, Taniguchi H, Sakamoto H, Shimoda T, Nimura Y, Yoshida T, Sasaki H (2006) Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology 131:14-29
-
(2006)
Gastroenterology
, vol.131
, pp. 14-29
-
-
Fukaya, M.1
Isohata, N.2
Ohta, H.3
Aoyagi, K.4
Ochiya, T.5
Saeki, N.6
Yanagihara, K.7
Nakanishi, Y.8
Taniguchi, H.9
Sakamoto, H.10
Shimoda, T.11
Nimura, Y.12
Yoshida, T.13
Sasaki, H.14
-
23
-
-
33746266049
-
Study of Sonic hedgehog signaling pathway related molecules in gastric carcinoma
-
16810741 1:CAS:528:DC%2BD28XotFaqsro%3D
-
Ma XL, Sun HJ, Wang YS, Huang SH, Xie JW, Zhang HW (2006) Study of Sonic hedgehog signaling pathway related molecules in gastric carcinoma. World J Gastroenterol 12:3965-3969
-
(2006)
World J Gastroenterol
, vol.12
, pp. 3965-3969
-
-
Ma, X.L.1
Sun, H.J.2
Wang, Y.S.3
Huang, S.H.4
Xie, J.W.5
Zhang, H.W.6
-
24
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
10.1056/NEJMoa0905360
-
Von Hoff DD, Lorusso PM, Rudin CM, Reddy JC, Yauch RL, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JR, Mackey HM, Lum BL, Darbonne WC, Marsters JC Jr, De Sauvage FJ, Low JA (2009) Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 361:1164-1172
-
(2009)
N Engl J Med
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
Lorusso, P.M.2
Rudin, C.M.3
Reddy, J.C.4
Yauch, R.L.5
Tibes, R.6
Weiss, G.J.7
Borad, M.J.8
Hann, C.L.9
Brahmer, J.R.10
Mackey, H.M.11
Lum, B.L.12
Darbonne, W.C.13
Marsters, Jr.J.C.14
De Sauvage, F.J.15
Low, J.A.16
-
25
-
-
0035818048
-
Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction
-
11547741 10.1056/NEJMoa010187 1:STN:280:DC%2BD3Mvps1Cqug%3D%3D
-
Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM, Martenson JA (2001) Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 345:725-730
-
(2001)
N Engl J Med
, vol.345
, pp. 725-730
-
-
Macdonald, J.S.1
Smalley, S.R.2
Benedetti, J.3
Hundahl, S.A.4
Estes, N.C.5
Stemmermann, G.N.6
Haller, D.G.7
Ajani, J.A.8
Gunderson, L.L.9
Jessup, J.M.10
Martenson, J.A.11
-
26
-
-
79952232216
-
Global cancer statistics
-
21296855 10.3322/caac.20107
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69-90
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
27
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
-
20728210 10.1016/S0140-6736(10)61121-X 1:CAS:528:DC%2BC3cXhtVymt7zO
-
Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, Aprile G, Kulikov E, Hill J, Lehle M, Ruschoff J, Kang YK (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 376:687-697
-
(2010)
Lancet
, vol.376
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
Chung, H.C.4
Shen, L.5
Sawaki, A.6
Lordick, F.7
Ohtsu, A.8
Omuro, Y.9
Satoh, T.10
Aprile, G.11
Kulikov, E.12
Hill, J.13
Lehle, M.14
Ruschoff, J.15
Kang, Y.K.16
-
28
-
-
58749087502
-
Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers
-
19107131 10.1038/sj.bjc.6604846 1:CAS:528:DC%2BD1MXpsVSqtw%3D%3D
-
Ohta H, Aoyagi K, Fukaya M, Danjoh I, Ohta A, Isohata N, Saeki N, Taniguchi H, Sakamoto H, Shimoda T, Tani T, Yoshida T, Sasaki H (2009) Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. Br J Cancer 100:389-398
-
(2009)
Br J Cancer
, vol.100
, pp. 389-398
-
-
Ohta, H.1
Aoyagi, K.2
Fukaya, M.3
Danjoh, I.4
Ohta, A.5
Isohata, N.6
Saeki, N.7
Taniguchi, H.8
Sakamoto, H.9
Shimoda, T.10
Tani, T.11
Yoshida, T.12
Sasaki, H.13
-
29
-
-
34548583593
-
Sonic hedgehog expression in gastric cancer and gastric adenoma
-
17390043
-
Lee SY, Han HS, Lee KY, Hwang TS, Kim JH, Sung IK, Park HS, Jin CJ, Choi KW (2007) Sonic hedgehog expression in gastric cancer and gastric adenoma. Oncol Rep 17:1051-1055
-
(2007)
Oncol Rep
, vol.17
, pp. 1051-1055
-
-
Lee, S.Y.1
Han, H.S.2
Lee, K.Y.3
Hwang, T.S.4
Kim, J.H.5
Sung, I.K.6
Park, H.S.7
Jin, C.J.8
Choi, K.W.9
-
30
-
-
34249011892
-
Gas1 extends the range of Hedgehog action by facilitating its signaling
-
17504940 10.1101/gad.1546307 1:CAS:528:DC%2BD2sXls1aqu7Y%3D
-
Martinelli DC, Fan CM (2007) Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev 21:1231-1243
-
(2007)
Genes Dev
, vol.21
, pp. 1231-1243
-
-
Martinelli, D.C.1
Fan, C.M.2
-
31
-
-
79958210024
-
Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation
-
21664577 10.1016/j.devcel.2011.04.017 1:CAS:528:DC%2BC3MXnsVCns7w%3D
-
Izzi L, Levesque M, Morin S, Laniel D, Wilkes BC, Mille F, Krauss RS, McMahon AP, Allen BL, Charron F (2011) Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell 20:788-801
-
(2011)
Dev Cell
, vol.20
, pp. 788-801
-
-
Izzi, L.1
Levesque, M.2
Morin, S.3
Laniel, D.4
Wilkes, B.C.5
Mille, F.6
Krauss, R.S.7
McMahon, A.P.8
Allen, B.L.9
Charron, F.10
-
32
-
-
79958207835
-
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
-
21664576 10.1016/j.devcel.2011.04.018 1:CAS:528:DC%2BC3MXnsVCns78%3D
-
Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, Krauss RS, McMahon AP (2011) Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev Cell 20:775-787
-
(2011)
Dev Cell
, vol.20
, pp. 775-787
-
-
Allen, B.L.1
Song, J.Y.2
Izzi, L.3
Althaus, I.W.4
Kang, J.S.5
Charron, F.6
Krauss, R.S.7
McMahon, A.P.8
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