On the selectivity of the Gαq inhibitor UBO-QIC: A comparison with the Gαi inhibitor pertussis toxin

Biochemical Pharmacology

Volumn 107, Issue , 2016, Pages 59-66

  Gao, Zhan Guo ^a   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

FR900359; G protein; GPCR; G q inhibitor; G subunits; UBO QIC

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENYLATE CYCLASE; CALCIUM; CARBACHOL; CYCLODEPSIPEPTIDE; G BETA GAMMA COMPLEX; GQ ALPHA SUBUNIT; GQ ALPHA SUBUNIT INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INOSITOL PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUSCARINIC RECEPTOR; N ACETYL 3 HYDROXY L LEUCYL (ALPHAR) ALPHA HYDROXYBENZENEPROPANOYL 2,3 DIDEHYDRO N METHYLALANYL L ALANYL N METHYL L ALANYL 3 [[(3 HYDROXY 4 METHYL 1 OXO 2 [(1 OXOPROPYL)AMINO]PENTYL]OXYL] L LEUCYL N,O DIMETHYL (7-A) LACTONE; PERTUSSIS TOXIN; PROTEIN KINASE B; PURINERGIC P2Y1 RECEPTOR; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; CHRM2 PROTEIN, HUMAN; DEPSIPEPTIDE; ENZYME INHIBITOR; FR900359; G-PROTEIN BETA GAMMA; GNAI1 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC M2 RECEPTOR; RECOMBINANT PROTEIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHO CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; HEK293 CELL LINE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN SUBUNIT; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; CRICETULUS; DRUG EFFECTS; GENETICS; METABOLISM;

ANIMALS; CHO CELLS; CRICETULUS; DEPSIPEPTIDES; ENZYME INHIBITORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; PERTUSSIS TOXIN; PLATELET AGGREGATION INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ADENOSINE A1; RECEPTOR, MUSCARINIC M2; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 84959863280     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2016.03.003     Document Type: Article

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