Characterization of UBO-QIC as a G α q inhibitor in platelets

Platelets

Volumn 26, Issue 8, 2015, Pages 771-778

  Inamdar, Vaishali ^a   Patel, Akruti ^a   Manne, Bhanu Kanth ^a   Dangelmaier, Carol ^a   Kunapuli, Satya P ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gq; GTP binding protein alpha subunit; platelet aggregation; platelets; specificity; YM 254890

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANTITHROMBOCYTIC AGENT; CALCIUM; COLLAGEN; PLECKSTRIN; PROTEINASE ACTIVATED RECEPTOR; UBO QIC; UNCLASSIFIED DRUG; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; DEPSIPEPTIDE; FIBRINOGEN RECEPTOR; FR900359; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PLATELET MEMBRANE GLYCOPROTEIN VI;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARDISIA; ARDISIA CRENATA; ARTICLE; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG SPECIFICITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE SHAPE; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; KNOCKOUT MOUSE; METABOLISM; SIGNAL TRANSDUCTION; THROMBOCYTE;

ADENOSINE DIPHOSPHATE; ANIMALS; ASPIRIN; BLOOD PLATELETS; CALCIUM; DEPSIPEPTIDES; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; MICE; MICE, KNOCKOUT; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; SIGNAL TRANSDUCTION;

EID: 84942981985     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2014.998993     Document Type: Article

References (19)

1. Broos K, De Meyer SF, Feys HB, Vanhoorelbeke K, Deckmyn H. Blood platelet biochemistry. Thromb Res 2012;129:245-249.
2. Clemetson KJ. Platelets and primary haemostasis. Thromb Res 1994;129:220-224.
3. Packham MA. Role of platelets in thrombosis and hemostasis. Can J Physiol Pharmacol 1994;72:278-284.
4. Shuman MA, Levine SP. Thrombin generation and secretion of platelet Factor 4 during blood clotting. J Clin Invest 1978;61: 1102-1106.
5. Offermanns S. Activation of platelet function through G proteincoupled receptors. Circ Res 2006;99:1293-1304.
6. Offermanns S, Toombs CF, Hu YH, Simon MI. Defective platelet activation in G alpha(q)-deficient mice. Nature 1997;389:183-186.
7. Jin J, Mao Y, Thomas D, Kim S, Daniel JL, Kunapuli SP. RhoA downstream of G(q) and G(12/13) pathways regulates proteaseactivated receptor-mediated dense granule release in platelets. Biochem Pharmacol 2009;77:835-844.
8. Kawasaki T, Uemura T, Taniguchi M, Takasaki J. [Pharmacological properties of a specific Gq/11 inhibitor, YM-254890]. Nihon Yakurigaku Zasshi 2006;128:23-31.
9. Kim S, Jin J, Kunapuli SP. Relative contribution of G-proteincoupled pathways to protease-activated receptor-mediated Akt phosphorylation in platelets. Blood 2006;107:947-954.
10. Uemura T, Kawasaki T, Taniguchi M, Moritani Y, Hayashi K, Saito T, Takasaki J, Uchida W, Miyata K. Biological properties of a specific Galpha q/11 inhibitor, YM-254890, on platelet functionsand thrombus formation under high-shear stress. Br J Pharmacol 2006;148:61-69.
11. Takasaki J, Saito T, Taniguchi M, Kawasaki T, Moritani Y, Hayashi K, Kobori M. A novel Galphaq/11-selective inhibitor. J Biol Chem 2004;279:47438-47445.
12. Zaima K, Deguchi J, Matsuno Y, Kaneda T, Hirasawa Y, Morita H. Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery. J Nat Med 2013;67:196-201.
13. Kim S, Kunapuli SP. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase. J Biol Chem 2011;286:24170-24179.
14. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-3450.
15. Karpinsky-Semper D, Volmar CH, Brothers SP, Slepak VZ. Differential effects of the Gbeta5-RGS7 complex on muscarinic M3 receptor-induced Ca2+ influx and release. Mol Pharmacol 2014; 85:758-768.
16. Dorsam RT, Kim S, Jin J, Kunapuli SP. Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets. J Biol Chem 2002;277: 47588-47595.
17. Murugappa S, Kunapuli SP. The role of ADP receptors in platelet function. Front Biosci 2006;11:1977-1986.
18. Yang J, Wu J, Kowalska MA, Dalvi A, Prevost N, O'Brien PJ, Manning D, Poncz M, Lucki I, Blendy JA, Brass LF. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci USA 2000;97:9984-9989.
19. Sudo T, Ito H, Kimura Y. Phosphorylation of the vasodilatorstimulated phosphoprotein (VASP) by the anti-platelet drug, cilostazol, in platelets. Platelets 2003;14:381-390.