Zika virus infection-the next wave after dengue?

Journal of the Formosan Medical Association

Volumn 115, Issue 4, 2016, Pages 226-242

  Wong, Samson Sai Yin ^a   Poon, Rosana Wing Shan ^b   Wong, Sally Cheuk Ying ^b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

Aedes; Congenital abnormalities; Flavivirus; Travel medicine; Zika virus

Indexed keywords

AMODIAQUINE; CHLOROQUINE; INSECT REPELLENT; MEFENAMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG; VACCINE; ZIKA VIRUS VACCINE;

AEDES AEGYPTI; AEDES ALBOPICTUS; AFRICA; CONGENITAL INFECTION; DENGUE; DISEASE CARRIER; DISEASE TRANSMISSION; EPIDEMIC; FEDERATED STATES OF MICRONESIA; GUILLAIN BARRE SYNDROME; HABITAT; HUMAN; MICROCEPHALY; NONHUMAN; RETINA MACULOPATHY; REVIEW; SOUTHEAST ASIA; TROPICS; VIRUS; VIRUS INFECTION; ZIKA VIRUS; AEDES; ANIMAL; COMPLICATION; EMPORIATRICS; GUILLAIN-BARRE SYNDROME; HISTORY; MACULAR DEGENERATION; NEWBORN; TRANSMISSION; VIROLOGY; ZIKA VIRUS INFECTION;

AEDES; ANIMALS; DISEASE OUTBREAKS; GUILLAIN-BARRE SYNDROME; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; INFANT, NEWBORN; MACULAR DEGENERATION; MICROCEPHALY; TRAVEL MEDICINE; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 84959521895     PISSN: 09296646     EISSN: 18760821     Source Type: Journal    
DOI: 10.1016/j.jfma.2016.02.002     Document Type: Review

References (184)

1. World Health Organization. Global Strategy for Dengue Prevention and Control, 2012-2020. Available at: [accessed 28.01.16]. http://www.who.int/denguecontrol/9789241504034/en/.
2. Weaver S.C., Lecuit M. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med 2015, 372:1231-1239.
3. Medlock J.M., Hansford K.M., Versteirt V., Cull B., Kampen H., Fontenille D., et al. An entomological review of invasive mosquitoes in Europe. Bull Entomol Res 2015, 105:637-663.
4. Kampen H., Werner D. Out of the bush: the Asian bush mosquito Aedes japonicus japonicus (Theobald, 1901) (Diptera, Culicidae) becomes invasive. Parasit Vectors 2014, 7:59.
5. Tomasello D., Schlagenhauf P. Chikungunya and dengue autochthonous cases in Europe, 2007-2012. Travel Med Infect Dis 2013, 11:274-284.
6. Kutsuna S., Kato Y., Moi M.L., Kotaki A., Ota M., Shinohara K., et al. Autochthonous dengue fever, Tokyo, Japan, 2014. Emerg Infect Dis 2015, 21:517-520.
7. Reed W. Recent researches concerning the etiology, propagation, and prevention of yellow fever, by the United States Army Commission. J Hyg (Lond) 1902, 2:101-119.
8. Chaves-Carballo E. Carlos Finlay and yellow fever: triumph over adversity. Mil Med 2005, 170:881-885.
9. International Committee on Taxonomy of Viruses. Available at [accessed 28.01.16.]. http://www.ictvonline.org/virusTaxonomy.asp.
10. Lindenbach B.D., Thiel H.J., Rice C.M. Flaviviridae: the viruses and their replication. Fields Virology 2007, 1102-1152. Lippincott, Williams & Wilkins, Philadelphia, PA. 5th ed. D.M. Knipe, P.M. Howley (Eds.).
11. Gubler D.J., Kuno G., Markoff L. Flaviviruses. Fields Virology 2007, 1154-1252. Lippincott, Williams & Wilkins, Philadelphia, PA. 5th ed. D.M. Knipe, P.M. Howley (Eds.).
12. Gaunt M.W., Sall A.A., de Lamballerie X., Falconar A.K., Dzhivanian T.I., Gould E.A. Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography. J Gen Virol 2001, 82:1867-1876.
13. Cook S., Holmes E.C. A multigene analysis of the phylogenetic relationships among the flaviviruses (Family: Flaviviridae) and the evolution of vector transmission. Arch Virol 2006, 151:309-325.
14. Rodenhuis-Zybert I.A., van der Schaar H.M., da Silva Voorham J.M., van der Ende-Metselaar H., Lei H.Y., Wilschut J., et al. Immature dengue virus: a veiled pathogen?. PLoS Pathog 2010, 6:e1000718.
15. Muller D.A., Young P.R. The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker. Antiviral Res 2013, 98:192-208.
16. Amorim J.H., Alves R.P., Boscardin S.B., Ferreira L.C. The dengue virus non-structural 1 protein: risks and benefits. Virus Res 2014, 181:53-60.
17. Crook K.R., Miller-Kittrell M., Morrison C.R., Scholle F. Modulation of innate immune signaling by the secreted form of the West Nile virus NS1 glycoprotein. Virology 2014, 458-459:172-182.
18. Melian E.B., Edmonds J.H., Nagasaki T.K., Hinzman E., Floden N., Khromykh A.A. West Nile virus NS2A protein facilitates virus-induced apoptosis independently of interferon response. J Gen Virol 2013, 94:308-313.
19. Liu W.J., Wang X.J., Clark D.C., Lobigs M., Hall R.A., Khromykh A.A. A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in mice. J Virol 2006, 80:2396-2404.
20. Duangchinda T., Dejnirattisai W., Vasanawathana S., Limpitikul W., Tangthawornchaikul N., Malasit P., et al. Immunodominant T-cell responses to dengue virus NS3 are associated with DHF. Proc Natl Acad Sci U S A 2010, 107:16922-16927.
21. Kakumani P.K., Rajgokul K.S., Ponia S.S., Kaur I., Mahanty S., Medigeshi G.R., et al. Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner. Biochem J 2015, 471:89-99.
22. McLean J.E., Wudzinska A., Datan E., Quaglino D., Zakeri Z. Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication. J Biol Chem 2011, 286:22147-22159.
23. Dalrymple N.A., Cimica V., Mackow E.R. Dengue virus NS proteins inhibit RIG-I/MAVS signaling by blocking TBK1/IRF3 phosphorylation: dengue virus serotype 1 NS4A is a unique interferon-regulating virulence determinant. MBio 2015, 6:e00553-15.
24. Zmurko J., Neyts J., Dallmeier K. Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention. Rev Med Virol 2015, 25:205-223.
25. Issur M., Geiss B.J., Bougie I., Picard-Jean F., Despins S., Mayette J., et al. The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure. RNA 2009, 15:2340-2350.
26. Davidson A.D. New insights into flavivirus nonstructural protein 5. Adv Virus Res 2009, 74:41-101.
27. Shi P.Y. Flavivirus NS5 prevents the InSTATement of IFN. Cell Host Microbe 2014, 16:269-271.
28. Dick G.W., Kitchen S.F., Haddow A.J. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg 1952, 46:509-520.
29. MacNamara F.N. Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria. Trans R Soc Trop Med Hyg 1954, 48:139-145.
30. Simpson D.I. Zika virus infection in man. Trans R Soc Trop Med Hyg 1964, 58:335-338.
31. NCBI Nucleotide Database. [accessed 11.02.16.]. http://www.ncbi.nlm.nih.gov/nuccore.
32. Wolfe M.S., Calisher C.H., McGuire K. Spondweni virus infection in a foreign resident of Upper Volta. Lancet 1982, 2:1306-1308.
33. Sips G.J., Wilschut J., Smit J.M. Neuroinvasive flavivirus infections. Rev Med Virol 2012, 22:69-87.
34. Nordin J.D., Parker E.D., Vazquez-Benitez G., Kharbanda E.O., Naleway A., Marcy S.M., Molitor B., Kuckler L., Baggs J. Safety of the yellow fever vaccine: a retrospective study. J Travel Med 2013, 20:368-373.
35. Kawano H., Rostapshov V., Rosen L., Lai C.J. Genetic determinants of dengue type 4 virus neurovirulence for mice. J Virol 1993, 67:6567-6575.
36. Arroyo J., Guirakhoo F., Fenner S., Zhang Z.X., Monath T.P., Chambers T.J. Molecular basis for attenuation of neurovirulence of a yellow fever virus/Japanese encephalitis virus chimera vaccine (ChimeriVax-JE). J Virol 2001, 75:934-942.
37. Zhang S., Li L., Woodson S.E., Huang C.Y., Kinney R.M., Barrett A.D., Beasley D.W. A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus. Virology 2006, 353:35-40.
38. Bordignon J., Strottmann D.M., Mosimann A.L., Probst C.M., Stella V., Noronha L., Zanata S.M., Dos Santos C.N. Dengue neurovirulence in mice: identification of molecular signatures in the E and NS3 helicase domains. J Med Virol 2007, 79:1506-1517.
39. Engel A.R., Rumyantsev A.A., Maximova O.A., Speicher J.M., Heiss B., Murphy B.R., Pletnev A.G. The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome. Virology 2010, 405:243-252.
40. Whiteman M.C., Wicker J.A., Kinney R.M., Huang C.Y., Solomon T., Barrett A.D. Multiple amino acid changes at the first glycosylation motif in NS1 protein of West Nile virus are necessary for complete attenuation for mouse neuroinvasiveness. Vaccine 2011, 29:9702-9710.
41. Donadieu E., Bahuon C., Lowenski S., Zientara S., Coulpier M., Lecollinet S. Differential virulence and pathogenesis of West Nile viruses. Viruses 2013, 5:2856-2880.
42. Mlakar J., Korva M., Tul N., Popoviæ M., Poljšak-Prijatelj M., Mraz J., et al. Zika virus associated with microcephaly. N Engl J Med 2016, [In press].
43. Kuno G., Chang G.J., Tsuchiya K.R., Karabatsos N., Cropp C.B. Phylogeny of the genus Flavivirus. J Virol 1998, 72:73-83.
44. Lanciotti R.S., Kosoy O.L., Laven J.J., Velez J.O., Lambert A.J., Johnson A.J., et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 2008, 14:1232-1239.
45. Haddow A.D., Schuh A.J., Yasuda C.Y., Kasper M.R., Heang V., Huy R., et al. Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage. PLoS Negl Trop Dis 2012, 6:e1477.
46. Faye O., Freire C.C., Iamarino A., Faye O., de Oliveira J.V., Diallo M., et al. Molecular evolution of Zika virus during its emergence in the 20th century. PLoS Negl Trop Dis 2014, 8:e2636.
47. Enfissi A., Codrington J., Roosblad J., Kazanji M., Rousset D. Zika virus genome from the Americas. Lancet 2016, 387:227-228.
48. Hamel R., Dejarnac O., Wichit S., Ekchariyawat P., Neyret A., Luplertlop N., et al. Biology of Zika virus infection in human skin cells. J Virol 2015, 89:8880-8896.
49. Tappe D., Pérez-Girón J.V., Zammarchi L., Rissland J., Ferreira D.F., Jaenisch T., et al. Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase. Med Microbiol Immunol 2015, [In press].
50. Hayes E.B. Zika virus outside Africa. Emerg Infect Dis 2009, 15:1347-1350.
51. Buathong R., Hermann L., Thaisomboonsuk B., Rutvisuttinunt W., Klungthong C., Chinnawirotpisan P., et al. Detection of Zika virus infection in Thailand, 2012-2014. Am J Trop Med Hyg 2015, 93:380-383.
52. Alera M.T., Hermann L., Tac-An I.A., Klungthong C., Rutvisuttinunt W., Manasatienkij W., et al. Zika virus infection, Philippines, 2012. Emerg Infect Dis 2015, 21:722-724.
53. Olson J.G., Ksiazek T.G., Suhandiman, Triwibowo Zika virus, a cause of fever in Central Java, Indonesia. Trans R Soc Trop Med Hyg 1981, 75:389-393.
54. Kwong J.C., Druce J.D., Leder K. Zika virus infection acquired during brief travel to Indonesia. Am J Trop Med Hyg 2013, 89:516-517.
55. Tappe D., Nachtigall S., Kapaun A., Schnitzler P., Günther S., Schmidt-Chanasit J. Acute Zika virus infection after travel to Malaysian Borneo, September 2014. Emerg Infect Dis 2015, 21:911-913.
56. Heang V., Yasuda C.Y., Sovann L., Haddow A.D., Travassos da Rosa A.P., Tesh R.B., et al. Zika virus infection, Cambodia, 2010. Emerg Infect Dis 2012, 18:349-351.
57. Zammarchi L., Tappe D., Fortuna C., Remoli M.E., Günther S., Venturi G., et al. Zika virus infection in a traveller returning to Europe from Brazil, March 2015. Euro Surveill 2015, 20(23). pii: 21153.
58. Kutsuna S., Kato Y., Takasaki T., Moi M., Kotaki A., Uemura H., et al. Two cases of Zika fever imported from French Polynesia to Japan, December 2013 to January 2014. Euro Surveill 2014, 19(4). pii: 20683.
59. Duffy M.R., Chen T.H., Hancock W.T., Powers A.M., Kool J.L., Lanciotti R.S., et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009, 360:2536-2543.
60. Grard G., Caron M., Mombo I.M., Nkoghe D., Mboui Ondo S., Jiolle D., et al. Zika virus in Gabon (Central Africa)-2007: a new threat from Aedes albopictus. PLoS Negl Trop Dis 2014, 8:e2681.
61. Roth A., Mercier A., Lepers C., Hoy D., Duituturaga S., Benyon E., et al. Concurrent outbreaks of dengue, chikungunya and Zika virus infections-an unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012-2014. Euro Surveill 2014, 19(41). pii: 20929.
62. Tognarelli J., Ulloa S., Villagra E., Lagos J., Aguayo C., Fasce R., et al. A report on the outbreak of Zika virus on Easter Island, South Pacific, 2014. Arch Virol 2015, [In press].
63. Pan American Health Organization. Zika Epidemiological Alerts and Updates. Available at:. [accessed 13.02.16]. http://www.paho.org/hq/index.php?option=com_content&view=article&id=11599&Itemid=41691&lang=en.
64. Cao-Lormeau V.M., Roche C., Teissier A., Robin E., Berry A.L., Mallet H.P., et al. Zika virus, French polynesia, South Pacific, 2013. Emerg Infect Dis 2014, 20:1085-1086.
65. Zanluca C., de Melo V.C., Mosimann A.L., Dos Santos G.I., Dos Santos C.N., Luz K. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz 2015, 110:569-572.
66. World Health Organization. Zika sitation report, 5 February 2016. Available at:. [accessed on 13.02.16.]. http://apps.who.int/iris/bitstream/10665/204348/1/zikasitrep_5Feb2016_eng.pdf?ua=1.
67. Centers for Disease Control and Prevention. Zika virus disease in the United States, 2015-2016. Available at:. [accessed 13.02.16]. http://www.cdc.gov/zika/geo/united-states.html.
68. World Health Organization. Zika virus infection - Region of the Americas. Disease Outbreak News. 8 February 2016. Available at:. [accessed 13.02.16]. http://www.who.int/csr/don/8-february-2016-zika-americas-region/en/.
69. Pan American Health Organization. Cumulative Zika confirmed and suspected cases reported by countries and territories in the Americas, 2015-2016. Updated as of February 12, 2016. Available at:. [accessed 13.02.16.]. http://ais.paho.org/phip/viz/ed_zika_cases.asp.
70. McCrae A.W., Kirya B.G. Yellow fever and Zika virus epizootics and enzootics in Uganda. Trans R Soc Trop Med Hyg 1982, 76:552-562.
71. Maciel-de-Freitas R., Codeço C.T., Lourenço-de-Oliveira R. Daily survival rates and dispersal of Aedes aegypti females in Rio de Janeiro, Brazil. Am J Trop Med Hyg 2007, 76:659-665.
72. Goindin D., Delannay C., Ramdini C., Gustave J., Fouque F. Parity and longevity of Aedes aegypti according to temperatures in controlled conditions and consequences on dengue transmission risks. PLoS One 2015, 10:e0135489.
73. Boorman J.P., Porterfield J.S. A simple technique for infection of mosquitoes with viruses; transmission of Zika virus. Trans R Soc Trop Med Hyg 1956, 50:238-242.
74. Haddow A.J., Williams M.C., Woodall J.P., Simpson D.I.H., Goma L.K.H. Twelve isolations of Zika virus from Aedes (Stegomyia) africanus (Theobald) taken in and above a Uganda forest. Bull World Health Organ 1964, 31:57-69.
75. Savage H.M., Ledermann J.P., Yug L., Burkhalter K.L., Marfel M., Hancock W.T. Incrimination of Aedes (Stegomyia) hensilli Farner as an epidemic vector of Chikungunya virus on Yap Island, Federated States of Micronesia, 2013. Am J Trop Med Hyg 2015, 92:429-436.
76. Savage H.M., Fritz C.L., Rutstein D., Yolwa A., Vorndam V., Gubler D.J. Epidemic of dengue-4 virus in Yap State, Federated States of Micronesia, and implication of Aedes hensilli as an epidemic vector. Am J Trop Med Hyg 1998, 58:519-524.
77. Ledermann J.P., Guillaumot L., Yug L., Saweyog S.C., Tided M., Machieng P., et al. Aedes hensilli as a potential vector of Chikungunya and Zika viruses. PLoS Negl Trop Dis 2014, 8:e3188.
78. Wong P.S., Li M.Z., Chong C.S., Ng L.C., Tan C.H. Aedes (Stegomyia) albopictus (Skuse): a potential vector of Zika virus in Singapore. PLoS Negl Trop Dis 2013, 7:e2348.
79. Berthet N., Nakouné E., Kamgang B., Selekon B., Descorps-Declère S., Gessain A., et al. Molecular characterization of three Zika flaviviruses obtained from sylvatic mosquitoes in the Central African Republic. Vector Borne Zoonotic Dis 2014, 14:862-865.
80. Reinert J.F., Harbach R.E., Kitching I.J. Phylogeny and classification of tribe Aedini (Diptera: Culicidae). Zool J Linn Soc 2009, 157:700-794.
81. Kraemer M.U., Sinka M.E., Duda K.A., Mylne A.Q., Shearer F.M., Barker C.M., et al. The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus. Elife 2015, 4:e08347.
82. European Centre for Disease Prevention and Control. Rapid risk assessment. Zika virus infection outbreak, French Polynesia, 14 February 2014. Available at:. [accessed 13.02.16.]. http://ecdc.europa.eu/en/publications/Publications/Zika-virus-French-Polynesia-rapid-risk-assessment.pdf.
83. Musso D., Nilles E.J., Cao-Lormeau V.M. Rapid spread of emerging Zika virus in the Pacific area. Clin Microbiol Infect 2014, 20:O595-O596.
84. Marcondes C.B., Ximenes M.F. Zika virus in Brazil and the danger of infestation by Aedes (Stegomyia) mosquitoes. Rev Soc Bras Med Trop 2015, [In press].
85. Brady O.J., Godfray H.C., Tatem A.J., Gething P.W., Cohen J.M., McKenzie F.E., et al. Vectorial capacity and vector control: reconsidering sensitivity to parameters for malaria elimination. Trans R Soc Trop Med Hyg 2016, 110:107-117.
86. Kramer L.D., Ciota A.T. Dissecting vectorial capacity for mosquito-borne viruses. Curr Opin Virol 2015, 15:112-118.
87. Diagne C.T., Diallo D., Faye O., Ba Y., Faye O., Gaye A., et al. Potential of selected Senegalese Aedes spp. mosquitoes (Diptera: Culicidae) to transmit Zika virus. BMC Infect Dis 2015, 15:492.
88. Leung G.H., Baird R.W., Druce J., Anstey N.M. Zika virus infection in Australia following a monkey bite in Indonesia. Southeast Asian J Trop Med Public Health 2015, 46:460-464.
89. Musso D., Roche C., Nhan T.X., Robin E., Teissier A., Cao-Lormeau V.M. Detection of Zika virus in saliva. J Clin Virol 2015, 68:53-55.
90. Foy B.D., Kobylinski K.C., Chilson Foy J.L., Blitvich B.J., Travassos da Rosa A., Haddow A.D., Lanciotti R.S., Tesh R.B. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis 2011, 17:880-882.
91. Musso D., Roche C., Robin E., Nhan T., Teissier A., Cao-Lormeau V.M. Potential sexual transmission of Zika virus. Emerg Infect Dis 2015, 21:359-361. Erratum in Emerg Infect Dis 2015;21:552.
92. Atkinson B., Hearn P., Afrough B., Lumley S., Carter D., Aarons E.J., et al. Detection of Zika virus in semen. Emerg Infect Dis 2016, [In press].
93. Besnard M., Lastere S., Teissier A., Cao-Lormeau V., Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill 2014, 19(13). pii: 20751.
94. Endy T.P., Anderson K.B., Nisalak A., Yoon I.K., Green S., Rothman A.L., Thomas S.J., Jarman R.G., Libraty D.H., Gibbons R.V. Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand. PLoS Negl Trop Dis 2011, 5:e975.
95. World Health Organization Japanese encephalitis vaccines: WHO position paper-February 2015. Wkly Epidemiol Rec 2015, 90:69-87.
96. Monath T.P., Vasconcelos P.F.C. Yellow fever. J Clin Virol 2015, 64:160-173.
97. Stramer S.L., Linnen J.M., Carrick J.M., Foster G.A., Krysztof D.E., Zou S., et al. Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico. Transfusion 2012, 52:1657-1666.
98. Centers for Disease Control and Prevention (CDC) West Nile virus transmission via organ transplantation and blood transfusion-Louisiana, 2008. MMWR Morb Mortal Wkly Rep 2009, 58:1263-1267.
99. Montgomery S.P., Brown J.A., Kuehnert M., Smith T.L., Crall N., Lanciotti R.S., et al. 2003 West Nile Virus Transfusion-Associated Transmission Investigation Team.Transfusion-associated transmission of West Nile virus, United States 2003 through 2005. Transfusion 2006, 46:2038-2046.
100. Leiby D.A., Gill J.E. Transfusion-transmitted tick-borne infections: a cornucopia of threats. Transfus Med Rev 2004, 18:293-306.
101. Petersen L.R., Busch M.P. Transfusion-transmitted arboviruses. Vox Sang 2010, 98:495-503.
102. Liumbruno G.M., Calteri D., Petropulacos K., Mattivi A., Po C., Macini P., et al. The chikungunya epidemic in Italy and its repercussion on the blood system. Blood Transfus 2008, 6:199-210.
103. Brouard C., Bernillon P., Quatresous I., Pillonel J., Assal A., de Valk H., et al. workgroup "Quantitative Estimation of the Risk of Blood Donation Contamination by Infectious Agents". Estimated risk of Chikungunya viremic blood donation during an epidemic on Reunion Island in the Indian Ocean, 2005 to 2007. Transfusion 2008, 48:1333-1341.
104. Musso D., Nhan T., Robin E., Roche C., Bierlaire D., Zisou K., et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Euro Surveill 2014, 19(14). pii: 20761.
105. Ioos S., Mallet H.P., Leparc Goffart I., Gauthier V., Cardoso T., Herida M. Current Zika virus epidemiology and recent epidemics. Med Mal Infect 2014, 44:302-307.
106. Vasilakis N., Cardosa J., Hanley K.A., Holmes E.C., Weaver S.C. Fever from the forest: prospects for the continued emergence of sylvatic dengue virus and its impact on public health. Nat Rev Microbiol 2011, 9:532-541.
107. Gubler D.J., Suharyono W., Tan R., Abidin M., Sie A. Viraemia in patients with naturally acquired dengue infection. Bull World Health Organ 1981, 59:623-630.
108. Tomashek K.M., Margolis H.S. Dengue: a potential transfusion-transmitted disease. Transfusion 2011, 51:1654-1660.
109. Burt F.J., Rolph M.S., Rulli N.E., Mahalingam S., Heise M.T. Chikungunya: a re-emerging virus. Lancet 2012, 379:662-671.
110. Villamil-Gómez W., Alba-Silvera L., Menco-Ramos A., Gonzalez-Vergara A., Molinares-Palacios T., Barrios-Corrales M., et al. Congenital chikungunya virus infection in Sincelejo, Colombia: a case series. J Trop Pediatr 2015, 61:386-392.
111. Vasani R., Kanhere S., Chaudhari K., Phadke V., Mukherjee P., Gupta S., Kasliwal C., Poojary S. Congenital chikungunya-a cause of neonatal hyperpigmentation. Pediatr Dermatol 2015, [In press].
112. Win M.K., Chow A., Dimatatac F., Go C.J., Leo Y.S. Chikungunya fever in Singapore: acute clinical and laboratory features, and factors associated with persistent arthralgia. J Clin Virol 2010, 49:111-114.
113. Sissoko D., Ezzedine K., Moendandzé A., Giry C., Renault P., Malvy D. Field evaluation of clinical features during chikungunya outbreak in Mayotte, 2005-2006. Trop Med Int Health 2010, 15:600-607.
114. Borgherini G., Poubeau P., Staikowsky F., Lory M., Le Moullec N., Becquart J.P., Wengling C., Michault A., Paganin F. Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis 2007, 44:1401-1407.
115. Oehler E., Watrin L., Larre P., Leparc-Goffart I., Lastere S., Valour F., et al. Zika virus infection complicated by Guillain-Barre syndrome-case report, French Polynesia, December 2013. Euro Surveill 2014, 19(9). pii: 20720.
116. Pan American Health Organization/World Health Organization. Epidemiological Alert. Neurological syndrome, congenital malformations, and Zika virus infection. Implications for public health in the Americas. 1 December 2015. Available at:. [accessed 13.02.16.]. http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=32405&lang=en.
117. Dupont-Rouzeyrol M., O'Connor O., Calvez E., Daurès M., John M., Grangeon J.P., Gourinat A.C. Co-infection with Zika and dengue viruses in 2 patients, New Caledonia, 2014. Emerg Infect Dis 2015, 21:381-382.
118. Ventura C.V., Maia M., Bravo-Filho V., Góis A.L., Belfort R. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet 2016, 387:228.
119. Oliveira Melo A.S., Malinger G., Ximenes R., Szejnfeld P.O., Alves Sampaio S., Bispo de Filippis A.M. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?. Ultrasound Obstet Gynecol 2016, 47:6-7.
120. Ventura C.V., Maia M., Ventura B.V., Linden V.V., Araújo E.B., Ramos R.C., et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol 2016, 79:1-3.
121. Royal College of Obstetricians and Gynaecologists. Interim clinical guidelines on Zika virus infection and pregnancy. 5 February 2016. Available at:. [accessed 13.02.16.]. https://www.rcog.org.uk/globalassets/documents/news/zika-virus-interim-guidelines.pdf.
122. Oduyebo T., Petersen E.E., Rasmussen S.A., Mead P.S., Meaney-Delman D., Renquist C.M., et al. Update: Interim guidelines for health care providers caring for pregnant women and women of reproductive age with possible Zika virus exposure-United States, 2016. MMWR Morb Mortal Wkly Rep 2016, 65:122-127.
123. Way J.H., Bowen E.T., Platt G.S. Comparative studies of some African arboviruses in cell culture and in mice. J Gen Virol 1976, 30:123-130.
124. Centers for Disease Control and Prevention Biosafety in Microbiological and Biomedical Laboratories 2009, Available at:, [accessed 13.02.16.]. http://www.cdc.gov/biosafety/publications/bmbl5/bmbl.pdf, 5th edition.
125. Advisory Committee on Dangerous Pathogens, UK The Approved List of Biological Agents 2013, Available at:, [accessed on 13.02.16.]. http://www.hse.gov.uk/pubns/misc208.pdf.
126. Tappe D., Rissland J., Gabriel M., Emmerich P., Gunther S., Held G., et al. First case of laboratory-confirmed Zika virus infection imported into Europe, November 2013. Euro Surveill 2014 Jan 30, 19(4). pii: 20685.
127. Faye O., Faye O., Dupressoir A., Weidmann M., Ndiaye M. Alpha Sall A. One-step RT-PCR for detection of Zika virus. J Clin Virol 2008, 43:96-101.
128. Faye O., Faye O., Diallo D., Diallo M., Weidmann M., Sall A.A. Quantitative real-time PCR detection of Zika virus and evaluation with field-caught mosquitoes. Virol J 2013, 10:311.
129. Balm M.N., Lee C.K., Lee H.K., Chiu L., Koay E.S., Tang J.W. A diagnostic polymerase chain reaction assay for Zika virus. J Med Virol 2012, 84:1501-1505.
130. Shinohara K., Kutsuna S., Takasaki T., Moi M.L., Ikeda M., Kotaki A., Yamamoto K., Fujiya Y., Mawatari M., Takeshita N., Hayakawa K., Kanagawa S., Kato Y., Ohmagari N. Zika fever imported from Thailand to Japan, and diagnosed by PCR in the urines. J Travel Med 2016, 23. pii: tav011.
131. Ratnam I., Leder K., Black J., Torresi J. Dengue fever and international travel. J Travel Med 2013, 20:384-393.
132. Kumar J.S., Parida M., Rao P.V. Monoclonal antibody-based antigen capture immunoassay for detection of circulating non-structural protein NS1: implications for early diagnosis of Japanese encephalitis virus infection. J Med Virol 2011, 83:1063-1070.
133. Saxena D., Kumar J.S., Parida M., Sivakumar R.R., Patro I.K. Development and evaluation of NS1 specific monoclonal antibody based antigen capture ELISA and its implications in clinical diagnosis of West Nile virus infection. J Clin Virol 2013, 58:528-534.
134. Gyurech D., Schilling J., Schmidt-Chanasit J., Cassinotti P., Kaeppeli F., Dobec M. False positive dengue NS1 antigen test in a traveller with an acute Zika virus infection imported into Switzerland. Swiss Med Wkly 2016, 146:w14296.
135. Chung S.J., Krishnan P.U., Leo Y.S. Two cases of false-positive dengue non-structural protein 1 (NS1) antigen in patients with hematological malignancies and a review of the literature on the use of NS1 for the detection of dengue infection. Am J Trop Med Hyg 2015, 92:367-369.
136. Fibriansah G., Lok S.M. The development of therapeutic antibodies against dengue virus. Antiviral Res 2016, [In press].
137. Idrees S., Ashfaq U.A. RNAi: antiviral therapy against dengue virus. Asian Pac J Trop Biomed 2013, 3:232-236.
138. Bollati M., Alvarez K., Assenberg R., Baronti C., Canard B., Cook S., et al. Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res 2010, 87:125-148.
139. Rothan H.A., Mohamed Z., Paydar M., Rahman N.A., Yusof R. Inhibitory effect of doxycycline against dengue virus replication in vitro. Arch Virol 2014, 159:711-718.
140. Rothan H.A., Buckle M.J., Ammar Y.A., Mohammadjavad P., Shatrah O., Noorsaadah A.R., et al. Study the antiviral activity of some derivatives of tetracycline and non-steroid anti inflammatory drugs towards dengue virus. Trop Biomed 2013, 30:681-690.
141. Farias K.J., Machado P.R., de Almeida Junior R.F., de Aquino A.A., da Fonseca B.A. Chloroquine interferes with dengue-2 virus replication in U937 cells. Microbiol Immunol 2014, 58:318-326.
142. Farias K.J., Machado P.R., da Fonseca B.A. Chloroquine inhibits dengue virus type 2 replication in Vero cells but not in C6/36 cells. ScientificWorldJournal 2013, 2013:282734.
143. Farias K.J., Machado P.R., Muniz J.A., Imbeloni A.A., da Fonseca B.A. Antiviral activity of chloroquine against dengue virus type 2 replication in Aotus monkeys. Viral Immunol 2015, 28:161-169.
144. Boonyasuppayakorn S., Reichert E.D., Manzano M., Nagarajan K., Padmanabhan R. Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity. Antiviral Res 2014, 106:125-134.
145. TravelHealthPro, National Travel Health Network and Centre. Zika virus - update and advice for travellers including pregnant women. Available at:. [accessed 13.02.16.]. http://travelhealthpro.org.uk/zika-virus-update-and-advice-for-travellers-including-pregnant-women/.
146. ScienceAlert. An Indian company says they have two Zika vaccine candidates ready for pre-clinical trials. Available at:. [accessed 13.02.16.]. http://www.sciencealert.com/an-indian-company-says-they-have-2-zika-vaccines-ready-for-pre-clinical-trials.
147. Delatte H., Desvars A., Bouétard A., Bord S., Gimonneau G., Vourc'h G., Fontenille D. Blood-feeding behavior of Aedes albopictus, a vector of Chikungunya on La Réunion. Vector Borne Zoonotic Dis 2010, 10:249-258.
148. Bonizzoni M., Gasperi G., Chen X., James A.A. The invasive mosquito species Aedes albopictus: current knowledge and future perspectives. Trends Parasitol 2013, 29:460-468.
149. Higa Y. Dengue vectors and their spatial distribution. Trop Med Health 2011, 39(4 Suppl):17-27.
150. Mukwaya L.G. Host preference in Aedes (Stegomyia) mosquitoes in Uganda. II. Studies on indoor and outdoor biting and resting behaviour with special reference to Aedes aegypti L. Acta Trop 1974, 31:165-176.
151. Lupi E., Hatz C., Schlagenhauf P. The efficacy of repellents against Aedes, Anopheles, Culex and Ixodes spp. - a literature review. Travel Med Infect Dis 2013, 11:374-411.
152. Sudakin D.L., Osimitz T. DEET. Hayes' Handbook of Pesticide Toxicology 2010, 2111-2125. Academic Press, London, UK. 3rd ed. R. Krieger (Ed.).
153. Selim S., Hartnagel R.E., Osimitz T.G., Gabriel K.L., Schoenig G.P. Absorption, metabolism, and excretion of N,N-diethyl-m-toluamide following dermal application to human volunteers. Fundam Appl Toxicol 1995, 25:95-100.
154. Tenenbein M. Severe toxic reactions and death following the ingestion of diethyltoluamide-containing insect repellents. JAMA 1987, 258:1509-1511.
155. Wiles D., Yee J., Castillo U., Russell J., Spiller H., Casavant M. A lethal case of DEET toxicity due to intentional ingestion. J Anal Toxicol 2014, 38:696-698.
156. Osimitz T.G., Murphy J.V., Fell L.A., Page B. Adverse events associated with the use of insect repellents containing N,N-diethyl-m-toluamide (DEET). Regul Toxicol Pharmacol 2010, 56:93-99.
157. Briassoulis G., Narlioglou M., Hatzis T. Toxic encephalopathy associated with use of DEET insect repellents: a case analysis of its toxicity in children. Hum Exp Toxicol 2001, 20:8-14.
158. Katz T.M., Miller J.H., Hebert A.A. Insect repellents: historical perspectives and new developments. J Am Acad Dermatol 2008, 58:865-871.
159. McGready R., Hamilton K.A., Simpson J.A., Cho T., Luxemburger C., Edwards R., et al. Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy. Am J Trop Med Hyg 2001, 65:285-289.
160. Public Health England. Guidelines for malaria prevention in travellers from the UK 2015. Available at:. [accessed 09.02.16.]. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/461295/2015.09.16_ACMP_guidelines_FINAL.pdf.
161. Onyett H; Canadian Paediatric Society Infectious Diseases and Immunization Committee Preventing mosquito and tick bites: a Canadian update. Paediatr Child Health 2014, 19:326-328.
162. Nasci R.S., Wirtz R.A., Brogdon W.G. Protection against mosquitoes, ticks, and other arthropods. The pre-travel consultation: counseling and advice for travelers. CDC Health Information for International Travel 2016, Available at:, [accessed 09.02.16.]. http://wwwnc.cdc.gov/travel/yellowbook/2016/the-pre-travel-consultation/protection-against-mosquitoes-ticks-other-arthropods.
163. Antwi F.B., Shama L.M., Peterson R.K. Risk assessments for the insect repellents DEET and picaridin. Regul Toxicol Pharmacol 2008, 51:31-36.
164. Koren G., Matsui D., Bailey B. DEET-based insect repellents: safety implications for children and pregnant and lactating women. CMAJ 2003, 169:209-212.
165. Goodyer L.I., Croft A.M., Frances S.P., Hill N., Moore S.J., Onyango S.P., Debboun M. Expert review of the evidence base for arthropod bite avoidance. J Travel Med 2010, 17:182-192.
166. Witting-Bissinger B.E., Stumpf C.F., Donohue K.V., Apperson C.S., Roe R.M. Novel arthropod repellent, BioUD, is an efficacious alternative to DEET. J Med Entomol 2008, 45:891-898.
167. Trongtokit Y., Rongsriyam Y., Komalamisra N., Apiwathnasorn C. Comparative repellency of 38 essential oils against mosquito bites. Phytother Res 2005, 19:303-309.
168. Amer A., Mehlhorn H. Repellency effect of forty-one essential oils against Aedes, Anopheles, and Culex mosquitoes. Parasitol Res 2006, 99:478-490.
169. PPAV Working Groups Personal protection against biting insects and ticks. Parasite 2011, 18:93-111.
170. World Health Organization. Yellow fever vaccination requirements and recommendations; malaria situation; and other vaccination requirements. Available at:. [accessed on 11.2.16.]. http://www.who.int/ith/ITH_country_list.pdf.
171. Chang S.C. Raising clinical awareness for better dengue fever outbreak control. J Formos Med Assoc 2015, 114:1025-1026.
172. Baldacchino F., Caputo B., Chandre F., Drago A., della Torre A., Montarsi F., et al. Control methods against invasive Aedes mosquitoes in Europe: a review. Pest Manag Sci 2015, 71:1471-1485.
173. Carvalho D.O., McKemey A.R., Garziera L., Lacroix R., Donnelly C.A., Alphey L., et al. Suppression of a field population of Aedes aegypti in Brazil by sustained release of transgenic male mosquitoes. PLoS Negl Trop Dis 2015, 9:e0003864.
174. Mogi M. Overwintering strategies of mosquitoes (Diptera: Culicidae) on warmer islands may predict impact of global warming on Kyushu, Japan. J Med Entomol 1996, 33:438-444.
175. Takumi K., Scholte E.J., Braks M., Reusken C., Avenell D., Medlock J.M. Introduction, scenarios for establishment and seasonal activity of Aedes albopictus in The Netherlands. Vector Borne Zoonotic Dis 2009, 9:191-196.
176. Faull K.J., Williams C.R. Intraspecific variation in desiccation survival time of Aedes aegypti (L.) mosquito eggs of Australian origin. J Vector Ecol 2015, 40:292-300.
177. Sanchez L., Vanlerberghe V., Alfonso L., Marquetti Mdel C., Guzman M.G., Bisset J., et al. Aedes aegypti larval indices and risk for dengue epidemics. Emerg Infect Dis 2006, 12:800-806.
178. Kim Lien P.T., Duoc V.T., Gavotte L., Cornillot E., Nga P.T., Briant L., et al. Role of Aedes aegypti and Aedes albopictus during the 2011 dengue fever epidemics in Hanoi, Vietnam. Asian Pac J Trop Med 2015, 8:543-548.
179. Bowman L.R., Runge-Ranzinger S., McCall P.J. Assessing the relationship between vector indices and dengue transmission: a systematic review of the evidence. PLoS Negl Trop Dis 2014, 8:e2848.
180. Taiwan National Infectious Disease Statistics System. Statistics for dengue fever, nationwide, indigenous and imported, by date of onset. Available at:. [accessed 18.2.16.]. http://nidss.cdc.gov.tw/en/SingleDisease.aspx?dc=1&dt=2&disease=061.
181. Chen T.H., Jian S.W., Wang C.Y., Lin C., Wang P.F., Su C.L., et al. Susceptibility of Aedes albopictus and Aedes aegypti to three imported Chikungunya virus strains, including the E1/226V variant in Taiwan. J Formos Med Assoc 2015, 114:546-552.
182. Wong S.S., Wong S.C. Ebola virus disease in nonendemic countries. J Formos Med Assoc 2015, 114:384-398.
183. Carroll I.D., Williams D.C. Pre-travel vaccination and medical prophylaxis in the pregnant traveler. Travel Med Infect Dis 2008, 6:259-275.
184. Oster A.M., Brooks J.T., Stryker J.E., Kachur R.E., Mead P., Pesik N.T., et al. Interim guidelines for prevention of sexual transmission of Zika virus-United States, 2016. MMWR Morb Mortal Wkly Rep 2016, 65:120-121.