Adverse events associated with the use of insect repellents containing N,N-diethyl-m-toluamide (DEET)

Regulatory Toxicology and Pharmacology

Volumn 56, Issue 1, 2010, Pages 93-99

  Osimitz, T G ^a   Murphy, J V ^b   Fell, L A ^c   Page, B ^d  

^a Science Strategies LLC   (United States)

^b CHILDREN S MERCY HOSPITAL   (United States)

^c ARCADIS   (United States)

^d PEGUS Research Inc   (United States)

Author keywords

Causality; DEET; Neurological events; Pesticide; Repellent; Seizures

Indexed keywords

DIETHYLTOLUAMIDE; INSECT REPELLENT;

ADVERSE OUTCOME; AGE DISTRIBUTION; ARTICLE; CHILD SAFETY; CONTROLLED STUDY; DISEASE SEVERITY; HUMAN; NEUROTOXICITY; PRIORITY JOURNAL; PROGNOSIS; REGISTER; SEIZURE; UNITED STATES;

ADOLESCENT; ADULT; AGE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; CONSUMER PRODUCT SAFETY; DEET; HUMANS; INSECT REPELLENTS; NERVOUS SYSTEM DISEASES; POISON CONTROL CENTERS; PRODUCT SURVEILLANCE, POSTMARKETING; REGISTRIES; SEIZURES; YOUNG ADULT;

HEXAPODA;

EID: 75549083104     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.09.004     Document Type: Article

References (17)

1. Boomsma, J.C., Parthasarathy, M., 1990. Human use and exposure to insect repellents containing DEET. Study submitted to the US Environmental Protection Agency in response to data call-in on DEET.
2. Bell J., et al. Human exposures to DEET insect repellents reported to American Association of Poison Control Centers (1993-1997). Int. J. Toxicol. 2002, 21:341-352.
3. Camfield P.R., et al. Epilepsy after a first unprovoked seizure in childhood. Neurology 1985, 35:1657-1660.
4. Centers for Disease Control and Prevention, 2008a. Division of Vector-Borne Infectious Diseases. Lyme Disease: Introduction. Available at: . http://www.cdc.gov/ncidod/dvbid/lymeinfo.htm.
5. Centers for Disease Control and Prevention, 2008b. Division of Vector-Borne Infectious Diseases. Lyme Disease: Prevention and Control. Available at: . http://www.cdc.gov/ncidod/dvbid/lyme/Prevention/ld_Prevention_Avoid.htm.
6. Centers for Disease Control and Prevention, 2008c. Division of Vector-Borne Infectious Diseases. West Nile Virus. Available at: . http://www.cdc.gov/ncidod/dvbid/westnile/qa/prevention.htm.
7. Costanzo S.D., Watkinson A.J., Murby E.J., Kolpin D.W., Sandstrom M.W. Is there a risk associated with the insect repellent DEET commonly found in aquatic environments?. Sci. Total Environ. 2007, 384(1-3):214-220.
8. Health Canada, 2002. Pesticide Management Regulatory Agency's Re-evaluation Decision on DEET. Document RRD2002-01 April 15.
9. Fradin M.S., Day J.F. Comparative efficacy of insect repellents against mosquito bites. N. Engl. J. Med. 2002, 347(1):13-18.
10. Hauser H. Epidemiology of epilepsy in children. Pediatric Epilepsy: Diagnosis and Therapy 2001, 69-80. Demos Medical Publishing, New York. J.M. Pellock, W.E. Dodson, B.F.D. Bourgeois (Eds.).
11. Hill A.B. The environment and disease: association or causation? Proceedings of the Royal Society of Medicine for Jan. 14, 1965. Occup. Med. 1965, 295-300.
12. Litovitz T. The TESS database: use in product safety assessment. Drug Saf. 1998, 18(1):9-19.
13. Osimitz T.G., Murphy J.G. Neurological effects associated with use of the insect repellent N,N-diethyl-m-toluamide (DEET). J. Toxicol. Clin. Toxicol. 1997, 35(5):435-441.
14. Sudakin D.L., Trevathan W.R. DEET: a review and update of safety and risk in the general population. J. Toxicol. Clin. Toxicol. 2003, 41(6):831-839.
15. USEPA, 1998. United States Environmental Protection Agency's (USEPA) Reregistration Eligibility Decision on DEET.
16. Veltri J.C., et al. Retrospective analysis of calls to PCC resulting from exposure to the insect repellent DEET from 1985-89. Clin. Toxicol. 1994, 32(1):1-16.
17. Weil, W.B., 2001. New information leads to changes in DEET recommendations. AAP News.