A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in mice

Journal of Virology

Volumn 80, Issue 5, 2006, Pages 2396-2404

  Liu, Wen Jun ^a   Wang, Xiang Ju ^a   Clark, David C ^a   Lobigs, Mario ^b   Hall, Roy A ^a   Khromykh, Alexander A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; NONSTRUCTURAL PROTEIN 2A; NONSTRUCTURAL PROTEIN 3; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBODY RESPONSE; ANTIVIRAL ACTIVITY; ARTICLE; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TARGETING; STRAIN DIFFERENCE; VIRUS GENOME; VIRUS INFECTION; VIRUS MUTANT; VIRUS VIRULENCE; WEST NILE FLAVIVIRUS; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, VIRAL; CELL LINE; CRICETINAE; DISEASE MODELS, ANIMAL; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; MICE; MICE, KNOCKOUT; PLAQUE ASSAY; RECEPTORS, INTERFERON; SURVIVAL ANALYSIS; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE; VIRUS REPLICATION; WEST NILE FEVER; WEST NILE VIRUS;

ANIMALIA; FLAVIVIRUS; WEST NILE VIRUS;

EID: 33144482922     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.80.5.2396-2404.2006     Document Type: Article

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