Drug design from the cryptic inhibitor envelope

Nature Communications

Volumn 7, Issue , 2016, Pages

  Lee, Chul Jin ^a   Liang, Xiaofei ^b   Wu, Qinglin ^a   Najeeb, Javaria ^a   Zhao, Jinshi ^a   Gopalaswamy, Ramesh ^b   Titecat, Marie ^c   Sebbane, Florent ^c   Lemaitre, Nadine ^c   Toone, Eric J ^a,b   Zhou, Pei ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

^c UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ENZYME INHIBITOR; LPXC INHIBITOR; UNCLASSIFIED DRUG; AMIDASE; ANTIINFECTIVE AGENT; CHIR 090; HYDROXAMIC ACID; LIGAND; LPC-011; LPXC DEACETYLASE, PSEUDOMONAS; THREONINE; UDP-3-O-ACYL-N-ACETYLGLUCOSAMINE DEACETYLASE;

ANTIBIOTICS; BACTERIUM; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; INHIBITION; INHIBITOR; LIGAND; LIPID; NUCLEAR MAGNETIC RESONANCE; OPTIMIZATION; PROTEIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG SYNTHESIS; ENZYMATIC ASSAY; GRAM NEGATIVE BACTERIUM; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROGEN BOND; IC50; INHIBITION CONSTANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STATIC ELECTRICITY; STEADY STATE; ANALOGS AND DERIVATIVES; CRYSTALLIZATION; DRUG EFFECTS; ESCHERICHIA COLI; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULARLY TARGETED THERAPY; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; X RAY CRYSTALLOGRAPHY;

NEGIBACTERIA;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; HYDROXAMIC ACIDS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR TARGETED THERAPY; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; THREONINE;

EID: 84959441617     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10638     Document Type: Article

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