메뉴 건너뛰기




Volumn 86, Issue , 2016, Pages 10-16

Role of the RANK/RANKL pathway in breast cancer

Author keywords

Breast; Cancer; Denosumab; Progesterone; Progestin; RANKL

Indexed keywords

DENOSUMAB; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROGESTERONE; PROGESTERONE RECEPTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; BONE DENSITY CONSERVATION AGENT;

EID: 84959422239     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2016.01.001     Document Type: Review
Times cited : (50)

References (110)
  • 1
    • 42049110350 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor B ligand and osteoprotegerin regulation of bone remodeling in health and disease
    • A.E. Kearns, S. Khosla, and P.J. Kostenuik Receptor activator of nuclear factor B ligand and osteoprotegerin regulation of bone remodeling in health and disease Endocr. Rev. 29 2 2008 155 192
    • (2008) Endocr. Rev. , vol.29 , Issue.2 , pp. 155-192
    • Kearns, A.E.1    Khosla, S.2    Kostenuik, P.J.3
  • 3
    • 0032404069 scopus 로고    scopus 로고
    • Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy
    • T. Akatsu, T. Murakami, K. Ono, M. Nishikawa, E. Tsuda, S.I. Mochizuki, N. Fujise, K. Higashio, K. Motoyoshi, M. Yamamoto, and N. Nagata Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy Bone 23 1998 495 498
    • (1998) Bone , vol.23 , pp. 495-498
    • Akatsu, T.1    Murakami, T.2    Ono, K.3    Nishikawa, M.4    Tsuda, E.5    Mochizuki, S.I.6    Fujise, N.7    Higashio, K.8    Motoyoshi, K.9    Yamamoto, M.10    Nagata, N.11
  • 7
    • 29244476052 scopus 로고    scopus 로고
    • Functional dissociation of osteoprotegerin and its interaction with receptor activator of NF-B ligand
    • L.A. Schneeweis, D. Willard, and M.E. Milla Functional dissociation of osteoprotegerin and its interaction with receptor activator of NF-B ligand J. Biol. Chem. 280 2005 41155 41164
    • (2005) J. Biol. Chem. , vol.280 , pp. 41155-41164
    • Schneeweis, L.A.1    Willard, D.2    Milla, M.E.3
  • 10
    • 84855999380 scopus 로고    scopus 로고
    • Molecular pathways: Osteoclast-dependent and osteoclast-independent roles of the RANKL/RANK/OPG pathway in tumorigenesis and metastasis
    • W.C. Dougall Molecular pathways: osteoclast-dependent and osteoclast-independent roles of the RANKL/RANK/OPG pathway in tumorigenesis and metastasis Clin. Cancer Res. 18 2012 326 335
    • (2012) Clin. Cancer Res. , vol.18 , pp. 326-335
    • Dougall, W.C.1
  • 11
    • 0031439265 scopus 로고    scopus 로고
    • TRANCE (tumor necrosis factor [TNF]-related activationinduced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
    • B. Wong, R. Josien, S.Y. Lee, B. Sauter, H.L. Li, R.M. Steinman, and Y. Choi TRANCE (tumor necrosis factor [TNF]-related activationinduced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor J. Exp. Med. 186 1997 2075 2080
    • (1997) J. Exp. Med. , vol.186 , pp. 2075-2080
    • Wong, B.1    Josien, R.2    Lee, S.Y.3    Sauter, B.4    Li, H.L.5    Steinman, R.M.6    Choi, Y.7
  • 12
    • 0037292208 scopus 로고    scopus 로고
    • The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts
    • S. Bord, D.C. Ireland, S.R. Beavan, and J.E. Compston The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts Bone 32 2003 136 141
    • (2003) Bone , vol.32 , pp. 136-141
    • Bord, S.1    Ireland, D.C.2    Beavan, S.R.3    Compston, J.E.4
  • 17
    • 0035054126 scopus 로고    scopus 로고
    • Determination of three isoforms of the receptor activator of nuclear factor-B ligand and their differential expression in bone and thymus
    • T. Ikeda, M. Kasai, M. Utsuyama, and K. Hirokawa Determination of three isoforms of the receptor activator of nuclear factor-B ligand and their differential expression in bone and thymus Endocrinology 142 2001 1419 1426
    • (2001) Endocrinology , vol.142 , pp. 1419-1426
    • Ikeda, T.1    Kasai, M.2    Utsuyama, M.3    Hirokawa, K.4
  • 25
    • 84956688452 scopus 로고    scopus 로고
    • Osteoprotegerin induces apoptosis of osteoclasts and osteoclast precursor cells via the fas/fas ligand pathway
    • W. Liu, C. Xu, H. Zhao, P. Xia, R. Song, J. Gu, X. Liu, J. Bian, Y. Yuan, and Z. Liu Osteoprotegerin induces apoptosis of osteoclasts and osteoclast precursor cells via the fas/fas ligand pathway PLoS One 10 November (11) 2015 e0142519
    • (2015) PLoS One , vol.10 , Issue.NOVEMBER 11 , pp. e0142519
    • Liu, W.1    Xu, C.2    Zhao, H.3    Xia, P.4    Song, R.5    Gu, J.6    Liu, X.7    Bian, J.8    Yuan, Y.9    Liu, Z.10
  • 27
    • 0032321972 scopus 로고    scopus 로고
    • Plasticity of mammary epithelia during normal development and neoplastic progression
    • A. Lochter Plasticity of mammary epithelia during normal development and neoplastic progression Biochem. Cell Biol. 76 6 1998 997 1008
    • (1998) Biochem. Cell Biol. , vol.76 , Issue.6 , pp. 997-1008
    • Lochter, A.1
  • 28
    • 84865494894 scopus 로고    scopus 로고
    • Stem cells in breast tumours: Are they ready for the clinic?
    • M.P. Ablett, J.K. Singh, and R.B. Clarke Stem cells in breast tumours: Are they ready for the clinic? Eur. J. Cancer 48 September (14) 2012 2104 2116
    • (2012) Eur. J. Cancer , vol.48 , Issue.SEPTEMBER 14 , pp. 2104-2116
    • Ablett, M.P.1    Singh, J.K.2    Clarke, R.B.3
  • 29
    • 84884332044 scopus 로고    scopus 로고
    • A new achilles heel in breast cancer?
    • G. Sflomos, and C. Brisken A new achilles heel in breast cancer? Oncotarget 4 2013 1126 1127
    • (2013) Oncotarget , vol.4 , pp. 1126-1127
    • Sflomos, G.1    Brisken, C.2
  • 32
    • 0033038368 scopus 로고    scopus 로고
    • Physiology of lactation
    • M.C. Neville Physiology of lactation Clin. Perinatol. 26 1999 251 279
    • (1999) Clin. Perinatol. , vol.26 , pp. 251-279
    • Neville, M.C.1
  • 34
    • 33846911452 scopus 로고    scopus 로고
    • RANK overexpression in transgenic mice with mouse mammary tumor virus promoter controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini
    • E. Gonzalez-Suarez, D. Branstetter, A. Armstrong, H. Dinh, H. Blumberg, and W.C. Dougall RANK overexpression in transgenic mice with mouse mammary tumor virus promoter controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini Mol. Cell. Biol. 27 4 2007 1442 1454
    • (2007) Mol. Cell. Biol. , vol.27 , Issue.4 , pp. 1442-1454
    • Gonzalez-Suarez, E.1    Branstetter, D.2    Armstrong, A.3    Dinh, H.4    Blumberg, H.5    Dougall, W.C.6
  • 36
    • 0033402201 scopus 로고    scopus 로고
    • The genetic transformation of bone biology
    • G. Karsenty The genetic transformation of bone biology Genes Dev. 13 1999 3037 3051
    • (1999) Genes Dev. , vol.13 , pp. 3037-3051
    • Karsenty, G.1
  • 37
    • 0032765892 scopus 로고    scopus 로고
    • Cell biology of the osteoclast
    • G.D. Roodman Cell biology of the osteoclast Exp. Hematol. 27 1999 1229 1241
    • (1999) Exp. Hematol. , vol.27 , pp. 1229-1241
    • Roodman, G.D.1
  • 38
    • 0034019171 scopus 로고    scopus 로고
    • RANKing the importance of measles virus in Paget's disease
    • F.P. Ross RANKing the importance of measles virus in Paget's disease J. Clin. Invest. 105 2000 555 558
    • (2000) J. Clin. Invest. , vol.105 , pp. 555-558
    • Ross, F.P.1
  • 39
    • 84855999380 scopus 로고    scopus 로고
    • Molecular pathways: Osteoclast-dependent and osteoclast-independent roles of the RANKL/RANK/OPG pathway in tumorigenesis and metastasis
    • W.C. Dougall Molecular pathways: osteoclast-dependent and osteoclast-independent roles of the RANKL/RANK/OPG pathway in tumorigenesis and metastasis Clin. Cancer Res. 18 2012 326 335
    • (2012) Clin. Cancer Res. , vol.18 , pp. 326-335
    • Dougall, W.C.1
  • 42
    • 78649821635 scopus 로고    scopus 로고
    • Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression
    • A. Mukherjee, S.M. Soyal, J. Li, Y. Ying, B. He, F.J. DeMayo, and et al. Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression FASEB J. 24 2010 4408 4419
    • (2010) FASEB J. , vol.24 , pp. 4408-4419
    • Mukherjee, A.1    Soyal, S.M.2    Li, J.3    Ying, Y.4    He, B.5    DeMayo, F.J.6
  • 43
    • 84907598828 scopus 로고    scopus 로고
    • RANKL expression in normal and malignant breast tissue responds to progesterone and is up-regulated during the luteal phase
    • H. Hu, J. Wang, A. Gupta, A. Shidfar, D. Branstetter, and et al. RANKL expression in normal and malignant breast tissue responds to progesterone and is up-regulated during the luteal phase Breast Cancer Res. Treat. 146 2014 515 523
    • (2014) Breast Cancer Res. Treat. , vol.146 , pp. 515-523
    • Hu, H.1    Wang, J.2    Gupta, A.3    Shidfar, A.4    Branstetter, D.5
  • 44
    • 0035861314 scopus 로고    scopus 로고
    • IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
    • Y. Cao, G. Bonizzi, T.N. Seagroves, F.R. Greten, R. Johnson, E.V. Schmidt, and M. Karin IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development Cell 107 2001 763 775
    • (2001) Cell , vol.107 , pp. 763-775
    • Cao, Y.1    Bonizzi, G.2    Seagroves, T.N.3    Greten, F.R.4    Johnson, R.5    Schmidt, E.V.6    Karin, M.7
  • 45
    • 35648970074 scopus 로고    scopus 로고
    • IκB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumorinitiating cells
    • Y. Cao, and et al. IκB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumorinitiating cells Proc. Natl. Acad. Sci. U. S. A. 104 2007 15852 15857
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 15852-15857
    • Cao, Y.1
  • 46
    • 31344455071 scopus 로고    scopus 로고
    • Receptor activator of NF-κB ligand regulates the proliferation of mammary epithelial cells via Id2
    • N.S. Kim, and et al. Receptor activator of NF-κB ligand regulates the proliferation of mammary epithelial cells via Id2 Mol. Cell. Biol. 26 2006 1002 1013
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 1002-1013
    • Kim, N.S.1
  • 47
    • 0033602163 scopus 로고    scopus 로고
    • Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    • Y. Yokota, and et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2 Nature 397 1999 702 706
    • (1999) Nature , vol.397 , pp. 702-706
    • Yokota, Y.1
  • 50
    • 51349092893 scopus 로고    scopus 로고
    • The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator
    • Y. Hikosaka, and et al. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator Immunity 29 2008 438 450
    • (2008) Immunity , vol.29 , pp. 438-450
    • Hikosaka, Y.1
  • 51
    • 61349178831 scopus 로고    scopus 로고
    • The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse
    • R. Fernandez-Valdivia, A. Mukherjee, Y. Ying, J. Li, M. Paquet, F.J. DeMayo, and J.P. Lydon The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse Dev. Biol. 328 2009 127 139
    • (2009) Dev. Biol. , vol.328 , pp. 127-139
    • Fernandez-Valdivia, R.1    Mukherjee, A.2    Ying, Y.3    Li, J.4    Paquet, M.5    DeMayo, F.J.6    Lydon, J.P.7
  • 52
    • 67650874081 scopus 로고    scopus 로고
    • Cancer statistics
    • A. Jemal, and et al. Cancer statistics CA Cancer J. Clin. 59 2009 225 249
    • (2009) CA Cancer J. Clin. , vol.59 , pp. 225-249
    • Jemal, A.1
  • 55
    • 81755162334 scopus 로고    scopus 로고
    • HRT and breast cancer risk: A realistic perspective
    • J.C. Stevenson, H.N. Hodis, J.H. Pickar, and R.A. Lobo HRT and breast cancer risk: A realistic perspective Climacteric 14 December (6) 2011 633 636
    • (2011) Climacteric , vol.14 , Issue.DECEMBER 6 , pp. 633-636
    • Stevenson, J.C.1    Hodis, H.N.2    Pickar, J.H.3    Lobo, R.A.4
  • 57
    • 84856015098 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition, cancer stem cells and treatment resistance
    • B. Dave, V. Mittal, N.M. Tan, and J.C. Chang Epithelial-mesenchymal transition, cancer stem cells and treatment resistance Breast Cancer Res. 14 2012 202
    • (2012) Breast Cancer Res. , vol.14 , pp. 202
    • Dave, B.1    Mittal, V.2    Tan, N.M.3    Chang, J.C.4
  • 58
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Y.Y. Kong, and et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature 397 1999 315 323
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1
  • 59
    • 36248949045 scopus 로고    scopus 로고
    • Stem cells and the stemcell niche in the breast: An integrated hormonal and developmental perspective
    • C. Brisken, and S. Duss Stem cells and the stemcell niche in the breast: An integrated hormonal and developmental perspective Stem Cell Rev. 3 2007 147 156
    • (2007) Stem Cell Rev. , vol.3 , pp. 147-156
    • Brisken, C.1    Duss, S.2
  • 63
    • 84893019097 scopus 로고    scopus 로고
    • Role of RANKL/RANK in primary and secondary breast cancer
    • Toshiyuki Yoneda, Soichi Tanaka, and Kenji Hata Role of RANKL/RANK in primary and secondary breast cancer World J. Orthop. 4 4 2013 178 185
    • (2013) World J. Orthop. , vol.4 , Issue.4 , pp. 178-185
    • Yoneda, T.1    Tanaka, S.2    Hata, K.3
  • 64
    • 84945566252 scopus 로고    scopus 로고
    • Epithelial-mesenchymal plasticity: A central regulator of cancer progression
    • X. Ye, and R.A. Weinberg Epithelial-mesenchymal plasticity: A central regulator of cancer progression Trends Cell Biol. 25 November (11) 2015 675 686
    • (2015) Trends Cell Biol. , vol.25 , Issue.NOVEMBER 11 , pp. 675-686
    • Ye, X.1    Weinberg, R.A.2
  • 65
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: New insights in signaling, development, and disease
    • J.M. Lee, S. Dedhar, R. Kalluri, and E.W. Thompson The epithelial-mesenchymal transition: new insights in signaling, development, and disease J. Cell Biol. 172 2006 973 981
    • (2006) J. Cell Biol. , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 66
    • 34250174504 scopus 로고    scopus 로고
    • The role of epithelial-mesenchymal transition in cancer pathology
    • M. Guarino, B. Rubino, and G. Ballabio The role of epithelial-mesenchymal transition in cancer pathology Pathology 39 2007 305 318
    • (2007) Pathology , vol.39 , pp. 305-318
    • Guarino, M.1    Rubino, B.2    Ballabio, G.3
  • 67
    • 34250703744 scopus 로고    scopus 로고
    • Vimentin and epithelial-mesenchymal transition in human breast cancer - observations in vitro and in vivo
    • M.I. Kokkinos, R. Wafai, M.K. Wong, D.F. Newgreen, E.W. Thompson, and M. Waltham Vimentin and epithelial-mesenchymal transition in human breast cancer - observations in vitro and in vivo Cells Tissues Organs 185 2007 191 203
    • (2007) Cells Tissues Organs , vol.185 , pp. 191-203
    • Kokkinos, M.I.1    Wafai, R.2    Wong, M.K.3    Newgreen, D.F.4    Thompson, E.W.5    Waltham, M.6
  • 70
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • R. Kalluri, and E.G. Neilson Epithelial-mesenchymal transition and its implications for fibrosis J. Clin. Invest. 112 2003 1776 1784
    • (2003) J. Clin. Invest. , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 71
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformation
    • E.D. Hay An overview of epithelio-mesenchymal transformation Acta Anat. (Basel.) 154 1995 8 20
    • (1995) Acta Anat. (Basel.) , vol.154 , pp. 8-20
    • Hay, E.D.1
  • 73
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 74
    • 33645453481 scopus 로고    scopus 로고
    • Regulation of cancer cell migration and bone metastasis by RANKL
    • D. Holstead-Jones, and et al. Regulation of cancer cell migration and bone metastasis by RANKL Nature 440 2006 692 696
    • (2006) Nature , vol.440 , pp. 692-696
    • Holstead-Jones, D.1
  • 75
    • 33745874700 scopus 로고    scopus 로고
    • Expression of receptor activator of nuclear factor κβ ligand (RANKL) and tumour necrosis factor related, apoptosis inducing ligand (TRAIL) in breast cancer, and their relations with osteoprotegerin, oestrogen receptor, and clinicopathological variables
    • S.S. Cross, and et al. Expression of receptor activator of nuclear factor κβ ligand (RANKL) and tumour necrosis factor related, apoptosis inducing ligand (TRAIL) in breast cancer, and their relations with osteoprotegerin, oestrogen receptor, and clinicopathological variables J. Clin. Pathol. 59 2006 716 720
    • (2006) J. Clin. Pathol. , vol.59 , pp. 716-720
    • Cross, S.S.1
  • 76
    • 30444459116 scopus 로고    scopus 로고
    • Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor κb ligand (RANKL) in human breast tumours
    • C. Van Poznak, and et al. Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor κB ligand (RANKL) in human breast tumours J. Clin. Pathol. 59 2006 56 63
    • (2006) J. Clin. Pathol. , vol.59 , pp. 56-63
    • Van Poznak, C.1
  • 77
    • 79952193038 scopus 로고    scopus 로고
    • Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
    • W. Tan, and et al. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling Nature 470 2011 548 553
    • (2011) Nature , vol.470 , pp. 548-553
    • Tan, W.1
  • 79
    • 84951909171 scopus 로고    scopus 로고
    • Osteoprotegrin (OPG), the endogenous inhibitor of receptor activator of NF-kB ligand (RANKL) is dyregulated in BRCA mutation carriers
    • M. Windschwendter, M. Burnell, L. Fraser, and et al. Osteoprotegrin (OPG), the endogenous inhibitor of receptor activator of NF-kB ligand (RANKL) is dyregulated in BRCA mutation carriers EBioMedicine 2 2015 1331 1339
    • (2015) EBioMedicine , vol.2 , pp. 1331-1339
    • Windschwendter, M.1    Burnell, M.2    Fraser, L.3
  • 80
    • 58649113384 scopus 로고    scopus 로고
    • Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL
    • P.J. Kostenuik, H.Q. Nguyen, J. McCabe, K.S. Warmington, C. Kurahara, N. Sun, and et al. Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL J. Bone Min. Res. 24 2009 182 195
    • (2009) J. Bone Min. Res. , vol.24 , pp. 182-195
    • Kostenuik, P.J.1    Nguyen, H.Q.2    McCabe, J.3    Warmington, K.S.4    Kurahara, C.5    Sun, N.6
  • 81
    • 0034784606 scopus 로고    scopus 로고
    • Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity
    • J. Lam, C.A. Nelson, F.P. Ross, S.L. Teitelbaum, and D.H. Fremont Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity J. Clin. Invest. 108 2001 971 979
    • (2001) J. Clin. Invest. , vol.108 , pp. 971-979
    • Lam, J.1    Nelson, C.A.2    Ross, F.P.3    Teitelbaum, S.L.4    Fremont, D.H.5
  • 83
    • 75149145545 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of monoclonal antibodies: Concepts and lessons for drug development
    • D.R. Mould, and B. Green Pharmacokinetics and pharmacodynamics of monoclonal antibodies: concepts and lessons for drug development BioDrugs 24 2010 23 39
    • (2010) BioDrugs , vol.24 , pp. 23-39
    • Mould, D.R.1    Green, B.2
  • 84
    • 79952698455 scopus 로고    scopus 로고
    • Denosumab and bisphosphonates: Different mechanisms of action and effects
    • R. Baron, S. Ferrari, and R.G. Russell Denosumab and bisphosphonates: different mechanisms of action and effects Bone 48 2011 677 692
    • (2011) Bone , vol.48 , pp. 677-692
    • Baron, R.1    Ferrari, S.2    Russell, R.G.3
  • 87
    • 84949641579 scopus 로고    scopus 로고
    • Efficacy and safety of denosumab for the treatment of osteoporosis: A systematic review
    • D. Diédhiou, T. Cuny, A. Sarr, S. Norou Diop, M. Klein, and G. Weryha Efficacy and safety of denosumab for the treatment of osteoporosis: A systematic review Ann. Endocrinol. (Paris) 76 December (6) 2015 650 657
    • (2015) Ann. Endocrinol. (Paris) , vol.76 , Issue.DECEMBER 6 , pp. 650-657
    • Diédhiou, D.1    Cuny, T.2    Sarr, A.3    Norou Diop, S.4    Klein, M.5    Weryha, G.6
  • 88
    • 0037398261 scopus 로고    scopus 로고
    • Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
    • G. Eghbali-Fatourechi, and et al. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women J. Clin. Invest. 111 2003 1221 1230
    • (2003) J. Clin. Invest. , vol.111 , pp. 1221-1230
    • Eghbali-Fatourechi, G.1
  • 89
    • 18444365892 scopus 로고    scopus 로고
    • Increased RANKL/OPG mRNA ratio in iliac bone biopsies from women with hip fractures
    • B.M. Abdallah, and et al. Increased RANKL/OPG mRNA ratio in iliac bone biopsies from women with hip fractures Calcif. Tissue Int. 76 2005 90 97
    • (2005) Calcif. Tissue Int. , vol.76 , pp. 90-97
    • Abdallah, B.M.1
  • 90
    • 68849132198 scopus 로고    scopus 로고
    • Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin
    • X. Li, and et al. Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin Bone 45 2009 669 676
    • (2009) Bone , vol.45 , pp. 669-676
    • Li, X.1
  • 91
    • 42449146580 scopus 로고    scopus 로고
    • RANKL inhibition with osteoprotegerin increases bone strength by improving cortical and trabecular bone architecture in ovariectomized rats
    • M.S. Ominsky, and et al. RANKL inhibition with osteoprotegerin increases bone strength by improving cortical and trabecular bone architecture in ovariectomized rats J. Bone Min. Res. 23 2008 672 682
    • (2008) J. Bone Min. Res. , vol.23 , pp. 672-682
    • Ominsky, M.S.1
  • 92
    • 68849123934 scopus 로고    scopus 로고
    • Orchiectomy upregulates free soluble RANKL in bone marrow of aged rats
    • V. Proell, and et al. Orchiectomy upregulates free soluble RANKL in bone marrow of aged rats Bone 45 2009 677 681
    • (2009) Bone , vol.45 , pp. 677-681
    • Proell, V.1
  • 93
    • 79958772395 scopus 로고    scopus 로고
    • Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody
    • P.J. Kostenuik, and et al. Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody Bone 49 2011 151 161
    • (2011) Bone , vol.49 , pp. 151-161
    • Kostenuik, P.J.1
  • 94
    • 79958772773 scopus 로고    scopus 로고
    • Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys
    • M.S. Ominsky, and et al. Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys Bone 49 2011 162 173
    • (2011) Bone , vol.49 , pp. 162-173
    • Ominsky, M.S.1
  • 95
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • W.S. Simonet, and et al. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density Cell 89 1997 309 319
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1
  • 96
    • 0023037767 scopus 로고
    • Growth factors in bone matrix: Isolation of multiple types by affinity chromatography on heparin-sepharose
    • P.V. Hauschka, A.E. Mavrakos, M.D. Iafrati, S.E. Doleman, and M. Klagsbrun Growth factors in bone matrix: isolation of multiple types by affinity chromatography on heparin-sepharose J. Biol. Chem. 261 1986 12665 12674
    • (1986) J. Biol. Chem. , vol.261 , pp. 12665-12674
    • Hauschka, P.V.1    Mavrakos, A.E.2    Iafrati, M.D.3    Doleman, S.E.4    Klagsbrun, M.5
  • 97
    • 13444306377 scopus 로고    scopus 로고
    • Crosstalk between cancer cells and bone microenvironment in bone metastasis
    • T. Yoneda, and T. Hiraga Crosstalk between cancer cells and bone microenvironment in bone metastasis Biochem. Biophys. Res. Commun. 328 2005 679 687
    • (2005) Biochem. Biophys. Res. Commun. , vol.328 , pp. 679-687
    • Yoneda, T.1    Hiraga, T.2
  • 98
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • G.R. Mundy Metastasis to bone: causes, consequences and therapeutic opportunities Nat. Rev. Cancer 2 2002 584 593
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 99
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • G.D. Roodman Mechanisms of bone metastasis N. Engl. J. Med. 350 2004 1655 1664
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1655-1664
    • Roodman, G.D.1
  • 101
    • 0036200116 scopus 로고    scopus 로고
    • Immunohistochemical study of receptor activator of nuclear factor κ B ligand (RANK L) in human osteolytic bone tumors
    • C.R. Good, R.J. O'Keefe, J.E. Puzas, E.M. Schwarz, and R.N. Rosier Immunohistochemical study of receptor activator of nuclear factor κ B ligand (RANK L) in human osteolytic bone tumors J. Surg. Oncol. 79 2002 174 179
    • (2002) J. Surg. Oncol. , vol.79 , pp. 174-179
    • Good, C.R.1    O'Keefe, R.J.2    Puzas, J.E.3    Schwarz, E.M.4    Rosier, R.N.5
  • 102
    • 0142182080 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor κb ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis
    • E. Grimaud, and et al. Receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis Am. J. Pathol. 163 2003 2021 2031
    • (2003) Am. J. Pathol. , vol.163 , pp. 2021-2031
    • Grimaud, E.1
  • 103
    • 0036845366 scopus 로고    scopus 로고
    • Tumour cells produce receptor activator of NF κb ligand (RANKL) in skeletal metastases
    • L. Huang, Y.Y. Cheng, L.T. Chow, M.H. Zheng, and S.M. Kumta Tumour cells produce receptor activator of NF κB ligand (RANKL) in skeletal metastases J. Clin. Pathol. 55 2002 877 878
    • (2002) J. Clin. Pathol. , vol.55 , pp. 877-878
    • Huang, L.1    Cheng, Y.Y.2    Chow, L.T.3    Zheng, M.H.4    Kumta, S.M.5
  • 104
    • 0036773564 scopus 로고    scopus 로고
    • RANK ligand is a prerequisite for cancer-associated osteolytic lesions
    • S. Kitazawa, and R. Kitazawa RANK ligand is a prerequisite for cancer-associated osteolytic lesions J. Pathol. 198 2002 228 236
    • (2002) J. Pathol. , vol.198 , pp. 228-236
    • Kitazawa, S.1    Kitazawa, R.2
  • 105
    • 0038485707 scopus 로고    scopus 로고
    • Role of RANKL-induced osteoclast formation and MMPdependent matrix degradation in bone destruction by breast cancer metastasis
    • T. Ohshiba, C. Miyaura, M. Inada, and A. Ito Role of RANKL-induced osteoclast formation and MMPdependent matrix degradation in bone destruction by breast cancer metastasis Br. J. Cancer 88 2003 1318 1326
    • (2003) Br. J. Cancer , vol.88 , pp. 1318-1326
    • Ohshiba, T.1    Miyaura, C.2    Inada, M.3    Ito, A.4
  • 106
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • R.N. Pearse, and et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression Proc. Natl Acad. Sci. U. S. A. 98 2001 11581 11586
    • (2001) Proc. Natl Acad. Sci. U. S. A. , vol.98 , pp. 11581-11586
    • Pearse, R.N.1
  • 107
    • 34848827653 scopus 로고    scopus 로고
    • EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: Implications for osteolytic bone metastases
    • J. Zhu, and et al. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases J. Biol. Chem. 282 2007 26656 26664
    • (2007) J. Biol. Chem. , vol.282 , pp. 26656-26664
    • Zhu, J.1
  • 108
    • 42049110350 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor κb ligand and osteoprotegerin regulation of bone remodeling in health and disease
    • A.E. Kearns, S. Khosla, and P.J. Kostenuik Receptor activator of nuclear factor κB ligand and osteoprotegerin regulation of bone remodeling in health and disease Endocr. Rev. 29 2008 155 192
    • (2008) Endocr. Rev. , vol.29 , pp. 155-192
    • Kearns, A.E.1    Khosla, S.2    Kostenuik, P.J.3
  • 109
    • 41149094679 scopus 로고    scopus 로고
    • Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis
    • J. Canon, and et al. Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis Clin. Exp. Metastasis 25 2008 119 129
    • (2008) Clin. Exp. Metastasis , vol.25 , pp. 119-129
    • Canon, J.1
  • 110
    • 35148814409 scopus 로고    scopus 로고
    • Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone
    • Y. Zheng, and et al. Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone Cancer Res. 67 2007 9542 9548
    • (2007) Cancer Res. , vol.67 , pp. 9542-9548
    • Zheng, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.