메뉴 건너뛰기




Volumn 45, Issue 4, 2009, Pages 677-681

Orchiectomy upregulates free soluble RANKL in bone marrow of aged rats

Author keywords

Bone turnover; Male osteoporosis; Orchiectomy; RANKL; Testosterone

Indexed keywords

ADAM PROTEIN; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR;

EID: 68849123934     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.05.024     Document Type: Article
Times cited : (43)

References (36)
  • 2
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • Riggs B.L., Khosla S., and Melton III L.J. Sex steroids and the construction and conservation of the adult skeleton. Endocr. Rev. 23 (2002) 279-302
    • (2002) Endocr. Rev. , vol.23 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 3
    • 0026742706 scopus 로고
    • Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study
    • Devogelaer J.P., De Cooman S., and Nagant de Deuxchaisnes C. Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study. Maturitas 15 (1992) 17-23
    • (1992) Maturitas , vol.15 , pp. 17-23
    • Devogelaer, J.P.1    De Cooman, S.2    Nagant de Deuxchaisnes, C.3
  • 5
    • 0024424879 scopus 로고
    • Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling
    • Stepan J.J., Lachman M., Zverina J., Pacovsky V., and Baylink D.J. Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling. J. Clin. Endocrinol. Metab. 69 (1989) 523-527
    • (1989) J. Clin. Endocrinol. Metab. , vol.69 , pp. 523-527
    • Stepan, J.J.1    Lachman, M.2    Zverina, J.3    Pacovsky, V.4    Baylink, D.J.5
  • 6
    • 0031012642 scopus 로고    scopus 로고
    • Osteoporosis after orchiectomy for prostate cancer
    • Daniell H.W. Osteoporosis after orchiectomy for prostate cancer. J. Urol. 157 (1997) 439-444
    • (1997) J. Urol. , vol.157 , pp. 439-444
    • Daniell, H.W.1
  • 7
    • 0030802506 scopus 로고    scopus 로고
    • The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage
    • Weinstein R.S., Jilka R.L., Parfitt A.M., and Manolagas S.C. The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. Endocrinology 138 (1997) 4013-4021
    • (1997) Endocrinology , vol.138 , pp. 4013-4021
    • Weinstein, R.S.1    Jilka, R.L.2    Parfitt, A.M.3    Manolagas, S.C.4
  • 8
    • 0026750195 scopus 로고
    • Bone and mineral metabolism in aged male rats: short and long term effects of androgen deficiency
    • Vanderschueren D., Van Herck E., Suiker A.M., Visser W.J., Schot L.P., and Bouillon R. Bone and mineral metabolism in aged male rats: short and long term effects of androgen deficiency. Endocrinology 130 (1992) 2906-2916
    • (1992) Endocrinology , vol.130 , pp. 2906-2916
    • Vanderschueren, D.1    Van Herck, E.2    Suiker, A.M.3    Visser, W.J.4    Schot, L.P.5    Bouillon, R.6
  • 9
    • 0034088513 scopus 로고    scopus 로고
    • Androgen deficiency induces high turnover osteopenia in aged male rats: a sequential histomorphometric study
    • Erben R.G., Eberle J., Stahr K., and Goldberg M. Androgen deficiency induces high turnover osteopenia in aged male rats: a sequential histomorphometric study. J. Bone Miner. Res. 15 (2000) 1085-1098
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 1085-1098
    • Erben, R.G.1    Eberle, J.2    Stahr, K.3    Goldberg, M.4
  • 10
    • 0032531859 scopus 로고    scopus 로고
    • The effect of combined androgen blockade on bone turnover and bone mineral densities in men treated for prostate carcinoma-longitudinal evaluation and response to intermittent cyclic etidronate therapy
    • Diamond T., Campbell J., Bryant C., and Lynch W. The effect of combined androgen blockade on bone turnover and bone mineral densities in men treated for prostate carcinoma-longitudinal evaluation and response to intermittent cyclic etidronate therapy. Cancer 83 (1998) 1561-1566
    • (1998) Cancer , vol.83 , pp. 1561-1566
    • Diamond, T.1    Campbell, J.2    Bryant, C.3    Lynch, W.4
  • 11
    • 42449108658 scopus 로고    scopus 로고
    • Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling
    • Reim N.S., Breig B., Stahr K., Eberle J., Hoeflich A., Wolf E., et al. Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling. J. Bone Miner. Res. 23 (2008) 694-704
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 694-704
    • Reim, N.S.1    Breig, B.2    Stahr, K.3    Eberle, J.4    Hoeflich, A.5    Wolf, E.6
  • 12
    • 0031683631 scopus 로고    scopus 로고
    • Action of androgens versus estrogens in male skeletal homeostasis
    • Vanderschueren D., Boonen S., and Bouillon R. Action of androgens versus estrogens in male skeletal homeostasis. Bone 23 (1998) 391-394
    • (1998) Bone , vol.23 , pp. 391-394
    • Vanderschueren, D.1    Boonen, S.2    Bouillon, R.3
  • 13
    • 0034521393 scopus 로고    scopus 로고
    • Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
    • Falahati-Nini A., Riggs B.L., Atkinson E.J., O'Fallon W.M., Eastell R., and Khosla S. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J. Clin. Invest. 106 (2000) 1553-1560
    • (2000) J. Clin. Invest. , vol.106 , pp. 1553-1560
    • Falahati-Nini, A.1    Riggs, B.L.2    Atkinson, E.J.3    O'Fallon, W.M.4    Eastell, R.5    Khosla, S.6
  • 14
    • 0000176989 scopus 로고    scopus 로고
    • Skeletal effects of androgen withdrawal
    • Erben R.G. Skeletal effects of androgen withdrawal. J. Musculoskel. Neuron. Interact. 1 (2001) 225-233
    • (2001) J. Musculoskel. Neuron. Interact. , vol.1 , pp. 225-233
    • Erben, R.G.1
  • 15
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., Elliott R., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 (1998) 165-176
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3    Kelley, M.J.4    Dunstan, C.R.5    Burgess, T.6    Elliott, R.7
  • 16
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397 (1999) 315-323
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3    Tan, H.L.4    Timms, E.5    Capparelli, C.6
  • 17
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    • Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Lüthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89 (1997) 309-319
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3    Kelley, M.4    Chang, M.S.5    Lüthy, R.6
  • 18
    • 32544434560 scopus 로고    scopus 로고
    • Role of RANK ligand in normal and pathologic bone remodeling and the therapeutic potential of novel inhibitory molecules in musculoskeletal diseases
    • Cohen S. Role of RANK ligand in normal and pathologic bone remodeling and the therapeutic potential of novel inhibitory molecules in musculoskeletal diseases. Arthritis Rheum. 55 (2006) 15-18
    • (2006) Arthritis Rheum. , vol.55 , pp. 15-18
    • Cohen, S.1
  • 19
    • 3242781731 scopus 로고    scopus 로고
    • Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
    • Hofbauer L.C., and Schoppet M. Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA 292 (2004) 490-495
    • (2004) JAMA , vol.292 , pp. 490-495
    • Hofbauer, L.C.1    Schoppet, M.2
  • 20
    • 34250008136 scopus 로고    scopus 로고
    • Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway
    • Franklin M., Bu S.Y., Lerner M.R., Lancaster E.A., Bellmer D., Marlow D., et al. Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway. Bone 39 (2006) 1331-1342
    • (2006) Bone , vol.39 , pp. 1331-1342
    • Franklin, M.1    Bu, S.Y.2    Lerner, M.R.3    Lancaster, E.A.4    Bellmer, D.5    Marlow, D.6
  • 22
    • 0035660587 scopus 로고    scopus 로고
    • Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG/RANKL (osteoprotegerin/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male mice
    • Lindberg M.K., Erlandsson M., Alatalo S.L., Windahl S., Andersson G., Halleen J.M., et al. Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG/RANKL (osteoprotegerin/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male mice. J. Endocrinol. 171 (2001) 425-433
    • (2001) J. Endocrinol. , vol.171 , pp. 425-433
    • Lindberg, M.K.1    Erlandsson, M.2    Alatalo, S.L.3    Windahl, S.4    Andersson, G.5    Halleen, J.M.6
  • 25
    • 33845994375 scopus 로고    scopus 로고
    • Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand
    • Hikita A., Yana I., Wakeyama H., Nakamura M., Kadono Y., Oshima Y., et al. Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand. J. Biol. Chem. 281 (2006) 36846-36855
    • (2006) J. Biol. Chem. , vol.281 , pp. 36846-36855
    • Hikita, A.1    Yana, I.2    Wakeyama, H.3    Nakamura, M.4    Kadono, Y.5    Oshima, Y.6
  • 26
    • 33845940032 scopus 로고    scopus 로고
    • Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts
    • Nakamichi Y., Udagawa N., Kobayashi Y., Nakamura M., Yamamoto Y., Yamashita T., et al. Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J. Immunol. 178 (2007) 192-200
    • (2007) J. Immunol. , vol.178 , pp. 192-200
    • Nakamichi, Y.1    Udagawa, N.2    Kobayashi, Y.3    Nakamura, M.4    Yamamoto, Y.5    Yamashita, T.6
  • 27
    • 0001931284 scopus 로고
    • Preparation of calcified tissues for light microscopy
    • Dickson G.R. (Ed), Elsevier, Amsterdam
    • Schenk R.K., Olah A.J., and Herrmann W. Preparation of calcified tissues for light microscopy. In: Dickson G.R. (Ed). Methods of calcified tissue preparation (1984), Elsevier, Amsterdam 1-56
    • (1984) Methods of calcified tissue preparation , pp. 1-56
    • Schenk, R.K.1    Olah, A.J.2    Herrmann, W.3
  • 29
    • 0023488581 scopus 로고
    • Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2 (1987) 595-610
    • (1987) J. Bone Miner. Res. , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3    Kanis, J.A.4    Malluche, H.5    Meunier, P.J.6
  • 30
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29 (2001) e45
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 32
    • 50249095608 scopus 로고    scopus 로고
    • Inhibition of osteoblastic metalloproteinases in mice prevents bone loss induced by oestrogen deficiency
    • Schiltz C., Marty C., de Vernejoul M.C., and Geoffroy V. Inhibition of osteoblastic metalloproteinases in mice prevents bone loss induced by oestrogen deficiency. J. Cell. Biochem. 104 (2008) 1803-1817
    • (2008) J. Cell. Biochem. , vol.104 , pp. 1803-1817
    • Schiltz, C.1    Marty, C.2    de Vernejoul, M.C.3    Geoffroy, V.4
  • 33
    • 31544474860 scopus 로고    scopus 로고
    • Estrogen and androgen play distinct roles in bone turnover in male mice before and after reaching sexual maturity
    • Matsumoto C., Inada M., Toda K., and Miyaura C. Estrogen and androgen play distinct roles in bone turnover in male mice before and after reaching sexual maturity. Bone 38 (2006) 220-226
    • (2006) Bone , vol.38 , pp. 220-226
    • Matsumoto, C.1    Inada, M.2    Toda, K.3    Miyaura, C.4
  • 34
    • 0029791716 scopus 로고    scopus 로고
    • Aromatization of androgens is important for skeletal maintenance of aged male rats
    • Vanderschueren D., Van Herck E., De Coster R., and Bouillon R. Aromatization of androgens is important for skeletal maintenance of aged male rats. Calcif. Tissue Int. 59 (1996) 179-183
    • (1996) Calcif. Tissue Int. , vol.59 , pp. 179-183
    • Vanderschueren, D.1    Van Herck, E.2    De Coster, R.3    Bouillon, R.4
  • 35
    • 0035923727 scopus 로고    scopus 로고
    • Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo
    • Roggia C., Gao Y., Cenci S., Weitzmann M.N., Toraldo G., Isaia G., and Pacifici R. Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 13960-13965
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 13960-13965
    • Roggia, C.1    Gao, Y.2    Cenci, S.3    Weitzmann, M.N.4    Toraldo, G.5    Isaia, G.6    Pacifici, R.7
  • 36
    • 0034836658 scopus 로고    scopus 로고
    • B lymphopoiesis is upregulated after orchiectomy and is correlated with estradiol but not testosterone serum levels in aged male rats
    • Erben R.G., Eberle J., and Stangassinger M. B lymphopoiesis is upregulated after orchiectomy and is correlated with estradiol but not testosterone serum levels in aged male rats. Horm. Metab. Res. 33 (2001) 491-498
    • (2001) Horm. Metab. Res. , vol.33 , pp. 491-498
    • Erben, R.G.1    Eberle, J.2    Stangassinger, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.