Increased RANKL/OPG mRNA ratio in iliac bone biopsies from women with hip fractures

Calcified Tissue International

Volumn 76, Issue 2, 2005, Pages 90-97

  Abdallah, Basem M ^a   Stilgren, Lis S ^a   Nissen, Nis ^a   Kassem, Moustapha ^a   Jørgensen, Hans R I ^a   Abrahamsen, Bo ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Bone biopsy; Cytokines; Osteoporosis; Osteoprotegerin; PCR analysis

Indexed keywords

BETA ACTIN; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 7; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER; CARRIER PROTEIN; MEMBRANE PROTEIN; PRIMER DNA; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TNFRSF11A PROTEIN, HUMAN; TNFSF11 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BONE BIOPSY; BONE DENSITY; BONE MINERAL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE PREDISPOSITION; FEMALE; GENE EXPRESSION; HIP FRACTURE; HUMAN; HUMAN TISSUE; ILIAC BONE; LOGISTIC REGRESSION ANALYSIS; OSTEOLYSIS; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SCORING SYSTEM; BIOPSY; CHEMISTRY; GENETICS; METABOLISM; MIDDLE AGED; RADIODENSITOMETRY;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BIOPSY; BONE DENSITY; CARRIER PROTEINS; CYTOKINES; DENSITOMETRY, X-RAY; DNA PRIMERS; FEMALE; GENE EXPRESSION; HIP FRACTURES; HUMANS; ILIUM; INTERLEUKIN-6; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 18444365892     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-004-0074-4     Document Type: Article

References (40)

1. K Fuller B Wong S Fox Y Choi TJ Chambers 1998 TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts J Exp Med 188 997 1001
2. DL Lacey E Timms HL Tan MJ Kelley CR Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli YX Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney WJ Boyle 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 93 165 176
3. H Yasuda N Shima N Nakagawa K Yamaguchi M Kinosaki S Mochizuki A Tomoyasu K Yano M Goto A Murakami E Tsuda T Morinaga K Higashio N Udagawa N Takahashi T Suda 1998 Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inbibitory factor and is identical to TRANCE/RANKL Proc Natl Acad Sci USA 95 3597 3602
4. T Akatsu T Murakami M Nishikawa K Ono N Shinomiya E Tsuda S Mochizuki K Yamaguchi M Kinosaki K Higashio M Yamamoto K Motoyoshi N Nagata 1998 Osteoclastogenesis inhibitory factor suppresses osteoclast survival by interfering in the interaction of stromal cells with osteoclast Biochem Biophys Res Commun, 250 229 234
5. G Eghbali-Fatourechi S Khosla A Sanyal WJ Boyle DL Lacey BL Riggs 2003 Role of RANK ligand in mediating increased bone resorption in early postmenopausal women J Clin Invest 111 1221 1230
6. WS Simonet DL Lacey CR Dunstan M Kelley MS Chang R Luthy HQ Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero HL Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg TM Hughes D Hill W Pattison P Campbell WJ Boyle 1997 Osteoprotegerin: a novel secreted protein involved in the regulation of bone density Cell 89 309 319
7. H Yasuda N Shima N Nakagawa SI Mochizuki K Yano N Fujise Y Sato M Goto K Yamaguchi M Kuriyama T Kanno A Murakami E Tsuda T Morinaga K Higashio 1998 Identity of Osteoclastogenesis inhibitory factor (OCIF) and Osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits Osteoclastogenesis in vitro Endocrinology 139 1329 1337
8. PJ Bekker D Holloway A Nakanishi M Arrighi PT Leese CR Dunstan 2001 The effect of a single dose of Osteoprotegerin in postmenopausal women J Bone Miner Res 16 348 360
9. A Rogers G Saleh RA Hannon D Greenfield R Eastell 2002 Circulating estradiol and Osteoprotegerin as determinants of bone turnover and bone density in postmenopausal women J Clin Endocrinol Metab 87 4470 4475
10. WS Browner LY Lui SR Cummings 2001 Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women J Clin Endocrinol Metab 86 63l 637
11. K Tsukii N Shima S Mochizuki K Yamaguchi M Kinosaki K Yano O Shibata N Udagawa H Yasuda T Suda K Higashio 1998 Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha, 25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone Biochem Biophys Res Commun 246 337 341
12. H Brandstrom KB Jonsson O Vidal S Ljunghall C Ohlsson O Ljunggren 1998 Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcomaMG-63 cells Biochem Biophys Res Commun 248 454 457
13. ON Vidal K Sjogren BI Eriksson O Ljunggren C Ohlsson 1998 Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells Biochem Biophys Res Commun 248 696 700
14. T Murakami M Yamamoto K Ono M Nishikawa N Nagata K Motoyoshi T Akatsu 1998 Transforming growth factor-betal increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells Biochem Biophys Res Commun 252 747 752
15. MN Weitzmann S Cenci L Rifas C Brown R Pacifici 2000 Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines Blood 96 1873 1878
16. WP Arend 1990 Interleukin-1 receptor antagonist: discovery, structure and properties Prog Growth Factor Res 2 193 205
17. P Bordier H Matrajt L Miravet D Hioco 1964 Mesure histologique de la masse et de la résorption des travées osseuses Pathol Microbiol 12 1238 1243
18. M Sowers 2001 Epidemiology of risk factors for osteoarthritis: systemic factors Curr Opin Rheumatol 13 447 451
19. L Sharma 2001 Local factors in osteoarthritis Curr Opin Rheumatol 13 441 446
20. T Tamura N Udagawa N Takahashi C Miyaura S Tanaka Y Yamada Y Koishihara Y Ohsugi K Kumaki T Taga 1993 Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6 Proc Natl Acad Sci USA 90 11924 11928
21. Y Ishimi C Miyaura CH Jin T Akatsu E Abe Y Nakamura A Yamaguchi S Yoshiki MatsudaT T Hirano 1990 IL-6 is produced by osteoblasts and induces bone resorption J Immunol 145 3297 3303
22. N Takahashi N Udagawa T Suda 1999 A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function Biochem Biophys Res Commun 256 449 455
23. V Poli R Balena E Fattori A Markatos M Yamamoto H Tanaka G Ciliberto GA Rodan F Costantini 1994 Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion EMBO J 13 1189 1196
24. K Balto H Sasaki P Stashenko 2001 Interleukin-6 deficiency increases inflammatory bone destruction Infect Immun 69 744 750
25. P Palmqvist E Persson HH Conaway UH Lerner 2002 IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae J Immunol 169 3353 3362
26. O Kudo A Sabokbar A Pocock I Itonaga Y Fujikawa NA Athanasou 2003 Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism Bone 32 1 7
27. LM Salamone T Whiteside D Friberg RS Epstein LH Kuller JA Cauley 1998 Cytokine production and bone mineral density at the lumbar spine and femoral neck in premenopausal women Calcif Tissue Int. 63 466 470
28. B Abrahamsen LS Stilgren E Rettmer V Bonnevie-Nielsen H Beck-Nielsen 2003 Effects of the natural and artificial menstrual cycle on the production of osteoprotegerin and the bone resorptive cytokines IL-1b and IL-6 Calcif Tissue Int 72 18 23
29. B Abrahamsen V Bonnevie-Nielsen EN Ebbesen J Gram H Beck-Nielsen 2000 Cytokines and bone loss in a 5-year longitudinal study-hormone replacement therapy suppresses serum soluble interleukin-6 receptor and increases interleukin-1-receptor antagonist: the Danish Osteoporosis Prevention Study J Bone Miner.Res 15 1545 1554
30. N Franchimont V Gangji D Durant E Canalis 1997 Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts Endocrinology 138 5248 5255
31. W Huang MH Drissi RJ O'Keefe EM Schwarz 2003 A rapid multiparameter Approach to Study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-Mediated osteoclastogenesis Calcif tissue Int 73 584 593
32. G Toraldo C Roggia WP Qian R Pacifici MN Weitzmann 2003 IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells Proc Natl Acad Sci USA 100 125 130
33. D Marshall O Johnell H Wedel 1996 Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures BMJ 312 1254 1259
34. BL Langdahl M Carstens L Stenkjaer EF Eriksen 2002 Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures J Bone Miner Res 17 1245 1255
35. DJ Hart I Mootoosamy DV Doyle TD Spector 1994 The relationship between osteoarthritis and osteopprosis in the general population: the Chingford Study Ann Rheum Dis 53 158 162
36. J Glowacki S Hurwitz TS Thomhill M Kelly MS Leboff 2003 Osteoporosis and vitamin-D deficiency among postmenopausal women with osteoarthritis undergoing total hip arthroplasty J Bone Joint Surg Am 85 2371 2377
37. NL Fazzalari JS Kuliwaba GJ Atkins MR Forwood DM Findlay 2001 The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis J Bone Miner Res 16 1015 1027
38. LC Hofbauer F Gori BL Riggs DL Lacey CR Dunstan TC Spelsberg S Khosla 1999 Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis Endocrinology 140 4382 4389
39. S Khosla HM Arrighi LJ Melton III EJ Atkinson WM O'Fallon C Dunstan BL Riggs 2002 Correlates of osteoprotegerin levels in women and men Osteoporos Int 13 394 399
40. PR Odgren N Kim CA Mackay A Mason-Savas Y Choi SC Marks Jr 2003 The role of RANKL (TRANCE/TNFSF11), a tumor necrosis factor family member, in skeletal development: effects of gene knockout and transgenic rescue Connect Tissue Res 44 Suppl 1 264 71