메뉴 건너뛰기




Volumn 45, Issue 4, 2009, Pages 669-676

Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin

Author keywords

Androgen ablation; Micro CT; OPG; Orchiectomy; RANKL

Indexed keywords

HUMAN OSTEOPROTEGERIN FC; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 68849132198     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.06.011     Document Type: Article
Times cited : (65)

References (57)
  • 2
    • 11844252588 scopus 로고    scopus 로고
    • Risk of fracture after androgen deprivation for prostate cancer
    • Shahinian V.B., Kuo Y.F., Freeman J.L., and Goodwin J.S. Risk of fracture after androgen deprivation for prostate cancer. N. Engl. J. Med. 352 (2005) 154-164
    • (2005) N. Engl. J. Med. , vol.352 , pp. 154-164
    • Shahinian, V.B.1    Kuo, Y.F.2    Freeman, J.L.3    Goodwin, J.S.4
  • 4
    • 0024404114 scopus 로고
    • Differential effects of gonadal function on bone histomorphometry in male and female rats
    • Turner R.T., Hannon K.S., Demers L.M., Buchanan J., and Bell N.H. Differential effects of gonadal function on bone histomorphometry in male and female rats. J. Bone Miner. Res. 4 (1989) 557-563
    • (1989) J. Bone Miner. Res. , vol.4 , pp. 557-563
    • Turner, R.T.1    Hannon, K.S.2    Demers, L.M.3    Buchanan, J.4    Bell, N.H.5
  • 5
    • 0025457129 scopus 로고
    • Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats
    • Turner R.T., Wakley G.K., and Hannon K.S. Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats. J. Orthop. Res. 8 (1990) 612-617
    • (1990) J. Orthop. Res. , vol.8 , pp. 612-617
    • Turner, R.T.1    Wakley, G.K.2    Hannon, K.S.3
  • 6
    • 0034088513 scopus 로고    scopus 로고
    • Androgen deficiency induced high turnover osteopenia in aged male rats: a sequential histomorphometric study
    • Erben R.G., Eberle J., Stahr K., and Goldberg M. Androgen deficiency induced high turnover osteopenia in aged male rats: a sequential histomorphometric study. J. Bone Miner. Res. 15 (2000) 1085-1098
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 1085-1098
    • Erben, R.G.1    Eberle, J.2    Stahr, K.3    Goldberg, M.4
  • 7
    • 0034765125 scopus 로고    scopus 로고
    • Bone microarchitecture and bone fragility in men: DXA and histomorphometry in humans and in the orchidectomized rat model
    • Audran M., Chappard C., Legrand E., Libouban H., and Basle M.F. Bone microarchitecture and bone fragility in men: DXA and histomorphometry in humans and in the orchidectomized rat model. Calcif. Tissue Int. 69 (2001) 214-217
    • (2001) Calcif. Tissue Int. , vol.69 , pp. 214-217
    • Audran, M.1    Chappard, C.2    Legrand, E.3    Libouban, H.4    Basle, M.F.5
  • 8
    • 0028853770 scopus 로고
    • Early induction of alterations in cancellous and cortical bone histology after orchiectomy in mature rats
    • Gunness M., and Orwoll E. Early induction of alterations in cancellous and cortical bone histology after orchiectomy in mature rats. J. Bone Miner. Res. 10 (1995) 1735-1744
    • (1995) J. Bone Miner. Res. , vol.10 , pp. 1735-1744
    • Gunness, M.1    Orwoll, E.2
  • 10
    • 0036829959 scopus 로고    scopus 로고
    • Evidence from the aged orchidectomized male rat model that 17b-estradiol is a more effective bone-sparing and anabolic agent than 5a-dihydroxytestosterone
    • Vandenput L., Boonen S., van Herck E., Swinnen J.V., Bouillon R., and Vanderschueren D. Evidence from the aged orchidectomized male rat model that 17b-estradiol is a more effective bone-sparing and anabolic agent than 5a-dihydroxytestosterone. J. Bone Miner. Res. 17 (2002) 2080-2086
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 2080-2086
    • Vandenput, L.1    Boonen, S.2    van Herck, E.3    Swinnen, J.V.4    Bouillon, R.5    Vanderschueren, D.6
  • 11
    • 0034455308 scopus 로고    scopus 로고
    • An aged rat model of partial androgen deficiency: prevention of both loss of bone and lean body mass by low-dose androgen replacement
    • Vanderschueren D., Vandenput L., Boonen S., van Herck E., Swinnen J.V., and Bouillon R. An aged rat model of partial androgen deficiency: prevention of both loss of bone and lean body mass by low-dose androgen replacement. Endocrinology 141 (2000) 1642-1647
    • (2000) Endocrinology , vol.141 , pp. 1642-1647
    • Vanderschueren, D.1    Vandenput, L.2    Boonen, S.3    van Herck, E.4    Swinnen, J.V.5    Bouillon, R.6
  • 12
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C., Burgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 (1998) 165-176
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3    Kelley, M.J.4    Dunstan, C.5    Burgess, T.6
  • 13
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    • Simonet W.S., Lacey D.L., Dunstan C., Kelly M., Chang M.S., Luthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89 (1997) 309-319
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.3    Kelly, M.4    Chang, M.S.5    Luthy, R.6
  • 14
    • 0033519221 scopus 로고    scopus 로고
    • The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
    • Burgess T., Qian Y.X., Kaufman S., Ring B.D., Van G., Capparelli C., et al. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J. Cell Biol. 145 (1999) 527-538
    • (1999) J. Cell Biol. , vol.145 , pp. 527-538
    • Burgess, T.1    Qian, Y.X.2    Kaufman, S.3    Ring, B.D.4    Van, G.5    Capparelli, C.6
  • 15
    • 0033888977 scopus 로고    scopus 로고
    • Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo
    • Lacey D.L., Tan H.L., Lu J., Kaufman S., Van G., Qiu W., et al. Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am. J. Pathol. 157 (2000) 435-448
    • (2000) Am. J. Pathol. , vol.157 , pp. 435-448
    • Lacey, D.L.1    Tan, H.L.2    Lu, J.3    Kaufman, S.4    Van, G.5    Qiu, W.6
  • 16
    • 0142182080 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis
    • Grimaud E., Soubigou L., Couillaud S., Coipeau P., Moreau A., Passuti N., et al. Receptor activator of nuclear factor kB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis. Am. J. Pathol. 163 (2003) 2021-2031
    • (2003) Am. J. Pathol. , vol.163 , pp. 2021-2031
    • Grimaud, E.1    Soubigou, L.2    Couillaud, S.3    Coipeau, P.4    Moreau, A.5    Passuti, N.6
  • 17
    • 0034864155 scopus 로고    scopus 로고
    • Androgens suppress osteoclast formation induced by RANKL and macrophage colony-stimulating factor
    • Huber D.M., Bendixen A.C., Pathrose P., Srivastava S., Dienger K.M., Shevde N.K., et al. Androgens suppress osteoclast formation induced by RANKL and macrophage colony-stimulating factor. Endocrinology 142 (2001) 3800-3808
    • (2001) Endocrinology , vol.142 , pp. 3800-3808
    • Huber, D.M.1    Bendixen, A.C.2    Pathrose, P.3    Srivastava, S.4    Dienger, K.M.5    Shevde, N.K.6
  • 18
    • 27744431505 scopus 로고    scopus 로고
    • Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption
    • Michael H., and Harkonen P.L. Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption. J. Bone Miner. Res. 20 (2005) 2224-2232
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 2224-2232
    • Michael, H.1    Harkonen, P.L.2
  • 19
    • 0032854699 scopus 로고    scopus 로고
    • Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor
    • Udagawa N., Takahashi N., Jimi E., Matsuzaki K., Tsurakai T., Itoh K., et al. Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor. Bone 25 (1999) 517-523
    • (1999) Bone , vol.25 , pp. 517-523
    • Udagawa, N.1    Takahashi, N.2    Jimi, E.3    Matsuzaki, K.4    Tsurakai, T.5    Itoh, K.6
  • 20
    • 17744388339 scopus 로고    scopus 로고
    • Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function
    • Udagawa N., Takahashi N., Yasuda H., Mizuno A., Itoh K., Ueno Y., et al. Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology 141 (2000) 3478-3484
    • (2000) Endocrinology , vol.141 , pp. 3478-3484
    • Udagawa, N.1    Takahashi, N.2    Yasuda, H.3    Mizuno, A.4    Itoh, K.5    Ueno, Y.6
  • 21
    • 8444253709 scopus 로고    scopus 로고
    • Testosterone increases osteoprotegerin mRNA expression in mouse osteoblast cells
    • Chen Q., Kaji H., Kanatani M., Sugimoto T., and Chihara K. Testosterone increases osteoprotegerin mRNA expression in mouse osteoblast cells. Horm. Metab. Res. 36 (2004) 674-678
    • (2004) Horm. Metab. Res. , vol.36 , pp. 674-678
    • Chen, Q.1    Kaji, H.2    Kanatani, M.3    Sugimoto, T.4    Chihara, K.5
  • 23
    • 34250008136 scopus 로고    scopus 로고
    • Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway
    • Franklin M., Bu S.Y., Lerner M.R., Lancaster E.A., Bellmer D., Marlow D., et al. Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway. Bone 39 (2006) 1331-1342
    • (2006) Bone , vol.39 , pp. 1331-1342
    • Franklin, M.1    Bu, S.Y.2    Lerner, M.R.3    Lancaster, E.A.4    Bellmer, D.5    Marlow, D.6
  • 24
    • 0037214288 scopus 로고    scopus 로고
    • The structural and hormonal basis of sex differences in peak appendicular bone strength in rats
    • Kim B.T., Mosekilde L., Duan Y., Zhang X.Z., Tornvig L., Thomsen J.S., et al. The structural and hormonal basis of sex differences in peak appendicular bone strength in rats. J. Bone. Miner. Res. 18 (2003) 150-155
    • (2003) J. Bone. Miner. Res. , vol.18 , pp. 150-155
    • Kim, B.T.1    Mosekilde, L.2    Duan, Y.3    Zhang, X.Z.4    Tornvig, L.5    Thomsen, J.S.6
  • 25
    • 0032934097 scopus 로고    scopus 로고
    • Effects of growth hormone and testosterone on cortical bone formation and bone density in aged orchiectomized rats
    • Prakasam G., Yeh J.K., Chen M.M., Castro-Magana M., Liang C.T., and Alioa J.F. Effects of growth hormone and testosterone on cortical bone formation and bone density in aged orchiectomized rats. Bone 24 (1999) 491-497
    • (1999) Bone , vol.24 , pp. 491-497
    • Prakasam, G.1    Yeh, J.K.2    Chen, M.M.3    Castro-Magana, M.4    Liang, C.T.5    Alioa, J.F.6
  • 26
    • 0037215419 scopus 로고    scopus 로고
    • A novel immunoassay for the determination of tartrate-resistant acid phosphatase 5b from rat serum
    • Alatalo S.L., Peng Z., Janckila A.J., Kaija H., Vihko P., Vaananen H.K., et al. A novel immunoassay for the determination of tartrate-resistant acid phosphatase 5b from rat serum. J. Bone Miner. Res. 18 (2003) 134-139
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 134-139
    • Alatalo, S.L.1    Peng, Z.2    Janckila, A.J.3    Kaija, H.4    Vihko, P.5    Vaananen, H.K.6
  • 27
    • 0030958817 scopus 로고    scopus 로고
    • Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats
    • Vanderschueren D., van Herck E., Nijs J., Ederveen A., De Coster R., and Bouillon R. Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats. Endocrinology 138 (1997) 2301-2307
    • (1997) Endocrinology , vol.138 , pp. 2301-2307
    • Vanderschueren, D.1    van Herck, E.2    Nijs, J.3    Ederveen, A.4    De Coster, R.5    Bouillon, R.6
  • 28
    • 33845934478 scopus 로고    scopus 로고
    • Co-treatment of PTH with osteoprotegerin or alendronate increases its anabolic effect on the skeleton of oophorectomized mice
    • Samadfam R., Xia Q., and Goltzman D. Co-treatment of PTH with osteoprotegerin or alendronate increases its anabolic effect on the skeleton of oophorectomized mice. J. Bone Miner. Res. 22 (2007) 55-63
    • (2007) J. Bone Miner. Res. , vol.22 , pp. 55-63
    • Samadfam, R.1    Xia, Q.2    Goltzman, D.3
  • 29
    • 42449146580 scopus 로고    scopus 로고
    • RANKL inhibition with osteoprotegerin (OPG) increases bone strength by improving cortical and trabecular bone architecture in ovariectomized rats
    • Ominsky M.S., Li X., Asuncion F., Barrero M., Warmington K., Dwyer D., et al. RANKL inhibition with osteoprotegerin (OPG) increases bone strength by improving cortical and trabecular bone architecture in ovariectomized rats. J. Bone Miner. Res. 23 (2008) 672-682
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 672-682
    • Ominsky, M.S.1    Li, X.2    Asuncion, F.3    Barrero, M.4    Warmington, K.5    Dwyer, D.6
  • 31
    • 0036020416 scopus 로고    scopus 로고
    • Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone
    • Qiu S., Rao D.S., Palnitkar S., and Parfitt A.M. Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone. Bone 31 (2002) 313-318
    • (2002) Bone , vol.31 , pp. 313-318
    • Qiu, S.1    Rao, D.S.2    Palnitkar, S.3    Parfitt, A.M.4
  • 32
    • 0344874544 scopus 로고    scopus 로고
    • Increased risk of falls and increased bone resorption in elderly men with partial androgen deficiency: the MINOS study
    • Szulc P., Claustrat B., Marchand F., and Delmas P.D. Increased risk of falls and increased bone resorption in elderly men with partial androgen deficiency: the MINOS study. J. Clin. Endorinol. Metab. 88 (2003) 5240-5247
    • (2003) J. Clin. Endorinol. Metab. , vol.88 , pp. 5240-5247
    • Szulc, P.1    Claustrat, B.2    Marchand, F.3    Delmas, P.D.4
  • 33
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis
    • Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis. Nature 397 (1999) 315-323
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3    Tan, H.L.4    Timms, E.5    Capparelli, C.6
  • 34
    • 0034319084 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits tumor-induced osteoclastogenesis and bone tumor growth in osteopetrotic mice
    • Clohisy D.R., Ramnaraine M.L., Scully S., Qi M., Van G., Tan H.L., et al. Osteoprotegerin inhibits tumor-induced osteoclastogenesis and bone tumor growth in osteopetrotic mice. J. Orthop. Res. 18 (2000) 967-976
    • (2000) J. Orthop. Res. , vol.18 , pp. 967-976
    • Clohisy, D.R.1    Ramnaraine, M.L.2    Scully, S.3    Qi, M.4    Van, G.5    Tan, H.L.6
  • 35
    • 0035153246 scopus 로고    scopus 로고
    • TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis
    • Pettit A.R., Ji H., von Stechow D., Muller R., Goldring S.R., Choi Y., et al. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am. J. Pathol. 159 (2001) 1689-1699
    • (2001) Am. J. Pathol. , vol.159 , pp. 1689-1699
    • Pettit, A.R.1    Ji, H.2    von Stechow, D.3    Muller, R.4    Goldring, S.R.5    Choi, Y.6
  • 36
    • 24644434101 scopus 로고    scopus 로고
    • RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis
    • Stolina M., Adamu S., Ominsky M.S., Dzamba B.J., Asuncion F., Geng Z., et al. RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis. J. Bone. Miner. Res. 20 (2005) 1756-1765
    • (2005) J. Bone. Miner. Res. , vol.20 , pp. 1756-1765
    • Stolina, M.1    Adamu, S.2    Ominsky, M.S.3    Dzamba, B.J.4    Asuncion, F.5    Geng, Z.6
  • 38
    • 0037302038 scopus 로고    scopus 로고
    • Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice
    • Cao J., Venton L., Sakata T., and Halloran B.P. Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice. J. Bone Miner. Res. 18 (2003) 270-277
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 270-277
    • Cao, J.1    Venton, L.2    Sakata, T.3    Halloran, B.P.4
  • 39
    • 0036679261 scopus 로고    scopus 로고
    • Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells
    • Hofbauer L.C., Hicok K.C., Chen D., and Khosla S. Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells. Eur. J. Endocrinol. 147 (2002) 269-273
    • (2002) Eur. J. Endocrinol. , vol.147 , pp. 269-273
    • Hofbauer, L.C.1    Hicok, K.C.2    Chen, D.3    Khosla, S.4
  • 40
    • 0032949669 scopus 로고    scopus 로고
    • Expression of the vitamin D receptor, of estrogen and thyroid hormone receptor a- and b-isoforms, and of the androgen receptor in cultures of native mouse bone marrow and of stromal/osteoblastic cells
    • Gruber R., Czerwenka K., Wolf F., Ho G.M., Willheim M., and Peterlik M. Expression of the vitamin D receptor, of estrogen and thyroid hormone receptor a- and b-isoforms, and of the androgen receptor in cultures of native mouse bone marrow and of stromal/osteoblastic cells. Bone 24 (1999) 465-473
    • (1999) Bone , vol.24 , pp. 465-473
    • Gruber, R.1    Czerwenka, K.2    Wolf, F.3    Ho, G.M.4    Willheim, M.5    Peterlik, M.6
  • 43
    • 33645329097 scopus 로고    scopus 로고
    • Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model
    • Venken K., DeGendt K.D., Boonen S., Ophoff J., Bouillon R., Swinnen J.V., et al. Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model. J. Bone. Miner. Res. 21 (2006) 576-585
    • (2006) J. Bone. Miner. Res. , vol.21 , pp. 576-585
    • Venken, K.1    DeGendt, K.D.2    Boonen, S.3    Ophoff, J.4    Bouillon, R.5    Swinnen, J.V.6
  • 44
    • 37749029501 scopus 로고    scopus 로고
    • Estradiol rapidly inhibits osteoclastogenesis and RANKL expression in bone marrow cultures in postmenopausal women: a pilot study
    • Taxel P., Kaneko H., Lee S.K., Aguila H.L., Raisz L.G., and Lorenzo J.A. Estradiol rapidly inhibits osteoclastogenesis and RANKL expression in bone marrow cultures in postmenopausal women: a pilot study. Osteoporos. Int. 19 (2008) 193-199
    • (2008) Osteoporos. Int. , vol.19 , pp. 193-199
    • Taxel, P.1    Kaneko, H.2    Lee, S.K.3    Aguila, H.L.4    Raisz, L.G.5    Lorenzo, J.A.6
  • 45
    • 0035054126 scopus 로고    scopus 로고
    • Determination of three isoforms of the receptor activator of nuclear factor-kB ligand and their differential expression in bone and thymus
    • Ikeda T., Kasai M., Utsuyama M., and Hirokawa K. Determination of three isoforms of the receptor activator of nuclear factor-kB ligand and their differential expression in bone and thymus. Endocrinology 142 (2001) 1419-1426
    • (2001) Endocrinology , vol.142 , pp. 1419-1426
    • Ikeda, T.1    Kasai, M.2    Utsuyama, M.3    Hirokawa, K.4
  • 47
    • 25444504798 scopus 로고    scopus 로고
    • Effect of testosterone replacement on trabecular architecture in hypogonadal men
    • Benito M., Vasilic B., Wehrli F.W., Bunker B., Wald M., Gomberg B., et al. Effect of testosterone replacement on trabecular architecture in hypogonadal men. J. Bone Miner. Res. 20 (2005) 1785-1791
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 1785-1791
    • Benito, M.1    Vasilic, B.2    Wehrli, F.W.3    Bunker, B.4    Wald, M.5    Gomberg, B.6
  • 48
    • 0344825808 scopus 로고    scopus 로고
    • Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption
    • Nakamura M., Udagawa N., Matsuura S., Mogi M., Nakamura H., Horiuchi H., et al. Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption. Endocrinology 144 (2003) 5441-5449
    • (2003) Endocrinology , vol.144 , pp. 5441-5449
    • Nakamura, M.1    Udagawa, N.2    Matsuura, S.3    Mogi, M.4    Nakamura, H.5    Horiuchi, H.6
  • 49
    • 42449108658 scopus 로고    scopus 로고
    • Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling
    • Reim N.S., Brieg B., Stahr K., Eberle J., Hoeflich A., Wolf E., et al. Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling. J. Bone Miner. Res. 23 (2008) 694-704
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 694-704
    • Reim, N.S.1    Brieg, B.2    Stahr, K.3    Eberle, J.4    Hoeflich, A.5    Wolf, E.6
  • 50
    • 0142122879 scopus 로고    scopus 로고
    • Sustained antiresorptive effects after a single treatment with human recombinant osteoprotegerin (OPG): a pharmacodynamic and pharmacokinetic analysis in rats
    • Capparelli C., Morony S., Warmington K., Adamu S., Lacey D., Dunstan C.R., et al. Sustained antiresorptive effects after a single treatment with human recombinant osteoprotegerin (OPG): a pharmacodynamic and pharmacokinetic analysis in rats. J. Bone Miner. Res. 18 (2003) 852-858
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 852-858
    • Capparelli, C.1    Morony, S.2    Warmington, K.3    Adamu, S.4    Lacey, D.5    Dunstan, C.R.6
  • 51
    • 0347475787 scopus 로고    scopus 로고
    • Anabolic action of parathyroid hormone on cortical and cancellous bone differs between axial and appendicular skeletal sites in mice
    • Zhou H., Iida-Klein A., Lu S.S., Ducayen-Knowles M., Levine L.R., Dempster D.W., et al. Anabolic action of parathyroid hormone on cortical and cancellous bone differs between axial and appendicular skeletal sites in mice. Bone 32 (2003) 513-520
    • (2003) Bone , vol.32 , pp. 513-520
    • Zhou, H.1    Iida-Klein, A.2    Lu, S.S.3    Ducayen-Knowles, M.4    Levine, L.R.5    Dempster, D.W.6
  • 52
    • 0030939655 scopus 로고    scopus 로고
    • Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro
    • Kasperk C.H., Wakley G.K., Hierl T., and Ziegler R. Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. J. Bone Miner. Res. 12 (1997) 464-471
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 464-471
    • Kasperk, C.H.1    Wakley, G.K.2    Hierl, T.3    Ziegler, R.4
  • 53
    • 37349043960 scopus 로고    scopus 로고
    • Structural and cellular differences between metaphyseal and diaphyseal periosteum in different aged rats
    • Fan W., Crawford R., and Xiao Y. Structural and cellular differences between metaphyseal and diaphyseal periosteum in different aged rats. Bone 42 (2008) 81-89
    • (2008) Bone , vol.42 , pp. 81-89
    • Fan, W.1    Crawford, R.2    Xiao, Y.3
  • 56
    • 27744599521 scopus 로고    scopus 로고
    • Circulating osteoprotegerin ligand and receptor activator for nuclear factor kB ligand: clinical utility in metabolic bone disease assessment
    • Review
    • Review. Rogers A., and Eastell R. Circulating osteoprotegerin ligand and receptor activator for nuclear factor kB ligand: clinical utility in metabolic bone disease assessment. J. Clin. Endorinol. Metab. 90 (2005) 6323-6331
    • (2005) J. Clin. Endorinol. Metab. , vol.90 , pp. 6323-6331
    • Rogers, A.1    Eastell, R.2
  • 57
    • 27744529640 scopus 로고    scopus 로고
    • Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength
    • Kostenuik P.J. Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength. Curr. Opin. Pharmacol. 5 (2005) 618-625
    • (2005) Curr. Opin. Pharmacol. , vol.5 , pp. 618-625
    • Kostenuik, P.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.