Surface charge determines the lung inflammogenicity: A study with polystyrene nanoparticles

Nanotoxicology

Volumn 10, Issue 1, 2016, Pages 94-101

  Kim, Jeongeun ^a   Chankeshwara, Sunay V ^b   Thielbeer, Frank ^b   Jeong, Jiyoung ^a   Donaldson, Ken ^b   Bradley, Mark ^b   Cho, Wan Seob ^a  

^a Dong A University   (South Korea)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Acute lung inflammation; functional group; particle pathogenicity paradigm; pharyngeal aspiration; surface charge paradigm

Indexed keywords

AMPHOLYTE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; FLUORESCENT POLYMERIC NANOPARTICLE; GUANIDINE; INTERLEUKIN 1BETA; NANOPARTICLE; POLYSTYRENE; UNCLASSIFIED DRUG; CYTOKINE; POLYSTYRENE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CARBOXYLATION; FEMALE; HYDRODYNAMICS; HYDROXYLATION; LUNG LAVAGE; NANOTOXICOLOGY; NASOPHARYNGEAL ASPIRATION; NEUTROPHIL; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PNEUMONIA; PRIORITY JOURNAL; RAT; SULFATION; SURFACE CHARGE; SYNTHESIS; ZETA POTENTIAL; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; FLUORESCENCE; METABOLISM; SURFACE PROPERTY; WISTAR RAT;

ANIMALS; CYTOKINES; FEMALE; FLUORESCENCE; NANOPARTICLES; PARTICLE SIZE; PNEUMONIA; POLYSTYRENES; RATS; RATS, WISTAR; SURFACE PROPERTIES;

EID: 84959342277     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2015.1022887     Document Type: Article

References (32)

1. Asati A, Santra S, Kaittanis C, Perez JM. 2010. Surface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticles. ACS Nano 4:5321-31.
2. Brown DM, Kanase N, Gaiser B, Johnston H, Stone V. 2014. Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: effect of size, dispersion medium and particle surface charge. Toxicol Lett 224:147-56.
3. Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K. 2001. Sizedependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol 175:191-9.
4. Cho WS, Duffin R, Poland CA, Howie SE, MacNee W, Bradley M, et al. 2010. Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect 118:1699-706.
5. Cho WS, Duffin R, Thielbeer F, Bradley M, Megson IL, Macnee W, et al. 2012. Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles. Toxicol Sci 126:469-77.
6. Cho WS, Thielbeer F, Duffin R, Johansson EM, Megson IL, MacNee W, et al. 2014. Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles. Nanotoxicology 8:202-11.
7. Chompoosor A, Saha K, Ghosh PS, Macarthy DJ, Miranda OR, Zhu ZJ, et al. 2010. The role of surface functionality on acute cytotoxicity, ROS generation and DNA damage by cationic gold nanoparticles. Small 6: 2246-9.
8. Donaldson K, Poland CA, Schins RP. 2010. Possible genotoxic mechanisms of nanoparticles: criteria for improved test strategies. Nanotoxicology 4:414-20.
9. Donaldson K, Schinwald A, Murphy F, Cho WS, Duffin R, Tran L, et al. 2013. The biologically effective dose in inhalation nanotoxicology. Acc Chem Res 46:723-32.
10. Duffin R, Tran L, Brown D, Stone V, Donaldson K. 2007. Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity. Inhal Toxicol 19:849-56.
11. Goodman CM, McCusker CD, Yilmaz T, Rotello VM. 2004. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug Chem 15:897-900.
12. Gude M, Ryf J, White P. 2002. An accurate method for the quantitation of Fmoc-derivatized solid phase supports. Lett Pept Sci 9:203-6.
13. Kaiser E, Colescott RL, Bossinger CD, Cook PI. 1970. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides. Anal Biochem 34:595-8.
14. Kim JA, Salvati A, Aberg C, Dawson KA. 2014. Suppression of nanoparticle cytotoxicity approaching in vivo serum concentrations: limitations of in vitro testing for nanosafety. Nanoscale 6:14180-4.
15. Li R, Wang X, Ji Z, Sun B, Zhang H, Chang CH, et al. 2013. Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity. ACS Nano 7: 2352-68.
16. Mout R, Moyano DF, Rana S, Rotello VM. 2012. Surface functionalization of nanoparticles for nanomedicine. Chem Soc Rev 41:2539-44.
17. Nagy A, Steinbruck A, Gao J, Doggett N, Hollingsworth JA, Iyer R. 2012. Comprehensive analysis of the effects of CdSe quantum dot size, surface charge, and functionalization on primary human lung cells. ACS Nano 6:4748-62.
18. Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P, et al. 2009. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8:543-57.
19. Oberdorster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, et al. 2000. Acute pulmonary effects of ultrafine particles in rats and mice. Res Rep Health Eff Inst 5-74:disc 75-86.
20. Podila R, Brown JM. 2013. Toxicity of engineered nanomaterials: a physicochemical perspective. J Biochem Mol Toxicol 27:50-5.
21. Poland CA, Byrne F, Cho WS, Prina-Mello A, Murphy FA, Davies GL, et al. 2012. Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity. Nanotoxicology 6:899-911.
22. Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, et al. 2010. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. J Toxicol Environ Health A 73:445-61.
23. Sarlo K, Blackburn KL, Clark ED, Grothaus J, Chaney J, Neu S, et al. 2009. Tissue distribution of 20 nm, 100 nm and 1000 nm fluorescent polystyrene latex nanospheres following acute systemic or acute and repeat airway exposure in the rat. Toxicology 263:117-26.
24. Schinwald A, Murphy FA, Prina-Mello A, Poland CA, Byrne F, Movia D, et al. 2012. The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma. Toxicol Sci 128:461-70.
25. Thielbeer F, Chankeshwara SV, Bradley M. 2011a. Polymerizable fluorescein derivatives: synthesis of fluorescent particles and their cellular uptake. Biomacromolecules 12:4386-91.
26. Thielbeer F, Donaldson K, Bradley M. 2011b. Zeta potential mediated reaction monitoring on nano and microparticles. Bioconjug Chem 22: 144-50.
27. Wallace WE, Keane MJ, Mike PS, Hill CA, Vallyathan V, Regad ED. 1992. Contrasting respirable quartz and kaolin retention of lecithin surfactant and expression of membranolytic activity following phospholipase A2 digestion. J Toxicol Environ Health 37: 391-409.
28. Wang F, Bexiga MG, Anguissola S, Boya P, Simpson JC, Salvati A, et al. 2013a. Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles. Nanoscale 5:10868-76.
29. Wang F, Yu L, Monopoli MP, Sandin P, Mahon E, Salvati A, et al. 2013b. The biomolecular corona is retained during nanoparticle uptake and protects the cells from the damage induced by cationic nanoparticles until degraded in the lysosomes. Nanomedicine 9:1159-68.
30. Zhang H, Ji Z, Xia T, Meng H, Low-Kam C, Liu R, et al. 2012. Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano 6: 4349-68.
31. Zhao J, Castranova V. 2011. Toxicology of nanomaterials used in nanomedicine. J Toxicol Environ Health B Crit Rev 14: 593-632.
32. Zhu M, Nie G, Meng H, Xia T, Nel A, Zhao Y. 2013. Physicochemical properties determine nanomaterial cellular uptake, transport, and fate. Acc Chem Res 46:622-31.