The biomolecular corona is retained during nanoparticle uptake and protects the cells from the damage induced by cationic nanoparticles until degraded in the lysosomes

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 9, Issue 8, 2013, Pages 1159-1168

  Wang, Fengjuan ^a,b   Yu, Lu ^a   Monopoli, Marco P ^a   Sandin, Peter ^a   Mahon, Eugene ^a   Salvati, Anna ^a   Dawson, Kenneth A ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

Amino modified polystyrene; Corona; Lysosomal membrane permeabilization

Indexed keywords

AMINO MODIFIED POLYSTYRENE; BIOLOGICAL MEDIA; CATIONIC NANOPARTICLES; CELLULAR MACHINERY; CORONA; LYSOSOMAL MEMBRANES; NANOPARTICLE SURFACE; NANOPARTICLE UPTAKES;

CELL DEATH; MACHINERY; MOLECULAR BIOLOGY; POLYSTYRENES; PROTEINS;

NANOPARTICLES;

CELL PROTEIN; CORONA PROTEIN; NANOPARTICLE; POLYSTYRENE; UNCLASSIFIED DRUG;

ADSORPTION; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL INTERACTION; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; CELL PROTECTION; CONTROLLED STUDY; ENZYME KINETICS; HUMAN; HUMAN CELL; LYSOSOME; LYSOSOME MEMBRANE; PHYSICAL CHEMISTRY; PROTEIN DEGRADATION; SURFACE PROPERTY;

AMINO MODIFIED POLYSTYRENE; AMINO MODIFIED POLYSTYRENE FROM BANGS LAB; AMINO MODIFIED POLYSTYRENE FROM BANGS LAB FLUORESCENTLY LABELLED WITH ALEXA 488 DYE; AMINO MODIFIED POLYSTYRENE FROM SIGMA; CDMEM; COMPLETE DMEM; CORONA; CTRL; DMEM; DULBECCO'S MODIFIED EAGLE'S MEDIUM; GAPDH; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE; LAMP-1; LYSOSOMAL ASSOCIATED MEMBRANE PROTEIN-1; LYSOSOMAL MEMBRANE PERMEABILIZATION; NANOPARTICLES; NPS; PBS; PHOSPHATE BUFFERED SALINE; PI; PROPIDIUM IODIDE; PS-N(CH(3))(3)(+); PS-NH(2)-B; PS-NH(2)-F; PS-NH(2)-S; QUATERNARY AMINO MODIFIED POLYSTYRENE; SDS-PAGE; SERUM FREE DMEM; SFDMEM; SODIUM DODECYL SULFATE POLYACRYLAMIDE GEL ELECTROPHORESIS; UNTREATED CONTROL;

ADSORPTION; BLOOD PROTEINS; CATIONS; CELL DEATH; CELL LINE, TUMOR; HUMANS; LYSOSOMES; NANOPARTICLES; PEPTIDE HYDROLASES; PERMEABILITY; PROTEOLYSIS; SURFACE PROPERTIES;

EID: 84886447813     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2013.04.010     Document Type: Article

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