7-Chloro-5-(furan-3-yl)-3-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-Dioxide as Positive Allosteric Modulator of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor. The End of the Unsaturated-Inactive Paradigm?

ACS Chemical Neuroscience

Volumn 7, Issue 2, 2016, Pages 150-160

  Citti, Cinzia ^a   Battisti, Umberto M ^b,c   Cannazza, Giuseppe ^a,b   Jozwiak, Krzysztof ^d   Stasiak, Natalia ^b   Puja, Giulia ^b   Ravazzini, Federica ^b   Ciccarella, Giuseppe ^a   Braghiroli, Daniela ^b   Parenti, Carlo ^b   Troisi, Luigino ^a   Zoli, Michele ^b  

^a UNIVERSITY OF SALENTO   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

AMPA receptor; benzothiadiazines; central nervous system; hepatic metabolism; microdialysis; neurotransmitters

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 7 CHLORO 5 (FURAN 3 YL) 3 METHYL 4H BENZO[E][1,2,4]THIADIAZINE 1,1 DIOXIDE; ACETYLCHOLINE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; CYTOCHROME P450 2B6; CYTOCHROME P450 2D6; DOPAMINE; SEROTONIN; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG; 7-CHLORO-5-(FURAN-3-YL)-3-METHYL-4H-BENZO(E)(1,2,4)THIADIAZINE 1,1-DIOXIDE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; FURAN DERIVATIVE;

ACETYLCHOLINE BRAIN LEVEL; ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; BLOOD BRAIN BARRIER; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DOPAMINE BRAIN LEVEL; DRUG METABOLISM; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; HYDROGEN BOND; IN VITRO STUDY; LIGAND BINDING; LIVER METABOLISM; LIVER MICROSOME; MICRODIALYSIS; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; RACEMIZATION; RAT; SEROTONIN BRAIN LEVEL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY; ACTION POTENTIAL; ANIMAL; CELL CULTURE; CEREBELLUM; CHEMISTRY; CORPUS STRIATUM; CYTOLOGY; DRUG EFFECTS; METABOLISM; NERVE CELL; NEWBORN; SPRAGUE DAWLEY RAT; STEREOISOMERISM;

ACTION POTENTIALS; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CEREBELLUM; CORPUS STRIATUM; EXCITATORY AMINO ACID AGONISTS; FURANS; MICE; MICRODIALYSIS; MODELS, MOLECULAR; NEURONS; NEUROTRANSMITTER AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; THIADIAZINES;

EID: 84959335491     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00257     Document Type: Article

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