Molecular modeling studies, synthesis, configurational stability and biological activity of 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3- de]-1,2,4-benzothiadiazine 1,1-dioxide

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7111-7119

  Battisti, Umberto M ^a   Carrozzo, Marina M ^b   Cannazza, Giuseppe ^a   Puia, Giulia ^a   Troisi, Luigino ^b   Braghiroli, Daniela ^a   Parenti, Carlo ^a   Jozwiak, Krzysztof ^c  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF SALENTO   (Italy)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

AMPA receptor; Benzothiadiazines; Positive modulators

Indexed keywords

8 CHLORO 2,3,5,6 TETRAHYDRO 3,6 DIMETHYL PYRROLO[1,2,3 DE] 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; AMPA RECEPTOR AGONIST; BENZOTHIADIAZINE DERIVATIVE; KAINIC ACID; SOLVENT; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; BRAIN NERVE CELL; COMPUTER ANALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG MECHANISM; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; EPIMERIZATION; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR STABILITY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEWBORN; NONHUMAN; PATCH CLAMP; RAT; REACTION ANALYSIS; RECEPTOR UPREGULATION; STEREOCHEMISTRY; STEREOISOMERISM; WHOLE CELL;

ANIMALS; BENZOTHIADIAZINES; CELLS, CULTURED; DRUG STABILITY; HUMANS; MODELS, MOLECULAR; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80655136977     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.063     Document Type: Article

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