Development of an in vitro liquid chromatography-mass spectrometry method to evaluate stereo and chemical stability of new drug candidates employing immobilized artificial membrane column

Journal of Chromatography A

Volumn 1363, Issue , 2014, Pages 216-225

  Cannazza, Giuseppe ^a   Battisti, Umberto M ^a   Carrozzo, Marina M ^b   Cazzato, Addolorata S ^a   Braghiroli, Daniela ^a   Parenti, Carlo ^a   Troisi, Luigino ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF SALENTO   (Italy)

Author keywords

Benzothiadiazines; Chiral OD column; Hydrolysis; IAM column; Racemization

Indexed keywords

BIOLOGICAL MEMBRANES; COLUMN CHROMATOGRAPHY; CYTOLOGY; DRUG PRODUCTS; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHOSPHOLIPIDS; STEREOCHEMISTRY;

BENZOTHIADIAZINES; CONFIGURATIONAL STABILITY; IMMOBILIZED ARTIFICIAL MEMBRANES; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; NEW CHEMICAL ENTITIES; PHARMACEUTICAL COMPOUNDS; RACEMIZATION; SINGLE ENANTIOMERS;

CHEMICAL STABILITY;

5 ARYLBENZOTHIADIAZINE DERIVATIVE; BENZOTHIADIAZINE DERIVATIVE; NEW DRUG; PHOSPHOLIPID; UNCLASSIFIED DRUG; ARTIFICIAL MEMBRANE; SOLVENT;

ARTICLE; ARTIFICIAL MEMBRANE; DRUG STABILITY; ENANTIOMER; HYDROLYSIS; IMMOBILIZED ARTIFICIAL MEMBRANE; INTESTINE FLUID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RACEMIZATION; STOMACH JUICE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; KINETICS; PROCEDURES; STEREOISOMERISM;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; HYDROLYSIS; IN VITRO TECHNIQUES; KINETICS; MASS SPECTROMETRY; MEMBRANES, ARTIFICIAL; PHOSPHOLIPIDS; SOLVENTS; STEREOISOMERISM;

EID: 84908114125     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.05.073     Document Type: Article

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