Design, stereoselective synthesis, configurational stability and biological activity of 7-chloro-9-(furan-3-yl)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1- c][1,2,4]thiadiazine 5,5-dioxide

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4667-4676

  Carrozzo, Marina Maria ^a   Battisti, Umberto Maria ^b   Cannazza, Giuseppe ^b   Puia, Giulia ^b   Ravazzini, Federica ^b   Falchicchio, Aurelia ^c   Perrone, Serena ^a   Citti, Cinzia ^a   Jozwiak, Krzysztof ^d   Braghiroli, Daniela ^b   Parenti, Carlo ^b   Troisi, Luigino ^a  

^a UNIVERSITY OF SALENTO   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c CNR   (Italy)

^d MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

AMPAr; Chiral benzothiadiazines; Cognitive enhancers; Enantiomerization; Stopped flow chromatography

Indexed keywords

7 CHLORO 2,3,3A,4 TETRAHYDRO 1H PYRROLO[2,1 C][1,2,4]BENZOTHIADIAZINE 5,5 DIOXIDE; 7 CHLORO 5 (2 FURANYL) 3 METHYL 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 7 CHLORO 9 (3 FURANYL) 2,3 DIHYDRO 1H BENZO[E]PYRROLO[2,1 C][1,2,4]THIADIAZINE 5,5 DIOXIDE; 7 CHLORO 9 (FURAN 3 YL) 2,3,3A,4 TETRAHYDRO 1H BENZO[E]PYRROLO[2,1 C][1,2,4]THIADIAZINE 5,5 DIOXIDE; 9 BROMO 7 CHLORO 2,3,3A,4 TETRAHYDRO 1 H BENZO[E]PYRROLO[2,1 C][1,2,4]THIADIAZINE 5,5 DIOXIDE; AMPA RECEPTOR; BENZOTHIADIAZINE DERIVATIVE; BIOLOGICAL PRODUCT; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; 7-CHLORO-9-(FURAN-3-YL)-2,3,3A,4-TETRAHYDRO-1H-BENZO(E)PYRROLO(2,1-C)(1,2,4)THIADIAZINE 5,5-DIOXIDE; SULFOXIDE;

ANIMAL CELL; ARTICLE; ASYMMETRIC SYNTHESIS; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STABILITY; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR MODEL; NONHUMAN; PATCH CLAMP TECHNIQUE; RACEMIC MIXTURE; RAT; STEREOCHEMISTRY; X RAY; ALLOSTERISM; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; BENZOTHIADIAZINES; CRYSTALLOGRAPHY, X-RAY; CYCLIC S-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, AMPA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906935319     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.017     Document Type: Article

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